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Q921V5

- MGAT2_MOUSE

UniProt

Q921V5 - MGAT2_MOUSE

Protein

Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Gene

Mgat2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Catalyzes an essential step in the conversion of oligo-mannose to complex N-glycans.By similarity

    Catalytic activityi

    UDP-N-acetyl-D-glucosamine + 6-(alpha-D-mannosyl)-beta-D-mannosyl-R = UDP + 6-(2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R.

    Pathwayi

    GO - Molecular functioni

    1. alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity Source: MGI
    2. carbohydrate binding Source: Ensembl

    GO - Biological processi

    1. oligosaccharide biosynthetic process Source: InterPro
    2. protein N-linked glycosylation via asparagine Source: MGI

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    ReactomeiREACT_198568. Reactions specific to the complex N-glycan synthesis pathway.
    UniPathwayiUPA00378.

    Protein family/group databases

    CAZyiGT16. Glycosyltransferase Family 16.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (EC:2.4.1.143)
    Alternative name(s):
    Beta-1,2-N-acetylglucosaminyltransferase II
    GlcNAc-T II
    Short name:
    GNT-II
    Mannoside acetylglucosaminyltransferase 2
    N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II
    Gene namesi
    Name:Mgat2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:2384966. Mgat2.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi membrane Source: UniProtKB-SubCell
    2. Golgi stack Source: InterPro
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 442442Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferasePRO_0000080518Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi64 – 641N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi81 – 811N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ921V5.
    PaxDbiQ921V5.
    PRIDEiQ921V5.

    PTM databases

    PhosphoSiteiQ921V5.

    Expressioni

    Gene expression databases

    BgeeiQ921V5.
    CleanExiMM_MGAT2.
    GenevestigatoriQ921V5.

    Interactioni

    Protein-protein interaction databases

    IntActiQ921V5. 1 interaction.
    MINTiMINT-1864592.

    Structurei

    3D structure databases

    ProteinModelPortaliQ921V5.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 99CytoplasmicSequence Analysis
    Topological domaini30 – 442413LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei10 – 2920Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG239633.
    GeneTreeiENSGT00390000007341.
    HOGENOMiHOG000261661.
    HOVERGENiHBG052467.
    InParanoidiQ921V5.
    KOiK00736.
    OMAiHAGDCGM.
    OrthoDBiEOG7TF79W.
    PhylomeDBiQ921V5.
    TreeFamiTF314772.

    Family and domain databases

    Gene3Di3.90.550.10. 2 hits.
    InterProiIPR007754. GlcNAc_II.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view]
    PANTHERiPTHR12871. PTHR12871. 1 hit.
    PfamiPF05060. MGAT2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53448. SSF53448. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Q921V5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRFRIYKRKV LILTLVVAAC GFVLWSSNGR QRKSDALGPP LLDAEPVRGA    50
    GHLAVSVGIR RVSNESAAPL VPAVPRPEVD NLTLRYRSLV YQLNFDQMLR 100
    NVGNDGTWSP GELVLVVQVH NRPEYLRLLI DSLRKAQGIQ EVLVIFSHDF 150
    WSAEINSLIS RVDFCPVLQV FFPFSIQLYP NEFPGSDPRD CPRDLKKNAA 200
    LKLGCINAEY PDSFGHYREA KFSQTKHHWW WKLHFVWERV KVLQDYTGLI 250
    LFLEEDHYLA PDFYHVFKKM WKLKQQECPG CDVLSLGTYT TIRSFYGIAD 300
    KVDVKTWKST EHNMGLALTR DAYQKLIECT DTFCTYDDYN WDWTLQYLTL 350
    ACLPKIWKVL VPQAPRIFHA GDCGMHHKKT CRPSTQSAQI ESLLNSNKQY 400
    LFPETLVIGE KFPMAAISPP RKNGGWGDIR DHELCKSYRR LQ 442
    Length:442
    Mass (Da):51,030
    Last modified:December 1, 2001 - v1
    Checksum:iE32D078C4F209843
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti9 – 91K → E in BAC38888. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK083370 mRNA. Translation: BAC38888.1.
    AK152925 mRNA. Translation: BAE31600.1.
    BC010583 mRNA. Translation: AAH10583.1.
    BC027169 mRNA. Translation: AAH27169.1.
    CCDSiCCDS25947.1.
    RefSeqiNP_666147.1. NM_146035.2.
    UniGeneiMm.206642.
    Mm.398746.
    Mm.483133.

    Genome annotation databases

    EnsembliENSMUST00000060579; ENSMUSP00000057905; ENSMUSG00000043998.
    GeneIDi217664.
    KEGGimmu:217664.
    UCSCiuc011ymy.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK083370 mRNA. Translation: BAC38888.1 .
    AK152925 mRNA. Translation: BAE31600.1 .
    BC010583 mRNA. Translation: AAH10583.1 .
    BC027169 mRNA. Translation: AAH27169.1 .
    CCDSi CCDS25947.1.
    RefSeqi NP_666147.1. NM_146035.2.
    UniGenei Mm.206642.
    Mm.398746.
    Mm.483133.

    3D structure databases

    ProteinModelPortali Q921V5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q921V5. 1 interaction.
    MINTi MINT-1864592.

    Chemistry

    ChEMBLi CHEMBL2375203.

    Protein family/group databases

    CAZyi GT16. Glycosyltransferase Family 16.

    PTM databases

    PhosphoSitei Q921V5.

    Proteomic databases

    MaxQBi Q921V5.
    PaxDbi Q921V5.
    PRIDEi Q921V5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000060579 ; ENSMUSP00000057905 ; ENSMUSG00000043998 .
    GeneIDi 217664.
    KEGGi mmu:217664.
    UCSCi uc011ymy.1. mouse.

    Organism-specific databases

    CTDi 4247.
    MGIi MGI:2384966. Mgat2.

    Phylogenomic databases

    eggNOGi NOG239633.
    GeneTreei ENSGT00390000007341.
    HOGENOMi HOG000261661.
    HOVERGENi HBG052467.
    InParanoidi Q921V5.
    KOi K00736.
    OMAi HAGDCGM.
    OrthoDBi EOG7TF79W.
    PhylomeDBi Q921V5.
    TreeFami TF314772.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .
    Reactomei REACT_198568. Reactions specific to the complex N-glycan synthesis pathway.

    Miscellaneous databases

    NextBioi 375938.
    PROi Q921V5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q921V5.
    CleanExi MM_MGAT2.
    Genevestigatori Q921V5.

    Family and domain databases

    Gene3Di 3.90.550.10. 2 hits.
    InterProi IPR007754. GlcNAc_II.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view ]
    PANTHERi PTHR12871. PTHR12871. 1 hit.
    Pfami PF05060. MGAT2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53448. SSF53448. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Bone marrow.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiMGAT2_MOUSE
    AccessioniPrimary (citable) accession number: Q921V5
    Secondary accession number(s): Q3U6X4, Q8C3Z6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 21, 2005
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways

    External Data

    Dasty 3