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Q921Q3

- ALG1_MOUSE

UniProt

Q921Q3 - ALG1_MOUSE

Protein

Chitobiosyldiphosphodolichol beta-mannosyltransferase

Gene

Alg1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 3 (13 Oct 2009)
      Previous versions | rss
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    Functioni

    Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man5 intermediate on the cytoplasmic surface of the ER By similarity.By similarity

    Catalytic activityi

    GDP-mannose + chitobiosyldiphosphodolichol = GDP + beta-1,4-D-mannosylchitobiosyldiphosphodolichol.

    Pathwayi

    GO - Molecular functioni

    1. chitobiosyldiphosphodolichol beta-mannosyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. protein glycosylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    UniPathwayiUPA00378.

    Protein family/group databases

    CAZyiGT33. Glycosyltransferase Family 33.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chitobiosyldiphosphodolichol beta-mannosyltransferase (EC:2.4.1.142)
    Alternative name(s):
    Asparagine-linked glycosylation protein 1 homolog
    Beta-1,4-mannosyltransferase
    GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase
    GDP-mannose-dolichol diphosphochitobiose mannosyltransferase
    Gene namesi
    Name:Alg1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:2384774. Alg1.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 482482Chitobiosyldiphosphodolichol beta-mannosyltransferasePRO_0000080250Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei242 – 2421PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ921Q3.
    PRIDEiQ921Q3.

    PTM databases

    PhosphoSiteiQ921Q3.

    Expressioni

    Gene expression databases

    BgeeiQ921Q3.
    GenevestigatoriQ921Q3.

    Structurei

    3D structure databases

    ProteinModelPortaliQ921Q3.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 22CytoplasmicSequence Analysis
    Topological domaini24 – 482459LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei3 – 2321Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0438.
    GeneTreeiENSGT00390000008647.
    HOGENOMiHOG000216716.
    HOVERGENiHBG055036.
    InParanoidiQ921Q3.
    KOiK03842.
    OMAiIVGYKET.
    OrthoDBiEOG70W3DB.
    PhylomeDBiQ921Q3.
    TreeFamiTF314121.

    Family and domain databases

    InterProiIPR026051. ALG1-like.
    [Graphical view]
    PANTHERiPTHR13036. PTHR13036. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q921Q3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAASCVALLV LALLLLVLLL GLWKRGRQTG RARHMVVVVL GDVGRSPRMQ    50
    YHALSLAQSG FSVTLLGFYN SKPRDELLQN DRIRIVKLTD LRGLGAGPRI 100
    LQYGVKVVFQ AVYLLWKMMR MDPAAYIFLQ NPPGLPAIAV CWFVGCICGS 150
    KLVIDWHNYG YSIMGLVHGP RHPIVLLAKW YEKFFGRLSH LNLCVTNAMR 200
    EDLAENWCVR AVTLYDKPAS FFKETPLDLQ HELFMKLSHT YSPFQSCSDP 250
    SHPDTERSAF TERDCQSGVV RRLHGRPALL VSSTSWTEDE DFSILLRALE 300
    KFEQQALTGD SLPSLVCVIT GKGPLREHYR HLISQKHLQH VRFCTPWLEA 350
    EDYPLLLGSA DLGVCLHMSS SGLDLPMKVV DMFGCHLPVC AVNFKCLHEL 400
    VRHGENGLVF KDAEELAAQL QMLFSKFPDP AGKLSQFRKK LQESGQQRWD 450
    ESWQHTVLPL LAHSQMTPRP HPPCGHPSCR GF 482
    Length:482
    Mass (Da):54,417
    Last modified:October 13, 2009 - v3
    Checksum:iFA98A1062D8A53F6
    GO
    Isoform 2 (identifier: Q921Q3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         70-96: NSKPRDELLQNDRIRIVKLTDLRGLGA → T

    Show »
    Length:456
    Mass (Da):51,445
    Checksum:i6DFDF1F48D1C938A
    GO

    Sequence cautioni

    The sequence BC011281 differs from that shown. Reason: Frameshift at position 462.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti339 – 3413QHV → RHI in BC011281. (PubMed:15489334)Curated
    Sequence conflicti445 – 4451G → R in BC011281. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei70 – 9627NSKPR…RGLGA → T in isoform 2. 1 PublicationVSP_032516Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK145871 mRNA. Translation: BAE26713.1.
    BC011281 mRNA. No translation available.
    CCDSiCCDS49753.1. [Q921Q3-1]
    RefSeqiNP_663337.2. NM_145362.2. [Q921Q3-1]
    UniGeneiMm.34581.
    Mm.45780.

    Genome annotation databases

    EnsembliENSMUST00000049207; ENSMUSP00000046534; ENSMUSG00000039427. [Q921Q3-2]
    ENSMUST00000100196; ENSMUSP00000097770; ENSMUSG00000039427. [Q921Q3-1]
    GeneIDi208211.
    KEGGimmu:208211.
    UCSCiuc007yby.2. mouse. [Q921Q3-1]
    uc012aba.2. mouse. [Q921Q3-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK145871 mRNA. Translation: BAE26713.1 .
    BC011281 mRNA. No translation available.
    CCDSi CCDS49753.1. [Q921Q3-1 ]
    RefSeqi NP_663337.2. NM_145362.2. [Q921Q3-1 ]
    UniGenei Mm.34581.
    Mm.45780.

    3D structure databases

    ProteinModelPortali Q921Q3.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GT33. Glycosyltransferase Family 33.

    PTM databases

    PhosphoSitei Q921Q3.

    Proteomic databases

    PaxDbi Q921Q3.
    PRIDEi Q921Q3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000049207 ; ENSMUSP00000046534 ; ENSMUSG00000039427 . [Q921Q3-2 ]
    ENSMUST00000100196 ; ENSMUSP00000097770 ; ENSMUSG00000039427 . [Q921Q3-1 ]
    GeneIDi 208211.
    KEGGi mmu:208211.
    UCSCi uc007yby.2. mouse. [Q921Q3-1 ]
    uc012aba.2. mouse. [Q921Q3-2 ]

    Organism-specific databases

    CTDi 56052.
    MGIi MGI:2384774. Alg1.

    Phylogenomic databases

    eggNOGi COG0438.
    GeneTreei ENSGT00390000008647.
    HOGENOMi HOG000216716.
    HOVERGENi HBG055036.
    InParanoidi Q921Q3.
    KOi K03842.
    OMAi IVGYKET.
    OrthoDBi EOG70W3DB.
    PhylomeDBi Q921Q3.
    TreeFami TF314121.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .

    Miscellaneous databases

    ChiTaRSi ALG1. mouse.
    NextBioi 372220.
    PROi Q921Q3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q921Q3.
    Genevestigatori Q921Q3.

    Family and domain databases

    InterProi IPR026051. ALG1-like.
    [Graphical view ]
    PANTHERi PTHR13036. PTHR13036. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Placenta.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: FVB/N.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiALG1_MOUSE
    AccessioniPrimary (citable) accession number: Q921Q3
    Secondary accession number(s): Q3UKT8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2005
    Last sequence update: October 13, 2009
    Last modified: October 1, 2014
    This is version 99 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3