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Protein

DnaJ homolog subfamily C member 14

Gene

Dnajc14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily C member 14
Gene namesi
Name:Dnajc14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1921580. Dnajc14.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei305 – 32521HelicalSequence analysisAdd
BLAST
Transmembranei327 – 34721HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 703703DnaJ homolog subfamily C member 14PRO_0000247494Add
BLAST

Proteomic databases

EPDiQ921R4.
MaxQBiQ921R4.
PaxDbiQ921R4.
PRIDEiQ921R4.

PTM databases

PhosphoSiteiQ921R4.

Expressioni

Gene expression databases

BgeeiQ921R4.
CleanExiMM_DNAJC14.
GenevisibleiQ921R4. MM.

Interactioni

Subunit structurei

Interacts with the FxxxFxxxF motif of DRD1 via its C-terminal domain.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026410.

Structurei

3D structure databases

ProteinModelPortaliQ921R4.
SMRiQ921R4. Positions 446-564.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini444 – 50865JPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi149 – 1524Poly-Ser

Sequence similaritiesi

Contains 1 J domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0720. Eukaryota.
ENOG410Z2TP. LUCA.
GeneTreeiENSGT00840000129767.
HOGENOMiHOG000290199.
HOVERGENiHBG059561.
InParanoidiQ921R4.
KOiK09534.
OMAiPPGQMSN.
OrthoDBiEOG7HTHGK.
PhylomeDBiQ921R4.
TreeFamiTF105173.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
IPR032843. Jiv.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
PF14901. Jiv90. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS50076. DNAJ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q921R4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQKHPGERR LCGAHRSGGT SLSTSGSSVD PEILSFSGLR DSAETAPNGT
60 70 80 90 100
RCLKEHSGPK YTQPPNPAHW SDPSHGPPRG PGPPRGGGYP DESETGSEES
110 120 130 140 150
GVDQELSREN ETGYQEDGSP SFLSIPSACN CQGSPGVPEG TYSEEGDGSS
160 170 180 190 200
SSLCHHCTSP ALGEDEELEE EYDDEEPLKF PSDFSRVSSG KKPLSRRQKH
210 220 230 240 250
RFLIKEDVRD SGRREPKAPG RHRLARKRSQ TDKRRGLGLW GVEELCQLGQ
260 270 280 290 300
AGFWWLIELL VLVGEYVETC GHLIYACRKL KGSDLDLFRV WVGVWARRLG
310 320 330 340 350
GWARMMFQFL SQSFFCVVGL LIRILRVVGA FLLLALALFL GCLQLGWRFS
360 370 380 390 400
VGLGNRLGWR DKTAWLFSWL GSPALHHCLT LLKDSRPWQQ LVRLIQWGWQ
410 420 430 440 450
ELPWVKQRTK KQGNAPVASG RYCQPEEEVT RLLTMAGVPE DELNPFHVLG
460 470 480 490 500
VEATASDTEL KKAYRQLAVM VHPDKNHHPR AEEAFKILRA AWDIVSNPER
510 520 530 540 550
RKEYEMKRMA ENELSRSVNE FLSKLQDDLK EAMNTMMCSR CQGKHRRFEM
560 570 580 590 600
DREPKSARYC AECNRLHPAE EGDFWAESSM LGLKITYFAL MDGKVYDITE
610 620 630 640 650
WAGCQRVGIS PDTHRVPYHI SFGSRVPGTS GRQRATPESP PADLQDFLSR
660 670 680 690 700
IFQVPPGPMS NGNFFAAPHP GPGTTSTSRP NSSVPKGEAK PKRRKKVRRP

FQR
Length:703
Mass (Da):78,919
Last modified:July 25, 2006 - v2
Checksum:iB320DB4FB06345FE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti268 – 2681E → K in BAE35043 (PubMed:16141072).Curated
Sequence conflicti558 – 5581R → G in BAC38536 (PubMed:16141072).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti203 – 2031L → P in strain: Czech II. 1 Publication
Natural varianti642 – 6421A → V in strain: Czech II. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017830 mRNA. Translation: BAB30962.1.
AK045445 mRNA. Translation: BAC32372.1.
AK082579 mRNA. Translation: BAC38536.1.
AK159388 mRNA. Translation: BAE35043.1.
BC011146 mRNA. Translation: AAH11146.1.
CCDSiCCDS24294.1.
RefSeqiNP_083149.3. NM_028873.4.
XP_006514312.1. XM_006514249.2.
XP_006514313.1. XM_006514250.1.
XP_006514314.1. XM_006514251.1.
UniGeneiMm.296915.

Genome annotation databases

EnsembliENSMUST00000026410; ENSMUSP00000026410; ENSMUSG00000025354.
GeneIDi74330.
KEGGimmu:74330.
UCSCiuc007hok.1. mouse.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017830 mRNA. Translation: BAB30962.1.
AK045445 mRNA. Translation: BAC32372.1.
AK082579 mRNA. Translation: BAC38536.1.
AK159388 mRNA. Translation: BAE35043.1.
BC011146 mRNA. Translation: AAH11146.1.
CCDSiCCDS24294.1.
RefSeqiNP_083149.3. NM_028873.4.
XP_006514312.1. XM_006514249.2.
XP_006514313.1. XM_006514250.1.
XP_006514314.1. XM_006514251.1.
UniGeneiMm.296915.

3D structure databases

ProteinModelPortaliQ921R4.
SMRiQ921R4. Positions 446-564.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026410.

PTM databases

PhosphoSiteiQ921R4.

Proteomic databases

EPDiQ921R4.
MaxQBiQ921R4.
PaxDbiQ921R4.
PRIDEiQ921R4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026410; ENSMUSP00000026410; ENSMUSG00000025354.
GeneIDi74330.
KEGGimmu:74330.
UCSCiuc007hok.1. mouse.

Organism-specific databases

CTDi85406.
MGIiMGI:1921580. Dnajc14.

Phylogenomic databases

eggNOGiKOG0720. Eukaryota.
ENOG410Z2TP. LUCA.
GeneTreeiENSGT00840000129767.
HOGENOMiHOG000290199.
HOVERGENiHBG059561.
InParanoidiQ921R4.
KOiK09534.
OMAiPPGQMSN.
OrthoDBiEOG7HTHGK.
PhylomeDBiQ921R4.
TreeFamiTF105173.

Miscellaneous databases

NextBioi340465.
PROiQ921R4.
SOURCEiSearch...

Gene expression databases

BgeeiQ921R4.
CleanExiMM_DNAJC14.
GenevisibleiQ921R4. MM.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
IPR032843. Jiv.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
PF14901. Jiv90. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS50076. DNAJ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum, Corpora quadrigemina and Embryo.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS PRO-203 AND VAL-642.
    Strain: Czech II.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiDJC14_MOUSE
AccessioniPrimary (citable) accession number: Q921R4
Secondary accession number(s): Q3TX73, Q8BUU3, Q9CYB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 25, 2006
Last modified: May 11, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.