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Protein

Homoserine kinase

Gene

THR1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.By similarity

Catalytic activityi

ATP + L-homoserine = ADP + O-phospho-L-homoserine.

Pathwayi: L-threonine biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes L-threonine from L-aspartate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. Homoserine dehydrogenase (HOM6)
  4. Homoserine kinase (THR1)
  5. no protein annotated in this organism
This subpathway is part of the pathway L-threonine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-threonine from L-aspartate, the pathway L-threonine biosynthesis and in Amino-acid biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi99 – 109ATPSequence analysisAdd BLAST11

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processAmino-acid biosynthesis, Threonine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00050; UER00064

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine kinase (EC:2.7.1.39)
Short name:
HK
Short name:
HSK
Gene namesi
Name:THR1
Ordered Locus Names:CAALFM_C500650CA
ORF Names:CaO19.923
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 5

Organism-specific databases

CGDiCAL0000196189 THR1
EuPathDBiFungiDB:C5_00650C_A

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001566541 – 357Homoserine kinaseAdd BLAST357

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ92209
SMRiQ92209
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

InParanoidiQ92209
KOiK00872
OMAiPDNVAPC
OrthoDBiEOG092C3N9W

Family and domain databases

Gene3Di3.30.230.10, 1 hit
3.30.70.890, 1 hit
HAMAPiMF_00384 Homoser_kinase, 1 hit
InterProiView protein in InterPro
IPR036554 GHMP_kinase_C_sf
IPR006204 GHMP_kinase_N_dom
IPR006203 GHMP_knse_ATP-bd_CS
IPR000870 Homoserine_kinase
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
PANTHERiPTHR20861:SF1 PTHR20861:SF1, 1 hit
PfamiView protein in Pfam
PF00288 GHMP_kinases_N, 1 hit
PIRSFiPIRSF000676 Homoser_kin, 1 hit
SUPFAMiSSF54211 SSF54211, 1 hit
SSF55060 SSF55060, 1 hit
TIGRFAMsiTIGR00191 thrB, 1 hit
PROSITEiView protein in PROSITE
PS00627 GHMP_KINASES_ATP, 1 hit

Sequencei

Sequence statusi: Complete.

Q92209-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVISFKIKV PASSANIGPG FDVLGIGLQL YLTITVTIDP SIDTSSDPHH
60 70 80 90 100
ALLSYEGDGK VPFESNENLI TQTALYVMRC NGIKDFPRGT HIHVNNPIPL
110 120 130 140 150
GRGLGSSASA IVAGVYLGNE IGNLKLDKYR LLDYCLMIER HPDNIAAAML
160 170 180 190 200
GGFIGSYLNE LSSEDSQLTT VPLDYILPKV KNGELITPQD KIVSQQPPNN
210 220 230 240 250
IGQYVEYKWN KKIKCLTIIP NFELSTDLSR SVLPKNYQLP DIVYNLQRIA
260 270 280 290 300
ILTTALTQDP PNHKVIYQSM KDKLHQPYRF GLIPGLNTVL QKITPESYPG
310 320 330 340 350
LCGICLSGAG PTILCLATDG FEKIANDVIE IFKQEGIECD SKLLDLAYDG

ATVEYGS
Length:357
Mass (Da):39,130
Last modified:May 10, 2017 - v3
Checksum:i9F5F3BD019881D93
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4I → T in AAB08101 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017627 Genomic DNA Translation: AOW29508.1
U67193 Genomic DNA Translation: AAB08101.1
RefSeqiXP_716762.2, XM_711669.2

Genome annotation databases

EnsemblFungiiAOW29508; AOW29508; CAALFM_C500650CA
GeneIDi3641572
KEGGical:CAALFM_C500650CA

Similar proteinsi

Entry informationi

Entry nameiKHSE_CANAL
AccessioniPrimary (citable) accession number: Q92209
Secondary accession number(s): A0A1D8PN04, Q5A523
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 10, 2017
Last modified: May 23, 2018
This is version 103 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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