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Protein
Submitted name:

Tgfb2 protein

Gene

Tgfb2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. beta-amyloid binding Source: MGI
  2. cytokine activity Source: GO_Central
  3. protein homodimerization activity Source: MGI
  4. receptor binding Source: MGI
  5. receptor signaling protein serine/threonine kinase activity Source: MGI
  6. transforming growth factor beta receptor binding Source: MGI
  7. type II transforming growth factor beta receptor binding Source: MGI

GO - Biological processi

  1. activation of protein kinase activity Source: MGI
  2. axon guidance Source: MGI
  3. blood vessel development Source: MGI
  4. blood vessel remodeling Source: MGI
  5. cardiac epithelial to mesenchymal transition Source: MGI
  6. cardiac muscle cell proliferation Source: MGI
  7. cardioblast differentiation Source: MGI
  8. cartilage condensation Source: MGI
  9. cell-cell junction organization Source: MGI
  10. cell cycle arrest Source: MGI
  11. cell death Source: MGI
  12. cell growth Source: InterPro
  13. cell migration Source: MGI
  14. cell morphogenesis Source: MGI
  15. collagen fibril organization Source: MGI
  16. epithelial to mesenchymal transition Source: MGI
  17. extracellular matrix organization Source: MGI
  18. extrinsic apoptotic signaling pathway Source: MGI
  19. eye development Source: MGI
  20. glial cell migration Source: MGI
  21. hair follicle development Source: MGI
  22. heart development Source: MGI
  23. heart morphogenesis Source: MGI
  24. heart valve morphogenesis Source: MGI
  25. negative regulation of alkaline phosphatase activity Source: MGI
  26. negative regulation of cartilage development Source: MGI
  27. negative regulation of cell growth Source: MGI
  28. negative regulation of cell proliferation Source: MGI
  29. negative regulation of epithelial cell proliferation Source: MGI
  30. negative regulation of macrophage cytokine production Source: MGI
  31. neuron fate commitment Source: MGI
  32. pathway-restricted SMAD protein phosphorylation Source: MGI
  33. positive regulation of activation-induced cell death of T cells Source: MGI
  34. positive regulation of cardioblast differentiation Source: MGI
  35. positive regulation of catagen Source: MGI
  36. positive regulation of cell adhesion mediated by integrin Source: MGI
  37. positive regulation of cell growth Source: MGI
  38. positive regulation of cell proliferation Source: MGI
  39. positive regulation of epithelial cell migration Source: MGI
  40. positive regulation of epithelial to mesenchymal transition Source: MGI
  41. positive regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
  42. positive regulation of heart contraction Source: MGI
  43. positive regulation of integrin biosynthetic process Source: MGI
  44. positive regulation of neuron apoptotic process Source: MGI
  45. positive regulation of pathway-restricted SMAD protein phosphorylation Source: GO_Central
  46. positive regulation of phosphatidylinositol 3-kinase signaling Source: MGI
  47. positive regulation of protein secretion Source: MGI
  48. positive regulation of stress-activated MAPK cascade Source: MGI
  49. protein phosphorylation Source: MGI
  50. regulation of apoptotic process Source: MGI
  51. regulation of cell proliferation Source: GO_Central
  52. regulation of extracellular matrix organization Source: MGI
  53. regulation of MAPK cascade Source: GO_Central
  54. regulation of transforming growth factor beta2 production Source: MGI
  55. response to drug Source: MGI
  56. response to hypoxia Source: MGI
  57. response to progesterone Source: MGI
  58. signal transduction by phosphorylation Source: MGI
  59. skeletal system development Source: MGI
  60. SMAD protein import into nucleus Source: MGI
  61. SMAD protein signal transduction Source: GO_Central
  62. transforming growth factor beta receptor signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Growth factorUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Tgfb2 proteinImported
Gene namesi
Name:Tgfb2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:98726. Tgfb2.

Subcellular locationi

GO - Cellular componenti

  1. extracellular matrix Source: MGI
  2. extracellular region Source: MGI
  3. extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

SecretedSAAS annotation

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PRIDEiQ921T1.

Expressioni

Gene expression databases

GenevestigatoriQ921T1.

Structurei

3D structure databases

ProteinModelPortaliQ921T1.
SMRiQ921T1. Positions 144-255.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG074115.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR016319. TGF-beta.
IPR015615. TGF-beta-rel.
IPR003940. TGFb2.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSiPR01423. TGFBETA.
PR01425. TGFBETA2.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q921T1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFRVEEATHV QILKSKDLTS PTQRYIDSKV VKTRAEGEWL SFDVTDAVQE
60 70 80 90 100
WLHHKDRNLG FKISLHCPCC TFVPSNNYII PNKSEELEAR FAGIDGTSTY
110 120 130 140 150
ASGDQKTIKS TRKKTSGKTP HLLLMLLPSY RLESQQSSRR KKRALDAAYC
160 170 180 190 200
FRNVQDNCCL RPLYIDFKRD LGWKWIHEPK GYNANFCAGA CPYLWSSDTQ
210 220 230 240 250
HTKVLSLYNT INPEASASPC CVSQDLEPLT ILYYIGNTPK IEQLSNMIVK

SCKCS
Length:255
Mass (Da):29,087
Last modified:December 1, 2001 - v1
Checksum:i94540017F3C5C219
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC011055 mRNA. Translation: AAH11055.1.
UniGeneiMm.18213.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC011055 mRNA. Translation: AAH11055.1.
UniGeneiMm.18213.

3D structure databases

ProteinModelPortaliQ921T1.
SMRiQ921T1. Positions 144-255.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ921T1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:98726. Tgfb2.

Phylogenomic databases

HOVERGENiHBG074115.

Miscellaneous databases

ChiTaRSiTgfb2. mouse.
SOURCEiSearch...

Gene expression databases

GenevestigatoriQ921T1.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR016319. TGF-beta.
IPR015615. TGF-beta-rel.
IPR003940. TGFb2.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSiPR01423. TGFBETA.
PR01425. TGFBETA2.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/NImported.
    Tissue: Mammary tumor. Metallothionien-TGF alpha model. 10 month old virgin mouse. Taken by biopsy.Imported.

Entry informationi

Entry nameiQ921T1_MOUSE
AccessioniPrimary (citable) accession number: Q921T1
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: February 4, 2015
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.