Q92209 (KHSE_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homoserine kinase
Short name=HK
Short name=HSK
EC=2.7.1.39

Gene names

Name:	THR1
ORF Names:	CaO19.923

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	357 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate By similarity.
Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine.
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the GHMP kinase family. Homoserine kinase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 357	357	Homoserine kinase		PRO_0000156654
Regions
	Nucleotide binding	99 – 109	11	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q92209 [UniParc]. Last modified May 5, 2009. Version 2. Checksum: 40DA798DCF83DBC8	FASTA	357	39,129
	10 20 30 40 50 60 MSVTSFKIKV PASSANIGPG FDVLGIGLQL YLTITVTIDP SIDTSSDPHH ALLSYEGDGK 70 80 90 100 110 120 VPFESNENLI TQTALYVMRC NGIKDFPRGT HIHVNNPIPL GRGLGSSASA IVAGVYLGNE 130 140 150 160 170 180 IGNLKLDKYR LLDYCLMIER HPDNIAAAML GGFIGSYLNE LSSEDSQLIT VPLDYILPKV 190 200 210 220 230 240 KNGELITPQN KIVSQQPPNN IGQYVEYKWN KKIKCLTIIP NFELSTDLSR SVLPKNYQLP 250 260 270 280 290 300 DIVYNLQRIA ILTTALTQDP PNHKVIYQSM KDKLHQPYRF GLIPGLNTVL QKITPESYPG 310 320 330 340 350 LCGICLSGAG PTILCLATDG FEKIANDVIE IFKQEGIECD SKLLDLAYDG ATVEYGS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.
[2]	White T.C. Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-147. Strain: SS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AACQ01000063 Genomic DNA. Translation: EAK97775.1. U67193 Genomic DNA. Translation: AAB08101.1.
RefSeq	XP_716762.1. XM_711669.1.
3D structure databases
ProteinModelPortal	Q92209.
ModBase	Search...
Protein-protein interaction databases
STRING	5476.CAL0003628.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3641572.
KEGG	cal:CaO19.923.
Organism-specific databases
CGD	CAL0003628. THR1.
Phylogenomic databases
eggNOG	COG0083.
KO	K00872.
Enzyme and pathway databases
UniPathway	UPA00050; UER00064.
Family and domain databases
Gene3D	3.30.230.10. 1 hit.
InterPro	IPR006204. GHMP_kinase_N_dom. IPR006203. GHMP_knse_ATP-bd_CS. IPR000870. Homoserine_kinase. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. [Graphical view]
Pfam	PF00288. GHMP_kinases_N. 1 hit. [Graphical view]
PIRSF	PIRSF000676. Homoser_kin. 1 hit.
PRINTS	PR00958. HOMSERKINASE.
SUPFAM	SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMs	TIGR00191. thrB. 1 hit.
PROSITE	PS00627. GHMP_KINASES_ATP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KHSE_CANAL

Accession

Primary (citable) accession number: Q92209
Secondary accession number(s): Q5A523

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	May 5, 2009
Last modified:	April 3, 2013
This is version 78 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program