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Q921T1 (Q921T1_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesSubmitted name:
Tgfb2 protein EMBL AAH11055.1
Gene names
Name:Tgfb2 MGI 98726
OrganismMus musculus (Mouse) EMBL AAH11055.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length255 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the TGF-beta family. RuleBase RU000354

Ontologies

Keywords
   Cellular componentSecreted SAAS SAAS001111
   Molecular functionGrowth factor RuleBase RU000354 SAAS SAAS001111
   PTMDisulfide bond SAAS SAAS001111
Gene Ontology (GO)
   Biological_processaxon guidance

Inferred from mutant phenotype PubMed 15528466. Source: MGI

blood vessel development

Inferred from mutant phenotype PubMed 15528466. Source: MGI

blood vessel remodeling

Inferred from mutant phenotype PubMed 12393102. Source: MGI

cartilage condensation

Inferred from genetic interaction PubMed 8565825. Source: MGI

cell growth

Inferred from electronic annotation. Source: InterPro

extracellular matrix organization

Inferred from mutant phenotype PubMed 11784073PubMed 15528466. Source: MGI

hair follicle development

Inferred from mutant phenotype PubMed 15630473. Source: MGI

heart development

Inferred from mutant phenotype PubMed 15528466. Source: MGI

neuron fate commitment

Inferred from direct assay PubMed 15744664. Source: MGI

positive regulation of activation-induced cell death of T cells

Inferred from direct assay PubMed 8206089. Source: MGI

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Inferred from direct assay PubMed 8206089. Source: MGI

regulation of apoptotic process

Inferred from mutant phenotype PubMed 12393102. Source: MGI

skeletal system development

Inferred from mutant phenotype PubMed 15531369. Source: MGI

   Cellular_componentextracellular space

Inferred from direct assay PubMed 8164195. Source: MGI

   Molecular_functionprotein binding

Inferred from physical interaction PubMed 14985127. Source: MGI

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q921T1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 94540017F3C5C219

FASTA25529,087
        10         20         30         40         50         60 
MFRVEEATHV QILKSKDLTS PTQRYIDSKV VKTRAEGEWL SFDVTDAVQE WLHHKDRNLG 

        70         80         90        100        110        120 
FKISLHCPCC TFVPSNNYII PNKSEELEAR FAGIDGTSTY ASGDQKTIKS TRKKTSGKTP 

       130        140        150        160        170        180 
HLLLMLLPSY RLESQQSSRR KKRALDAAYC FRNVQDNCCL RPLYIDFKRD LGWKWIHEPK 

       190        200        210        220        230        240 
GYNANFCAGA CPYLWSSDTQ HTKVLSLYNT INPEASASPC CVSQDLEPLT ILYYIGNTPK 

       250 
IEQLSNMIVK SCKCS

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N EMBL AAH11055.1.
Tissue: Mammary tumor. Metallothionien-TGF alpha model. 10 month old virgin mouse. Taken by biopsy. EMBL AAH11055.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC011055 mRNA. Translation: AAH11055.1.
UniGeneMm.18213.

3D structure databases

ProteinModelPortalQ921T1.
SMRQ921T1. Positions 144-255.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ921T1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:98726. Tgfb2.

Phylogenomic databases

HOVERGENHBG074115.
InParanoidQ921T1.

Gene expression databases

GenevestigatorQ921T1.

Family and domain databases

Gene3D2.10.90.10. 1 hit.
InterProIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR016319. TGF-beta.
IPR015615. TGF-beta-rel.
IPR003940. TGFb2.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERPTHR11848. PTHR11848. 1 hit.
PfamPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSPR01423. TGFBETA.
PR01425. TGFBETA2.
SMARTSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMSSF57501. SSF57501. 1 hit.
PROSITEPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTGFB2. mouse.
SOURCESearch...

Entry information

Entry nameQ921T1_MOUSE
AccessionPrimary (citable) accession number: Q921T1
Entry history
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: June 11, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info