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Protein

U3 small nucleolar ribonucleoprotein protein IMP3

Gene

Imp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • rRNA processing Source: MGI

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding, rRNA-binding
Biological processRibosome biogenesis, rRNA processing

Enzyme and pathway databases

ReactomeiR-MMU-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
U3 small nucleolar ribonucleoprotein protein IMP3
Short name:
U3 snoRNP protein IMP3
Gene namesi
Name:Imp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1916119 Imp3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001327101 – 184U3 small nucleolar ribonucleoprotein protein IMP3Add BLAST184

Proteomic databases

EPDiQ921Y2
MaxQBiQ921Y2
PaxDbiQ921Y2
PeptideAtlasiQ921Y2
PRIDEiQ921Y2

PTM databases

PhosphoSitePlusiQ921Y2
SwissPalmiQ921Y2

Expressioni

Gene expression databases

BgeeiENSMUSG00000032288
GenevisibleiQ921Y2 MM

Interactioni

Subunit structurei

Component of a heterotrimeric complex containing IMP3, IMP4 and MPHOSPH10. Interacts with MPHOSPH10 (By similarity).By similarity

Protein-protein interaction databases

BioGridi221882, 2 interactors
STRINGi10090.ENSMUSP00000034827

Structurei

3D structure databases

ProteinModelPortaliQ921Y2
SMRiQ921Y2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini109 – 175S4 RNA-bindingPROSITE-ProRule annotationAdd BLAST67

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi32 – 74Arg-richAdd BLAST43

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4655 Eukaryota
COG0522 LUCA
GeneTreeiENSGT00550000075090
HOGENOMiHOG000213883
HOVERGENiHBG052121
InParanoidiQ921Y2
KOiK14560
OMAiKVDFLNW
OrthoDBiEOG091G0QKK
PhylomeDBiQ921Y2
TreeFamiTF300149

Family and domain databases

CDDicd00165 S4, 1 hit
Gene3Di3.10.290.10, 1 hit
InterProiView protein in InterPro
IPR022801 Ribosomal_S4/S9
IPR001912 Ribosomal_S4/S9_N
IPR002942 S4_RNA-bd
IPR036986 S4_RNA-bd_sf
PANTHERiPTHR11831 PTHR11831, 1 hit
PfamiView protein in Pfam
PF00163 Ribosomal_S4, 1 hit
PF01479 S4, 1 hit
SMARTiView protein in SMART
SM01390 Ribosomal_S4, 1 hit
SM00363 S4, 1 hit
PROSITEiView protein in PROSITE
PS50889 S4, 1 hit

Sequencei

Sequence statusi: Complete.

Q921Y2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRKLKFHEQ KLLKQVDFLN WEVTDHNLHE LRVLRRYRLQ RREEYTRYNQ
60 70 80 90 100
LSRAVRELAR RLRDLPERDP FRVRASAALL DKLYAMGLVP TRGSLELCDS
110 120 130 140 150
VSASSFCRRR LPTLLLKLRM AQHLQAAVAF VEQGHVRVGP DVVTDPAFLV
160 170 180
TRSMEDFVTW VDSSKIKRHV LEYNEERDDF DLDA
Length:184
Mass (Da):21,777
Last modified:December 1, 2001 - v1
Checksum:i5BFC2B6C600B8166
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC009145 mRNA Translation: AAH09145.1
CCDSiCCDS23213.1
RefSeqiNP_598737.1, NM_133976.2
UniGeneiMm.12864

Genome annotation databases

EnsembliENSMUST00000034827; ENSMUSP00000034827; ENSMUSG00000032288
GeneIDi102462
KEGGimmu:102462
UCSCiuc009ptq.1 mouse

Similar proteinsi

Entry informationi

Entry nameiIMP3_MOUSE
AccessioniPrimary (citable) accession number: Q921Y2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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