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Q921R8 (S41A3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier family 41 member 3
Gene names
Name:Slc41a3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length488 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Cell membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the SLC41A transporter family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncation transmembrane transporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q921R8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q921R8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-90: MEGTEARQRR...SWAGLLLNYF → MVVTQLSLEF...MTAGLVMNTV

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 488488Solute carrier family 41 member 3
PRO_0000295593

Regions

Transmembrane63 – 8321Helical; Potential
Transmembrane147 – 16721Helical; Potential
Transmembrane189 – 20921Helical; Potential
Transmembrane220 – 24021Helical; Potential
Transmembrane251 – 27121Helical; Potential
Transmembrane284 – 30421Helical; Potential
Transmembrane377 – 39721Helical; Potential
Transmembrane406 – 42621Helical; Potential
Transmembrane450 – 47021Helical; Potential

Natural variations

Alternative sequence1 – 9090MEGTE…LLNYF → MVVTQLSLEFRFQGKKLRGF SCELTRSPHGILPEPVLTTT CQVAIPILLSGLGMMTAGLV MNTV in isoform 2.
VSP_026939

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: E43401605DC1EEC0

FASTA48853,257
        10         20         30         40         50         60 
MEGTEARQRR LEGCGRLKEL GPLPSHDAGR LPKASEEGHL AVSESQLVDA KSLEAPPGRE 

        70         80         90        100        110        120 
TSLIIGFQVV IPFLLAGVGL SWAGLLLNYF QHWPVFKDVK DLMTLVPPLV GLKGNLEMTL 

       130        140        150        160        170        180 
ASRLSTSANT GQIDDRQERY KIISSNLAVV QVQATVVGLL AAVASLMLGT VSHEEFDWSK 

       190        200        210        220        230        240 
VALLCTSSVI TAFLAALALG ILMICIVIGA RKFGVNPDNI ATPIAASLGD LITLSILALM 

       250        260        270        280        290        300 
SSFFYSHKDT WYLTPLVCVG FLALTPLWLF IAKQNPPIMK ILKYGWFPII LAMIISSFGG 

       310        320        330        340        350        360 
LILSKTISKH EFKGMAVLTP VMCGVGGNLV AIQTSRISTF LHMWSTPGVL PVQMKRFWPN 

       370        380        390        400        410        420 
PCFIFCSSEI NSVSARVLLF LVVPGHLIFF YLICLVEGQS VTNSKIFILL YLVAGVVQVV 

       430        440        450        460        470        480 
ILLYLAEVTV RLTWHQALDP DNHCIPYLTG LGDLLGTSLL ALCFFLDWLL RGRANLQELV 


SELVSVPP

« Hide

Isoform 2 [UniParc].

Checksum: 078F8221C77F0875
Show »

FASTA46250,537

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: C57BL/6J.
Tissue: Heart.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: Czech II.
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK003140 mRNA. Translation: BAB22598.1.
BC011108 mRNA. Translation: AAH11108.1.
IPIIPI00120207.
IPI00310991.
RefSeqNP_001032570.1. NM_001037493.1.
NP_082144.2. NM_027868.2.
UniGeneMm.272633.

3D structure databases

ProteinModelPortalQ921R8.
ModBaseSearch...

Protein-protein interaction databases

IntActQ921R8. 1 interaction.
MINTMINT-217456.
STRING10090.ENSMUSP00000037473.

PTM databases

PhosphoSiteQ921R8.

Proteomic databases

PaxDbQ921R8.
PRIDEQ921R8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000032177; ENSMUSP00000032177; ENSMUSG00000030089.
GeneID71699.
KEGGmmu:71699.
UCSCuc009cxp.1. mouse.

Organism-specific databases

CTD54946.
MGIMGI:1918949. Slc41a3.

Phylogenomic databases

eggNOGCOG1824.
GeneTreeENSGT00390000016816.
HOGENOMHOG000007017.
HOVERGENHBG057187.
InParanoidQ921R8.
KOK15122.
OMASHCIPYL.
OrthoDBEOG42JNRB.

Gene expression databases

ArrayExpressQ921R8.
BgeeQ921R8.
CleanExMM_SLC41A3.
GenevestigatorQ921R8.

Family and domain databases

Gene3D1.10.357.20. 2 hits.
InterProIPR006667. SLC41_membr_dom.
[Graphical view]
PfamPF01769. MgtE. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio334257.
SOURCESearch...

Entry information

Entry nameS41A3_MOUSE
AccessionPrimary (citable) accession number: Q921R8
Secondary accession number(s): Q9DC67
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: December 1, 2001
Last modified: May 29, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents