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Q921T1

- Q921T1_MOUSE

UniProt

Q921T1 - Q921T1_MOUSE

Protein
Submitted name:

Tgfb2 protein

Gene

Tgfb2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: MGI

    GO - Biological processi

    1. axon guidance Source: MGI
    2. blood vessel development Source: MGI
    3. blood vessel remodeling Source: MGI
    4. cartilage condensation Source: MGI
    5. cell growth Source: InterPro
    6. extracellular matrix organization Source: MGI
    7. hair follicle development Source: MGI
    8. heart development Source: MGI
    9. heart valve morphogenesis Source: MGI
    10. negative regulation of cartilage development Source: MGI
    11. neuron fate commitment Source: MGI
    12. positive regulation of activation-induced cell death of T cells Source: MGI
    13. positive regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
    14. regulation of apoptotic process Source: MGI
    15. regulation of extracellular matrix organization Source: MGI
    16. skeletal system development Source: MGI

    Keywords - Molecular functioni

    Growth factorUniRule annotationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Tgfb2 proteinImported
    Gene namesi
    Name:Tgfb2Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:98726. Tgfb2.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: MGI

    Keywords - Cellular componenti

    SecretedSAAS annotation

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Proteomic databases

    PRIDEiQ921T1.

    Expressioni

    Gene expression databases

    GenevestigatoriQ921T1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ921T1.
    SMRiQ921T1. Positions 144-255.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TGF-beta family.UniRule annotation

    Phylogenomic databases

    HOVERGENiHBG074115.
    InParanoidiQ921T1.

    Family and domain databases

    Gene3Di2.10.90.10. 1 hit.
    InterProiIPR029034. Cystine-knot_cytokine.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR016319. TGF-beta.
    IPR015615. TGF-beta-rel.
    IPR003940. TGFb2.
    IPR017948. TGFb_CS.
    [Graphical view]
    PANTHERiPTHR11848. PTHR11848. 1 hit.
    PfamiPF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view]
    PRINTSiPR01423. TGFBETA.
    PR01425. TGFBETA2.
    SMARTiSM00204. TGFB. 1 hit.
    [Graphical view]
    SUPFAMiSSF57501. SSF57501. 1 hit.
    PROSITEiPS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q921T1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFRVEEATHV QILKSKDLTS PTQRYIDSKV VKTRAEGEWL SFDVTDAVQE    50
    WLHHKDRNLG FKISLHCPCC TFVPSNNYII PNKSEELEAR FAGIDGTSTY 100
    ASGDQKTIKS TRKKTSGKTP HLLLMLLPSY RLESQQSSRR KKRALDAAYC 150
    FRNVQDNCCL RPLYIDFKRD LGWKWIHEPK GYNANFCAGA CPYLWSSDTQ 200
    HTKVLSLYNT INPEASASPC CVSQDLEPLT ILYYIGNTPK IEQLSNMIVK 250
    SCKCS 255
    Length:255
    Mass (Da):29,087
    Last modified:December 1, 2001 - v1
    Checksum:i94540017F3C5C219
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC011055 mRNA. Translation: AAH11055.1.
    UniGeneiMm.18213.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC011055 mRNA. Translation: AAH11055.1 .
    UniGenei Mm.18213.

    3D structure databases

    ProteinModelPortali Q921T1.
    SMRi Q921T1. Positions 144-255.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q921T1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:98726. Tgfb2.

    Phylogenomic databases

    HOVERGENi HBG074115.
    InParanoidi Q921T1.

    Miscellaneous databases

    ChiTaRSi TGFB2. mouse.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q921T1.

    Family and domain databases

    Gene3Di 2.10.90.10. 1 hit.
    InterProi IPR029034. Cystine-knot_cytokine.
    IPR001839. TGF-b_C.
    IPR001111. TGF-b_N.
    IPR016319. TGF-beta.
    IPR015615. TGF-beta-rel.
    IPR003940. TGFb2.
    IPR017948. TGFb_CS.
    [Graphical view ]
    PANTHERi PTHR11848. PTHR11848. 1 hit.
    Pfami PF00019. TGF_beta. 1 hit.
    PF00688. TGFb_propeptide. 1 hit.
    [Graphical view ]
    PRINTSi PR01423. TGFBETA.
    PR01425. TGFBETA2.
    SMARTi SM00204. TGFB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57501. SSF57501. 1 hit.
    PROSITEi PS00250. TGF_BETA_1. 1 hit.
    PS51362. TGF_BETA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/NImported.
      Tissue: Mammary tumor. Metallothionien-TGF alpha model. 10 month old virgin mouse. Taken by biopsy.Imported.

    Entry informationi

    Entry nameiQ921T1_MOUSE
    AccessioniPrimary (citable) accession number: Q921T1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 1, 2001
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)