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Q92209

- KHSE_CANAL

UniProt

Q92209 - KHSE_CANAL

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Protein

Homoserine kinase

Gene

THR1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.By similarity

Catalytic activityi

ATP + L-homoserine = ADP + O-phospho-L-homoserine.

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi99 – 10911ATPSequence AnalysisAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. homoserine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. threonine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Threonine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00050; UER00064.

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine kinase (EC:2.7.1.39)
Short name:
HK
Short name:
HSK
Gene namesi
Name:THR1
ORF Names:CaO19.923
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0003628. THR1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 357357Homoserine kinasePRO_0000156654Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi1224666. 1 interaction.
STRINGi5476.CAL0003628.

Structurei

3D structure databases

ProteinModelPortaliQ92209.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0083.
InParanoidiQ92209.
KOiK00872.
OrthoDBiEOG7Q8CXX.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
HAMAPiMF_00384. Homoser_kinase.
InterProiIPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR000870. Homoserine_kinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PfamiPF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000676. Homoser_kin. 1 hit.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsiTIGR00191. thrB. 1 hit.
PROSITEiPS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92209-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSVTSFKIKV PASSANIGPG FDVLGIGLQL YLTITVTIDP SIDTSSDPHH
60 70 80 90 100
ALLSYEGDGK VPFESNENLI TQTALYVMRC NGIKDFPRGT HIHVNNPIPL
110 120 130 140 150
GRGLGSSASA IVAGVYLGNE IGNLKLDKYR LLDYCLMIER HPDNIAAAML
160 170 180 190 200
GGFIGSYLNE LSSEDSQLIT VPLDYILPKV KNGELITPQN KIVSQQPPNN
210 220 230 240 250
IGQYVEYKWN KKIKCLTIIP NFELSTDLSR SVLPKNYQLP DIVYNLQRIA
260 270 280 290 300
ILTTALTQDP PNHKVIYQSM KDKLHQPYRF GLIPGLNTVL QKITPESYPG
310 320 330 340 350
LCGICLSGAG PTILCLATDG FEKIANDVIE IFKQEGIECD SKLLDLAYDG

ATVEYGS
Length:357
Mass (Da):39,129
Last modified:May 5, 2009 - v2
Checksum:i40DA798DCF83DBC8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000063 Genomic DNA. Translation: EAK97775.1.
U67193 Genomic DNA. Translation: AAB08101.1.
RefSeqiXP_716762.1. XM_711669.1.

Genome annotation databases

GeneIDi3641572.
KEGGical:CaO19.923.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AACQ01000063 Genomic DNA. Translation: EAK97775.1 .
U67193 Genomic DNA. Translation: AAB08101.1 .
RefSeqi XP_716762.1. XM_711669.1.

3D structure databases

ProteinModelPortali Q92209.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 1224666. 1 interaction.
STRINGi 5476.CAL0003628.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3641572.
KEGGi cal:CaO19.923.

Organism-specific databases

CGDi CAL0003628. THR1.

Phylogenomic databases

eggNOGi COG0083.
InParanoidi Q92209.
KOi K00872.
OrthoDBi EOG7Q8CXX.

Enzyme and pathway databases

UniPathwayi UPA00050 ; UER00064 .

Family and domain databases

Gene3Di 3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
HAMAPi MF_00384. Homoser_kinase.
InterProi IPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR000870. Homoserine_kinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view ]
Pfami PF00288. GHMP_kinases_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000676. Homoser_kin. 1 hit.
SUPFAMi SSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsi TIGR00191. thrB. 1 hit.
PROSITEi PS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.
  2. White T.C.
    Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-147.
    Strain: SS.

Entry informationi

Entry nameiKHSE_CANAL
AccessioniPrimary (citable) accession number: Q92209
Secondary accession number(s): Q5A523
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 5, 2009
Last modified: October 29, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3