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Protein

Charged multivesicular body protein 1a

Gene

Chmp1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Cell cycle, Cell division, Protein transport, Transcription, Transcription regulation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Charged multivesicular body protein 1a
Alternative name(s):
Chromatin-modifying protein 1a
Short name:
CHMP1a
Gene namesi
Name:Chmp1a
Synonyms:Chmp1By similarity, Pcoln3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1920159. Chmp1a.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Endosome membrane 1 Publication; Peripheral membrane protein 1 Publication
  • Nucleus matrix 1 Publication

  • Note: The cytoplasmic form is partially membrane-associated and localizes to early endosomes. The nuclear form remains associated with the chromosome scaffold during mitosis. On overexpression, it localizes to nuclear bodies characterized by nuclease-resistant condensed chromatin.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endosome, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002114491 – 196Charged multivesicular body protein 1aAdd BLAST196

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei101PhosphoserineBy similarity1
Modified residuei173PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ921W0.
MaxQBiQ921W0.
PaxDbiQ921W0.
PeptideAtlasiQ921W0.
PRIDEiQ921W0.

PTM databases

iPTMnetiQ921W0.
PhosphoSitePlusiQ921W0.

Expressioni

Tissue specificityi

Highly expressed in adult heart, kidney and liver. Expressed at lower levels in adult colon, spleen, lung, brain, testis and muscle. Also expressed in myoblasts and embryo fibroblasts.1 Publication

Gene expression databases

BgeeiENSMUSG00000000743.
CleanExiMM_CHMP1A.
GenevisibleiQ921W0. MM.

Interactioni

Subunit structurei

Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Several assembly forms of ESCRT-III may exist that interact and act sequentally. Self-associates. Interacts with CHMP1B. Interacts with VPS4A. Interacts with VPS4B. Interacts with PHF1. Interacts with IST1. Interacts with MITD1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi231588. 1 interactor.
STRINGi10090.ENSMUSP00000000759.

Structurei

3D structure databases

ProteinModelPortaliQ921W0.
SMRiQ921W0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili5 – 42Sequence analysisAdd BLAST38
Coiled coili102 – 124Sequence analysisAdd BLAST23

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi185 – 195MIT-interacting motifAdd BLAST11

Sequence similaritiesi

Belongs to the SNF7 family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3232. Eukaryota.
COG5491. LUCA.
GeneTreeiENSGT00550000074957.
HOGENOMiHOG000241980.
HOVERGENiHBG080200.
InParanoidiQ921W0.
KOiK12197.
OMAiRVQSAMM.
OrthoDBiEOG091G0S04.
PhylomeDBiQ921W0.
TreeFamiTF300076.

Family and domain databases

InterProiIPR029888. CHMP1A.
IPR005024. Snf7_fam.
[Graphical view]
PANTHERiPTHR10476:SF17. PTHR10476:SF17. 1 hit.
PfamiPF03357. Snf7. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q921W0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDTLFQLKF TAKQLEKLAK KAEKDSKAEQ AKVKKALQQK NVECARVYAE
60 70 80 90 100
NAIRKKNEGV NWLRMASRVD AVASKVQTAV TMKGVTKNMA QVTKALDKAL
110 120 130 140 150
SAMDLQKVSA VMDRFEQQVQ NLDVHTSVME DSVSSATTLT TPQEQVDSLI
160 170 180 190
VQIAEENGLE VLDQLSQLPE GASAVGESSV RSQEDQLSRR LAALRN
Length:196
Mass (Da):21,608
Last modified:December 1, 2001 - v1
Checksum:i19A01EB7C900E858
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK046416 mRNA. Translation: BAC32719.1.
AK159830 mRNA. Translation: BAE35409.1.
BC010524 mRNA. Translation: AAH10524.1.
BC023807 mRNA. Translation: AAH23807.1.
BC036138 mRNA. Translation: AAH36138.1.
BC036152 mRNA. Translation: AAH36152.1.
CCDSiCCDS40509.1.
RefSeqiNP_663581.1. NM_145606.3.
UniGeneiMm.41596.

Genome annotation databases

EnsembliENSMUST00000000759; ENSMUSP00000000759; ENSMUSG00000000743.
GeneIDi234852.
KEGGimmu:234852.
UCSCiuc009nuk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK046416 mRNA. Translation: BAC32719.1.
AK159830 mRNA. Translation: BAE35409.1.
BC010524 mRNA. Translation: AAH10524.1.
BC023807 mRNA. Translation: AAH23807.1.
BC036138 mRNA. Translation: AAH36138.1.
BC036152 mRNA. Translation: AAH36152.1.
CCDSiCCDS40509.1.
RefSeqiNP_663581.1. NM_145606.3.
UniGeneiMm.41596.

3D structure databases

ProteinModelPortaliQ921W0.
SMRiQ921W0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231588. 1 interactor.
STRINGi10090.ENSMUSP00000000759.

PTM databases

iPTMnetiQ921W0.
PhosphoSitePlusiQ921W0.

Proteomic databases

EPDiQ921W0.
MaxQBiQ921W0.
PaxDbiQ921W0.
PeptideAtlasiQ921W0.
PRIDEiQ921W0.

Protocols and materials databases

DNASUi234852.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000759; ENSMUSP00000000759; ENSMUSG00000000743.
GeneIDi234852.
KEGGimmu:234852.
UCSCiuc009nuk.2. mouse.

Organism-specific databases

CTDi5119.
MGIiMGI:1920159. Chmp1a.

Phylogenomic databases

eggNOGiKOG3232. Eukaryota.
COG5491. LUCA.
GeneTreeiENSGT00550000074957.
HOGENOMiHOG000241980.
HOVERGENiHBG080200.
InParanoidiQ921W0.
KOiK12197.
OMAiRVQSAMM.
OrthoDBiEOG091G0S04.
PhylomeDBiQ921W0.
TreeFamiTF300076.

Miscellaneous databases

ChiTaRSiChmp1a. mouse.
PROiQ921W0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000743.
CleanExiMM_CHMP1A.
GenevisibleiQ921W0. MM.

Family and domain databases

InterProiIPR029888. CHMP1A.
IPR005024. Snf7_fam.
[Graphical view]
PANTHERiPTHR10476:SF17. PTHR10476:SF17. 1 hit.
PfamiPF03357. Snf7. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCHM1A_MOUSE
AccessioniPrimary (citable) accession number: Q921W0
Secondary accession number(s): Q3TW57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.