Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q921M4 (GOGA2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Golgin subfamily A member 2
Alternative name(s):
130 kDa cis-Golgi matrix protein
Short name=GM130
Gene names
Name:Golga2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length999 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probably involved in maintaining cis-Golgi structure By similarity.

Subunit structure

Part of a larger oligomeric complex. Interacts with p115. Interacts with RAB1B that has been activated by GTP-binding. Interacts with GORASP1/GRASP65 and ZFPL1 By similarity.

Subcellular location

Golgi apparatusGolgi stack membrane; Peripheral membrane protein.

Domain

Extended rod-like protein with coiled-coil domains By similarity.

Sequence similarities

Belongs to the GOLGA2 family.

Sequence caution

The sequence AAH11407.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence CAM15849.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q921M4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q921M4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     70-101: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 999999Golgin subfamily A member 2
PRO_0000190055

Regions

Coiled coil147 – 895749 Potential
Compositional bias45 – 517Poly-Lys
Compositional bias449 – 4557Poly-Pro
Compositional bias603 – 69593Gln-rich

Amino acid modifications

Modified residue371Phosphoserine By similarity
Modified residue4381Phosphoserine By similarity

Natural variations

Alternative sequence70 – 10132Missing in isoform 2.
VSP_039027

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 20, 2010. Version 3.
Checksum: 0D84161E727EA9F5

FASTA999113,278
        10         20         30         40         50         60 
MWPPRFPPPR PGMSEETRQS KLAAAKKKLR EYQQKNSPGV PAGAKKKKKI KNGHSPERPT 

        70         80         90        100        110        120 
ASDCQSPENV PTDHIAPAPP TAATDTMFLG VTPSPDADLT QSHDAGNCSN LMEETKTFSS 

       130        140        150        160        170        180 
TESLRQLSQQ LNGLVSESTS YINGEGLTSS NMKELENRYQ ELAVALDSSY VTNKQLSSTI 

       190        200        210        220        230        240 
EELKQQNQDT LDQLEKEKKD YQQKLAKEQG SLREQLQVHI QTIGILVSEK AELQTALAHT 

       250        260        270        280        290        300 
QQAARQKAGE SEDLASRLQS SRQRVGELER TLSTVSTQQK QADRYNKDLT KERDALKLEL 

       310        320        330        340        350        360 
YKNSKSNEDL RQQNSELEEK LRVLVAEKAA AQLGVEELQK KLEMSELLLQ QFSSQSSAAG 

       370        380        390        400        410        420 
GNEQLQHAME ERAQLETHVS QLMESLKQLQ VERDQYAENL KGESAMWQQR VQQMAEQVHT 

       430        440        450        460        470        480 
LKEEKEHRER QVQELETSLA ALRSQMEEPP PPEPPAGPSE AEEQLQGEVE QLHKELERLT 

       490        500        510        520        530        540 
GQLRAQVQDN ESLSHLNREQ EGRLLELERE AQRWSEQAEE RKQILESMQS DRTTISRALS 

       550        560        570        580        590        600 
QNRELKEQLA ELQNGFVRLT NENMEITSAL QSEQHVKKEL ARKLGELQER LGELKETVEL 

       610        620        630        640        650        660 
KSQEAQGLQE QRDQCLSHLQ QYAAAYQQHL AAYEQLTSEK EAIHKQLLLQ TQLMDQLQHE 

       670        680        690        700        710        720 
EVQGKMAAEL ARQELQEAQE RLKATSQENQ QLQAQLSLLV LPGEGDVDQE EEDEEVPQSS 

       730        740        750        760        770        780 
LAIPEDLDSR EAMVAFFNAA IARAEEEQAR LRVQLKEQKA RCRSLSHLAA PVQSKLEKEA 

       790        800        810        820        830        840 
VVPRNVDDSA SEESNQALHV AMEKLQSRFL EVMQEKVELK ERVEELEHCC IQLSGETDTI 

       850        860        870        880        890        900 
GEYIALYQNQ RAVLKARHLE KEEYISRLAQ DKEEMKVKLL ELQELVLRLV NERNEWQGKF 

       910        920        930        940        950        960 
LAVSQNPGDV LTPVPTGSQE FGAADQQDDL REVSLADDIE PAQGEAGVPA PHENPTAQQI 

       970        980        990 
MQLLREIQNP RERPGLGSNP CIPFFYRADE NDEVKIMVV 

« Hide

Isoform 2 [UniParc].

Checksum: C8AB99D83B3205A7
Show »

FASTA967110,048

References

[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[2]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 16-999 (ISOFORM 2).
Tissue: Mammary cancer.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL808027 Genomic DNA. Translation: CAM15845.1.
AL808027 Genomic DNA. Translation: CAM15849.1. Different initiation.
CH466542 Genomic DNA. Translation: EDL08537.1.
BC011407 mRNA. Translation: AAH11407.1. Different initiation.
RefSeqNP_001074437.1. NM_001080968.1.
XP_006498556.1. XM_006498493.1.
UniGeneMm.106376.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ921M4. 6 interactions.
MINTMINT-4096435.
STRING10090.ENSMUSP00000097768.

PTM databases

PhosphoSiteQ921M4.

Proteomic databases

PaxDbQ921M4.
PRIDEQ921M4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000113377; ENSMUSP00000109004; ENSMUSG00000002546. [Q921M4-1]
GeneID99412.
KEGGmmu:99412.
UCSCuc008jew.1. mouse. [Q921M4-1]
uc008jex.1. mouse. [Q921M4-2]

Organism-specific databases

CTD2801.
MGIMGI:2139395. Golga2.

Phylogenomic databases

eggNOGNOG304043.
GeneTreeENSGT00530000062932.
HOGENOMHOG000218631.
HOVERGENHBG051752.
InParanoidQ921M4.
OrthoDBEOG71P29T.
PhylomeDBQ921M4.
TreeFamTF316990.

Gene expression databases

BgeeQ921M4.
CleanExMM_GOLGA2.
GenevestigatorQ921M4.

Family and domain databases

InterProIPR024858. Golgin_A.
[Graphical view]
PANTHERPTHR10881. PTHR10881. 1 hit.
ProtoNetSearch...

Other

ChiTaRSGOLGA2. mouse.
NextBio353919.
PROQ921M4.
SOURCESearch...

Entry information

Entry nameGOGA2_MOUSE
AccessionPrimary (citable) accession number: Q921M4
Secondary accession number(s): A2AN43, A2AN47
Entry history
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: April 20, 2010
Last modified: April 16, 2014
This is version 97 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot