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Q92213

- VPS34_CANAX

UniProt

Q92213 - VPS34_CANAX

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Protein
Phosphatidylinositol 3-kinase VPS34
Gene
VPS34
Organism
Candida albicans (Yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Phosphatidylinositol 3-kinase homolog required for vacuolar sorting and segregation.

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.

GO - Molecular functioni

  1. 1-phosphatidylinositol-3-kinase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. phosphatidylinositol-mediated signaling Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.137. 1096.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 3-kinase VPS34 (EC:2.7.1.137)
Short name:
PI3-kinase VPS34
Short name:
PI3K VPS34
Short name:
PtdIns-3-kinase VPS34
Alternative name(s):
Vacuolar protein sorting-associated protein 34
Gene namesi
Name:VPS34
OrganismiCandida albicans (Yeast)
Taxonomic identifieri5476 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10201020Phosphatidylinositol 3-kinase VPS34
PRO_0000088816Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ92213.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 210162C2 PI3K-type
Add
BLAST
Domaini331 – 577247PIK helical
Add
BLAST
Domaini764 – 1018255PI3K/PI4K
Add
BLAST

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.
Contains 1 PI3K/PI4K domain.
Contains 1 PIK helical domain.

Phylogenomic databases

eggNOGiCOG5032.

Family and domain databases

Gene3Di1.10.1070.11. 2 hits.
1.25.40.70. 2 hits.
2.60.40.150. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR002420. PI3K_C2_dom.
IPR008290. PI3K_Vps34.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
[Graphical view]
PANTHERiPTHR10048. PTHR10048. 1 hit.
PfamiPF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF00613. PI3Ka. 2 hits.
[Graphical view]
PIRSFiPIRSF000587. PI3K_Vps34. 1 hit.
SMARTiSM00142. PI3K_C2. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
SSF49562. SSF49562. 1 hit.
SSF56112. SSF56112. 2 hits.
PROSITEiPS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92213-1 [UniParc]FASTAAdd to Basket

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MATLSQPQSA LPKTKIATTF GLSKDLKSPI SVKVCYLECT RNNVSLVPLS     50
TKFEDPTVFK KLSQIYKNSD LFVEIRVYDG KNNNLISTPV RTSYKAFNNK 100
GRTWNQQLKL NIDYNQISID AYLKFSICEI IDTKPSVFGV SYLSLFSHDS 150
STLRSGSHKI PVFMEDDPQY SKNIQYGTLI GLTDLEKRLI DYENGKYPRL 200
NWLDKMVLPK VDATFLKTNN KDHDYYLYIE LPQFEFPIVY SDIIYQIPTI 250
EPITETTSKI PPDDTLNSNI IINSIDIPMA TSHDPSIMKV YDPDFHITAN 300
NHLNPNATTF DPVELKYRKL ERNIDNNTIL DKELKPTPQL RDELLRIMIK 350
PSNAESTDNE KNLIWKFRYY FSKNNSGNDP SNKSVKSFLP KFLRSINWEN 400
DYELDHTFKE IIPFYWNVDK LQIGDALELL GDYFNPYTLG KPTYQDDSMT 450
SKSSKMKSDE KRFIKIYNNV CFLRKLAVER LKLANSEELL LYLLQLVQAL 500
KYEALIYEKS PPFCERSDQI EDNASSTLKS PLADFLIERA VENEKLGNFF 550
YWYVKVENED QLNNPHIDGP IKIYMDILNR YIELLKAHCH ENRLPYYKHL 600
KHQIWFIKKL TSLVELLRAS FKKNEATAKK VEYLREYLAN SGNELLKFPE 650
PFPLPLDPSV MICGCYPEES SVFKSSLAPL KITLKTIEKK KHGHATSQLF 700
GKRSRYGKYP LMFKIGDDLR QDQLVIQIID LMDQLLKNEN LDLKLTPYKI 750
LATSPISGLI QFVPNETLDS ILSKTYPTSV TYSGGGETSD GPPSVSNNGI 800
LNYLRLHSQE QQSEEPISKS ILSTNTSQSN TEIPVLPRQP KPTITSDLGV 850
SPILMDNYVK SCAGYCVITY ILGVGDRHLD NLLLSPNGKF WHADFGYILG 900
RDPKPFPPLM KLPIQVIDGM GGLHHENYNV FKSYCFITYT TLRKNSNLIL 950
NLFQLMLDAN IPDIQFDPSR VIEKVQEKFC LQMTEEEAIL HFQNLINDSV 1000
NAFLPVVIDR LHSLAQYWRA 1020
Length:1,020
Mass (Da):117,401
Last modified:February 1, 1997 - v1
Checksum:iFF798F55AD2C8231
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y09043 Genomic DNA. Translation: CAA70254.1.
PIRiT18260.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y09043 Genomic DNA. Translation: CAA70254.1 .
PIRi T18260.

3D structure databases

ProteinModelPortali Q92213.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG5032.

Enzyme and pathway databases

BRENDAi 2.7.1.137. 1096.

Family and domain databases

Gene3Di 1.10.1070.11. 2 hits.
1.25.40.70. 2 hits.
2.60.40.150. 1 hit.
InterProi IPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR002420. PI3K_C2_dom.
IPR008290. PI3K_Vps34.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
[Graphical view ]
PANTHERi PTHR10048. PTHR10048. 1 hit.
Pfami PF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF00613. PI3Ka. 2 hits.
[Graphical view ]
PIRSFi PIRSF000587. PI3K_Vps34. 1 hit.
SMARTi SM00142. PI3K_C2. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 2 hits.
SSF49562. SSF49562. 1 hit.
SSF56112. SSF56112. 2 hits.
PROSITEi PS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A phosphatidylinositol 3-kinase of Candida albicans: molecular cloning and characterization."
    Eck R., Bruckmann A., Wetzker R., Kunkel W.
    Yeast 16:933-944(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 3153A.

Entry informationi

Entry nameiVPS34_CANAX
AccessioniPrimary (citable) accession number: Q92213
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: April 16, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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