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Protein

Homoserine kinase

Gene

THR1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.By similarity

Catalytic activityi

ATP + L-homoserine = ADP + O-phospho-L-homoserine.

Pathwayi: L-threonine biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes L-threonine from L-aspartate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Aspartate-semialdehyde dehydrogenase (HOM2)
  3. Homoserine dehydrogenase (HOM6)
  4. Homoserine kinase (THR1)
  5. no protein annotated in this organism
This subpathway is part of the pathway L-threonine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-threonine from L-aspartate, the pathway L-threonine biosynthesis and in Amino-acid biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi99 – 109ATPSequence analysisAdd BLAST11

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Threonine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00050; UER00064.

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine kinase (EC:2.7.1.39)
Short name:
HK
Short name:
HSK
Gene namesi
Name:THR1
ORF Names:CaO19.923
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0000196189. THR1.
EuPathDBiFungiDB:C5_00650C_A.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001566541 – 357Homoserine kinaseAdd BLAST357

Proteomic databases

PRIDEiQ92209.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ92209.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

InParanoidiQ92209.
KOiK00872.
OrthoDBiEOG092C3N9W.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
HAMAPiMF_00384. Homoser_kinase. 1 hit.
InterProiIPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR000870. Homoserine_kinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PfamiPF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000676. Homoser_kin. 1 hit.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsiTIGR00191. thrB. 1 hit.
PROSITEiPS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92209-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVTSFKIKV PASSANIGPG FDVLGIGLQL YLTITVTIDP SIDTSSDPHH
60 70 80 90 100
ALLSYEGDGK VPFESNENLI TQTALYVMRC NGIKDFPRGT HIHVNNPIPL
110 120 130 140 150
GRGLGSSASA IVAGVYLGNE IGNLKLDKYR LLDYCLMIER HPDNIAAAML
160 170 180 190 200
GGFIGSYLNE LSSEDSQLIT VPLDYILPKV KNGELITPQN KIVSQQPPNN
210 220 230 240 250
IGQYVEYKWN KKIKCLTIIP NFELSTDLSR SVLPKNYQLP DIVYNLQRIA
260 270 280 290 300
ILTTALTQDP PNHKVIYQSM KDKLHQPYRF GLIPGLNTVL QKITPESYPG
310 320 330 340 350
LCGICLSGAG PTILCLATDG FEKIANDVIE IFKQEGIECD SKLLDLAYDG

ATVEYGS
Length:357
Mass (Da):39,129
Last modified:May 5, 2009 - v2
Checksum:i40DA798DCF83DBC8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000063 Genomic DNA. Translation: EAK97775.1.
U67193 Genomic DNA. Translation: AAB08101.1.
RefSeqiXP_716762.1. XM_711669.1.

Genome annotation databases

EnsemblFungiiEAK97775; EAK97775; CaO19.923.
GeneIDi3641572.
KEGGical:CaO19.923.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACQ01000063 Genomic DNA. Translation: EAK97775.1.
U67193 Genomic DNA. Translation: AAB08101.1.
RefSeqiXP_716762.1. XM_711669.1.

3D structure databases

ProteinModelPortaliQ92209.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ92209.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAK97775; EAK97775; CaO19.923.
GeneIDi3641572.
KEGGical:CaO19.923.

Organism-specific databases

CGDiCAL0000196189. THR1.
EuPathDBiFungiDB:C5_00650C_A.

Phylogenomic databases

InParanoidiQ92209.
KOiK00872.
OrthoDBiEOG092C3N9W.

Enzyme and pathway databases

UniPathwayiUPA00050; UER00064.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
HAMAPiMF_00384. Homoser_kinase. 1 hit.
InterProiIPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR000870. Homoserine_kinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PfamiPF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000676. Homoser_kin. 1 hit.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsiTIGR00191. thrB. 1 hit.
PROSITEiPS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKHSE_CANAL
AccessioniPrimary (citable) accession number: Q92209
Secondary accession number(s): Q5A523
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 5, 2009
Last modified: November 30, 2016
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.