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Q92213

- VPS34_CANAX

UniProt

Q92213 - VPS34_CANAX

Protein

Phosphatidylinositol 3-kinase VPS34

Gene

VPS34

Organism
Candida albicans (Yeast)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Phosphatidylinositol 3-kinase homolog required for vacuolar sorting and segregation.

    Catalytic activityi

    ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.

    GO - Molecular functioni

    1. 1-phosphatidylinositol-3-kinase activity Source: UniProtKB-EC
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. phosphatidylinositol-mediated signaling Source: InterPro

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.1.137. 1096.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidylinositol 3-kinase VPS34 (EC:2.7.1.137)
    Short name:
    PI3-kinase VPS34
    Short name:
    PI3K VPS34
    Short name:
    PtdIns-3-kinase VPS34
    Alternative name(s):
    Vacuolar protein sorting-associated protein 34
    Gene namesi
    Name:VPS34
    OrganismiCandida albicans (Yeast)
    Taxonomic identifieri5476 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10201020Phosphatidylinositol 3-kinase VPS34PRO_0000088816Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ92213.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini49 – 210162C2 PI3K-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini331 – 577247PIK helicalPROSITE-ProRule annotationAdd
    BLAST
    Domaini764 – 1018255PI3K/PI4KPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PI3/PI4-kinase family.PROSITE-ProRule annotation
    Contains 1 C2 PI3K-type domain.PROSITE-ProRule annotation
    Contains 1 PI3K/PI4K domain.PROSITE-ProRule annotation
    Contains 1 PIK helical domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5032.

    Family and domain databases

    Gene3Di1.10.1070.11. 2 hits.
    1.25.40.70. 2 hits.
    2.60.40.150. 1 hit.
    InterProiIPR016024. ARM-type_fold.
    IPR000008. C2_dom.
    IPR011009. Kinase-like_dom.
    IPR000403. PI3/4_kinase_cat_dom.
    IPR018936. PI3/4_kinase_CS.
    IPR002420. PI3K_C2_dom.
    IPR008290. PI3K_Vps34.
    IPR015433. PI_Kinase.
    IPR001263. PInositide-3_kin_accessory_dom.
    [Graphical view]
    PANTHERiPTHR10048. PTHR10048. 1 hit.
    PfamiPF00454. PI3_PI4_kinase. 1 hit.
    PF00792. PI3K_C2. 1 hit.
    PF00613. PI3Ka. 2 hits.
    [Graphical view]
    PIRSFiPIRSF000587. PI3K_Vps34. 1 hit.
    SMARTiSM00142. PI3K_C2. 1 hit.
    SM00145. PI3Ka. 1 hit.
    SM00146. PI3Kc. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 2 hits.
    SSF49562. SSF49562. 1 hit.
    SSF56112. SSF56112. 2 hits.
    PROSITEiPS00915. PI3_4_KINASE_1. 1 hit.
    PS00916. PI3_4_KINASE_2. 1 hit.
    PS50290. PI3_4_KINASE_3. 1 hit.
    PS51547. PI3K_C2. 1 hit.
    PS51545. PIK_HELICAL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92213-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATLSQPQSA LPKTKIATTF GLSKDLKSPI SVKVCYLECT RNNVSLVPLS     50
    TKFEDPTVFK KLSQIYKNSD LFVEIRVYDG KNNNLISTPV RTSYKAFNNK 100
    GRTWNQQLKL NIDYNQISID AYLKFSICEI IDTKPSVFGV SYLSLFSHDS 150
    STLRSGSHKI PVFMEDDPQY SKNIQYGTLI GLTDLEKRLI DYENGKYPRL 200
    NWLDKMVLPK VDATFLKTNN KDHDYYLYIE LPQFEFPIVY SDIIYQIPTI 250
    EPITETTSKI PPDDTLNSNI IINSIDIPMA TSHDPSIMKV YDPDFHITAN 300
    NHLNPNATTF DPVELKYRKL ERNIDNNTIL DKELKPTPQL RDELLRIMIK 350
    PSNAESTDNE KNLIWKFRYY FSKNNSGNDP SNKSVKSFLP KFLRSINWEN 400
    DYELDHTFKE IIPFYWNVDK LQIGDALELL GDYFNPYTLG KPTYQDDSMT 450
    SKSSKMKSDE KRFIKIYNNV CFLRKLAVER LKLANSEELL LYLLQLVQAL 500
    KYEALIYEKS PPFCERSDQI EDNASSTLKS PLADFLIERA VENEKLGNFF 550
    YWYVKVENED QLNNPHIDGP IKIYMDILNR YIELLKAHCH ENRLPYYKHL 600
    KHQIWFIKKL TSLVELLRAS FKKNEATAKK VEYLREYLAN SGNELLKFPE 650
    PFPLPLDPSV MICGCYPEES SVFKSSLAPL KITLKTIEKK KHGHATSQLF 700
    GKRSRYGKYP LMFKIGDDLR QDQLVIQIID LMDQLLKNEN LDLKLTPYKI 750
    LATSPISGLI QFVPNETLDS ILSKTYPTSV TYSGGGETSD GPPSVSNNGI 800
    LNYLRLHSQE QQSEEPISKS ILSTNTSQSN TEIPVLPRQP KPTITSDLGV 850
    SPILMDNYVK SCAGYCVITY ILGVGDRHLD NLLLSPNGKF WHADFGYILG 900
    RDPKPFPPLM KLPIQVIDGM GGLHHENYNV FKSYCFITYT TLRKNSNLIL 950
    NLFQLMLDAN IPDIQFDPSR VIEKVQEKFC LQMTEEEAIL HFQNLINDSV 1000
    NAFLPVVIDR LHSLAQYWRA 1020
    Length:1,020
    Mass (Da):117,401
    Last modified:February 1, 1997 - v1
    Checksum:iFF798F55AD2C8231
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y09043 Genomic DNA. Translation: CAA70254.1.
    PIRiT18260.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y09043 Genomic DNA. Translation: CAA70254.1 .
    PIRi T18260.

