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Protein

Smoothelin

Gene

Smtn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Structural protein of the cytoskeleton.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Smoothelin
Gene namesi
Name:Smtn
Synonyms:Smsmo
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1354727. Smtn.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003185932 – 923SmoothelinAdd BLAST922

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei299PhosphoserineBy similarity1
Modified residuei301PhosphoserineBy similarity1
Modified residuei304PhosphoserineBy similarity1
Modified residuei340PhosphoserineBy similarity1
Modified residuei359PhosphothreonineBy similarity1
Modified residuei372PhosphothreonineBy similarity1
Modified residuei501PhosphoserineBy similarity1
Modified residuei521PhosphoserineBy similarity1
Modified residuei574PhosphoserineBy similarity1
Modified residuei641PhosphoserineCombined sources1
Modified residuei735PhosphoserineBy similarity1
Modified residuei798PhosphoserineBy similarity1
Isoform L2 (identifier: Q921U8-2)
Modified residuei372PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ921U8.
PeptideAtlasiQ921U8.
PRIDEiQ921U8.

PTM databases

iPTMnetiQ921U8.
PhosphoSitePlusiQ921U8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020439.
CleanExiMM_SMTN.
ExpressionAtlasiQ921U8. baseline and differential.
GenevisibleiQ921U8. MM.

Interactioni

Protein-protein interaction databases

BioGridi205923. 1 interactor.
IntActiQ921U8. 3 interactors.
MINTiMINT-4130954.
STRINGi10090.ENSMUSP00000020721.

Structurei

3D structure databases

ProteinModelPortaliQ921U8.
SMRiQ921U8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini805 – 909Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST105

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili24 – 89Sequence analysisAdd BLAST66
Coiled coili601 – 628Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi194 – 272Pro-richAdd BLAST79
Compositional biasi367 – 391Ser-richAdd BLAST25
Compositional biasi645 – 709Thr-richAdd BLAST65
Compositional biasi697 – 740Ser-richAdd BLAST44

Sequence similaritiesi

Belongs to the smoothelin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4678. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00760000118856.
HOVERGENiHBG076678.
InParanoidiQ921U8.
TreeFamiTF316716.

Family and domain databases

CDDicd00014. CH. 1 hit.
Gene3Di1.10.418.10. 1 hit.
InterProiView protein in InterPro
IPR001715. CH-domain.
IPR022189. SMTN.
PfamiView protein in Pfam
PF00307. CH. 1 hit.
PF12510. Smoothelin. 3 hits.
SMARTiView protein in SMART
SM00033. CH. 1 hit.
SUPFAMiSSF47576. SSF47576. 1 hit.
PROSITEiView protein in PROSITE
PS50021. CH. 1 hit.

