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Q921M4

- GOGA2_MOUSE

UniProt

Q921M4 - GOGA2_MOUSE

Protein

Golgin subfamily A member 2

Gene

Golga2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 3 (20 Apr 2010)
      Previous versions | rss
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    Functioni

    Probably involved in maintaining cis-Golgi structure.By similarity

    GO - Molecular functioni

    1. protein binding Source: MGI

    GO - Biological processi

    1. Golgi localization Source: MGI
    2. positive regulation of axonogenesis Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Golgin subfamily A member 2
    Alternative name(s):
    130 kDa cis-Golgi matrix protein
    Short name:
    GM130
    Gene namesi
    Name:Golga2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:2139395. Golga2.

    Subcellular locationi

    GO - Cellular componenti

    1. cis-Golgi network Source: MGI
    2. Golgi apparatus Source: MGI
    3. Golgi cisterna membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 999999Golgin subfamily A member 2PRO_0000190055Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei37 – 371PhosphoserineBy similarity
    Modified residuei438 – 4381PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ921M4.
    PaxDbiQ921M4.
    PRIDEiQ921M4.

    PTM databases

    PhosphoSiteiQ921M4.

    Expressioni

    Gene expression databases

    BgeeiQ921M4.
    CleanExiMM_GOLGA2.
    GenevestigatoriQ921M4.

    Interactioni

    Subunit structurei

    Part of a larger oligomeric complex. Interacts with p115. Interacts with RAB1B that has been activated by GTP-binding. Interacts with GORASP1/GRASP65 and ZFPL1 By similarity.By similarity

    Protein-protein interaction databases

    IntActiQ921M4. 6 interactions.
    MINTiMINT-4096435.
    STRINGi10090.ENSMUSP00000097768.

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili147 – 895749Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi45 – 517Poly-Lys
    Compositional biasi449 – 4557Poly-Pro
    Compositional biasi603 – 69593Gln-richAdd
    BLAST

    Domaini

    Extended rod-like protein with coiled-coil domains.By similarity

    Sequence similaritiesi

    Belongs to the GOLGA2 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG304043.
    GeneTreeiENSGT00530000062932.
    HOGENOMiHOG000218631.
    HOVERGENiHBG051752.
    InParanoidiQ921M4.
    OrthoDBiEOG71P29T.
    PhylomeDBiQ921M4.
    TreeFamiTF316990.

    Family and domain databases

    InterProiIPR024858. Golgin_A.
    [Graphical view]
    PANTHERiPTHR10881. PTHR10881. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q921M4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MWPPRFPPPR PGMSEETRQS KLAAAKKKLR EYQQKNSPGV PAGAKKKKKI    50
    KNGHSPERPT ASDCQSPENV PTDHIAPAPP TAATDTMFLG VTPSPDADLT 100
    QSHDAGNCSN LMEETKTFSS TESLRQLSQQ LNGLVSESTS YINGEGLTSS 150
    NMKELENRYQ ELAVALDSSY VTNKQLSSTI EELKQQNQDT LDQLEKEKKD 200
    YQQKLAKEQG SLREQLQVHI QTIGILVSEK AELQTALAHT QQAARQKAGE 250
    SEDLASRLQS SRQRVGELER TLSTVSTQQK QADRYNKDLT KERDALKLEL 300
    YKNSKSNEDL RQQNSELEEK LRVLVAEKAA AQLGVEELQK KLEMSELLLQ 350
    QFSSQSSAAG GNEQLQHAME ERAQLETHVS QLMESLKQLQ VERDQYAENL 400
    KGESAMWQQR VQQMAEQVHT LKEEKEHRER QVQELETSLA ALRSQMEEPP 450
    PPEPPAGPSE AEEQLQGEVE QLHKELERLT GQLRAQVQDN ESLSHLNREQ 500
    EGRLLELERE AQRWSEQAEE RKQILESMQS DRTTISRALS QNRELKEQLA 550
    ELQNGFVRLT NENMEITSAL QSEQHVKKEL ARKLGELQER LGELKETVEL 600
    KSQEAQGLQE QRDQCLSHLQ QYAAAYQQHL AAYEQLTSEK EAIHKQLLLQ 650
    TQLMDQLQHE EVQGKMAAEL ARQELQEAQE RLKATSQENQ QLQAQLSLLV 700
    LPGEGDVDQE EEDEEVPQSS LAIPEDLDSR EAMVAFFNAA IARAEEEQAR 750
    LRVQLKEQKA RCRSLSHLAA PVQSKLEKEA VVPRNVDDSA SEESNQALHV 800
    AMEKLQSRFL EVMQEKVELK ERVEELEHCC IQLSGETDTI GEYIALYQNQ 850
    RAVLKARHLE KEEYISRLAQ DKEEMKVKLL ELQELVLRLV NERNEWQGKF 900
    LAVSQNPGDV LTPVPTGSQE FGAADQQDDL REVSLADDIE PAQGEAGVPA 950
    PHENPTAQQI MQLLREIQNP RERPGLGSNP CIPFFYRADE NDEVKIMVV 999
    Length:999
    Mass (Da):113,278
    Last modified:April 20, 2010 - v3
    Checksum:i0D84161E727EA9F5
    GO
    Isoform 2 (identifier: Q921M4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         70-101: Missing.