    3D structure databases

    ProteinModelPortali Q92213.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG5032.

    Enzyme and pathway databases

    BRENDAi 2.7.1.137. 1096.

    Family and domain databases

    Gene3Di 1.10.1070.11. 2 hits.
    1.25.40.70. 2 hits.
    2.60.40.150. 1 hit.
    InterProi IPR016024. ARM-type_fold.
    IPR000008. C2_dom.
    IPR011009. Kinase-like_dom.
    IPR000403. PI3/4_kinase_cat_dom.
    IPR018936. PI3/4_kinase_CS.
    IPR002420. PI3K_C2_dom.
    IPR008290. PI3K_Vps34.
    IPR015433. PI_Kinase.
    IPR001263. PInositide-3_kin_accessory_dom.
    [Graphical view ]
    PANTHERi PTHR10048. PTHR10048. 1 hit.
    Pfami PF00454. PI3_PI4_kinase. 1 hit.
    PF00792. PI3K_C2. 1 hit.
    PF00613. PI3Ka. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF000587. PI3K_Vps34. 1 hit.
    SMARTi SM00142. PI3K_C2. 1 hit.
    SM00145. PI3Ka. 1 hit.
    SM00146. PI3Kc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 2 hits.
    SSF49562. SSF49562. 1 hit.
    SSF56112. SSF56112. 2 hits.
    PROSITEi PS00915. PI3_4_KINASE_1. 1 hit.
    PS00916. PI3_4_KINASE_2. 1 hit.
    PS50290. PI3_4_KINASE_3. 1 hit.
    PS51547. PI3K_C2. 1 hit.
    PS51545. PIK_HELICAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A phosphatidylinositol 3-kinase of Candida albicans: molecular cloning and characterization."
      Eck R., Bruckmann A., Wetzker R., Kunkel W.
      Yeast 16:933-944(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 3153A.

    Entry informationi

    Entry nameiVPS34_CANAX
    AccessioniPrimary (citable) accession number: Q92213
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3