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Protein
Submitted name:

G protein pathway suppressor 2

Gene

Gps2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. transcription corepressor activity Source: MGI

GO - Biological processi

  1. negative regulation of JNK cascade Source: MGI
  2. negative regulation of transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_257106. HDACs deacetylate histones.

Names & Taxonomyi

Protein namesi
Submitted name:
G protein pathway suppressor 2Imported
Submitted name:
MCG22494, isoform CRA_bImported
Submitted name:
Protein Gps2Imported
Gene namesi
Name:Gps2Imported
ORF Names:mCG_22494Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1891751. Gps2.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: MGI
  2. transcriptional repressor complex Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ921N8.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054072.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG46035.
GeneTreeiENSGT00390000004049.
HOGENOMiHOG000112796.
HOVERGENiHBG005905.
KOiK15307.
OMAiKHIMRER.
TreeFamiTF329067.

Family and domain databases

InterProiIPR026094. GPS2.
[Graphical view]
PANTHERiPTHR22654. PTHR22654. 1 hit.

Sequencei

Sequence statusi: Complete.

Q921N8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPALLERPKL SNAMARALHR HIMMERERKR QEEEEVDKMM EQKMKEEQER
60 70 80 90 100
RKKKEMEERM SLEETKEQIL KLQEKLSALQ EEKHQLFLQL KKVLHEEEKR
110 120 130 140 150
RRKEQSDLTT LTSAAYQQSL TVHTGTHLLS MQGSPGGHNR PGTLMAADRA
160 170 180 190 200
KQMFGPQVLT TRHYVGSAAA FAGTPEHGQF QGSPGGAYGT AQPPPHYGPT
210 220 230 240 250
QPAYSPSQQL RAPSAFPAVQ YLSQPQPQPY AVHGHFQPTQ TGFLQPGSTL
260 270 280 290 300
SLQKQMEHAN QQTSFSDSSS LRPMHPQALH PAPGLLASPQ LPVQIQAAGK
310 320
SGFATTSQPG PRLPFIQHSQ NPRFYHK
Length:327
Mass (Da):36,738
Last modified:December 1, 2001 - v1
Checksum:i3008661CE6579F4B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596185 Genomic DNA. No translation available.
BC011317 mRNA. Translation: AAH11317.1.
BC138879 mRNA. Translation: AAI38880.1.
BC138880 mRNA. Translation: AAI38881.1.
CH466596 Genomic DNA. Translation: EDL12472.1.
CH466596 Genomic DNA. Translation: EDL12474.1.
RefSeqiNP_062700.2. NM_019726.3.
XP_006533850.1. XM_006533787.1.
XP_006537253.1. XM_006537190.1.
UniGeneiMm.477738.

Genome annotation databases

EnsembliENSMUST00000057884; ENSMUSP00000054072; ENSMUSG00000023170.
ENSMUST00000072581; ENSMUSP00000072389; ENSMUSG00000023170.
ENSMUST00000116358; ENSMUSP00000112062; ENSMUSG00000023170.
GeneIDi56310.
KEGGimmu:56310.
UCSCiuc007jsp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596185 Genomic DNA. No translation available.
BC011317 mRNA. Translation: AAH11317.1.
BC138879 mRNA. Translation: AAI38880.1.
BC138880 mRNA. Translation: AAI38881.1.
CH466596 Genomic DNA. Translation: EDL12472.1.
CH466596 Genomic DNA. Translation: EDL12474.1.
RefSeqiNP_062700.2. NM_019726.3.
XP_006533850.1. XM_006533787.1.
XP_006537253.1. XM_006537190.1.
UniGeneiMm.477738.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054072.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057884; ENSMUSP00000054072; ENSMUSG00000023170.
ENSMUST00000072581; ENSMUSP00000072389; ENSMUSG00000023170.
ENSMUST00000116358; ENSMUSP00000112062; ENSMUSG00000023170.
GeneIDi56310.
KEGGimmu:56310.
UCSCiuc007jsp.1. mouse.

Organism-specific databases

CTDi2874.
MGIiMGI:1891751. Gps2.

Phylogenomic databases

eggNOGiNOG46035.
GeneTreeiENSGT00390000004049.
HOGENOMiHOG000112796.
HOVERGENiHBG005905.
KOiK15307.
OMAiKHIMRER.
TreeFamiTF329067.

Enzyme and pathway databases

ReactomeiREACT_257106. HDACs deacetylate histones.

Miscellaneous databases

NextBioi312252.
PROiQ921N8.
SOURCEiSearch...

Gene expression databases

GenevestigatoriQ921N8.

Family and domain databases

InterProiIPR026094. GPS2.
[Graphical view]
PANTHERiPTHR22654. PTHR22654. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/NImported.
    Tissue: BrainImported and Mammary tumor. Metallothionien-TGF alpha model. 10 month old virgin mouse. Taken by biopsy.Imported.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  5. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ921N8_MOUSE
AccessioniPrimary (citable) accession number: Q921N8
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: March 4, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.