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Protein

Squalene monooxygenase

Gene

ERG1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway.By similarity

Catalytic activityi

Squalene + [reduced NADPH--hemoprotein reductase] + O2 = (3S)-2,3-epoxy-2,3-dihydrosqualene + [oxidized NADPH--hemoprotein reductase] + H2O.By similarity

Cofactori

Pathwayi: lanosterol biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes lanosterol from farnesyl diphosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Squalene monooxygenase (ERG1)
  3. Lanosterol synthase (ERG7)
This subpathway is part of the pathway lanosterol biosynthesis, which is itself part of Terpene metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes lanosterol from farnesyl diphosphate, the pathway lanosterol biosynthesis and in Terpene metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 35FADSequence analysisAdd BLAST28

GO - Molecular functioni

  • flavin adenine dinucleotide binding Source: InterPro
  • squalene monooxygenase activity Source: CGD

GO - Biological processi

  • cell growth mode switching, budding to filamentous Source: CGD
  • cellular response to drug Source: CGD
  • cellular response to starvation Source: CGD
  • ergosterol biosynthetic process Source: CGD
  • filamentous growth Source: CGD
  • filamentous growth of a population of unicellular organisms in response to biotic stimulus Source: CGD
  • filamentous growth of a population of unicellular organisms in response to chemical stimulus Source: CGD
  • filamentous growth of a population of unicellular organisms in response to starvation Source: CGD
  • localization within membrane Source: CGD

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00767; UER00752

Names & Taxonomyi

Protein namesi
Recommended name:
Squalene monooxygenase (EC:1.14.14.17By similarity)
Alternative name(s):
Squalene epoxidase
Short name:
SE
Gene namesi
Name:ERG1
Ordered Locus Names:CAALFM_C108590CA
ORF Names:CaO19.406, CaO19.8036
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 1

Organism-specific databases

CGDiCAL0000179458 ERG1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4 – 24HelicalSequence analysisAdd BLAST21
Transmembranei431 – 451HelicalSequence analysisAdd BLAST21
Transmembranei466 – 486HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Chemistry databases

DrugBankiDB00525 Tolnaftate

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002098481 – 496Squalene monooxygenaseAdd BLAST496

Proteomic databases

PRIDEiQ92206

Structurei

3D structure databases

ProteinModelPortaliQ92206
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the squalene monooxygenase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ92206
KOiK00511
OMAiSSHFVGC
OrthoDBiEOG092C1N2D

Family and domain databases

Gene3Di3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR013698 Squalene_epoxidase
PfamiView protein in Pfam
PF08491 SE, 1 hit
SUPFAMiSSF51905 SSF51905, 3 hits

Sequencei

Sequence statusi: Complete.

Q92206-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSVKYDAII IGAGVIGPTI ATAFARQGRK VLIVERDWSK PDRIVGELMQ
60 70 80 90 100
PAGIKALREL GMIKAINNIR AVDCTGYYIK YYDETITIPY PLKKDACITN
110 120 130 140 150
PVKPVPDAVD GVNDKLDSDS TLNVDDWDFD ERVRGAAFHH GDFLMNLRQI
160 170 180 190 200
CRDEPNVTAV EATVTKILRD PSDPNTVIGV QTKQPSGTVD YHAKLTISCD
210 220 230 240 250
GIYSKFRKEL SPTNVPTIGS YFIGLYLKNA ELPAKGKGHV LLGGHAPALI
260 270 280 290 300
YSVSPTETRV LCVYVSSKPP SAANDAVYKY LRDNILPAIP KETVPAFKEA
310 320 330 340 350
LEERKFRIMP NQYLSAMKQG SENHKGFILL GDSLNMRHPL TGGGMTVGLN
360 370 380 390 400
DSVLLAKLLH PKFVEDFDDH QLIAKRLKTF HRKRKNLDAV INTLSISLYS
410 420 430 440 450
LFAADKKPLR ILRNGCFKYF QRGGECVNGP IGLLSGMLPF PMLLFNHFFS
460 470 480 490
VAFYSVYLNF IERGLLGFPL ALFEAFEVLF TAIVIFTPYL WNEIVR
Length:496
Mass (Da):55,298
Last modified:February 1, 1997 - v1
Checksum:iC844CE43A679B920
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88252 Genomic DNA Translation: BAA13565.1
U69674 Genomic DNA Translation: AAC49715.1
CP017623 Genomic DNA Translation: AOW26497.1
RefSeqiXP_711894.1, XM_706801.1

Genome annotation databases

EnsemblFungiiAOW26497; AOW26497; CAALFM_C108590CA
GeneIDi3646509
KEGGical:CAALFM_C108590CA

Similar proteinsi

Entry informationi

Entry nameiERG1_CANAL
AccessioniPrimary (citable) accession number: Q92206
Secondary accession number(s): A0A1D8PEC8, Q59QB2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: March 28, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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