    Show »
    Length:967
    Mass (Da):110,048
    Checksum:iC8AB99D83B3205A7
    GO

    Sequence cautioni

    The sequence AAH11407.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence CAM15849.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei70 – 10132Missing in isoform 2. 1 PublicationVSP_039027Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL808027 Genomic DNA. Translation: CAM15845.1.
    AL808027 Genomic DNA. Translation: CAM15849.1. Different initiation.
    CH466542 Genomic DNA. Translation: EDL08537.1.
    BC011407 mRNA. Translation: AAH11407.1. Different initiation.
    CCDSiCCDS38101.1. [Q921M4-1]
    RefSeqiNP_001074437.1. NM_001080968.1. [Q921M4-1]
    XP_006498556.1. XM_006498493.1. [Q921M4-2]
    UniGeneiMm.106376.

    Genome annotation databases

    EnsembliENSMUST00000113377; ENSMUSP00000109004; ENSMUSG00000002546. [Q921M4-1]
    GeneIDi99412.
    KEGGimmu:99412.
    UCSCiuc008jew.1. mouse. [Q921M4-1]
    uc008jex.1. mouse. [Q921M4-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL808027 Genomic DNA. Translation: CAM15845.1 .
    AL808027 Genomic DNA. Translation: CAM15849.1 . Different initiation.
    CH466542 Genomic DNA. Translation: EDL08537.1 .
    BC011407 mRNA. Translation: AAH11407.1 . Different initiation.
    CCDSi CCDS38101.1. [Q921M4-1 ]
    RefSeqi NP_001074437.1. NM_001080968.1. [Q921M4-1 ]
    XP_006498556.1. XM_006498493.1. [Q921M4-2 ]
    UniGenei Mm.106376.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q921M4. 6 interactions.
    MINTi MINT-4096435.
    STRINGi 10090.ENSMUSP00000097768.

    PTM databases

    PhosphoSitei Q921M4.

    Proteomic databases

    MaxQBi Q921M4.
    PaxDbi Q921M4.
    PRIDEi Q921M4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000113377 ; ENSMUSP00000109004 ; ENSMUSG00000002546 . [Q921M4-1 ]
    GeneIDi 99412.
    KEGGi mmu:99412.
    UCSCi uc008jew.1. mouse. [Q921M4-1 ]
    uc008jex.1. mouse. [Q921M4-2 ]

    Organism-specific databases

    CTDi 2801.
    MGIi MGI:2139395. Golga2.

    Phylogenomic databases

    eggNOGi NOG304043.
    GeneTreei ENSGT00530000062932.
    HOGENOMi HOG000218631.
    HOVERGENi HBG051752.
    InParanoidi Q921M4.
    OrthoDBi EOG71P29T.
    PhylomeDBi Q921M4.
    TreeFami TF316990.

    Miscellaneous databases

    ChiTaRSi GOLGA2. mouse.
    NextBioi 353919.
    PROi Q921M4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q921M4.
    CleanExi MM_GOLGA2.
    Genevestigatori Q921M4.

    Family and domain databases

    InterProi IPR024858. Golgin_A.
    [Graphical view ]
    PANTHERi PTHR10881. PTHR10881. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 16-999 (ISOFORM 2).
      Tissue: Mammary cancer.

    Entry informationi

    Entry nameiGOGA2_MOUSE
    AccessioniPrimary (citable) accession number: Q921M4
    Secondary accession number(s): A2AN43, A2AN47
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 3, 2003
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 101 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3