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Q921R8

- S41A3_MOUSE

UniProt

Q921R8 - S41A3_MOUSE

Protein

Solute carrier family 41 member 3

Gene

Slc41a3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. cation transmembrane transporter activity Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 41 member 3
    Gene namesi
    Name:Slc41a3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:1918949. Slc41a3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 488488Solute carrier family 41 member 3PRO_0000295593Add
    BLAST

    Proteomic databases

    PaxDbiQ921R8.
    PRIDEiQ921R8.

    PTM databases

    PhosphoSiteiQ921R8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ921R8.
    BgeeiQ921R8.
    CleanExiMM_SLC41A3.
    GenevestigatoriQ921R8.

    Interactioni

    Protein-protein interaction databases

    IntActiQ921R8. 1 interaction.
    MINTiMINT-217456.
    STRINGi10090.ENSMUSP00000037473.

    Structurei

    3D structure databases

    ProteinModelPortaliQ921R8.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei63 – 8321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei147 – 16721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei189 – 20921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei220 – 24021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei251 – 27121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei284 – 30421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei377 – 39721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei406 – 42621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei450 – 47021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SLC41A transporter family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1824.
    GeneTreeiENSGT00390000016816.
    HOGENOMiHOG000007017.
    HOVERGENiHBG057187.
    InParanoidiQ921R8.
    KOiK15122.
    OMAiTFCSSEI.
    PhylomeDBiQ921R8.

    Family and domain databases

    Gene3Di1.10.357.20. 2 hits.
    InterProiIPR006667. SLC41_membr_dom.
    [Graphical view]
    PfamiPF01769. MgtE. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q921R8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEGTEARQRR LEGCGRLKEL GPLPSHDAGR LPKASEEGHL AVSESQLVDA    50
    KSLEAPPGRE TSLIIGFQVV IPFLLAGVGL SWAGLLLNYF QHWPVFKDVK 100
    DLMTLVPPLV GLKGNLEMTL ASRLSTSANT GQIDDRQERY KIISSNLAVV 150
    QVQATVVGLL AAVASLMLGT VSHEEFDWSK VALLCTSSVI TAFLAALALG 200
    ILMICIVIGA RKFGVNPDNI ATPIAASLGD LITLSILALM SSFFYSHKDT 250
    WYLTPLVCVG FLALTPLWLF IAKQNPPIMK ILKYGWFPII LAMIISSFGG 300
    LILSKTISKH EFKGMAVLTP VMCGVGGNLV AIQTSRISTF LHMWSTPGVL 350
    PVQMKRFWPN PCFIFCSSEI NSVSARVLLF LVVPGHLIFF YLICLVEGQS 400
    VTNSKIFILL YLVAGVVQVV ILLYLAEVTV RLTWHQALDP DNHCIPYLTG 450
    LGDLLGTSLL ALCFFLDWLL RGRANLQELV SELVSVPP 488
    Length:488
    Mass (Da):53,257
    Last modified:December 1, 2001 - v1
    Checksum:iE43401605DC1EEC0
    GO
    Isoform 2 (identifier: Q921R8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-90: MEGTEARQRR...SWAGLLLNYF → MVVTQLSLEF...MTAGLVMNTV

    Show »
    Length:462
    Mass (Da):50,537
    Checksum:i078F8221C77F0875
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 9090MEGTE…LLNYF → MVVTQLSLEFRFQGKKLRGF SCELTRSPHGILPEPVLTTT CQVAIPILLSGLGMMTAGLV MNTV in isoform 2. 1 PublicationVSP_026939Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK003140 mRNA. Translation: BAB22598.1.
    BC011108 mRNA. Translation: AAH11108.1.
    CCDSiCCDS20362.1. [Q921R8-1]
    CCDS20363.1. [Q921R8-2]
    RefSeqiNP_001032570.1. NM_001037493.2. [Q921R8-2]
    NP_082144.2. NM_027868.2.
    UniGeneiMm.272633.

    Genome annotation databases

    EnsembliENSMUST00000032177; ENSMUSP00000032177; ENSMUSG00000030089. [Q921R8-2]
    GeneIDi71699.
    KEGGimmu:71699.
    UCSCiuc009cxp.1. mouse. [Q921R8-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK003140 mRNA. Translation: BAB22598.1 .
    BC011108 mRNA. Translation: AAH11108.1 .
    CCDSi CCDS20362.1. [Q921R8-1 ]
    CCDS20363.1. [Q921R8-2 ]
    RefSeqi NP_001032570.1. NM_001037493.2. [Q921R8-2 ]
    NP_082144.2. NM_027868.2.
    UniGenei Mm.272633.

    3D structure databases

    ProteinModelPortali Q921R8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q921R8. 1 interaction.
    MINTi MINT-217456.
    STRINGi 10090.ENSMUSP00000037473.

    PTM databases

    PhosphoSitei Q921R8.

    Proteomic databases

    PaxDbi Q921R8.
    PRIDEi Q921R8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000032177 ; ENSMUSP00000032177 ; ENSMUSG00000030089 . [Q921R8-2 ]
    GeneIDi 71699.
    KEGGi mmu:71699.
    UCSCi uc009cxp.1. mouse. [Q921R8-2 ]

    Organism-specific databases

    CTDi 54946.
    MGIi MGI:1918949. Slc41a3.

    Phylogenomic databases

    eggNOGi COG1824.
    GeneTreei ENSGT00390000016816.
    HOGENOMi HOG000007017.
    HOVERGENi HBG057187.
    InParanoidi Q921R8.
    KOi K15122.
    OMAi TFCSSEI.
    PhylomeDBi Q921R8.

    Miscellaneous databases

    NextBioi 334257.
    PROi Q921R8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q921R8.
    Bgeei Q921R8.
    CleanExi MM_SLC41A3.
    Genevestigatori Q921R8.

    Family and domain databases

    Gene3Di 1.10.357.20. 2 hits.
    InterProi IPR006667. SLC41_membr_dom.
    [Graphical view ]
    Pfami PF01769. MgtE. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6J.
      Tissue: Heart.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: Czech II.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiS41A3_MOUSE
    AccessioniPrimary (citable) accession number: Q921R8
    Secondary accession number(s): Q9DC67
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2007
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3