Tgfb2

Functionⁱ

GO - Molecular functionⁱ

amyloid-beta binding Source: AgBase
growth factor activity Source: UniProtKB-KW
protein homodimerization activity Source: AgBase
receptor binding Source: AgBase
transforming growth factor beta receptor binding Source: AgBase
type III transforming growth factor beta receptor binding Source: AgBase
type II transforming growth factor beta receptor binding Source: AgBase

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of protein kinase activity Source: AgBase
cardiac epithelial to mesenchymal transition Source: AgBase
cardiac muscle cell proliferation Source: AgBase
cardioblast differentiation Source: AgBase
cell-cell junction organization Source: AgBase
cell cycle arrest Source: AgBase
cell death Source: AgBase
cell growth Source: InterPro
cell migration Source: AgBase
cell morphogenesis Source: AgBase
collagen fibril organization Source: AgBase
embryonic digestive tract development Source: AgBase
epithelial to mesenchymal transition Source: AgBase
extrinsic apoptotic signaling pathway Source: AgBase
eye development Source: AgBase
glial cell migration Source: AgBase
hair follicle development Source: AgBase
heart development Source: AgBase
heart morphogenesis Source: AgBase
negative regulation of alkaline phosphatase activity Source: AgBase
negative regulation of cell growth Source: AgBase
negative regulation of cell proliferation Source: AgBase
negative regulation of epithelial cell proliferation Source: AgBase
negative regulation of macrophage cytokine production Source: AgBase
pathway-restricted SMAD protein phosphorylation Source: AgBase
positive regulation of cardioblast differentiation Source: AgBase
positive regulation of cell adhesion mediated by integrin Source: AgBase
positive regulation of cell growth Source: AgBase
positive regulation of cell proliferation Source: AgBase
positive regulation of epithelial cell migration Source: AgBase
positive regulation of epithelial to mesenchymal transition Source: AgBase
positive regulation of heart contraction Source: AgBase
positive regulation of integrin biosynthetic process Source: AgBase
positive regulation of neuron apoptotic process Source: AgBase
positive regulation of ossification Source: AgBase
positive regulation of phosphatidylinositol 3-kinase signaling Source: AgBase
positive regulation of protein secretion Source: AgBase
positive regulation of stress-activated MAPK cascade Source: AgBase
positive regulation of timing of catagen Source: AgBase
protein phosphorylation Source: AgBase
regulation of transforming growth factor beta2 production Source: AgBase
response to drug Source: AgBase
response to progesterone Source: AgBase
response to wounding Source: AgBase
salivary gland morphogenesis Source: AgBase
signal transduction by protein phosphorylation Source: AgBase
SMAD protein signal transduction Source: BHF-UCL
transforming growth factor beta receptor signaling pathway Source: AgBase

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Growth factorUniRule annotationSAAS annotation

Molecular function

Growth factorUniRule annotationSAAS annotation

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Tgfb2 proteinImported
Gene namesⁱ	Name:Tgfb2Imported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus

Organism-specific databases

MGIⁱ	MGI:98726. Tgfb2.

Keywords - Cellular componentⁱ

SecretedSAAS annotation

PTM / Processingⁱ

Keywords - PTMⁱ

Disulfide bondSAAS annotation

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	Q921T1.

PeptideAtlasⁱ

Q921T1.

Interactionⁱ

GO - Molecular functionⁱ

growth factor activity Source: UniProtKB-KW
protein homodimerization activity Source: AgBase
receptor binding Source: AgBase
transforming growth factor beta receptor binding Source: AgBase
type III transforming growth factor beta receptor binding Source: AgBase
type II transforming growth factor beta receptor binding Source: AgBase

View the complete GO annotation on QuickGO ...

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q921T1.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	140 – 255	TGF_BETA_2InterPro annotationAdd BLAST		116

Sequence similaritiesⁱ

Belongs to the TGF-beta family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGⁱ	KOG3900. Eukaryota. ENOG410XT8Z. LUCA.
HOVERGENⁱ	HBG074115.

