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Protein

Transmembrane protein 70, mitochondrial

Gene

Tmem70

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in biogenesis of mitochondrial ATP synthase.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 70, mitochondrial
Gene namesi
Name:Tmem70
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1915068. Tmem70.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 77MitochondrionSequence analysisAdd BLAST77
ChainiPRO_000025147378 – 253Transmembrane protein 70, mitochondrialAdd BLAST176

Proteomic databases

MaxQBiQ921N7.
PaxDbiQ921N7.
PeptideAtlasiQ921N7.
PRIDEiQ921N7.

PTM databases

PhosphoSitePlusiQ921N7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000025940.
CleanExiMM_TMEM70.
ExpressionAtlasiQ921N7. baseline and differential.
GenevisibleiQ921N7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000135483.

Structurei

3D structure databases

ProteinModelPortaliQ921N7.
SMRiQ921N7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM70 family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4478. Eukaryota.
ENOG4111HEE. LUCA.
GeneTreeiENSGT00390000018710.
HOGENOMiHOG000045718.
HOVERGENiHBG073273.
InParanoidiQ921N7.
KOiK17966.
PhylomeDBiQ921N7.
TreeFamiTF314656.

Family and domain databases

InterProiIPR009724. TMEM70.
[Graphical view]
PANTHERiPTHR13281. PTHR13281. 1 hit.
PfamiPF06979. TMEM70. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q921N7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLGLGGRWA AGLWPGRTRT TWCVAAALRG SGIAFWRAAS LAEPERLRSG
60 70 80 90 100
GHLALAESCG PPGRAQIPVC WEQCVRCFHT QVDKPENGRL IYTGNLARTI
110 120 130 140 150
FGVKCFSYST SVVSLAFLPY LLSQNNMMFG SLPLQVLFYG VMGSFTVITP
160 170 180 190 200
TLLHLLTKGY VIRLYHEATS DTYRAVTYNV MLSETSTVFH QDDVTIPESA
210 220 230 240 250
HIFTSFYAKT KSLLVNPALF LNPEDYNHLM GYDKPFTFDM EEVDEKKLHE

GEK
Length:253
Mass (Da):28,275
Last modified:October 3, 2006 - v2
Checksum:i43495724B0F45D56
GO

Sequence cautioni

The sequence BAB25987 differs from that shown. Reason: Frameshift at positions 57 and 234.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7G → D in BAE30266 (PubMed:16141072).Curated1
Sequence conflicti56A → T in BAB25987 (PubMed:16141072).Curated1
Sequence conflicti57E → V in BAE30266 (PubMed:16141072).Curated1
Sequence conflicti65A → AQ in BAE39229 (PubMed:16141072).Curated1
Sequence conflicti73Q → R in AAH11320 (PubMed:15489334).Curated1
Sequence conflicti233D → E in BAB25987 (PubMed:16141072).Curated1
Sequence conflicti244D → A in AAH11320 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003839 mRNA. Translation: BAB23030.1.
AK005075 mRNA. Translation: BAB23799.1.
AK008955 mRNA. Translation: BAB25987.1. Frameshift.
AK151280 mRNA. Translation: BAE30266.1.
AK167069 mRNA. Translation: BAE39229.1.
AK169031 mRNA. Translation: BAE40822.1.
BC011320 mRNA. Translation: AAH11320.1.
CCDSiCCDS56623.1.
RefSeqiNP_080668.1. NM_026392.1.
NP_081691.2. NM_027415.2.
UniGeneiMm.194225.

Genome annotation databases

EnsembliENSMUST00000065373; ENSMUSP00000070497; ENSMUSG00000025940.
GeneIDi70397.
KEGGimmu:70397.
UCSCiuc007ajx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003839 mRNA. Translation: BAB23030.1.
AK005075 mRNA. Translation: BAB23799.1.
AK008955 mRNA. Translation: BAB25987.1. Frameshift.
AK151280 mRNA. Translation: BAE30266.1.
AK167069 mRNA. Translation: BAE39229.1.
AK169031 mRNA. Translation: BAE40822.1.
BC011320 mRNA. Translation: AAH11320.1.
CCDSiCCDS56623.1.
RefSeqiNP_080668.1. NM_026392.1.
NP_081691.2. NM_027415.2.
UniGeneiMm.194225.

3D structure databases

ProteinModelPortaliQ921N7.
SMRiQ921N7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000135483.

PTM databases

PhosphoSitePlusiQ921N7.

Proteomic databases

MaxQBiQ921N7.
PaxDbiQ921N7.
PeptideAtlasiQ921N7.
PRIDEiQ921N7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000065373; ENSMUSP00000070497; ENSMUSG00000025940.
GeneIDi70397.
KEGGimmu:70397.
UCSCiuc007ajx.1. mouse.

Organism-specific databases

CTDi54968.
MGIiMGI:1915068. Tmem70.

Phylogenomic databases

eggNOGiKOG4478. Eukaryota.
ENOG4111HEE. LUCA.
GeneTreeiENSGT00390000018710.
HOGENOMiHOG000045718.
HOVERGENiHBG073273.
InParanoidiQ921N7.
KOiK17966.
PhylomeDBiQ921N7.
TreeFamiTF314656.

Miscellaneous databases

ChiTaRSiTmem70. mouse.
PROiQ921N7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025940.
CleanExiMM_TMEM70.
ExpressionAtlasiQ921N7. baseline and differential.
GenevisibleiQ921N7. MM.

Family and domain databases

InterProiIPR009724. TMEM70.
[Graphical view]
PANTHERiPTHR13281. PTHR13281. 1 hit.
PfamiPF06979. TMEM70. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTMM70_MOUSE
AccessioniPrimary (citable) accession number: Q921N7
Secondary accession number(s): Q3TKB6
, Q3UAP8, Q9CQY4, Q9D7R8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: November 30, 2016
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.