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Protein

Golgin subfamily A member 2

Gene

Golga2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Probably involved in maintaining cis-Golgi structure.By similarity

GO - Molecular functioni

  1. protein kinase binding Source: MGI
  2. syntaxin binding Source: MGI

GO - Biological processi

  1. Golgi localization Source: MGI
  2. negative regulation of protein binding Source: MGI
  3. positive regulation of axonogenesis Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_257344. Golgi Cisternae Pericentriolar Stack Reorganization.

Names & Taxonomyi

Protein namesi
Recommended name:
Golgin subfamily A member 2
Alternative name(s):
130 kDa cis-Golgi matrix protein
Short name:
GM130
Gene namesi
Name:Golga2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:2139395. Golga2.

Subcellular locationi

GO - Cellular componenti

  1. cis-Golgi network Source: MGI
  2. ER to Golgi transport vesicle Source: MGI
  3. Golgi apparatus Source: MGI
  4. Golgi cisterna membrane Source: UniProtKB-SubCell
  5. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 999999Golgin subfamily A member 2PRO_0000190055Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei37 – 371PhosphoserineBy similarity
Modified residuei273 – 2731PhosphoserineBy similarity
Modified residuei438 – 4381PhosphoserineBy similarity
Modified residuei697 – 6971PhosphoserineBy similarity
Modified residuei934 – 9341PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ921M4.
PaxDbiQ921M4.
PRIDEiQ921M4.

PTM databases

PhosphoSiteiQ921M4.

Expressioni

Gene expression databases

BgeeiQ921M4.
CleanExiMM_GOLGA2.
ExpressionAtlasiQ921M4. baseline.
GenevestigatoriQ921M4.

Interactioni

Subunit structurei

Part of a larger oligomeric complex. Interacts with p115. Interacts with RAB1B that has been activated by GTP-binding. Interacts with GORASP1/GRASP65 and ZFPL1 (By similarity).By similarity

Protein-protein interaction databases

IntActiQ921M4. 6 interactions.
MINTiMINT-4096435.
STRINGi10090.ENSMUSP00000097768.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili147 – 895749Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi45 – 517Poly-Lys
Compositional biasi449 – 4557Poly-Pro
Compositional biasi603 – 69593Gln-richAdd
BLAST

Domaini

Extended rod-like protein with coiled-coil domains.By similarity

Sequence similaritiesi

Belongs to the GOLGA2 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG304043.
GeneTreeiENSGT00530000062932.
HOGENOMiHOG000218631.
HOVERGENiHBG051752.
InParanoidiQ921M4.
OrthoDBiEOG71P29T.
PhylomeDBiQ921M4.
TreeFamiTF316990.

Family and domain databases

InterProiIPR024858. Golgin_A.
[Graphical view]
PANTHERiPTHR10881. PTHR10881. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q921M4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWPPRFPPPR PGMSEETRQS KLAAAKKKLR EYQQKNSPGV PAGAKKKKKI
60 70 80 90 100
KNGHSPERPT ASDCQSPENV PTDHIAPAPP TAATDTMFLG VTPSPDADLT
110 120 130 140 150
QSHDAGNCSN LMEETKTFSS TESLRQLSQQ LNGLVSESTS YINGEGLTSS
160 170 180 190 200
NMKELENRYQ ELAVALDSSY VTNKQLSSTI EELKQQNQDT LDQLEKEKKD
210 220 230 240 250
YQQKLAKEQG SLREQLQVHI QTIGILVSEK AELQTALAHT QQAARQKAGE
260 270 280 290 300
SEDLASRLQS SRQRVGELER TLSTVSTQQK QADRYNKDLT KERDALKLEL
310 320 330 340 350
YKNSKSNEDL RQQNSELEEK LRVLVAEKAA AQLGVEELQK KLEMSELLLQ
360 370 380 390 400
QFSSQSSAAG GNEQLQHAME ERAQLETHVS QLMESLKQLQ VERDQYAENL
410 420 430 440 450
KGESAMWQQR VQQMAEQVHT LKEEKEHRER QVQELETSLA ALRSQMEEPP
460 470 480 490 500
PPEPPAGPSE AEEQLQGEVE QLHKELERLT GQLRAQVQDN ESLSHLNREQ
510 520 530 540 550
EGRLLELERE AQRWSEQAEE RKQILESMQS DRTTISRALS QNRELKEQLA
560 570 580 590 600
ELQNGFVRLT NENMEITSAL QSEQHVKKEL ARKLGELQER LGELKETVEL
610 620 630 640 650
KSQEAQGLQE QRDQCLSHLQ QYAAAYQQHL AAYEQLTSEK EAIHKQLLLQ
660 670 680 690 700
TQLMDQLQHE EVQGKMAAEL ARQELQEAQE RLKATSQENQ QLQAQLSLLV
710 720 730 740 750
LPGEGDVDQE EEDEEVPQSS LAIPEDLDSR EAMVAFFNAA IARAEEEQAR
760 770 780 790 800
LRVQLKEQKA RCRSLSHLAA PVQSKLEKEA VVPRNVDDSA SEESNQALHV
810 820 830 840 850
AMEKLQSRFL EVMQEKVELK ERVEELEHCC IQLSGETDTI GEYIALYQNQ
860 870 880 890 900
RAVLKARHLE KEEYISRLAQ DKEEMKVKLL ELQELVLRLV NERNEWQGKF
910 920 930 940 950
LAVSQNPGDV LTPVPTGSQE FGAADQQDDL REVSLADDIE PAQGEAGVPA
960 970 980 990
PHENPTAQQI MQLLREIQNP RERPGLGSNP CIPFFYRADE NDEVKIMVV
Length:999
Mass (Da):113,278
Last modified:April 20, 2010 - v3
Checksum:i0D84161E727EA9F5
GO
Isoform 2 (identifier: Q921M4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     70-101: Missing.

