Q921M4 (GOGA2_MOUSE) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 89.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Golgin subfamily A member 2 Alternative name(s): 130 kDa cis-Golgi matrix protein Short name=GM130 | ||
| Gene names |
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| Organism | Mus musculus (Mouse) [Reference proteome] | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus |
Protein attributes
| Sequence length | 999 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Probably involved in maintaining cis-Golgi structure By similarity. |
| Subunit structure | Part of a larger oligomeric complex. Interacts with p115. Interacts with RAB1B that has been activated by GTP-binding. Interacts with GORASP1/GRASP65 and ZFPL1 By similarity. |
| Subcellular location | Golgi apparatus › Golgi stack membrane; Peripheral membrane protein. |
| Domain | Extended rod-like protein with coiled-coil domains By similarity. |
| Sequence similarities | Belongs to the GOLGA2 family. |
| Sequence caution | The sequence AAH11407.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence CAM15849.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Golgi apparatus Membrane |
| Coding sequence diversity | Alternative splicing |
| Domain | Coiled coil |
| PTM | Phosphoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | Golgi localization Inferred from mutant phenotype PubMed 21111240. Source: MGI positive regulation of axonogenesisInferred from mutant phenotype PubMed 21111240. Source: MGI |
| Cellular_component | Golgi apparatus Inferred from direct assay PubMed 12646573PubMed 14718562PubMed 15078902PubMed 15452145PubMed 15800058PubMed 16336229PubMed 17003038PubMed 17204322PubMed 19061864PubMed 20368623PubMed 20943658. Source: MGI Golgi cisterna membraneInferred from electronic annotation. Source: UniProtKB-SubCell cis-Golgi networkInferred from direct assay PubMed 11784862PubMed 14728599PubMed 16399995PubMed 19956733PubMed 21111240. Source: MGI |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q921M4-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q921M4-2) The sequence of this isoform differs from the canonical sequence as follows: 70-101: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 999 | 999 | Golgin subfamily A member 2 | PRO_0000190055 | |||||
Regions | |||||||||
| Coiled coil | 147 – 895 | 749 | Potential | ||||||
| Compositional bias | 45 – 51 | 7 | Poly-Lys | ||||||
| Compositional bias | 449 – 455 | 7 | Poly-Pro | ||||||
| Compositional bias | 603 – 695 | 93 | Gln-rich | ||||||
Amino acid modifications | |||||||||
| Modified residue | 37 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 55 | 1 | Phosphoserine Ref.5 | ||||||
| Modified residue | 120 | 1 | Phosphoserine Ref.4 | ||||||
| Modified residue | 438 | 1 | Phosphoserine By similarity | ||||||
Natural variations | |||||||||
| Alternative sequence | 70 – 101 | 32 | Missing in isoform 2. | VSP_039027 | |||||
Sequences
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References
| [1] | "Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.  Ponting C.P.PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J. |
| [2] | Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 16-999 (ISOFORM 2). Tissue: Mammary cancer. |
| [4] | "Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-120, MASS SPECTROMETRY. Tissue: Liver. |
| [5] | "Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry." Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M. J. Proteome Res. 7:5314-5326(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-55, MASS SPECTROMETRY. Tissue: Melanoma. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AL808027 Genomic DNA. Translation: CAM15845.1. AL808027 Genomic DNA. Translation: CAM15849.1. Different initiation. CH466542 Genomic DNA. Translation: EDL08537.1. BC011407 mRNA. Translation: AAH11407.1. Different initiation. |
| IPI | IPI00122012. IPI00753818. |
| RefSeq | NP_001074437.1. NM_001080968.1. |
| UniGene | Mm.106376. |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q921M4. 4 interactions. |
| STRING | 10090.ENSMUSP00000097768. |
PTM databases | |
| PhosphoSite | Q921M4. |
Proteomic databases | |
| PaxDb | Q921M4. |
| PRIDE | Q921M4. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENSMUST00000081670; ENSMUSP00000080374; ENSMUSG00000002546. ENSMUST00000113377; ENSMUSP00000109004; ENSMUSG00000002546. |
| GeneID | 99412. |
| KEGG | mmu:99412. |
| UCSC | uc008jew.1. mouse. uc008jex.1. mouse. |
Organism-specific databases | |
| CTD | 2801. |
| MGI | MGI:2139395. Golga2. |
Phylogenomic databases | |
| eggNOG | NOG304043. |
| GeneTree | ENSGT00530000062932. |
| HOGENOM | HOG000218631. |
| HOVERGEN | HBG051752. |
| InParanoid | Q921M4. |
| OrthoDB | EOG48WC1G. |
Gene expression databases | |
| ArrayExpress | Q921M4. |
| Bgee | Q921M4. |
| CleanEx | MM_GOLGA2. |
| Genevestigator | Q921M4. |
| GermOnline | ENSMUSG00000002546. Mus musculus. |
Family and domain databases | |
| InterPro | IPR024858. Golgin_A. [Graphical view] |
| PANTHER | PTHR10881. PTHR10881. 1 hit. |
| ProtoNet | Search... |
Other | |
| ChiTaRS | GOLGA2. mouse. |
| NextBio | 353919. |
| SOURCE | Search... |
Entry information
| Entry name | GOGA2_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q921M4 Secondary accession number(s): A2AN43, A2AN47 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |