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Q921N8

- Q921N8_MOUSE

UniProt

Q921N8 - Q921N8_MOUSE

Protein
Submitted name:

G protein pathway suppressor 2

Gene

Gps2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: MGI
    2. transcription corepressor activity Source: Ensembl

    GO - Biological processi

    1. negative regulation of JNK cascade Source: Ensembl
    2. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    G protein pathway suppressor 2Imported
    Submitted name:
    MCG22494, isoform CRA_bImported
    Submitted name:
    Protein Gps2Imported
    Gene namesi
    Name:Gps2Imported
    ORF Names:mCG_22494Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1891751. Gps2.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: MGI
    2. transcriptional repressor complex Source: Ensembl

    Expressioni

    Gene expression databases

    GenevestigatoriQ921N8.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000054072.

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG46035.
    GeneTreeiENSGT00390000004049.
    HOGENOMiHOG000112796.
    HOVERGENiHBG005905.
    InParanoidiQ921N8.
    KOiK15307.
    OMAiKHIMRER.
    TreeFamiTF329067.

    Family and domain databases

    InterProiIPR026094. GPS2.
    [Graphical view]
    PANTHERiPTHR22654. PTHR22654. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q921N8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPALLERPKL SNAMARALHR HIMMERERKR QEEEEVDKMM EQKMKEEQER    50
    RKKKEMEERM SLEETKEQIL KLQEKLSALQ EEKHQLFLQL KKVLHEEEKR 100
    RRKEQSDLTT LTSAAYQQSL TVHTGTHLLS MQGSPGGHNR PGTLMAADRA 150
    KQMFGPQVLT TRHYVGSAAA FAGTPEHGQF QGSPGGAYGT AQPPPHYGPT 200
    QPAYSPSQQL RAPSAFPAVQ YLSQPQPQPY AVHGHFQPTQ TGFLQPGSTL 250
    SLQKQMEHAN QQTSFSDSSS LRPMHPQALH PAPGLLASPQ LPVQIQAAGK 300
    SGFATTSQPG PRLPFIQHSQ NPRFYHK 327
    Length:327
    Mass (Da):36,738
    Last modified:December 1, 2001 - v1
    Checksum:i3008661CE6579F4B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL596185 Genomic DNA. No translation available.
    BC011317 mRNA. Translation: AAH11317.1.
    BC138879 mRNA. Translation: AAI38880.1.
    BC138880 mRNA. Translation: AAI38881.1.
    CH466596 Genomic DNA. Translation: EDL12472.1.
    CH466596 Genomic DNA. Translation: EDL12474.1.
    RefSeqiNP_062700.2. NM_019726.3.
    XP_006533850.1. XM_006533787.1.
    XP_006537253.1. XM_006537190.1.
    UniGeneiMm.477738.

    Genome annotation databases

    EnsembliENSMUST00000057884; ENSMUSP00000054072; ENSMUSG00000023170.
    ENSMUST00000072581; ENSMUSP00000072389; ENSMUSG00000023170.
    ENSMUST00000116358; ENSMUSP00000112062; ENSMUSG00000023170.
    GeneIDi56310.
    KEGGimmu:56310.
    UCSCiuc007jsp.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL596185 Genomic DNA. No translation available.
    BC011317 mRNA. Translation: AAH11317.1 .
    BC138879 mRNA. Translation: AAI38880.1 .
    BC138880 mRNA. Translation: AAI38881.1 .
    CH466596 Genomic DNA. Translation: EDL12472.1 .
    CH466596 Genomic DNA. Translation: EDL12474.1 .
    RefSeqi NP_062700.2. NM_019726.3.
    XP_006533850.1. XM_006533787.1.
    XP_006537253.1. XM_006537190.1.
    UniGenei Mm.477738.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000054072.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000057884 ; ENSMUSP00000054072 ; ENSMUSG00000023170 .
    ENSMUST00000072581 ; ENSMUSP00000072389 ; ENSMUSG00000023170 .
    ENSMUST00000116358 ; ENSMUSP00000112062 ; ENSMUSG00000023170 .
    GeneIDi 56310.
    KEGGi mmu:56310.
    UCSCi uc007jsp.1. mouse.

    Organism-specific databases

    CTDi 2874.
    MGIi MGI:1891751. Gps2.

    Phylogenomic databases

    eggNOGi NOG46035.
    GeneTreei ENSGT00390000004049.
    HOGENOMi HOG000112796.
    HOVERGENi HBG005905.
    InParanoidi Q921N8.
    KOi K15307.
    OMAi KHIMRER.
    TreeFami TF329067.

    Miscellaneous databases

    NextBioi 312252.
    PROi Q921N8.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q921N8.

    Family and domain databases

    InterProi IPR026094. GPS2.
    [Graphical view ]
    PANTHERi PTHR22654. PTHR22654. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
      Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
      , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
      Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/NImported.
      Tissue: BrainImported and Mammary tumor. Metallothionien-TGF alpha model. 10 month old virgin mouse. Taken by biopsy.Imported.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    5. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiQ921N8_MOUSE
    AccessioniPrimary (citable) accession number: Q921N8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 1, 2001
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3