Show »
Length:967
Mass (Da):110,048
Checksum:iC8AB99D83B3205A7
GO

Sequence cautioni

The sequence AAH11407.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAM15849.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei70 – 10132Missing in isoform 2. 1 PublicationVSP_039027Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL808027 Genomic DNA. Translation: CAM15845.1.
AL808027 Genomic DNA. Translation: CAM15849.1. Different initiation.
CH466542 Genomic DNA. Translation: EDL08537.1.
BC011407 mRNA. Translation: AAH11407.1. Different initiation.
CCDSiCCDS38101.1. [Q921M4-1]
RefSeqiNP_001074437.1. NM_001080968.1. [Q921M4-1]
XP_006498556.1. XM_006498493.1. [Q921M4-2]
UniGeneiMm.106376.

Genome annotation databases

EnsembliENSMUST00000113377; ENSMUSP00000109004; ENSMUSG00000002546. [Q921M4-1]
GeneIDi99412.
KEGGimmu:99412.
UCSCiuc008jew.1. mouse. [Q921M4-1]
uc008jex.1. mouse. [Q921M4-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL808027 Genomic DNA. Translation: CAM15845.1.
AL808027 Genomic DNA. Translation: CAM15849.1. Different initiation.
CH466542 Genomic DNA. Translation: EDL08537.1.
BC011407 mRNA. Translation: AAH11407.1. Different initiation.
CCDSiCCDS38101.1. [Q921M4-1]
RefSeqiNP_001074437.1. NM_001080968.1. [Q921M4-1]
XP_006498556.1. XM_006498493.1. [Q921M4-2]
UniGeneiMm.106376.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ921M4. 6 interactions.
MINTiMINT-4096435.
STRINGi10090.ENSMUSP00000097768.

PTM databases

PhosphoSiteiQ921M4.

Proteomic databases

MaxQBiQ921M4.
PaxDbiQ921M4.
PRIDEiQ921M4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000113377; ENSMUSP00000109004; ENSMUSG00000002546. [Q921M4-1]
GeneIDi99412.
KEGGimmu:99412.
UCSCiuc008jew.1. mouse. [Q921M4-1]
uc008jex.1. mouse. [Q921M4-2]

Organism-specific databases

CTDi2801.
MGIiMGI:2139395. Golga2.

Phylogenomic databases

eggNOGiNOG304043.
GeneTreeiENSGT00530000062932.
HOGENOMiHOG000218631.
HOVERGENiHBG051752.
InParanoidiQ921M4.
OrthoDBiEOG71P29T.
PhylomeDBiQ921M4.
TreeFamiTF316990.

Enzyme and pathway databases

ReactomeiREACT_257344. Golgi Cisternae Pericentriolar Stack Reorganization.

Miscellaneous databases

ChiTaRSiGolga2. mouse.
NextBioi353919.
PROiQ921M4.
SOURCEiSearch...

Gene expression databases

BgeeiQ921M4.
CleanExiMM_GOLGA2.
ExpressionAtlasiQ921M4. baseline.
GenevestigatoriQ921M4.

Family and domain databases

InterProiIPR024858. Golgin_A.
[Graphical view]
PANTHERiPTHR10881. PTHR10881. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 16-999 (ISOFORM 2).
    Tissue: Mammary cancer.

Entry informationi

Entry nameiGOGA2_MOUSE
AccessioniPrimary (citable) accession number: Q921M4
Secondary accession number(s): A2AN43, A2AN47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: April 20, 2010
Last modified: March 4, 2015
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.