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Protein

Probable UDP-sugar transporter protein SLC35A5

Gene

Slc35a5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Probable UDP-sugar transporter protein SLC35A5
Alternative name(s):
Solute carrier family 35 member A5
Gene namesi
Name:Slc35a5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1921352. Slc35a5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei22 – 4221HelicalSequence analysisAdd
BLAST
Transmembranei66 – 8621HelicalSequence analysisAdd
BLAST
Transmembranei107 – 12923HelicalSequence analysisAdd
BLAST
Transmembranei133 – 15523HelicalSequence analysisAdd
BLAST
Transmembranei159 – 17921HelicalSequence analysisAdd
BLAST
Transmembranei242 – 26221HelicalSequence analysisAdd
BLAST
Transmembranei277 – 29721HelicalSequence analysisAdd
BLAST
Transmembranei317 – 33721HelicalSequence analysisAdd
BLAST
Transmembranei344 – 36421HelicalSequence analysisAdd
BLAST
Transmembranei368 – 38821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 437437Probable UDP-sugar transporter protein SLC35A5PRO_0000309356Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi217 – 2171N-linked (GlcNAc...)Sequence analysis
Modified residuei407 – 4071PhosphoserineBy similarity
Modified residuei429 – 4291PhosphoserineCombined sources
Modified residuei432 – 4321PhosphoserineCombined sources

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ921R7.
PRIDEiQ921R7.

PTM databases

iPTMnetiQ921R7.
PhosphoSiteiQ921R7.

Expressioni

Gene expression databases

BgeeiQ921R7.
CleanExiMM_SLC35A5.
ExpressionAtlasiQ921R7. baseline and differential.
GenevisibleiQ921R7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023344.

Structurei

3D structure databases

ProteinModelPortaliQ921R7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2234. Eukaryota.
COG0697. LUCA.
GeneTreeiENSGT00550000074563.
HOGENOMiHOG000154236.
HOVERGENiHBG056977.
InParanoidiQ921R7.
KOiK15274.
OMAiVLIIVQC.
OrthoDBiEOG7M6D79.
PhylomeDBiQ921R7.
TreeFamiTF354304.

Family and domain databases

InterProiIPR007271. Nuc_sug_transpt.
[Graphical view]
PANTHERiPTHR10231. PTHR10231. 2 hits.
PfamiPF04142. Nuc_sug_transp. 1 hit.
[Graphical view]
PIRSFiPIRSF005799. UDP-gal_transpt. 1 hit.

Sequencei

Sequence statusi: Complete.

Q921R7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVIFLRQLK TRGMERKCSR RPGLGPPTLY TFLLGIIFIT LSSSRILLVK
60 70 80 90 100
YSANEENKYD YLPTTVNVCS ELMKLILCIL VSLCVIKKED HQSRHLRCTS
110 120 130 140 150
WKEFSSFMKW SIPAFLYFLD NLIVFYVLSY LQPAMAVIFS NFSIITTALL
160 170 180 190 200
FRIVLKRHLN WIQWASLLIL FLSIVALTAS TKTSQHELAG HGFHHDAFFT
210 220 230 240 250
PSNSCLHFRR DCSLRDNCTS KEWTFSEVQW NTTARVFSHI RLGLGHVLII
260 270 280 290 300
VQCFISSMAN IYNEKILKEG TQLTESIFIQ NSKLYFFGIV FNGLTLVLQS
310 320 330 340 350
SNRDQIQNCG FFYGHNAFSV VLIFVTAFQG LSVAFILKFL DNMFHVLMAQ
360 370 380 390 400
VTTVIITTVS VLVFDFRPSL DFFLEAPSVL LSIFIYNASK PQNLECAPKQ
410 420 430
ERIRHLSGSL WERSSGDGEE LERLTKLKSD DSDDDTL
Length:437
Mass (Da):50,115
Last modified:November 13, 2007 - v3
Checksum:iFCA918697246A697
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti36 – 361I → M in AAH11115 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003124 mRNA. Translation: BAB22584.2.
AK030566 mRNA. Translation: BAC27026.1.
AK033921 mRNA. Translation: BAC28515.1.
AK150825 mRNA. Translation: BAE29887.1.
AK151484 mRNA. Translation: BAE30437.1.
BC011115 mRNA. Translation: AAH11115.2.
CCDSiCCDS28193.1.
RefSeqiNP_083032.2. NM_028756.4.
UniGeneiMm.264984.

Genome annotation databases

EnsembliENSMUST00000023344; ENSMUSP00000023344; ENSMUSG00000022664.
GeneIDi74102.
KEGGimmu:74102.
UCSCiuc007zih.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003124 mRNA. Translation: BAB22584.2.
AK030566 mRNA. Translation: BAC27026.1.
AK033921 mRNA. Translation: BAC28515.1.
AK150825 mRNA. Translation: BAE29887.1.
AK151484 mRNA. Translation: BAE30437.1.
BC011115 mRNA. Translation: AAH11115.2.
CCDSiCCDS28193.1.
RefSeqiNP_083032.2. NM_028756.4.
UniGeneiMm.264984.

3D structure databases

ProteinModelPortaliQ921R7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023344.

PTM databases

iPTMnetiQ921R7.
PhosphoSiteiQ921R7.

Proteomic databases

PaxDbiQ921R7.
PRIDEiQ921R7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023344; ENSMUSP00000023344; ENSMUSG00000022664.
GeneIDi74102.
KEGGimmu:74102.
UCSCiuc007zih.2. mouse.

Organism-specific databases

CTDi55032.
MGIiMGI:1921352. Slc35a5.

Phylogenomic databases

eggNOGiKOG2234. Eukaryota.
COG0697. LUCA.
GeneTreeiENSGT00550000074563.
HOGENOMiHOG000154236.
HOVERGENiHBG056977.
InParanoidiQ921R7.
KOiK15274.
OMAiVLIIVQC.
OrthoDBiEOG7M6D79.
PhylomeDBiQ921R7.
TreeFamiTF354304.

Miscellaneous databases

PROiQ921R7.
SOURCEiSearch...

Gene expression databases

BgeeiQ921R7.
CleanExiMM_SLC35A5.
ExpressionAtlasiQ921R7. baseline and differential.
GenevisibleiQ921R7. MM.

Family and domain databases

InterProiIPR007271. Nuc_sug_transpt.
[Graphical view]
PANTHERiPTHR10231. PTHR10231. 2 hits.
PfamiPF04142. Nuc_sug_transp. 1 hit.
[Graphical view]
PIRSFiPIRSF005799. UDP-gal_transpt. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow, Diencephalon, Heart and Pituitary.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary tumor.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-432, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  4. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-432, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-429 AND SER-432, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Lung, Pancreas and Testis.

Entry informationi

Entry nameiS35A5_MOUSE
AccessioniPrimary (citable) accession number: Q921R7
Secondary accession number(s): Q9DC72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 13, 2007
Last modified: June 8, 2016
This is version 91 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-14 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.