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Protein

HemK methyltransferase family member 1

Gene

Hemk1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

N5-glutamine methyltransferase responsible for the methylation of the GGQ triplet of the mitochondrial translation release factor MTRF1L.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei191 – 1911S-adenosyl-L-methionineBy similarity
Binding sitei241 – 2411S-adenosyl-L-methionineBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
HemK methyltransferase family member 1 (EC:2.1.1.-)
Gene namesi
Name:Hemk1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1916786. Hemk1.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 340340HemK methyltransferase family member 1PRO_0000157179Add
BLAST

Proteomic databases

EPDiQ921L7.
MaxQBiQ921L7.
PaxDbiQ921L7.
PRIDEiQ921L7.
TopDownProteomicsiQ921L7.

PTM databases

PhosphoSiteiQ921L7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000032579.
CleanExiMM_HEMK1.
ExpressionAtlasiQ921L7. baseline and differential.
GenevisibleiQ921L7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035196.

Structurei

3D structure databases

ProteinModelPortaliQ921L7.
SMRiQ921L7. Positions 68-274.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni168 – 1725S-adenosyl-L-methionine bindingBy similarity
Regioni241 – 2444Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2904. Eukaryota.
COG2890. LUCA.
GeneTreeiENSGT00390000014125.
HOGENOMiHOG000076274.
HOVERGENiHBG081597.
InParanoidiQ921L7.
KOiK02493.
OMAiWTAVFEK.
OrthoDBiEOG091G0BZV.
TreeFamiTF324423.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR002052. DNA_methylase_N6_adenine_CS.
IPR004556. Modification_methylase_HemK.
IPR019874. Release_fac_Glu-N5_MeTfrase.
IPR029063. SAM-dependent_MTases.
IPR007848. Small_mtfrase_dom.
[Graphical view]
PfamiPF05175. MTS. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00536. hemK_fam. 1 hit.
TIGR03534. RF_mod_PrmC. 1 hit.
PROSITEiPS00092. N6_MTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q921L7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLWGQILWT LLSVPRGRRG VLQGWAFNSW KTYSSLTGPL SATGMVNHWT
60 70 80 90 100
RVFEERGIPE ARESSEYIVA HVLGAKTFQS LKPALWTKPL TPQQLECIQE
110 120 130 140 150
LCGRRLQRMP VQYILGEWDF QGLSLKMVPP VFIPRPETEE LVEWVLEEVA
160 170 180 190 200
QRPHAVRAQD GPLILEVGCG SGAITLSLLS QLPKSRVVAV DKEEAAVSLT
210 220 230 240 250
HENAQRLQLQ DRIRIIHLDI TSEGCCTHLL PWSPLDLVVS NPPYIFRKDM
260 270 280 290 300
EQLAPEICSY EDLVALDGGD EGMDIITHIL TLAPQLLNAS GSIFLEVDPR
310 320 330 340
HPELVSSWLQ SHPDLHLSLV GVREDFCGRP RFLHVQKSAP
Length:340
Mass (Da):38,233
Last modified:October 3, 2012 - v2
Checksum:i379E5932CE302053
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti51 – 511R → Q in AAH11431 (PubMed:15489334).Curated
Sequence conflicti104 – 1041R → H in AAH11431 (PubMed:15489334).Curated
Sequence conflicti151 – 1511Q → R in AAH11431 (PubMed:15489334).Curated
Sequence conflicti205 – 2051Q → R in AAH11431 (PubMed:15489334).Curated
Sequence conflicti217 – 2171H → C in AAH11431 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL672070 Genomic DNA. Translation: CAQ12135.1.
BC011431 mRNA. Translation: AAH11431.1.
BC024428 mRNA. Translation: AAH24428.1.
CCDSiCCDS23488.1.
RefSeqiNP_598745.2. NM_133984.2.
XP_006511882.1. XM_006511819.1.
XP_011241215.1. XM_011242913.1.
UniGeneiMm.259467.

Genome annotation databases

EnsembliENSMUST00000035196; ENSMUSP00000035196; ENSMUSG00000032579.
GeneIDi69536.
KEGGimmu:69536.
UCSCiuc009rle.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL672070 Genomic DNA. Translation: CAQ12135.1.
BC011431 mRNA. Translation: AAH11431.1.
BC024428 mRNA. Translation: AAH24428.1.
CCDSiCCDS23488.1.
RefSeqiNP_598745.2. NM_133984.2.
XP_006511882.1. XM_006511819.1.
XP_011241215.1. XM_011242913.1.
UniGeneiMm.259467.

3D structure databases

ProteinModelPortaliQ921L7.
SMRiQ921L7. Positions 68-274.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035196.

PTM databases

PhosphoSiteiQ921L7.

Proteomic databases

EPDiQ921L7.
MaxQBiQ921L7.
PaxDbiQ921L7.
PRIDEiQ921L7.
TopDownProteomicsiQ921L7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035196; ENSMUSP00000035196; ENSMUSG00000032579.
GeneIDi69536.
KEGGimmu:69536.
UCSCiuc009rle.2. mouse.

Organism-specific databases

CTDi51409.
MGIiMGI:1916786. Hemk1.

Phylogenomic databases

eggNOGiKOG2904. Eukaryota.
COG2890. LUCA.
GeneTreeiENSGT00390000014125.
HOGENOMiHOG000076274.
HOVERGENiHBG081597.
InParanoidiQ921L7.
KOiK02493.
OMAiWTAVFEK.
OrthoDBiEOG091G0BZV.
TreeFamiTF324423.

Miscellaneous databases

PROiQ921L7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032579.
CleanExiMM_HEMK1.
ExpressionAtlasiQ921L7. baseline and differential.
GenevisibleiQ921L7. MM.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR002052. DNA_methylase_N6_adenine_CS.
IPR004556. Modification_methylase_HemK.
IPR019874. Release_fac_Glu-N5_MeTfrase.
IPR029063. SAM-dependent_MTases.
IPR007848. Small_mtfrase_dom.
[Graphical view]
PfamiPF05175. MTS. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00536. hemK_fam. 1 hit.
TIGR03534. RF_mod_PrmC. 1 hit.
PROSITEiPS00092. N6_MTASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHEMK1_MOUSE
AccessioniPrimary (citable) accession number: Q921L7
Secondary accession number(s): B0QZU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: October 3, 2012
Last modified: September 7, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.