Q921T1 (Q921T1_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Tgfb2 protein EMBL AAH11055.1

Gene names

Name:

Tgfb2 MGI 98726

Organism

Mus musculus (Mouse) EMBL AAH11055.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	255 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the TGF-beta family. RuleBase RU000354

Ontologies

Keywords
Cellular component	Secreted SAAS SAAS001839
Molecular function	Growth factor SAAS SAAS001839 RuleBase RU000354
PTM	Disulfide bond SAAS SAAS001839
Gene Ontology (GO)
Biological_process	axon guidance Inferred from mutant phenotype PubMed 15528466. Source: MGI blood vessel development Inferred from mutant phenotype PubMed 15528466. Source: MGI blood vessel remodeling Inferred from mutant phenotype PubMed 12393102. Source: MGI cartilage condensation Inferred from genetic interaction PubMed 8565825. Source: MGI cell growth Inferred from electronic annotation. Source: InterPro extracellular matrix organization Inferred from mutant phenotype PubMed 11784073PubMed 15528466. Source: MGI hair follicle development Inferred from mutant phenotype PubMed 15630473. Source: MGI heart development Inferred from mutant phenotype PubMed 15528466. Source: MGI neuron fate commitment Inferred from direct assay PubMed 15744664. Source: MGI positive regulation of activation-induced cell death of T cells Inferred from direct assay PubMed 8206089. Source: MGI positive regulation of extrinsic apoptotic signaling pathway in absence of ligand Inferred from direct assay PubMed 8206089. Source: MGI
Cellular_component	extracellular space Inferred from direct assay PubMed 8164195. Source: MGI
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q921T1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 94540017F3C5C219	FASTA	255	29,087
	10 20 30 40 50 60 MFRVEEATHV QILKSKDLTS PTQRYIDSKV VKTRAEGEWL SFDVTDAVQE WLHHKDRNLG 70 80 90 100 110 120 FKISLHCPCC TFVPSNNYII PNKSEELEAR FAGIDGTSTY ASGDQKTIKS TRKKTSGKTP 130 140 150 160 170 180 HLLLMLLPSY RLESQQSSRR KKRALDAAYC FRNVQDNCCL RPLYIDFKRD LGWKWIHEPK 190 200 210 220 230 240 GYNANFCAGA CPYLWSSDTQ HTKVLSLYNT INPEASASPC CVSQDLEPLT ILYYIGNTPK 250 IEQLSNMIVK SCKCS

References

[1]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J. Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N EMBL AAH11055.1. Tissue: Mammary tumor. Metallothionien-TGF alpha model. 10 month old virgin mouse. Taken by biopsy. EMBL AAH11055.1.

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Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC011055 mRNA. Translation: AAH11055.1.
IPI	IPI00114180.
UniGene	Mm.18213.
3D structure databases
ProteinModelPortal	Q921T1.
SMR	Q921T1. Positions 144-255.
ModBase	Search...
Proteomic databases
PRIDE	Q921T1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:98726. Tgfb2.
Phylogenomic databases
HOVERGEN	HBG074115.
InParanoid	Q921T1.
Gene expression databases
Genevestigator	Q921T1.
Family and domain databases
InterPro	IPR001839. TGF-b_C. IPR001111. TGF-b_N. IPR016319. TGF-beta. IPR015615. TGF-beta-rel. IPR003940. TGFb2. IPR017948. TGFb_CS. [Graphical view]
PANTHER	PTHR11848. PTHR11848. 1 hit.
Pfam	PF00019. TGF_beta. 1 hit. PF00688. TGFb_propeptide. 1 hit. [Graphical view]
PRINTS	PR01423. TGFBETA. PR01425. TGFBETA2.
SMART	SM00204. TGFB. 1 hit. [Graphical view]
PROSITE	PS00250. TGF_BETA_1. 1 hit. PS51362. TGF_BETA_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	TGFB2. mouse.
SOURCE	Search...

Entry information

Entry name

Q921T1_MOUSE

Accession

Primary (citable) accession number: Q921T1

Entry history

Integrated into UniProtKB/TrEMBL:	December 1, 2001
Last sequence update:	December 1, 2001
Last modified:	October 16, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)