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Protein

Mitogen-activated protein kinase HOG1

Gene

HOG1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes. Regulates stress-induced production and accumulation of glycerol and D-arabitol. HOG1 is also involved in virulence, morphogenesis and oxidative stress response especially through its role in chlamydospore formation, an oxygen-dependent morphogenetic program.10 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+By similarity

Enzyme regulationi

Activated by tyrosine and threonine phosphorylation.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei52ATPPROSITE-ProRule annotation1
Active sitei144Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi29 – 37ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • MAP kinase activity Source: CGD
  • protein kinase activity Source: CGD

GO - Biological processi

  • cellular response to cadmium ion Source: CGD
  • cellular response to heat Source: CGD
  • cellular response to osmotic stress Source: CGD
  • cellular response to oxidative stress Source: CGD
  • cellular response to pH Source: CGD
  • chlamydospore formation Source: CGD
  • filamentous growth Source: CGD
  • filamentous growth of a population of unicellular organisms Source: CGD
  • filamentous growth of a population of unicellular organisms in response to biotic stimulus Source: CGD
  • filamentous growth of a population of unicellular organisms in response to heat Source: CGD
  • fungal-type cell wall organization Source: CGD
  • intracellular accumulation of glycerol Source: CGD
  • negative regulation of filamentous growth of a population of unicellular organisms Source: CGD
  • negative regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus Source: CGD
  • negative regulation of filamentous growth of a population of unicellular organisms in response to heat Source: CGD
  • pathogenesis Source: CGD
  • polyol biosynthetic process Source: CGD
  • protein phosphorylation Source: CGD
  • regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus Source: CGD
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • response to salt stress Source: CGD
  • stress-activated MAPK cascade Source: CGD
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, Kinase, Serine/threonine-protein kinase, Transferase
Biological processTranscription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.24 1096

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase HOG1 (EC:2.7.11.24)
Short name:
MAP kinase HOG1
Gene namesi
Name:HOG1
Ordered Locus Names:CAALFM_C203330CA
ORF Names:CaO19.8514, CaO19.895
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 2

Organism-specific databases

CGDiCAL0000197240 HOG1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001863281 – 377Mitogen-activated protein kinase HOG1Add BLAST377

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei174PhosphothreonineBy similarity1
Modified residuei176PhosphotyrosineBy similarity1

Post-translational modificationi

Dually phosphorylated on Thr-174 and Tyr-176, which activates the enzyme (By similarity). Phosphorylated in response to oxidative and salt stress.By similarity5 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ92207

Interactioni

Protein-protein interaction databases

BioGridi1220364, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliQ92207
SMRiQ92207
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 305Protein kinasePROSITE-ProRule annotationAdd BLAST283

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi174 – 176TXY3

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiQ92207
KOiK04441
OrthoDBiEOG092C2FL8

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR003527 MAP_kinase_CS
IPR038783 MAPK_Sty1/Hog1
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR24055:SF247 PTHR24055:SF247, 1 hit
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS01351 MAPK, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q92207-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSADGEFTRT QIFGTVFEIT NRYTELNPVG MGAFGLVCSA VDRLTGQNVA
60 70 80 90 100
VKKVMKPFST SVLAKRTYRE LKLLKHLKHE NLITLDDIFI SPLEDIYFVN
110 120 130 140 150
ELQGTDLHRL LNSRPLEKQF IQYFTYQIMR GLKYIHSAGV IHRDLKPSNI
160 170 180 190 200
LINENCDLKI CDFGLARLQD PQMTGYVSTR YYRAPEIMLT WQKYDTEVDL
210 220 230 240 250
WSVGCILAEM IEGKPLFPGK DHVHQFSIIT ELLGSPPADV IDTICSENTL
260 270 280 290 300
RFVQSLPHRD PIPFSERFAS CTHVEPEAID LLAKLLVFDP KKRISAVEGL
310 320 330 340 350
THPYMEAYHD PTDEPVCESK FDWSFNDADL PVDTWRVMMY SEILDFHQTV
360 370
GVANETEGSE QPDSQVEQNN LDSANGA
Length:377
Mass (Da):42,947
Last modified:May 29, 2007 - v2
Checksum:i8DB21BD497A4F52E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti298E → Q in CAA62214 (PubMed:8824643).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90586 Genomic DNA Translation: CAA62214.1
CP017624 Genomic DNA Translation: AOW27369.1
RefSeqiXP_721016.1, XM_715923.1

Genome annotation databases

EnsemblFungiiAOW27369; AOW27369; CAALFM_C203330CA
GeneIDi3637393
KEGGical:CAALFM_C203330CA

Similar proteinsi

Entry informationi

Entry nameiHOG1_CANAL
AccessioniPrimary (citable) accession number: Q92207
Secondary accession number(s): A0A1D8PGU7, Q5AHA1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 29, 2007
Last modified: May 23, 2018
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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