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Protein

MOB kinase activator 1A

Gene

Mob1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38 (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi79 – 791ZincBy similarity
Metal bindingi84 – 841ZincBy similarity
Metal bindingi161 – 1611ZincBy similarity
Metal bindingi166 – 1661ZincBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-2028269. Signaling by Hippo.

Names & Taxonomyi

Protein namesi
Recommended name:
MOB kinase activator 1A
Alternative name(s):
Mob1 homolog 1B
Mps one binder kinase activator-like 1B
Gene namesi
Name:Mob1a
Synonyms:Mobk1b, Mobkl1b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2442631. Mob1a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 216215MOB kinase activator 1APRO_0000193567Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei12 – 121PhosphothreonineBy similarity
Modified residuei35 – 351PhosphothreonineBy similarity
Modified residuei74 – 741Phosphothreonine; by STK3/MST2By similarity
Modified residuei181 – 1811PhosphothreonineBy similarity

Post-translational modificationi

Phosphorylated by STK3/MST2 and STK4/MST1 and this phosphorylation enhances its binding to LATS1.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ921Y0.
MaxQBiQ921Y0.
PaxDbiQ921Y0.
PeptideAtlasiQ921Y0.
PRIDEiQ921Y0.

PTM databases

iPTMnetiQ921Y0.
PhosphoSiteiQ921Y0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000043131.
ExpressionAtlasiQ921Y0. baseline and differential.
GenevisibleiQ921Y0. MM.

Interactioni

Subunit structurei

Binds STK38 and STK38L. Interacts with LATS1 and LATS2 (By similarity). Forms a tripartite complex with STK38 and STK3/MST2 (By similarity).By similarity

Protein-protein interaction databases

IntActiQ921Y0. 1 interaction.
STRINGi10090.ENSMUSP00000054452.

Structurei

3D structure databases

ProteinModelPortaliQ921Y0.
SMRiQ921Y0. Positions 10-216.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MOB1/phocein family.Curated

Phylogenomic databases

eggNOGiKOG0440. Eukaryota.
ENOG410XSUJ. LUCA.
GeneTreeiENSGT00550000074456.
HOGENOMiHOG000164685.
HOVERGENiHBG052489.
InParanoidiQ921Y0.
KOiK06685.
OMAiEFCTETS.
OrthoDBiEOG091G0LDA.
PhylomeDBiQ921Y0.
TreeFamiTF300789.

Family and domain databases

Gene3Di1.20.140.30. 1 hit.
InterProiIPR005301. MOB_kinase_act_fam.
[Graphical view]
PANTHERiPTHR22599. PTHR22599. 1 hit.
PfamiPF03637. Mob1_phocein. 1 hit.
[Graphical view]
SMARTiSM01388. Mob1_phocein. 1 hit.
[Graphical view]
SUPFAMiSSF101152. SSF101152. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q921Y0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSFLFSSRSS KTFKPKKNIP EGSHQYELLK HAEATLGSGN LRQAVMLPEG
60 70 80 90 100
EDLNEWIAVN TVDFFNQINM LYGTITEFCT EASCPVMSAG PRYEYHWADG
110 120 130 140 150
TNIKKPIKCS APKYIDYLMT WVQDQLDDET LFPSKIGVPF PKNFMSVAKT
160 170 180 190 200
ILKRLFRVYA HIYHQHFDSV MQLQEEAHLN TSFKHFIFFV QEFNLIDRRE
210
LAPLQELIEK LGSKDR
Length:216
Mass (Da):25,080
Last modified:January 23, 2007 - v3
Checksum:i58043AECAD1F5987
GO
Isoform 2 (identifier: Q921Y0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     61-137: TVDFFNQINM...DETLFPSKIG → S

Note: No experimental confirmation available.
Show »
Length:140
Mass (Da):16,336
Checksum:iC6D139AAFF545181
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti105 – 1062KP → NA in BAC25938 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei61 – 13777TVDFF…PSKIG → S in isoform 2. 1 PublicationVSP_012297Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028416 mRNA. Translation: BAC25938.1.
AK028695 mRNA. Translation: BAC26070.1.
AK167515 mRNA. Translation: BAE39589.1.
AK172205 mRNA. Translation: BAE42880.1.
BC009149 mRNA. Translation: AAH09149.1.
BC033463 mRNA. Translation: AAH33463.1.
CCDSiCCDS39533.1. [Q921Y0-1]
RefSeqiNP_663546.1. NM_145571.2. [Q921Y0-1]
UniGeneiMm.29500.