Family and domain databases

Gene3Dⁱ	2.10.90.10. 1 hit.
InterProⁱ	View protein in InterPro IPR029034. Cystine-knot_cytokine. IPR001839. TGF-b_C. IPR001111. TGF-b_propeptide. IPR016319. TGF-beta. IPR015615. TGF-beta-rel. IPR003940. TGFb2. IPR017948. TGFb_CS.
PANTHERⁱ	PTHR11848. PTHR11848. 1 hit. PTHR11848:SF141. PTHR11848:SF141. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00019. TGF_beta. 1 hit. PF00688. TGFb_propeptide. 1 hit.
PRINTSⁱ	PR01423. TGFBETA. PR01425. TGFBETA2.
SMARTⁱ	View protein in SMART SM00204. TGFB. 1 hit.
SUPFAMⁱ	SSF57501. SSF57501. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00250. TGF_BETA_1. 1 hit. PS51362. TGF_BETA_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q921T1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MFRVEEATHV QILKSKDLTS PTQRYIDSKV VKTRAEGEWL SFDVTDAVQE 
        60         70         80         90        100
WLHHKDRNLG FKISLHCPCC TFVPSNNYII PNKSEELEAR FAGIDGTSTY 
       110        120        130        140        150
ASGDQKTIKS TRKKTSGKTP HLLLMLLPSY RLESQQSSRR KKRALDAAYC 
       160        170        180        190        200
FRNVQDNCCL RPLYIDFKRD LGWKWIHEPK GYNANFCAGA CPYLWSSDTQ 
       210        220        230        240        250
HTKVLSLYNT INPEASASPC CVSQDLEPLT ILYYIGNTPK IEQLSNMIVK 

SCKCS

Length:255

Mass (Da):29,087

Last modified:December 1, 2001 - v1

Checksum:ⁱ94540017F3C5C219

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC011055 mRNA. Translation: AAH11055.1.
UniGeneⁱ	Mm.18213.

Similar proteinsⁱ

50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q921T1	L9LD07 UPI00053F908B UPI0004ED4ECA UPI0003C120F1 UPI0005282420 UPI000778984A A0A2K6QVP4 A0A2I3T259 F6ZJW6 UPI000350AADE	Tupaia chinensis (Chinese tree shrew) Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis) Nannospalax galili (Northern Israeli blind subterranean mole rat) (Spalax galili) Latimeria chalumnae (West Indian ocean coelacanth) Eurypyga helias (Sunbittern) Python bivittatus (Burmese python) (Python molurus bivittatus) Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana) Pan troglodytes (Chimpanzee) Macaca mulatta (Rhesus macaque) Anas platyrhynchos (Mallard) (Anas boschas)	377	UniRef50_L9LD07	Cluster: Transforming growth factor beta-2	11

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC011055 mRNA. Translation: AAH11055.1.
UniGeneⁱ	Mm.18213.

3D structure databases

ProteinModelPortalⁱ	Q921T1.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	Q921T1.

PeptideAtlasⁱ

Q921T1.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Organism-specific databases

MGIⁱ	MGI:98726. Tgfb2.

Phylogenomic databases

eggNOGⁱ	KOG3900. Eukaryota. ENOG410XT8Z. LUCA.
HOVERGENⁱ	HBG074115.

Miscellaneous databases

ChiTaRSⁱ	Tgfb2. mouse.
SOURCEⁱ	Search...

Family and domain databases

Gene3Dⁱ	2.10.90.10. 1 hit.
InterProⁱ	View protein in InterPro IPR029034. Cystine-knot_cytokine. IPR001839. TGF-b_C. IPR001111. TGF-b_propeptide. IPR016319. TGF-beta. IPR015615. TGF-beta-rel. IPR003940. TGFb2. IPR017948. TGFb_CS.
PANTHERⁱ	PTHR11848. PTHR11848. 1 hit. PTHR11848:SF141. PTHR11848:SF141. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00019. TGF_beta. 1 hit. PF00688. TGFb_propeptide. 1 hit.
PRINTSⁱ	PR01423. TGFBETA. PR01425. TGFBETA2.
SMARTⁱ	View protein in SMART SM00204. TGFB. 1 hit.
SUPFAMⁱ	SSF57501. SSF57501. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00250. TGF_BETA_1. 1 hit. PS51362. TGF_BETA_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q921T1_MOUSE
Accessionⁱ	Q921T1Primary (citable) accession number: Q921T1
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	December 1, 2001
	Last sequence update:	December 1, 2001
	Last modified:	February 28, 2018
	This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

UniProtKB - Q921T1 (Q921T1_MOUSE)

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Tgfb2 protein

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Organism-specific databases

Subcellular locationⁱ

Extracellular region or secreted

Extracellular region or secreted

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Proteomic databases

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

3D structure databases

Family & Domainsⁱ

Domains and Repeats

Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

Entry informationⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q921T1 (Q921T1_MOUSE)

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Tgfb2 protein

Tgfb2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