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Q92209 (KHSE_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homoserine kinase

Short name=HK
Short name=HSK
EC=2.7.1.39
Gene names
Name:THR1
ORF Names:CaO19.923
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length357 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate By similarity. HAMAP-Rule MF_00384

Catalytic activity

ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP-Rule MF_00384

Pathway

Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP-Rule MF_00384

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00384

Sequence similarities

Belongs to the GHMP kinase family. Homoserine kinase subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Threonine biosynthesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processthreonine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

homoserine kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 357357Homoserine kinase HAMAP-Rule MF_00384
PRO_0000156654

Regions

Nucleotide binding99 – 10911ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q92209 [UniParc].

Last modified May 5, 2009. Version 2.
Checksum: 40DA798DCF83DBC8

FASTA35739,129
        10         20         30         40         50         60 
MSVTSFKIKV PASSANIGPG FDVLGIGLQL YLTITVTIDP SIDTSSDPHH ALLSYEGDGK 

        70         80         90        100        110        120 
VPFESNENLI TQTALYVMRC NGIKDFPRGT HIHVNNPIPL GRGLGSSASA IVAGVYLGNE 

       130        140        150        160        170        180 
IGNLKLDKYR LLDYCLMIER HPDNIAAAML GGFIGSYLNE LSSEDSQLIT VPLDYILPKV 

       190        200        210        220        230        240 
KNGELITPQN KIVSQQPPNN IGQYVEYKWN KKIKCLTIIP NFELSTDLSR SVLPKNYQLP 

       250        260        270        280        290        300 
DIVYNLQRIA ILTTALTQDP PNHKVIYQSM KDKLHQPYRF GLIPGLNTVL QKITPESYPG 

       310        320        330        340        350 
LCGICLSGAG PTILCLATDG FEKIANDVIE IFKQEGIECD SKLLDLAYDG ATVEYGS 

« Hide

References

« Hide 'large scale' references
[1]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.
[2]White T.C.
Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-147.
Strain: SS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AACQ01000063 Genomic DNA. Translation: EAK97775.1.
U67193 Genomic DNA. Translation: AAB08101.1.
RefSeqXP_716762.1. XM_711669.1.

3D structure databases

ProteinModelPortalQ92209.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid1224666. 1 interaction.
STRING5476.CAL0003628.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3641572.
KEGGcal:CaO19.923.

Organism-specific databases

CGDCAL0003628. THR1.

Phylogenomic databases

eggNOGCOG0083.
KOK00872.
OrthoDBEOG7Q8CXX.

Enzyme and pathway databases

UniPathwayUPA00050; UER00064.

Family and domain databases

Gene3D3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
HAMAPMF_00384. Homoser_kinase.
InterProIPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR000870. Homoserine_kinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PfamPF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFPIRSF000676. Homoser_kin. 1 hit.
SUPFAMSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsTIGR00191. thrB. 1 hit.
PROSITEPS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKHSE_CANAL
AccessionPrimary (citable) accession number: Q92209
Secondary accession number(s): Q5A523
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 5, 2009
Last modified: April 16, 2014
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Candida albicans

Candida albicans: entries and gene names