Genome annotation databases

EnsembliENSMUST00000038658; ENSMUSP00000039115; ENSMUSG00000043131. [Q921Y0-2]
ENSMUST00000055261; ENSMUSP00000054452; ENSMUSG00000043131. [Q921Y0-1]
ENSMUST00000101245; ENSMUSP00000098802; ENSMUSG00000043131. [Q921Y0-1]
GeneIDi232157.
KEGGimmu:232157.
UCSCiuc009cnf.1. mouse. [Q921Y0-1]
uc012eny.1. mouse. [Q921Y0-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK028416 mRNA. Translation: BAC25938.1.
AK028695 mRNA. Translation: BAC26070.1.
AK167515 mRNA. Translation: BAE39589.1.
AK172205 mRNA. Translation: BAE42880.1.
BC009149 mRNA. Translation: AAH09149.1.
BC033463 mRNA. Translation: AAH33463.1.
CCDSiCCDS39533.1. [Q921Y0-1]
RefSeqiNP_663546.1. NM_145571.2. [Q921Y0-1]
UniGeneiMm.29500.

3D structure databases

ProteinModelPortaliQ921Y0.
SMRiQ921Y0. Positions 10-216.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ921Y0. 1 interaction.
STRINGi10090.ENSMUSP00000054452.

PTM databases

iPTMnetiQ921Y0.
PhosphoSiteiQ921Y0.

Proteomic databases

EPDiQ921Y0.
MaxQBiQ921Y0.
PaxDbiQ921Y0.
PeptideAtlasiQ921Y0.
PRIDEiQ921Y0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038658; ENSMUSP00000039115; ENSMUSG00000043131. [Q921Y0-2]
ENSMUST00000055261; ENSMUSP00000054452; ENSMUSG00000043131. [Q921Y0-1]
ENSMUST00000101245; ENSMUSP00000098802; ENSMUSG00000043131. [Q921Y0-1]
GeneIDi232157.
KEGGimmu:232157.
UCSCiuc009cnf.1. mouse. [Q921Y0-1]
uc012eny.1. mouse. [Q921Y0-2]

Organism-specific databases

CTDi55233.
MGIiMGI:2442631. Mob1a.

Phylogenomic databases

eggNOGiKOG0440. Eukaryota.
ENOG410XSUJ. LUCA.
GeneTreeiENSGT00550000074456.
HOGENOMiHOG000164685.
HOVERGENiHBG052489.
InParanoidiQ921Y0.
KOiK06685.
OMAiEFCTETS.
OrthoDBiEOG091G0LDA.
PhylomeDBiQ921Y0.
TreeFamiTF300789.

Enzyme and pathway databases

ReactomeiR-MMU-2028269. Signaling by Hippo.

Miscellaneous databases

PROiQ921Y0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000043131.
ExpressionAtlasiQ921Y0. baseline and differential.
GenevisibleiQ921Y0. MM.

Family and domain databases

Gene3Di1.20.140.30. 1 hit.
InterProiIPR005301. MOB_kinase_act_fam.
[Graphical view]
PANTHERiPTHR22599. PTHR22599. 1 hit.
PfamiPF03637. Mob1_phocein. 1 hit.
[Graphical view]
SMARTiSM01388. Mob1_phocein. 1 hit.
[Graphical view]
SUPFAMiSSF101152. SSF101152. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMOB1A_MOUSE
AccessioniPrimary (citable) accession number: Q921Y0
Secondary accession number(s): Q3TJA6, Q8C194, Q8C1C7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.