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Q92213

- VPS34_CANAX

UniProt

Q92213 - VPS34_CANAX

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Protein

Phosphatidylinositol 3-kinase VPS34

Gene

VPS34

Organism
Candida albicans (Yeast)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Phosphatidylinositol 3-kinase homolog required for vacuolar sorting and segregation.

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.

GO - Molecular functioni

  1. 1-phosphatidylinositol-3-kinase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. phosphatidylinositol-mediated signaling Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.137. 1096.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 3-kinase VPS34 (EC:2.7.1.137)
Short name:
PI3-kinase VPS34
Short name:
PI3K VPS34
Short name:
PtdIns-3-kinase VPS34
Alternative name(s):
Vacuolar protein sorting-associated protein 34
Gene namesi
Name:VPS34
OrganismiCandida albicans (Yeast)
Taxonomic identifieri5476 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10201020Phosphatidylinositol 3-kinase VPS34PRO_0000088816Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ92213.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 210162C2 PI3K-typePROSITE-ProRule annotationAdd
BLAST
Domaini331 – 577247PIK helicalPROSITE-ProRule annotationAdd
BLAST
Domaini764 – 1018255PI3K/PI4KPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.PROSITE-ProRule annotation
Contains 1 C2 PI3K-type domain.PROSITE-ProRule annotation
Contains 1 PI3K/PI4K domain.PROSITE-ProRule annotation
Contains 1 PIK helical domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5032.

Family and domain databases

Gene3Di1.10.1070.11. 2 hits.
1.25.40.70. 2 hits.
2.60.40.150. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR002420. PI3K_C2_dom.
IPR008290. PI3K_Vps34.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
[Graphical view]
PANTHERiPTHR10048. PTHR10048. 1 hit.
PfamiPF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF00613. PI3Ka. 2 hits.
[Graphical view]
PIRSFiPIRSF000587. PI3K_Vps34. 1 hit.
SMARTiSM00142. PI3K_C2. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
SSF49562. SSF49562. 1 hit.
SSF56112. SSF56112. 2 hits.
PROSITEiPS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92213-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATLSQPQSA LPKTKIATTF GLSKDLKSPI SVKVCYLECT RNNVSLVPLS
60 70 80 90 100
TKFEDPTVFK KLSQIYKNSD LFVEIRVYDG KNNNLISTPV RTSYKAFNNK
110 120 130 140 150
GRTWNQQLKL NIDYNQISID AYLKFSICEI IDTKPSVFGV SYLSLFSHDS
160 170 180 190 200
STLRSGSHKI PVFMEDDPQY SKNIQYGTLI GLTDLEKRLI DYENGKYPRL
210 220 230 240 250
NWLDKMVLPK VDATFLKTNN KDHDYYLYIE LPQFEFPIVY SDIIYQIPTI
260 270 280 290 300
EPITETTSKI PPDDTLNSNI IINSIDIPMA TSHDPSIMKV YDPDFHITAN
310 320 330 340 350
NHLNPNATTF DPVELKYRKL ERNIDNNTIL DKELKPTPQL RDELLRIMIK
360 370 380 390 400
PSNAESTDNE KNLIWKFRYY FSKNNSGNDP SNKSVKSFLP KFLRSINWEN
410 420 430 440 450
DYELDHTFKE IIPFYWNVDK LQIGDALELL GDYFNPYTLG KPTYQDDSMT
460 470 480 490 500
SKSSKMKSDE KRFIKIYNNV CFLRKLAVER LKLANSEELL LYLLQLVQAL
510 520 530 540 550
KYEALIYEKS PPFCERSDQI EDNASSTLKS PLADFLIERA VENEKLGNFF
560 570 580 590 600
YWYVKVENED QLNNPHIDGP IKIYMDILNR YIELLKAHCH ENRLPYYKHL
610 620 630 640 650
KHQIWFIKKL TSLVELLRAS FKKNEATAKK VEYLREYLAN SGNELLKFPE
660 670 680 690 700
PFPLPLDPSV MICGCYPEES SVFKSSLAPL KITLKTIEKK KHGHATSQLF
710 720 730 740 750
GKRSRYGKYP LMFKIGDDLR QDQLVIQIID LMDQLLKNEN LDLKLTPYKI
760 770 780 790 800
LATSPISGLI QFVPNETLDS ILSKTYPTSV TYSGGGETSD GPPSVSNNGI
810 820 830 840 850
LNYLRLHSQE QQSEEPISKS ILSTNTSQSN TEIPVLPRQP KPTITSDLGV
860 870 880 890 900
SPILMDNYVK SCAGYCVITY ILGVGDRHLD NLLLSPNGKF WHADFGYILG
910 920 930 940 950
RDPKPFPPLM KLPIQVIDGM GGLHHENYNV FKSYCFITYT TLRKNSNLIL
960 970 980 990 1000
NLFQLMLDAN IPDIQFDPSR VIEKVQEKFC LQMTEEEAIL HFQNLINDSV
1010 1020
NAFLPVVIDR LHSLAQYWRA
Length:1,020
Mass (Da):117,401
Last modified:February 1, 1997 - v1
Checksum:iFF798F55AD2C8231
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y09043 Genomic DNA. Translation: CAA70254.1.
PIRiT18260.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y09043 Genomic DNA. Translation: CAA70254.1 .
PIRi T18260.

3D structure databases

ProteinModelPortali Q92213.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG5032.

Enzyme and pathway databases

BRENDAi 2.7.1.137. 1096.

Family and domain databases

Gene3Di 1.10.1070.11. 2 hits.
1.25.40.70. 2 hits.
2.60.40.150. 1 hit.
InterProi IPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR002420. PI3K_C2_dom.
IPR008290. PI3K_Vps34.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
[Graphical view ]
PANTHERi PTHR10048. PTHR10048. 1 hit.
Pfami PF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF00613. PI3Ka. 2 hits.
[Graphical view ]
PIRSFi PIRSF000587. PI3K_Vps34. 1 hit.
SMARTi SM00142. PI3K_C2. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 2 hits.
SSF49562. SSF49562. 1 hit.
SSF56112. SSF56112. 2 hits.
PROSITEi PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A phosphatidylinositol 3-kinase of Candida albicans: molecular cloning and characterization."
    Eck R., Bruckmann A., Wetzker R., Kunkel W.
    Yeast 16:933-944(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 3153A.

Entry informationi

Entry nameiVPS34_CANAX
AccessioniPrimary (citable) accession number: Q92213
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3