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Protein

Transmembrane protein 70, mitochondrial

Gene

Tmem70

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in biogenesis of mitochondrial ATP synthase.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 70, mitochondrial
Gene namesi
Name:Tmem70
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1915068. Tmem70.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei100 – 12021HelicalSequence analysisAdd
BLAST
Transmembranei136 – 15621HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 7777MitochondrionSequence analysisAdd
BLAST
Chaini78 – 253176Transmembrane protein 70, mitochondrialPRO_0000251473Add
BLAST

Proteomic databases

EPDiQ921N7.
MaxQBiQ921N7.
PaxDbiQ921N7.
PeptideAtlasiQ921N7.
PRIDEiQ921N7.

PTM databases

PhosphoSiteiQ921N7.

Expressioni

Gene expression databases

BgeeiQ921N7.
CleanExiMM_TMEM70.
GenevisibleiQ921N7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000135483.

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM70 family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4478. Eukaryota.
ENOG4111HEE. LUCA.
GeneTreeiENSGT00390000018710.
HOGENOMiHOG000045718.
HOVERGENiHBG073273.
InParanoidiQ921N7.
KOiK17966.
OrthoDBiEOG761BWB.
PhylomeDBiQ921N7.
TreeFamiTF314656.

Family and domain databases

InterProiIPR009724. TMEM70.
[Graphical view]
PANTHERiPTHR13281. PTHR13281. 1 hit.
PfamiPF06979. TMEM70. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q921N7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLGLGGRWA AGLWPGRTRT TWCVAAALRG SGIAFWRAAS LAEPERLRSG
60 70 80 90 100
GHLALAESCG PPGRAQIPVC WEQCVRCFHT QVDKPENGRL IYTGNLARTI
110 120 130 140 150
FGVKCFSYST SVVSLAFLPY LLSQNNMMFG SLPLQVLFYG VMGSFTVITP
160 170 180 190 200
TLLHLLTKGY VIRLYHEATS DTYRAVTYNV MLSETSTVFH QDDVTIPESA
210 220 230 240 250
HIFTSFYAKT KSLLVNPALF LNPEDYNHLM GYDKPFTFDM EEVDEKKLHE

GEK
Length:253
Mass (Da):28,275
Last modified:October 3, 2006 - v2
Checksum:i43495724B0F45D56
GO

Sequence cautioni

The sequence BAB25987.1 differs from that shown. Reason: Frameshift at positions 57 and 234. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71G → D in BAE30266 (PubMed:16141072).Curated
Sequence conflicti56 – 561A → T in BAB25987 (PubMed:16141072).Curated
Sequence conflicti57 – 571E → V in BAE30266 (PubMed:16141072).Curated
Sequence conflicti65 – 651A → AQ in BAE39229 (PubMed:16141072).Curated
Sequence conflicti73 – 731Q → R in AAH11320 (PubMed:15489334).Curated
Sequence conflicti233 – 2331D → E in BAB25987 (PubMed:16141072).Curated
Sequence conflicti244 – 2441D → A in AAH11320 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003839 mRNA. Translation: BAB23030.1.
AK005075 mRNA. Translation: BAB23799.1.
AK008955 mRNA. Translation: BAB25987.1. Frameshift.
AK151280 mRNA. Translation: BAE30266.1.
AK167069 mRNA. Translation: BAE39229.1.
AK169031 mRNA. Translation: BAE40822.1.
BC011320 mRNA. Translation: AAH11320.1.
CCDSiCCDS56623.1.
RefSeqiNP_080668.1. NM_026392.1.
NP_081691.2. NM_027415.2.
UniGeneiMm.194225.

Genome annotation databases

EnsembliENSMUST00000065373; ENSMUSP00000070497; ENSMUSG00000025940.
GeneIDi70397.
KEGGimmu:70397.
UCSCiuc007ajx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003839 mRNA. Translation: BAB23030.1.
AK005075 mRNA. Translation: BAB23799.1.
AK008955 mRNA. Translation: BAB25987.1. Frameshift.
AK151280 mRNA. Translation: BAE30266.1.
AK167069 mRNA. Translation: BAE39229.1.
AK169031 mRNA. Translation: BAE40822.1.
BC011320 mRNA. Translation: AAH11320.1.
CCDSiCCDS56623.1.
RefSeqiNP_080668.1. NM_026392.1.
NP_081691.2. NM_027415.2.
UniGeneiMm.194225.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000135483.

PTM databases

PhosphoSiteiQ921N7.

Proteomic databases

EPDiQ921N7.
MaxQBiQ921N7.
PaxDbiQ921N7.
PeptideAtlasiQ921N7.
PRIDEiQ921N7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000065373; ENSMUSP00000070497; ENSMUSG00000025940.
GeneIDi70397.
KEGGimmu:70397.
UCSCiuc007ajx.1. mouse.

Organism-specific databases

CTDi54968.
MGIiMGI:1915068. Tmem70.

Phylogenomic databases

eggNOGiKOG4478. Eukaryota.
ENOG4111HEE. LUCA.
GeneTreeiENSGT00390000018710.
HOGENOMiHOG000045718.
HOVERGENiHBG073273.
InParanoidiQ921N7.
KOiK17966.
OrthoDBiEOG761BWB.
PhylomeDBiQ921N7.
TreeFamiTF314656.

Miscellaneous databases

ChiTaRSiTmem70. mouse.
PROiQ921N7.
SOURCEiSearch...

Gene expression databases

BgeeiQ921N7.
CleanExiMM_TMEM70.
GenevisibleiQ921N7. MM.

Family and domain databases

InterProiIPR009724. TMEM70.
[Graphical view]
PANTHERiPTHR13281. PTHR13281. 1 hit.
PfamiPF06979. TMEM70. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow, Cerebellum, Embryo and Heart.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiTMM70_MOUSE
AccessioniPrimary (citable) accession number: Q921N7
Secondary accession number(s): Q3TKB6
, Q3UAP8, Q9CQY4, Q9D7R8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: July 6, 2016
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.