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Q921X9 (PDIA5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Protein disulfide-isomerase A5
EC=5.3.4.1
Alternative name(s):
Protein disulfide isomerase-related protein
Gene names
Name:Pdia5
Synonyms:Pdir
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length517 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Catalyzes the rearrangement of -S-S- bonds in proteins.

Subcellular location

Endoplasmic reticulum lumen By similarity.

Sequence similarities

Belongs to the protein disulfide isomerase family.

Contains 3 thioredoxin domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 517496Protein disulfide-isomerase A5
PRO_0000034234

Regions

Domain132 – 259128Thioredoxin 1
Domain268 – 382115Thioredoxin 2
Domain376 – 504129Thioredoxin 3
Motif514 – 5174Prevents secretion from ER Potential

Amino acid modifications

Disulfide bond180 ↔ 183Redox-active By similarity
Disulfide bond303 ↔ 306Redox-active By similarity
Disulfide bond424 ↔ 427Redox-active By similarity

Sequences

Sequence LengthMass (Da)Tools
Q921X9 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 6702B9C5EF9F1C84

FASTA51759,267
        10         20         30         40         50         60 
MARAWGLLLA IGVVLPTWLS STKVSSLIER ISDPKDLKKL LRTRNNVLVL YSESEVAAES 

        70         80         90        100        110        120 
HLKLLSTVAQ AVKGQGTVCW VDCGDAESRK LCKKMKVDLS PKDKKIELFH YQDGAFHMQY 

       130        140        150        160        170        180 
DRAVTLKSIV AFLKDPKGPP LWEEDPGAKD VVHIDSEKDF RRLLKREEKP LLMMFYAPWC 

       190        200        210        220        230        240 
SMCKRIMPHF QKAATQVRGH IVLAGMNVYP SEFENIKEEY NVRGYPTICY FEKGRFLFPY 

       250        260        270        280        290        300 
ENYGSTAEDI VEWLKNPLPP QPQVPETPWA DEGGSVYHLT DEDFDQFVKE HSSVLVMFHA 

       310        320        330        340        350        360 
PWCGHCKKMK PEFESAAEVL HGDAESSGVL AAVDATVNEA LAGRFHISAF PTLKYFKNGE 

       370        380        390        400        410        420 
QQAVPALRTK KKFIEWMQNP EAPPPPEPTW EEQQTSVLHL VGDNFRDTLK KKKHTLVMFY 

       430        440        450        460        470        480 
APWCPHCKKV IPHFTATADA FKEDRKIACA AVDCVKDKNQ DLCQQEAVKA YPTFHYYHYG 

       490        500        510 
KLVEKYESDR TELGFTSFIR TLREGDLKRL EKRREEL

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC009151 mRNA. Translation: AAH09151.1.
IPIIPI00122362.
RefSeqNP_082571.1. NM_028295.1.
UniGeneMm.71015.

3D structure databases

ProteinModelPortalQ921X9.
SMRQ921X9. Positions 69-500.
ModBaseSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000023550.

PTM databases

PhosphoSiteQ921X9.

Proteomic databases

PaxDbQ921X9.
PRIDEQ921X9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000023550; ENSMUSP00000023550; ENSMUSG00000022844.
GeneID72599.
KEGGmmu:72599.
UCSCuc007zbl.1. mouse.

Organism-specific databases

CTD10954.
MGIMGI:1919849. Pdia5.

Phylogenomic databases

eggNOGCOG0526.
GeneTreeENSGT00700000104354.
HOGENOMHOG000039967.
HOVERGENHBG053547.
InParanoidQ921X9.
KOK09583.
OMALAGMNVY.
OrthoDBEOG49KFQF.

Gene expression databases

ArrayExpressQ921X9.
BgeeQ921X9.
CleanExMM_PDIA5.
GenevestigatorQ921X9.
GermOnlineENSMUSG00000022844. Mus musculus.

Family and domain databases

Gene3D3.40.30.10. 4 hits.
InterProIPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamPF00085. Thioredoxin. 3 hits.
[Graphical view]
PRINTSPR00421. THIOREDOXIN.
SUPFAMSSF52833. Thiordxn-like_fd. 4 hits.
PROSITEPS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 2 hits.
PS51352. THIOREDOXIN_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPDIA5. mouse.
NextBio336573.
SOURCESearch...

Entry information

Entry namePDIA5_MOUSE
AccessionPrimary (citable) accession number: Q921X9
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: December 1, 2001
Last modified: May 1, 2013
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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