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Q92213 (VPS34_CANAX) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphatidylinositol 3-kinase VPS34

Short name=PI3-kinase VPS34
Short name=PI3K VPS34
Short name=PtdIns-3-kinase VPS34
EC=2.7.1.137
Alternative name(s):
Vacuolar protein sorting-associated protein 34
Gene names
Name:VPS34
OrganismCandida albicans (Yeast)
Taxonomic identifier5476 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length1020 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Phosphatidylinositol 3-kinase homolog required for vacuolar sorting and segregation.

Catalytic activity

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.

Sequence similarities

Belongs to the PI3/PI4-kinase family.

Contains 1 C2 PI3K-type domain.

Contains 1 PI3K/PI4K domain.

Contains 1 PIK helical domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10201020Phosphatidylinositol 3-kinase VPS34
PRO_0000088816

Regions

Domain49 – 210162C2 PI3K-type
Domain331 – 577247PIK helical
Domain764 – 1018255PI3K/PI4K

Sequences

Sequence LengthMass (Da)Tools
Q92213 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: FF798F55AD2C8231

FASTA1,020117,401
        10         20         30         40         50         60 
MATLSQPQSA LPKTKIATTF GLSKDLKSPI SVKVCYLECT RNNVSLVPLS TKFEDPTVFK 

        70         80         90        100        110        120 
KLSQIYKNSD LFVEIRVYDG KNNNLISTPV RTSYKAFNNK GRTWNQQLKL NIDYNQISID 

       130        140        150        160        170        180 
AYLKFSICEI IDTKPSVFGV SYLSLFSHDS STLRSGSHKI PVFMEDDPQY SKNIQYGTLI 

       190        200        210        220        230        240 
GLTDLEKRLI DYENGKYPRL NWLDKMVLPK VDATFLKTNN KDHDYYLYIE LPQFEFPIVY 

       250        260        270        280        290        300 
SDIIYQIPTI EPITETTSKI PPDDTLNSNI IINSIDIPMA TSHDPSIMKV YDPDFHITAN 

       310        320        330        340        350        360 
NHLNPNATTF DPVELKYRKL ERNIDNNTIL DKELKPTPQL RDELLRIMIK PSNAESTDNE 

       370        380        390        400        410        420 
KNLIWKFRYY FSKNNSGNDP SNKSVKSFLP KFLRSINWEN DYELDHTFKE IIPFYWNVDK 

       430        440        450        460        470        480 
LQIGDALELL GDYFNPYTLG KPTYQDDSMT SKSSKMKSDE KRFIKIYNNV CFLRKLAVER 

       490        500        510        520        530        540 
LKLANSEELL LYLLQLVQAL KYEALIYEKS PPFCERSDQI EDNASSTLKS PLADFLIERA 

       550        560        570        580        590        600 
VENEKLGNFF YWYVKVENED QLNNPHIDGP IKIYMDILNR YIELLKAHCH ENRLPYYKHL 

       610        620        630        640        650        660 
KHQIWFIKKL TSLVELLRAS FKKNEATAKK VEYLREYLAN SGNELLKFPE PFPLPLDPSV 

       670        680        690        700        710        720 
MICGCYPEES SVFKSSLAPL KITLKTIEKK KHGHATSQLF GKRSRYGKYP LMFKIGDDLR 

       730        740        750        760        770        780 
QDQLVIQIID LMDQLLKNEN LDLKLTPYKI LATSPISGLI QFVPNETLDS ILSKTYPTSV 

       790        800        810        820        830        840 
TYSGGGETSD GPPSVSNNGI LNYLRLHSQE QQSEEPISKS ILSTNTSQSN TEIPVLPRQP 

       850        860        870        880        890        900 
KPTITSDLGV SPILMDNYVK SCAGYCVITY ILGVGDRHLD NLLLSPNGKF WHADFGYILG 

       910        920        930        940        950        960 
RDPKPFPPLM KLPIQVIDGM GGLHHENYNV FKSYCFITYT TLRKNSNLIL NLFQLMLDAN 

       970        980        990       1000       1010       1020 
IPDIQFDPSR VIEKVQEKFC LQMTEEEAIL HFQNLINDSV NAFLPVVIDR LHSLAQYWRA 

« Hide

References

[1]"A phosphatidylinositol 3-kinase of Candida albicans: molecular cloning and characterization."
Eck R., Bruckmann A., Wetzker R., Kunkel W.
Yeast 16:933-944(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 3153A.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y09043 Genomic DNA. Translation: CAA70254.1.
PIRT18260.

3D structure databases

ProteinModelPortalQ92213.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG5032.

Enzyme and pathway databases

BRENDA2.7.1.137. 1096.

Family and domain databases

Gene3D1.10.1070.11. 2 hits.
1.25.40.70. 2 hits.
2.60.40.150. 1 hit.
InterProIPR016024. ARM-type_fold.
IPR000008. C2_dom.
IPR011009. Kinase-like_dom.
IPR000403. PI3/4_kinase_cat_dom.
IPR018936. PI3/4_kinase_CS.
IPR002420. PI3K_C2_dom.
IPR008290. PI3K_Vps34.
IPR015433. PI_Kinase.
IPR001263. PInositide-3_kin_accessory_dom.
[Graphical view]
PANTHERPTHR10048. PTHR10048. 1 hit.
PfamPF00454. PI3_PI4_kinase. 1 hit.
PF00792. PI3K_C2. 1 hit.
PF00613. PI3Ka. 2 hits.
[Graphical view]
PIRSFPIRSF000587. PI3K_Vps34. 1 hit.
SMARTSM00142. PI3K_C2. 1 hit.
SM00145. PI3Ka. 1 hit.
SM00146. PI3Kc. 1 hit.
[Graphical view]
SUPFAMSSF48371. SSF48371. 2 hits.
SSF49562. SSF49562. 1 hit.
SSF56112. SSF56112. 2 hits.
PROSITEPS00915. PI3_4_KINASE_1. 1 hit.
PS00916. PI3_4_KINASE_2. 1 hit.
PS50290. PI3_4_KINASE_3. 1 hit.
PS51547. PI3K_C2. 1 hit.
PS51545. PIK_HELICAL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameVPS34_CANAX
AccessionPrimary (citable) accession number: Q92213
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: April 16, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families