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Protein

Protein disulfide-isomerase A5

Gene

Pdia5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Catalyzes the rearrangement of -S-S- bonds in proteins.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Names & Taxonomyi

Protein namesi
Recommended name:
Protein disulfide-isomerase A5 (EC:5.3.4.1)
Alternative name(s):
Protein disulfide isomerase-related protein
Gene namesi
Name:Pdia5
Synonyms:Pdir
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1919849. Pdia5.

Subcellular locationi

  • Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000003423422 – 517Protein disulfide-isomerase A5Add BLAST496

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi180 ↔ 183Redox-activePROSITE-ProRule annotation
Disulfide bondi303 ↔ 306Redox-activePROSITE-ProRule annotation
Disulfide bondi424 ↔ 427Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ921X9.
MaxQBiQ921X9.
PaxDbiQ921X9.
PeptideAtlasiQ921X9.
PRIDEiQ921X9.

PTM databases

iPTMnetiQ921X9.
PhosphoSitePlusiQ921X9.
SwissPalmiQ921X9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000022844.
CleanExiMM_PDIA5.
GenevisibleiQ921X9. MM.

Interactioni

Protein-protein interaction databases

IntActiQ921X9. 2 interactors.
MINTiMINT-4122674.
STRINGi10090.ENSMUSP00000023550.

Structurei

3D structure databases

ProteinModelPortaliQ921X9.
SMRiQ921X9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini132 – 259Thioredoxin 1PROSITE-ProRule annotationAdd BLAST128
Domaini268 – 382Thioredoxin 2PROSITE-ProRule annotationAdd BLAST115
Domaini376 – 504Thioredoxin 3PROSITE-ProRule annotationAdd BLAST129

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi514 – 517Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the protein disulfide isomerase family.Curated
Contains 3 thioredoxin domains.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0191. Eukaryota.
COG0526. LUCA.
GeneTreeiENSGT00860000133723.
HOGENOMiHOG000039967.
HOVERGENiHBG053547.
InParanoidiQ921X9.
KOiK09583.
OMAiHKDYDRQ.
OrthoDBiEOG091G04ZS.
PhylomeDBiQ921X9.
TreeFamiTF106379.

Family and domain databases

Gene3Di3.40.30.10. 4 hits.
InterProiIPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 3 hits.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 4 hits.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 2 hits.
PS51352. THIOREDOXIN_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q921X9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARAWGLLLA IGVVLPTWLS STKVSSLIER ISDPKDLKKL LRTRNNVLVL
60 70 80 90 100
YSESEVAAES HLKLLSTVAQ AVKGQGTVCW VDCGDAESRK LCKKMKVDLS
110 120 130 140 150
PKDKKIELFH YQDGAFHMQY DRAVTLKSIV AFLKDPKGPP LWEEDPGAKD
160 170 180 190 200
VVHIDSEKDF RRLLKREEKP LLMMFYAPWC SMCKRIMPHF QKAATQVRGH
210 220 230 240 250
IVLAGMNVYP SEFENIKEEY NVRGYPTICY FEKGRFLFPY ENYGSTAEDI
260 270 280 290 300
VEWLKNPLPP QPQVPETPWA DEGGSVYHLT DEDFDQFVKE HSSVLVMFHA
310 320 330 340 350
PWCGHCKKMK PEFESAAEVL HGDAESSGVL AAVDATVNEA LAGRFHISAF
360 370 380 390 400
PTLKYFKNGE QQAVPALRTK KKFIEWMQNP EAPPPPEPTW EEQQTSVLHL
410 420 430 440 450
VGDNFRDTLK KKKHTLVMFY APWCPHCKKV IPHFTATADA FKEDRKIACA
460 470 480 490 500
AVDCVKDKNQ DLCQQEAVKA YPTFHYYHYG KLVEKYESDR TELGFTSFIR
510
TLREGDLKRL EKRREEL
Length:517
Mass (Da):59,267
Last modified:December 1, 2001 - v1
Checksum:i6702B9C5EF9F1C84
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC009151 mRNA. Translation: AAH09151.1.
CCDSiCCDS37323.1.
RefSeqiNP_082571.1. NM_028295.1.
UniGeneiMm.71015.

Genome annotation databases

EnsembliENSMUST00000023550; ENSMUSP00000023550; ENSMUSG00000022844.
GeneIDi72599.
KEGGimmu:72599.
UCSCiuc007zbl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC009151 mRNA. Translation: AAH09151.1.
CCDSiCCDS37323.1.
RefSeqiNP_082571.1. NM_028295.1.
UniGeneiMm.71015.

3D structure databases

ProteinModelPortaliQ921X9.
SMRiQ921X9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ921X9. 2 interactors.
MINTiMINT-4122674.
STRINGi10090.ENSMUSP00000023550.

PTM databases

iPTMnetiQ921X9.
PhosphoSitePlusiQ921X9.
SwissPalmiQ921X9.

Proteomic databases

EPDiQ921X9.
MaxQBiQ921X9.
PaxDbiQ921X9.
PeptideAtlasiQ921X9.
PRIDEiQ921X9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023550; ENSMUSP00000023550; ENSMUSG00000022844.
GeneIDi72599.
KEGGimmu:72599.
UCSCiuc007zbl.1. mouse.

Organism-specific databases

CTDi10954.
MGIiMGI:1919849. Pdia5.

Phylogenomic databases

eggNOGiKOG0191. Eukaryota.
COG0526. LUCA.
GeneTreeiENSGT00860000133723.
HOGENOMiHOG000039967.
HOVERGENiHBG053547.
InParanoidiQ921X9.
KOiK09583.
OMAiHKDYDRQ.
OrthoDBiEOG091G04ZS.
PhylomeDBiQ921X9.
TreeFamiTF106379.

Miscellaneous databases

ChiTaRSiPdia5. mouse.
PROiQ921X9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022844.
CleanExiMM_PDIA5.
GenevisibleiQ921X9. MM.

Family and domain databases

Gene3Di3.40.30.10. 4 hits.
InterProiIPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 3 hits.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 4 hits.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00194. THIOREDOXIN_1. 2 hits.
PS51352. THIOREDOXIN_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPDIA5_MOUSE
AccessioniPrimary (citable) accession number: Q921X9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.