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform L1 (identifier: Q921U8-1) [UniParc]FASTAAdd to basket
Also known as: B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADEALAGLD EGALRKLLEV TADLAERRRI RSAIRELQRQ ELEREEEALA
60 70 80 90 100
SKRFRAERQD NKENWLHSQQ REAEQQAALA RLAGRLESMN DVEELTTLLR
110 120 130 140 150
SAGEYEERKL IRAAIRRVRA QEIKAATLAG RLCSRLPSSG PREDSRRQAA
160 170 180 190 200
HTLDPGKVPE PEQQEQQTEV LEPTPTPEDT SQDVTTVTLL LRAPPGGRPS
210 220 230 240 250
SPASPHNSPT SASPEPLLEP AGAQCPAVEA PVSSEPLPHP SEAPSPEPPM
260 270 280 290 300
SPVPSSSRGR VISKPLPGPT EPSDTLDSIR GFSNTKRADP SETKSCQRSL
310 320 330 340 350
SVLSPRQPTP NREPTSLAGP SQFRRVGSVR DRVQKFTSDS PVVARLQDGP
360 370 380 390 400
PRTALASPTP TRLPGPSLIS TTPASSSSSN SSSPSPSDTS SHKKQRELAH
410 420 430 440 450
SLAELQSCPQ EEGPGGRGLA LRSLENRAGG PKPCSEEPST PPPVAVGTGE
460 470 480 490 500
PGGSMKTTFT IEIKDGRGQA STGRVLLPTG NQRAELTLGL RAPPTLLSTS
510 520 530 540 550
SGGKNTITHI SNPGTVTRLG SVTHVTTFSH ASPGNRGGCN FKMEPDPAEP
560 570 580 590 600
PSTTVEAANG AEQARVDKGP EGRSPLSAEE LTAIEDEGVL DKMLDQTTNF
610 620 630 640 650
EERKLIRAAL RELRQRKRDQ RDKERERRLR EARARPGESR SNVATETTTR
660 670 680 690 700
HSQRAADGST VGTVTKTERL VHSNDGTQTA RTTTVESSFM RRLENGSSSS
710 720 730 740 750
STTTTTVQTK SFSSSSSSSS SKKMGSIFDR EDQTSSRPGS LAALERRQAE
760 770 780 790 800
KKKELMKAQS LPKTSASQAR KAMIEKLEKE GSAGGPGTPR TAVQRSTSFG
810 820 830 840 850
VPNANSIKQM LLDWCRAKTR GYEHVDIQNF SSSWSDGMAF CALVHNFFPE
860 870 880 890 900
AFDYGQLSPQ NRRQNFEMAF SSAEMLVDCV PLVEVEDMMI MGKKPDPKCV
910 920
FTYVQSLYNH LRRHELRLRG KNV
Length:923
Mass (Da):100,289
Last modified:February 5, 2008 - v2
Checksum:i2E70E413C8B487C7
GO
Isoform L2 (identifier: Q921U8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     875-923: MLVDCVPLVE...HELRLRGKNV → THADCPQLLD...QKGLVKTKKS

Show »
Length:921
Mass (Da):100,135
Checksum:i019B4D29FC07BACF
GO
Isoform S1 (identifier: Q921U8-3) [UniParc]FASTAAdd to basket
Also known as: A

The sequence of this isoform differs from the canonical sequence as follows:
     1-454: Missing.

Show »
Length:469
Mass (Da):51,657
Checksum:i7DB57BDE4A611CA1
GO
Isoform S2 (identifier: Q921U8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-454: Missing.
     875-923: MLVDCVPLVE...HELRLRGKNV → THADCPQLLD...QKGLVKTKKS

Show »
Length:467
Mass (Da):51,503
Checksum:iCE56CFFC6761D5A4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti173P → S in AAD29628 (PubMed:10965129).Curated1
Sequence conflicti173P → S in AAF01480 (PubMed:10023782).Curated1
Sequence conflicti173P → S in CAA09076 (PubMed:10023782).Curated1
Sequence conflicti173P → S in AAF25577 (Ref. 3) Curated1
Sequence conflicti173P → S in AAF25578 (Ref. 3) Curated1
Sequence conflicti379Missing in AAH69839 (PubMed:15489334).Curated1
Sequence conflicti379Missing in AAH69836 (PubMed:15489334).Curated1
Sequence conflicti379Missing in AAH66192 (PubMed:15489334).Curated1
Sequence conflicti441P → Q in BAE41853 (PubMed:16141072).Curated1
Sequence conflicti448T → N in BAC27188 (PubMed:16141072).Curated1
Sequence conflicti450E → G in AAH69839 (PubMed:15489334).Curated1
Sequence conflicti450E → G in AAH69836 (PubMed:15489334).Curated1
Sequence conflicti450E → G in AAH66192 (PubMed:15489334).Curated1
Sequence conflicti711S → N in AAD29628 (PubMed:10965129).Curated1
Sequence conflicti711S → N in AAF67392 (PubMed:10965129).Curated1
Sequence conflicti711S → N in AAF01480 (PubMed:10023782).Curated1
Sequence conflicti711S → N in CAA09076 (PubMed:10023782).Curated1
Sequence conflicti711S → N in AAF25577 (Ref. 3) Curated1
Sequence conflicti711S → N in AAF25578 (Ref. 3) Curated1
Sequence conflicti711S → N in AAF25579 (Ref. 3) Curated1
Sequence conflicti711S → N in AAF25580 (Ref. 3) Curated1
Sequence conflicti756M → V in AAH69839 (PubMed:15489334).Curated1
Sequence conflicti756M → V in AAH69836 (PubMed:15489334).Curated1
Sequence conflicti756M → V in AAH66192 (PubMed:15489334).Curated1
Sequence conflicti837G → R in AAD29628 (PubMed:10965129).Curated1
Sequence conflicti837G → R in AAF67392 (PubMed:10965129).Curated1
Sequence conflicti837G → R in AAF01480 (PubMed:10023782).Curated1
Sequence conflicti837G → R in CAA09076 (PubMed:10023782).Curated1
Sequence conflicti837G → R in AAF25577 (Ref. 3) Curated1
Sequence conflicti837G → R in AAF25578 (Ref. 3) Curated1
Sequence conflicti837G → R in AAF25579 (Ref. 3) Curated1
Sequence conflicti837G → R in AAF25580 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0312431 – 454Missing in isoform S1 and isoform S2. CuratedAdd BLAST454
Alternative sequenceiVSP_031244875 – 923MLVDC…RGKNV → THADCPQLLDTEDMVRLREP DWKCVYTYIQEFYRCLVQKG LVKTKKS in isoform L2 and isoform S2. 3 PublicationsAdd BLAST49

