UniProtKB - Q921T1 (Q921T1_MOUSE)
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Protein
Submitted name:
Tgfb2 protein
Gene
Tgfb2
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- amyloid-beta binding Source: AgBase
- growth factor activity Source: UniProtKB-KW
- protein homodimerization activity Source: AgBase
- receptor binding Source: AgBase
- transforming growth factor beta receptor binding Source: AgBase
- type III transforming growth factor beta receptor binding Source: AgBase
- type II transforming growth factor beta receptor binding Source: AgBase
GO - Biological processi
- activation of protein kinase activity Source: AgBase
- cardiac epithelial to mesenchymal transition Source: AgBase
- cardiac muscle cell proliferation Source: AgBase
- cardioblast differentiation Source: AgBase
- cell-cell junction organization Source: AgBase
- cell cycle arrest Source: AgBase
- cell death Source: AgBase
- cell growth Source: InterPro
- cell migration Source: AgBase
- cell morphogenesis Source: AgBase
- collagen fibril organization Source: AgBase
- embryonic digestive tract development Source: AgBase
- epithelial to mesenchymal transition Source: AgBase
- extrinsic apoptotic signaling pathway Source: AgBase
- eye development Source: AgBase
- glial cell migration Source: AgBase
- hair follicle development Source: AgBase
- heart development Source: AgBase
- heart morphogenesis Source: AgBase
- negative regulation of alkaline phosphatase activity Source: AgBase
- negative regulation of cell growth Source: AgBase
- negative regulation of cell proliferation Source: AgBase
- negative regulation of epithelial cell proliferation Source: AgBase
- negative regulation of macrophage cytokine production Source: AgBase
- pathway-restricted SMAD protein phosphorylation Source: AgBase
- positive regulation of cardioblast differentiation Source: AgBase
- positive regulation of cell adhesion mediated by integrin Source: AgBase
- positive regulation of cell growth Source: AgBase
- positive regulation of cell proliferation Source: AgBase
- positive regulation of epithelial cell migration Source: AgBase
- positive regulation of epithelial to mesenchymal transition Source: AgBase
- positive regulation of heart contraction Source: AgBase
- positive regulation of integrin biosynthetic process Source: AgBase
- positive regulation of neuron apoptotic process Source: AgBase
- positive regulation of ossification Source: AgBase
- positive regulation of phosphatidylinositol 3-kinase signaling Source: AgBase
- positive regulation of protein secretion Source: AgBase
- positive regulation of stress-activated MAPK cascade Source: AgBase
- positive regulation of timing of catagen Source: AgBase
- protein phosphorylation Source: AgBase
- regulation of transforming growth factor beta2 production Source: AgBase
- response to drug Source: AgBase
- response to progesterone Source: AgBase
- response to wounding Source: AgBase
- salivary gland morphogenesis Source: AgBase
- signal transduction by protein phosphorylation Source: AgBase
- SMAD protein signal transduction Source: BHF-UCL
- transforming growth factor beta receptor signaling pathway Source: AgBase
Keywordsi
Molecular function | Growth factorUniRule annotationSAAS annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Tgfb2 proteinImported |
Gene namesi | Name:Tgfb2Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:98726. Tgfb2. |
PTM / Processingi
Keywords - PTMi
Disulfide bondSAAS annotationProteomic databases
PeptideAtlasi | Q921T1. |
Interactioni
GO - Molecular functioni
- growth factor activity Source: UniProtKB-KW
- protein homodimerization activity Source: AgBase
- receptor binding Source: AgBase
- transforming growth factor beta receptor binding Source: AgBase
- type III transforming growth factor beta receptor binding Source: AgBase
- type II transforming growth factor beta receptor binding Source: AgBase
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 140 – 255 | TGF_BETA_2InterPro annotationAdd BLAST | 116 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3900. Eukaryota. ENOG410XT8Z. LUCA. |
HOVERGENi | HBG074115. |
Family and domain databases
Gene3Di | 2.10.90.10. 1 hit. |
InterProi | View protein in InterPro IPR029034. Cystine-knot_cytokine. IPR001839. TGF-b_C. IPR001111. TGF-b_propeptide. IPR016319. TGF-beta. IPR015615. TGF-beta-rel. IPR003940. TGFb2. IPR017948. TGFb_CS. |
PANTHERi | PTHR11848. PTHR11848. 1 hit. PTHR11848:SF141. PTHR11848:SF141. 1 hit. |
Pfami | View protein in Pfam PF00019. TGF_beta. 1 hit. PF00688. TGFb_propeptide. 1 hit. |
PRINTSi | PR01423. TGFBETA. PR01425. TGFBETA2. |
SMARTi | View protein in SMART SM00204. TGFB. 1 hit. |
SUPFAMi | SSF57501. SSF57501. 1 hit. |
PROSITEi | View protein in PROSITE PS00250. TGF_BETA_1. 1 hit. PS51362. TGF_BETA_2. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q921T1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFRVEEATHV QILKSKDLTS PTQRYIDSKV VKTRAEGEWL SFDVTDAVQE
60 70 80 90 100
WLHHKDRNLG FKISLHCPCC TFVPSNNYII PNKSEELEAR FAGIDGTSTY
110 120 130 140 150
ASGDQKTIKS TRKKTSGKTP HLLLMLLPSY RLESQQSSRR KKRALDAAYC
160 170 180 190 200
FRNVQDNCCL RPLYIDFKRD LGWKWIHEPK GYNANFCAGA CPYLWSSDTQ
210 220 230 240 250
HTKVLSLYNT INPEASASPC CVSQDLEPLT ILYYIGNTPK IEQLSNMIVK
SCKCS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC011055 mRNA. Translation: AAH11055.1. |
UniGenei | Mm.18213. |
Similar proteinsi
Entry informationi
Entry namei | Q921T1_MOUSE | |
Accessioni | Q921T1Primary (citable) accession number: Q921T1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 1, 2001 |
Last sequence update: | December 1, 2001 | |
Last modified: | February 28, 2018 | |
This is version 108 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |