Reviewed, UniProtKB/Swiss-Prot Q92210 (PUR6_CANAL)

Names and origin

Protein names

Recommended name:
    Phosphoribosylaminoimidazole carboxylase
    EC=4.1.1.21
Alternative name(s):
    AIR carboxylase
      Short name=AIRC

Gene names

Name:

ADE2

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	568 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2.
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.
Sequence similarities	In the C-terminal section; belongs to the AIR carboxylase family. Contains 1 ATP-grasp domain.

Ontologies

Keywords
Biological process	Purine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Decarboxylase Lyase
Gene Ontology (GO)
Biological process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylaminoimidazole carboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 568	568	Phosphoribosylaminoimidazole carboxylase		PRO_0000075021
Regions
	Domain	110 – 298	189	ATP-grasp
	Nucleotide binding	138 – 193	56	ATP By similarity
Experimental info
	Sequence conflict	219	1	W → C in AAC49742. Ref.2
	Sequence conflict	248	1	P → L in AAC49742. Ref.2
	Sequence conflict	332	1	S → L in AAC49742. Ref.2
	Sequence conflict	352	1	A → T in AAC49742. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q92210-1 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: B6A57EE6BCB2EA16	FASTA	568	62,410
	10 20 30 40 50 60 MDSKTVGILG GGQLGRMIVE AAHRLNIKTV ILDAAKSPAK QINALDDHVD GSFTNYDSIV 70 80 90 100 110 120 KLAEKADVLT VEIEHVDVDA LIKVQEKFPK VEIYPLPETI RLIQDKYLQK NHLIKHDVAV 130 140 150 160 170 180 TESVAVETNT VDDLLHIGEK FGYPYMLKSR TLAYDGRGNF VVKDKSYCEK ALEFLKDRPL 190 200 210 220 230 240 YAEKWCPFTK ELAVMVVRSL EGEVFAYPTV ETIHENNIWH LVYAPARIPD TLGQKASILA 250 260 270 280 290 300 KNAVKSFPGC GIFGVEMFLL ENNELLINEI APRPHNSGHY TIDACVTSQF EAHVRAVTGL 310 320 330 340 350 360 PMPKGFTEFS TSITNAIMLN VLGDKATPNK ESEICRRALE TPHASVYLYG KATRPERKMG 370 380 390 400 410 420 HINVVTSSMQ DAESRLSYIL GDTTEIPKSL ATDKESPLVG IIMGSDSDLP VMAVGARILK 430 440 450 460 470 480 QFGVPFELTI VSAHRTPHRM SEYAIEAPKR GLKCIIAGAG GAAHLPGMVA AMTPLPVIGV 490 500 510 520 530 540 PVKGSTLDGV DSLHSIVQMP RGIPVATVAI NNSTNAALLA IRILGAYDSK WLTEMNQYML 550 560 NMETEVLGKA ETLEEIGYED YLTDKLKK

References

[1]	"Sequence analysis of the Candida albicans ADE2 gene and physical separation of the two functionally distinct domains of the phosphoribosylaminoimidazole carboxylase." Schmuke J.J., Davisson V.J., Bonar S.L., Gheesling-Mullis K., Dotson S.B. Yeast 13:769-776(1997) [PubMed: 9219341] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 32354 / B311.
[2]	"Sequence analysis of Candida albicans phosphoribosyl-aminoimidazole carboxylase (ADE2) gene." Tsang W.K.P., Cao B.-Y., Wang J. Yeast 13:673-676(1997) [PubMed: 9200816] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: SC5314.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U69606 Genomic DNA. Translation: AAC49755.1. U75582 Genomic DNA. Translation: AAC49742.1.
3D structure databases
SMR	Q92210. Positions 2-377, 397-565.
ModBase	Search...
Enzyme and pathway databases
BRENDA	4.1.1.21. 1124.
Family and domain databases
InterPro	IPR016301. AIR_COase. IPR005875. AIR_COase_ATPase-su. IPR000031. AIR_COase_core. IPR011761. ATP-grasp. IPR003135. ATP-grasp_carboxylate-amine. IPR013816. ATP_grasp_subdomain_2. IPR013817. Pre-ATP_grasp. IPR016185. PreATP-grasp-like. IPR011054. Rudment_hybrid_motif. [Graphical view]
Gene3D	G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit. G3DSA:3.40.50.20. Pre-ATP_grasp. 1 hit.
PANTHER	PTHR23047:SF1. PurK_ATP. 1 hit.
Pfam	PF00731. AIRC. 1 hit. PF02222. ATP-grasp. 1 hit. [Graphical view]
PIRSF	PIRSF001340. AIR_carboxylase. 1 hit.
TIGRFAMs	TIGR01162. purE. 1 hit. TIGR01161. purK. 1 hit.
PROSITE	PS50975. ATP_GRASP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PUR6_CANAL

Accession

Primary (citable) accession number: Q92210
Secondary accession number(s): P78597

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	February 9, 2010
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)