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Protein

Solute carrier family 41 member 3

Gene

Slc41a3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. cation transmembrane transporter activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 41 member 3
Gene namesi
Name:Slc41a3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1918949. Slc41a3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei63 – 8321HelicalSequence AnalysisAdd
BLAST
Transmembranei147 – 16721HelicalSequence AnalysisAdd
BLAST
Transmembranei189 – 20921HelicalSequence AnalysisAdd
BLAST
Transmembranei220 – 24021HelicalSequence AnalysisAdd
BLAST
Transmembranei251 – 27121HelicalSequence AnalysisAdd
BLAST
Transmembranei284 – 30421HelicalSequence AnalysisAdd
BLAST
Transmembranei377 – 39721HelicalSequence AnalysisAdd
BLAST
Transmembranei406 – 42621HelicalSequence AnalysisAdd
BLAST
Transmembranei450 – 47021HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 488488Solute carrier family 41 member 3PRO_0000295593Add
BLAST

Proteomic databases

MaxQBiQ921R8.
PaxDbiQ921R8.
PRIDEiQ921R8.

PTM databases

PhosphoSiteiQ921R8.

Expressioni

Gene expression databases

BgeeiQ921R8.
CleanExiMM_SLC41A3.
ExpressionAtlasiQ921R8. baseline and differential.
GenevestigatoriQ921R8.

Interactioni

Protein-protein interaction databases

IntActiQ921R8. 1 interaction.
MINTiMINT-217456.
STRINGi10090.ENSMUSP00000037473.

Family & Domainsi

Sequence similaritiesi

Belongs to the SLC41A transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1824.
GeneTreeiENSGT00390000016816.
HOGENOMiHOG000007017.
HOVERGENiHBG057187.
InParanoidiQ921R8.
KOiK15122.
OMAiTQLNLEF.
PhylomeDBiQ921R8.

Family and domain databases

Gene3Di1.10.357.20. 2 hits.
InterProiIPR006667. SLC41_membr_dom.
[Graphical view]
PfamiPF01769. MgtE. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q921R8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEGTEARQRR LEGCGRLKEL GPLPSHDAGR LPKASEEGHL AVSESQLVDA
60 70 80 90 100
KSLEAPPGRE TSLIIGFQVV IPFLLAGVGL SWAGLLLNYF QHWPVFKDVK
110 120 130 140 150
DLMTLVPPLV GLKGNLEMTL ASRLSTSANT GQIDDRQERY KIISSNLAVV
160 170 180 190 200
QVQATVVGLL AAVASLMLGT VSHEEFDWSK VALLCTSSVI TAFLAALALG
210 220 230 240 250
ILMICIVIGA RKFGVNPDNI ATPIAASLGD LITLSILALM SSFFYSHKDT
260 270 280 290 300
WYLTPLVCVG FLALTPLWLF IAKQNPPIMK ILKYGWFPII LAMIISSFGG
310 320 330 340 350
LILSKTISKH EFKGMAVLTP VMCGVGGNLV AIQTSRISTF LHMWSTPGVL
360 370 380 390 400
PVQMKRFWPN PCFIFCSSEI NSVSARVLLF LVVPGHLIFF YLICLVEGQS
410 420 430 440 450
VTNSKIFILL YLVAGVVQVV ILLYLAEVTV RLTWHQALDP DNHCIPYLTG
460 470 480
LGDLLGTSLL ALCFFLDWLL RGRANLQELV SELVSVPP
Length:488
Mass (Da):53,257
Last modified:December 1, 2001 - v1
Checksum:iE43401605DC1EEC0
GO
Isoform 2 (identifier: Q921R8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-90: MEGTEARQRR...SWAGLLLNYF → MVVTQLSLEF...MTAGLVMNTV

Show »
Length:462
Mass (Da):50,537
Checksum:i078F8221C77F0875
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9090MEGTE…LLNYF → MVVTQLSLEFRFQGKKLRGF SCELTRSPHGILPEPVLTTT CQVAIPILLSGLGMMTAGLV MNTV in isoform 2. 1 PublicationVSP_026939Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003140 mRNA. Translation: BAB22598.1.
BC011108 mRNA. Translation: AAH11108.1.
CCDSiCCDS20362.1. [Q921R8-1]
CCDS20363.1. [Q921R8-2]
RefSeqiNP_001032570.1. NM_001037493.2. [Q921R8-2]
NP_082144.2. NM_027868.2.
UniGeneiMm.272633.

Genome annotation databases

EnsembliENSMUST00000032177; ENSMUSP00000032177; ENSMUSG00000030089. [Q921R8-2]
GeneIDi71699.
KEGGimmu:71699.
UCSCiuc009cxp.1. mouse. [Q921R8-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003140 mRNA. Translation: BAB22598.1.
BC011108 mRNA. Translation: AAH11108.1.
CCDSiCCDS20362.1. [Q921R8-1]
CCDS20363.1. [Q921R8-2]
RefSeqiNP_001032570.1. NM_001037493.2. [Q921R8-2]
NP_082144.2. NM_027868.2.
UniGeneiMm.272633.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ921R8. 1 interaction.
MINTiMINT-217456.
STRINGi10090.ENSMUSP00000037473.

PTM databases

PhosphoSiteiQ921R8.

Proteomic databases

MaxQBiQ921R8.
PaxDbiQ921R8.
PRIDEiQ921R8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032177; ENSMUSP00000032177; ENSMUSG00000030089. [Q921R8-2]
GeneIDi71699.
KEGGimmu:71699.
UCSCiuc009cxp.1. mouse. [Q921R8-2]

Organism-specific databases

CTDi54946.
MGIiMGI:1918949. Slc41a3.

Phylogenomic databases

eggNOGiCOG1824.
GeneTreeiENSGT00390000016816.
HOGENOMiHOG000007017.
HOVERGENiHBG057187.
InParanoidiQ921R8.
KOiK15122.
OMAiTQLNLEF.
PhylomeDBiQ921R8.

Miscellaneous databases

NextBioi334257.
PROiQ921R8.
SOURCEiSearch...

Gene expression databases

BgeeiQ921R8.
CleanExiMM_SLC41A3.
ExpressionAtlasiQ921R8. baseline and differential.
GenevestigatoriQ921R8.

Family and domain databases

Gene3Di1.10.357.20. 2 hits.
InterProiIPR006667. SLC41_membr_dom.
[Graphical view]
PfamiPF01769. MgtE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Heart.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: Czech II.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiS41A3_MOUSE
AccessioniPrimary (citable) accession number: Q921R8
Secondary accession number(s): Q9DC67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: December 1, 2001
Last modified: April 1, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.