Tgfb2 protein

<p>Provides any useful information about the protein, mostly biological knowledge.</p><p><a href='../manual/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• beta-amyloid binding Source: AgBase
• protein homodimerization activity Source: AgBase
• receptor binding Source: AgBase
• receptor signaling protein serine/threonine kinase activity Source: AgBase
• transforming growth factor beta receptor binding Source: AgBase
• type III transforming growth factor beta receptor binding Source: AgBase
• type II transforming growth factor beta receptor binding Source: AgBase

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• activation of protein kinase activity Source: AgBase
• cardiac epithelial to mesenchymal transition Source: AgBase
• cardiac muscle cell proliferation Source: AgBase
• cardioblast differentiation Source: AgBase
• cell-cell junction organization Source: AgBase
• cell cycle arrest Source: AgBase
• cell death Source: AgBase
• cell growth Source: InterPro
• cell migration Source: AgBase
• cell morphogenesis Source: AgBase
• collagen fibril organization Source: AgBase
• embryonic digestive tract development Source: AgBase
• epithelial to mesenchymal transition Source: AgBase
• extrinsic apoptotic signaling pathway Source: AgBase
• eye development Source: AgBase
• glial cell migration Source: AgBase
• hair follicle development Source: AgBase
• heart development Source: AgBase
• heart morphogenesis Source: AgBase
• negative regulation of alkaline phosphatase activity Source: AgBase
• negative regulation of cell growth Source: AgBase
• negative regulation of cell proliferation Source: AgBase
• negative regulation of epithelial cell proliferation Source: AgBase
• negative regulation of macrophage cytokine production Source: AgBase
• pathway-restricted SMAD protein phosphorylation Source: AgBase
• positive regulation of cardioblast differentiation Source: AgBase
• positive regulation of catagen Source: AgBase
• positive regulation of cell adhesion mediated by integrin Source: AgBase
• positive regulation of cell growth Source: AgBase
• positive regulation of cell proliferation Source: AgBase
• positive regulation of epithelial cell migration Source: AgBase
• positive regulation of epithelial to mesenchymal transition Source: AgBase
• positive regulation of heart contraction Source: AgBase
• positive regulation of integrin biosynthetic process Source: AgBase
• positive regulation of neuron apoptotic process Source: AgBase
• positive regulation of ossification Source: AgBase
• positive regulation of phosphatidylinositol 3-kinase signaling Source: AgBase
• positive regulation of protein secretion Source: AgBase
• positive regulation of stress-activated MAPK cascade Source: AgBase
• protein phosphorylation Source: AgBase
• regulation of transforming growth factor beta2 production Source: AgBase
• response to drug Source: AgBase
• response to progesterone Source: AgBase
• response to wounding Source: AgBase
• salivary gland morphogenesis Source: AgBase
• signal transduction by protein phosphorylation Source: AgBase
• SMAD protein import into nucleus Source: AgBase
• transforming growth factor beta receptor signaling pathway Source: AgBase

<p>UniProtKB Keywords constitute a <a target="_top" href="/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Molecular functionⁱ

<p>Provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.</p><p><a href='../manual/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>Provides information on the location and the topology of the mature protein in the cell.</p><p><a href='../manual/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Cellular componentⁱ

• extracellular matrix Source: AgBase
• extracellular space Source: InterPro
• intracellular Source: GOC

<p>UniProtKB Keywords constitute a <a target="_top" href="/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>Describes post-translational modifications (PTMs) and/or processing events.</p><p><a href='../manual/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

<p>UniProtKB Keywords constitute a <a target="_top" href="/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMⁱ

Proteomic databases

<p>Provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.</p><p><a href='../manual/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• protein homodimerization activity Source: AgBase
• receptor binding Source: AgBase
• transforming growth factor beta receptor binding Source: AgBase
• type III transforming growth factor beta receptor binding Source: AgBase
• type II transforming growth factor beta receptor binding Source: AgBase

Protein-protein interaction databases

<p>Provides information on the tertiary and secondary structure of a protein.</p><p><a href='../manual/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>Provides information on sequence similarities with other proteins and the domain(s) present in a protein.</p><p><a href='../manual/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
<p>Describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.</p><p><a href='../manual/domain' target='_top'>More...</a></p>Domaini	140 – 255	116	TGF_BETA_2InterPro annotation <p>Information which has been generated by the UniProtKB automatic annotation system, without manual validation.</p> <p><a href="/manual/evidences#ECO:0000259">More…</a></p> Automatic assertion inferred from signature matchi PROSITE:PS51362			Add BLAST

<p>Provides information about the sequence similarity with other proteins.</p><p><a href='../manual/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>Displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.</p><p><a href='../manual/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>Indicates if the <a href="/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.</p><p><a href='../manual/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MFRVEEATHV QILKSKDLTS PTQRYIDSKV VKTRAEGEWL SFDVTDAVQE 
        60         70         80         90        100
WLHHKDRNLG FKISLHCPCC TFVPSNNYII PNKSEELEAR FAGIDGTSTY 
       110        120        130        140        150
ASGDQKTIKS TRKKTSGKTP HLLLMLLPSY RLESQQSSRR KKRALDAAYC 
       160        170        180        190        200
FRNVQDNCCL RPLYIDFKRD LGWKWIHEPK GYNANFCAGA CPYLWSSDTQ 
       210        220        230        240        250
HTKVLSLYNT INPEASASPC CVSQDLEPLT ILYYIGNTPK IEQLSNMIVK 

SCKCS                                             

Sequence databases

<p>Is used to point to information related to entries and found in data collections other than UniProtKB.</p><p><a href='../manual/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>Provides general information on the entry.</p><p><a href='../manual/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>Provides links to the UniProt Reference Clusters (<a href="/help/uniref">UniRef</a>). UniRef consists of clusters for UniProtKB sequences (including isoforms) and selected UniParc sequences, in order to obtain complete coverage of the sequence space at resolutions of 100%, 90% and 50% identity.</p><p><a href='../manual/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