Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Conserved oligomeric Golgi complex subunit 2

Gene

Cog2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for normal Golgi morphology and function.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-6807878. COPI-mediated anterograde transport.
R-MMU-6811438. Intra-Golgi traffic.
R-MMU-6811440. Retrograde transport at the Trans-Golgi-Network.

Names & Taxonomyi

Protein namesi
Recommended name:
Conserved oligomeric Golgi complex subunit 2
Short name:
COG complex subunit 2
Alternative name(s):
Component of oligomeric Golgi complex 2
Low density lipoprotein receptor defect C-complementing protein
Gene namesi
Name:Cog2
Synonyms:Ldlc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1923582. Cog2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 731731Conserved oligomeric Golgi complex subunit 2PRO_0000213496Add
BLAST

Proteomic databases

EPDiQ921L5.
MaxQBiQ921L5.
PaxDbiQ921L5.
PeptideAtlasiQ921L5.
PRIDEiQ921L5.

PTM databases

iPTMnetiQ921L5.
PhosphoSiteiQ921L5.

Expressioni

Gene expression databases

BgeeiQ921L5.
CleanExiMM_COG2.
ExpressionAtlasiQ921L5. baseline and differential.
GenevisibleiQ921L5. MM.

Interactioni

Subunit structurei

Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.By similarity

Protein-protein interaction databases

BioGridi218073. 1 interaction.
IntActiQ921L5. 2 interactions.
STRINGi10090.ENSMUSP00000034460.

Structurei

3D structure databases

ProteinModelPortaliQ921L5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the COG2 family.Curated

Phylogenomic databases

eggNOGiKOG2307. Eukaryota.
ENOG410XU2D. LUCA.
GeneTreeiENSGT00390000012040.
HOGENOMiHOG000046032.
HOVERGENiHBG030902.
InParanoidiQ921L5.
OMAiVESHPNG.
OrthoDBiEOG7CZK59.
TreeFamiTF105824.

Family and domain databases

InterProiIPR009316. COG2.
IPR024603. COG_complex_COG2_C.
IPR024602. COG_su2_N.
[Graphical view]
PANTHERiPTHR12961. PTHR12961. 1 hit.
PfamiPF06148. COG2. 1 hit.
PF12022. DUF3510. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q921L5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKRRMNLPT GPDTLCFDKD EFMKEDFDVD HFVSDCRKRV QLEELRDDLE
60 70 80 90 100
LYYKLLKTAM VELINKDYAD FVNLSTNLVG MDRALNQLSV PLGQLREEVL
110 120 130 140 150
SLRSSVSEGI LAVDERMSKQ EDIRKKKMSV LRLIQVIRSV EKIEKILNSQ
160 170 180 190 200
SSKDVSSQEA SSPLLTGQVL ERIATEFNQL QFHAVQSKGM PLLDKVRPRI
210 220 230 240 250
AGITAMLQQS LEGLLLEGLQ TSDVDIVRHC LRTYATIDKT QDAEALVGQV
260 270 280 290 300
LVKPYVNEVI VEQFVESHPS SLQLMYNKLL EFVPHHCRLL REVTGGAVSS
310 320 330 340 350
EKGTIVPGYD FLVNSVWPEI VRGLEEKLPS LFNPGDPDAF HQKYTVSMDF
360 370 380 390 400
VQRFERQCGS QASVKRLRAH PAYHNFSNKW NLPVYFQIRF REVAGSLEAA
410 420 430 440 450
LTDGLEDAPA GSPYCLLASH RTWISLGKCW SDEMFLPLLA HRLWRLTLQI
460 470 480 490 500
LARFSVFVSE LSVRPVSNES AKETKKPLTG SKDPSEDQGS HASEASAASI
510 520 530 540 550
SSTQLVYVVS DLGRLQEWLP DLLETVKQKL EMIGFKNFSS ISAALEDSQS
560 570 580 590 600
ALSAHVPALS SRIVQDLSES CFSYLKSALE VPRLYRRTNK EVPSTASSYV
610 620 630 640 650
DSALKPLYQL QSGHGDKVQP AVMQSWLQEA LSDSTHRYFE TVSDVLNSVK
660 670 680 690 700
KMEESLKRLK QARRSPATNP VSSSGGGMSD DDKIRLQLAL DVEHLGEQIQ
710 720 730
RMGLQTSDIK SFPALMELVL AARDQAAAEQ P
Length:731
Mass (Da):82,040
Last modified:July 27, 2011 - v2
Checksum:i294F5594C48CA960
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti271 – 2711S → G in AAH11435 (PubMed:15489334).Curated
Sequence conflicti515 – 5151L → M in AAH11435 (PubMed:15489334).Curated
Sequence conflicti719 – 7191V → I in AAH11435 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC011435 mRNA. Translation: AAH11435.1.
AK012236 mRNA. Translation: BAB28112.1.
AK169298 mRNA. Translation: BAE41054.1.
CCDSiCCDS22771.1.
RefSeqiNP_084022.2. NM_029746.3.
UniGeneiMm.240108.

Genome annotation databases

EnsembliENSMUST00000034460; ENSMUSP00000034460; ENSMUSG00000031979.
GeneIDi76332.
KEGGimmu:76332.
UCSCiuc009nxd.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC011435 mRNA. Translation: AAH11435.1.
AK012236 mRNA. Translation: BAB28112.1.
AK169298 mRNA. Translation: BAE41054.1.
CCDSiCCDS22771.1.
RefSeqiNP_084022.2. NM_029746.3.
UniGeneiMm.240108.

3D structure databases

ProteinModelPortaliQ921L5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi218073. 1 interaction.
IntActiQ921L5. 2 interactions.
STRINGi10090.ENSMUSP00000034460.

PTM databases

iPTMnetiQ921L5.
PhosphoSiteiQ921L5.

Proteomic databases

EPDiQ921L5.
MaxQBiQ921L5.
PaxDbiQ921L5.
PeptideAtlasiQ921L5.
PRIDEiQ921L5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034460; ENSMUSP00000034460; ENSMUSG00000031979.
GeneIDi76332.
KEGGimmu:76332.
UCSCiuc009nxd.2. mouse.

Organism-specific databases

CTDi22796.
MGIiMGI:1923582. Cog2.

Phylogenomic databases

eggNOGiKOG2307. Eukaryota.
ENOG410XU2D. LUCA.
GeneTreeiENSGT00390000012040.
HOGENOMiHOG000046032.
HOVERGENiHBG030902.
InParanoidiQ921L5.
OMAiVESHPNG.
OrthoDBiEOG7CZK59.
TreeFamiTF105824.

Enzyme and pathway databases

ReactomeiR-MMU-6807878. COPI-mediated anterograde transport.
R-MMU-6811438. Intra-Golgi traffic.
R-MMU-6811440. Retrograde transport at the Trans-Golgi-Network.

Miscellaneous databases

ChiTaRSiCog2. mouse.
PROiQ921L5.
SOURCEiSearch...

Gene expression databases

BgeeiQ921L5.
CleanExiMM_COG2.
ExpressionAtlasiQ921L5. baseline and differential.
GenevisibleiQ921L5. MM.

Family and domain databases

InterProiIPR009316. COG2.
IPR024603. COG_complex_COG2_C.
IPR024602. COG_su2_N.
[Graphical view]
PANTHERiPTHR12961. PTHR12961. 1 hit.
PfamiPF06148. COG2. 1 hit.
PF12022. DUF3510. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiCOG2_MOUSE
AccessioniPrimary (citable) accession number: Q921L5
Secondary accession number(s): Q3TF44, Q9CSQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: July 27, 2011
Last modified: July 6, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.