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Q921Q3

- ALG1_MOUSE

UniProt

Q921Q3 - ALG1_MOUSE

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Protein

Chitobiosyldiphosphodolichol beta-mannosyltransferase

Gene
Alg1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man5 intermediate on the cytoplasmic surface of the ER By similarity.

Catalytic activityi

GDP-mannose + chitobiosyldiphosphodolichol = GDP + beta-1,4-D-mannosylchitobiosyldiphosphodolichol.

Pathwayi

GO - Molecular functioni

  1. chitobiosyldiphosphodolichol beta-mannosyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. protein glycosylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT33. Glycosyltransferase Family 33.

Names & Taxonomyi

Protein namesi
Recommended name:
Chitobiosyldiphosphodolichol beta-mannosyltransferase (EC:2.4.1.142)
Alternative name(s):
Asparagine-linked glycosylation protein 1 homolog
Beta-1,4-mannosyltransferase
GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase
GDP-mannose-dolichol diphosphochitobiose mannosyltransferase
Gene namesi
Name:Alg1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:2384774. Alg1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 22Cytoplasmic Reviewed prediction
Transmembranei3 – 2321Helical; Signal-anchor for type II membrane protein; Reviewed predictionAdd
BLAST
Topological domaini24 – 482459Lumenal Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 482482Chitobiosyldiphosphodolichol beta-mannosyltransferasePRO_0000080250Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei242 – 2421Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ921Q3.
PRIDEiQ921Q3.

PTM databases

PhosphoSiteiQ921Q3.

Expressioni

Gene expression databases

BgeeiQ921Q3.
GenevestigatoriQ921Q3.

Structurei

3D structure databases

ProteinModelPortaliQ921Q3.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0438.
GeneTreeiENSGT00390000008647.
HOGENOMiHOG000216716.
HOVERGENiHBG055036.
InParanoidiQ921Q3.
KOiK03842.
OMAiIVGYKET.
OrthoDBiEOG70W3DB.
PhylomeDBiQ921Q3.
TreeFamiTF314121.

Family and domain databases

InterProiIPR026051. ALG1-like.
[Graphical view]
PANTHERiPTHR13036. PTHR13036. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q921Q3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAASCVALLV LALLLLVLLL GLWKRGRQTG RARHMVVVVL GDVGRSPRMQ    50
YHALSLAQSG FSVTLLGFYN SKPRDELLQN DRIRIVKLTD LRGLGAGPRI 100
LQYGVKVVFQ AVYLLWKMMR MDPAAYIFLQ NPPGLPAIAV CWFVGCICGS 150
KLVIDWHNYG YSIMGLVHGP RHPIVLLAKW YEKFFGRLSH LNLCVTNAMR 200
EDLAENWCVR AVTLYDKPAS FFKETPLDLQ HELFMKLSHT YSPFQSCSDP 250
SHPDTERSAF TERDCQSGVV RRLHGRPALL VSSTSWTEDE DFSILLRALE 300
KFEQQALTGD SLPSLVCVIT GKGPLREHYR HLISQKHLQH VRFCTPWLEA 350
EDYPLLLGSA DLGVCLHMSS SGLDLPMKVV DMFGCHLPVC AVNFKCLHEL 400
VRHGENGLVF KDAEELAAQL QMLFSKFPDP AGKLSQFRKK LQESGQQRWD 450
ESWQHTVLPL LAHSQMTPRP HPPCGHPSCR GF 482
Length:482
Mass (Da):54,417
Last modified:October 13, 2009 - v3
Checksum:iFA98A1062D8A53F6
GO
Isoform 2 (identifier: Q921Q3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     70-96: NSKPRDELLQNDRIRIVKLTDLRGLGA → T

Show »
Length:456
Mass (Da):51,445
Checksum:i6DFDF1F48D1C938A
GO

Sequence cautioni

The sequence BC011281 differs from that shown. Reason: Frameshift at position 462.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei70 – 9627NSKPR…RGLGA → T in isoform 2. VSP_032516Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti339 – 3413QHV → RHI in BC011281. 1 Publication
Sequence conflicti445 – 4451G → R in BC011281. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK145871 mRNA. Translation: BAE26713.1.
BC011281 mRNA. No translation available.
CCDSiCCDS49753.1. [Q921Q3-1]
RefSeqiNP_663337.2. NM_145362.2. [Q921Q3-1]
UniGeneiMm.34581.
Mm.45780.

Genome annotation databases

EnsembliENSMUST00000049207; ENSMUSP00000046534; ENSMUSG00000039427. [Q921Q3-2]
ENSMUST00000100196; ENSMUSP00000097770; ENSMUSG00000039427. [Q921Q3-1]
GeneIDi208211.
KEGGimmu:208211.
UCSCiuc007yby.2. mouse. [Q921Q3-1]
uc012aba.2. mouse. [Q921Q3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK145871 mRNA. Translation: BAE26713.1 .
BC011281 mRNA. No translation available.
CCDSi CCDS49753.1. [Q921Q3-1 ]
RefSeqi NP_663337.2. NM_145362.2. [Q921Q3-1 ]
UniGenei Mm.34581.
Mm.45780.

3D structure databases

ProteinModelPortali Q921Q3.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GT33. Glycosyltransferase Family 33.

PTM databases

PhosphoSitei Q921Q3.

Proteomic databases

PaxDbi Q921Q3.
PRIDEi Q921Q3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000049207 ; ENSMUSP00000046534 ; ENSMUSG00000039427 . [Q921Q3-2 ]
ENSMUST00000100196 ; ENSMUSP00000097770 ; ENSMUSG00000039427 . [Q921Q3-1 ]
GeneIDi 208211.
KEGGi mmu:208211.
UCSCi uc007yby.2. mouse. [Q921Q3-1 ]
uc012aba.2. mouse. [Q921Q3-2 ]

Organism-specific databases

CTDi 56052.
MGIi MGI:2384774. Alg1.

Phylogenomic databases

eggNOGi COG0438.
GeneTreei ENSGT00390000008647.
HOGENOMi HOG000216716.
HOVERGENi HBG055036.
InParanoidi Q921Q3.
KOi K03842.
OMAi IVGYKET.
OrthoDBi EOG70W3DB.
PhylomeDBi Q921Q3.
TreeFami TF314121.

Enzyme and pathway databases

UniPathwayi UPA00378 .

Miscellaneous databases

ChiTaRSi ALG1. mouse.
NextBioi 372220.
PROi Q921Q3.
SOURCEi Search...

Gene expression databases

Bgeei Q921Q3.
Genevestigatori Q921Q3.

Family and domain databases

InterProi IPR026051. ALG1-like.
[Graphical view ]
PANTHERi PTHR13036. PTHR13036. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Placenta.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiALG1_MOUSE
AccessioniPrimary (citable) accession number: Q921Q3
Secondary accession number(s): Q3UKT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: October 13, 2009
Last modified: July 9, 2014
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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