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF218834
, AF116517, AF116518, AF195524, AF195525, AF218829, AF218830, AF218831, AF218832, AF218833 Genomic DNA. Translation: AAD29628.2.
AF218834
, AF116518, AF195525, AF218830, AF218831, AF218832, AF218833 Genomic DNA. Translation: AAF67392.1.
AF064236 mRNA. Translation: AAF01480.1.
AJ010305 mRNA. Translation: CAA09076.1.
AF132449 Genomic DNA. Translation: AAF25577.2.
AF132449 Genomic DNA. Translation: AAF25578.2.
AF132449 Genomic DNA. Translation: AAF25579.2.
AF132449 Genomic DNA. Translation: AAF25580.2.
AK030932 mRNA. Translation: BAC27188.1.
AK170516 mRNA. Translation: BAE41853.1.
BC010599 mRNA. Translation: AAH10599.1.
BC066192 mRNA. Translation: AAH66192.1.
BC069836 mRNA. Translation: AAH69836.1.
BC069839 mRNA. Translation: AAH69839.1.
CCDSiCCDS24366.1. [Q921U8-2]
CCDS70129.1. [Q921U8-1]
RefSeqiNP_001152756.1. NM_001159284.1. [Q921U8-2]
NP_001271356.1. NM_001284427.1. [Q921U8-1]
NP_001271357.1. NM_001284428.1. [Q921U8-2]
NP_001271358.1. NM_001284429.1.
NP_038898.2. NM_013870.3. [Q921U8-2]
XP_017170075.1. XM_017314586.1. [Q921U8-1]
UniGeneiMm.188516.

Genome annotation databases

EnsembliENSMUST00000020721; ENSMUSP00000020721; ENSMUSG00000020439. [Q921U8-2]
ENSMUST00000075118; ENSMUSP00000074621; ENSMUSG00000020439. [Q921U8-1]
ENSMUST00000170588; ENSMUSP00000133155; ENSMUSG00000020439. [Q921U8-2]
GeneIDi29856.
KEGGimmu:29856.
UCSCiuc007htf.2. mouse. [Q921U8-2]
uc007hti.2. mouse. [Q921U8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSMTN_MOUSE
AccessioniPrimary (citable) accession number: Q921U8
Secondary accession number(s): Q3TCV2
, Q6NSW1, Q8CD93, Q9JHG8, Q9JLU7, Q9R0D0, Q9R253, Q9Z0Q2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: September 27, 2017
This is version 102 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families