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Protein

U3 small nucleolar ribonucleoprotein protein IMP3

Gene

Imp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Keywords - Ligandi

RNA-binding, rRNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-6791226. Major pathway of rRNA processing in the nucleolus.

Names & Taxonomyi

Protein namesi
Recommended name:
U3 small nucleolar ribonucleoprotein protein IMP3
Short name:
U3 snoRNP protein IMP3
Gene namesi
Name:Imp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1916119. Imp3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 184184U3 small nucleolar ribonucleoprotein protein IMP3PRO_0000132710Add
BLAST

Proteomic databases

EPDiQ921Y2.
MaxQBiQ921Y2.
PaxDbiQ921Y2.
PeptideAtlasiQ921Y2.
PRIDEiQ921Y2.

PTM databases

PhosphoSiteiQ921Y2.
SwissPalmiQ921Y2.

Expressioni

Gene expression databases

BgeeiQ921Y2.
GenevisibleiQ921Y2. MM.

Interactioni

Subunit structurei

Component of a heterotrimeric complex containing IMP3, IMP4 and MPHOSPH10. Interacts with MPHOSPH10 (By similarity).By similarity

Protein-protein interaction databases

BioGridi221882. 1 interaction.
STRINGi10090.ENSMUSP00000034827.

Structurei

3D structure databases

ProteinModelPortaliQ921Y2.
SMRiQ921Y2. Positions 29-179.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini109 – 17567S4 RNA-bindingPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi32 – 7443Arg-richAdd
BLAST

Sequence similaritiesi

Belongs to the ribosomal protein S4P family.Curated
Contains 1 S4 RNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4655. Eukaryota.
COG0522. LUCA.
GeneTreeiENSGT00550000075090.
HOGENOMiHOG000213883.
HOVERGENiHBG052121.
InParanoidiQ921Y2.
KOiK14560.
OMAiKVDFLNW.
OrthoDBiEOG7HQN9J.
PhylomeDBiQ921Y2.
TreeFamiTF300149.

Family and domain databases

Gene3Di3.10.290.10. 1 hit.
InterProiIPR022801. Ribosomal_S4/S9.
IPR001912. Ribosomal_S4/S9_N.
IPR002942. S4_RNA-bd.
[Graphical view]
PANTHERiPTHR11831. PTHR11831. 1 hit.
PfamiPF00163. Ribosomal_S4. 1 hit.
PF01479. S4. 1 hit.
[Graphical view]
SMARTiSM01390. Ribosomal_S4. 1 hit.
SM00363. S4. 1 hit.
[Graphical view]
PROSITEiPS50889. S4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q921Y2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRKLKFHEQ KLLKQVDFLN WEVTDHNLHE LRVLRRYRLQ RREEYTRYNQ
60 70 80 90 100
LSRAVRELAR RLRDLPERDP FRVRASAALL DKLYAMGLVP TRGSLELCDS
110 120 130 140 150
VSASSFCRRR LPTLLLKLRM AQHLQAAVAF VEQGHVRVGP DVVTDPAFLV
160 170 180
TRSMEDFVTW VDSSKIKRHV LEYNEERDDF DLDA
Length:184
Mass (Da):21,777
Last modified:December 1, 2001 - v1
Checksum:i5BFC2B6C600B8166
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC009145 mRNA. Translation: AAH09145.1.
CCDSiCCDS23213.1.
RefSeqiNP_598737.1. NM_133976.2.
UniGeneiMm.12864.

Genome annotation databases

EnsembliENSMUST00000034827; ENSMUSP00000034827; ENSMUSG00000032288.
GeneIDi102462.
KEGGimmu:102462.
UCSCiuc009ptq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC009145 mRNA. Translation: AAH09145.1.
CCDSiCCDS23213.1.
RefSeqiNP_598737.1. NM_133976.2.
UniGeneiMm.12864.

3D structure databases

ProteinModelPortaliQ921Y2.
SMRiQ921Y2. Positions 29-179.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi221882. 1 interaction.
STRINGi10090.ENSMUSP00000034827.

PTM databases

PhosphoSiteiQ921Y2.
SwissPalmiQ921Y2.

Proteomic databases

EPDiQ921Y2.
MaxQBiQ921Y2.
PaxDbiQ921Y2.
PeptideAtlasiQ921Y2.
PRIDEiQ921Y2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034827; ENSMUSP00000034827; ENSMUSG00000032288.
GeneIDi102462.
KEGGimmu:102462.
UCSCiuc009ptq.1. mouse.

Organism-specific databases

CTDi55272.
MGIiMGI:1916119. Imp3.

Phylogenomic databases

eggNOGiKOG4655. Eukaryota.
COG0522. LUCA.
GeneTreeiENSGT00550000075090.
HOGENOMiHOG000213883.
HOVERGENiHBG052121.
InParanoidiQ921Y2.
KOiK14560.
OMAiKVDFLNW.
OrthoDBiEOG7HQN9J.
PhylomeDBiQ921Y2.
TreeFamiTF300149.

Enzyme and pathway databases

ReactomeiR-MMU-6791226. Major pathway of rRNA processing in the nucleolus.

Miscellaneous databases

PROiQ921Y2.
SOURCEiSearch...

Gene expression databases

BgeeiQ921Y2.
GenevisibleiQ921Y2. MM.

Family and domain databases

Gene3Di3.10.290.10. 1 hit.
InterProiIPR022801. Ribosomal_S4/S9.
IPR001912. Ribosomal_S4/S9_N.
IPR002942. S4_RNA-bd.
[Graphical view]
PANTHERiPTHR11831. PTHR11831. 1 hit.
PfamiPF00163. Ribosomal_S4. 1 hit.
PF01479. S4. 1 hit.
[Graphical view]
SMARTiSM01390. Ribosomal_S4. 1 hit.
SM00363. S4. 1 hit.
[Graphical view]
PROSITEiPS50889. S4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiIMP3_MOUSE
AccessioniPrimary (citable) accession number: Q921Y2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.