Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

B-cell CLL/lymphoma 7 protein family member B

Gene

Bcl7b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Positive regulator of apoptosis. Plays a role in the Wnt signaling pathway, negatively regulating the expression of Wnt signaling components CTNNB1 and HMGA1 (By similarity). Involved in cell cycle progression, maintenance of the nuclear structure and stem cell differentiation (By similarity). May play a role in lung tumor development or progression.By similarity1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis, Differentiation, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
B-cell CLL/lymphoma 7 protein family member B
Gene namesi
Name:Bcl7b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1332238. Bcl7b.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002398301 – 202B-cell CLL/lymphoma 7 protein family member BAdd BLAST202

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei114PhosphoserineCombined sources1
Modified residuei118PhosphoserineCombined sources1
Modified residuei120PhosphoserineCombined sources1
Modified residuei122PhosphoserineCombined sources1
Modified residuei127PhosphoserineCombined sources1
Modified residuei148PhosphoserineCombined sources1
Modified residuei152PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ921K9.
PaxDbiQ921K9.
PeptideAtlasiQ921K9.
PRIDEiQ921K9.

PTM databases

iPTMnetiQ921K9.
PhosphoSitePlusiQ921K9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000029681.
CleanExiMM_BCL7B.
ExpressionAtlasiQ921K9. baseline and differential.
GenevisibleiQ921K9. MM.

Interactioni

Protein-protein interaction databases

BioGridi198328. 19 interactors.
IntActiQ921K9. 18 interactors.
STRINGi10090.ENSMUSP00000031692.

Structurei

3D structure databases

ProteinModelPortaliQ921K9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BCL7 family.Curated

Phylogenomic databases

eggNOGiKOG4095. Eukaryota.
ENOG4111TES. LUCA.
GeneTreeiENSGT00390000002172.
HOGENOMiHOG000232196.
HOVERGENiHBG008481.
InParanoidiQ921K9.
OMAiDSQPPML.
OrthoDBiEOG091G0T7O.
PhylomeDBiQ921K9.
TreeFamiTF317441.

Family and domain databases

InterProiIPR006804. BCL7.
[Graphical view]
PANTHERiPTHR12767. PTHR12767. 1 hit.
PfamiPF04714. BCL_N. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q921K9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGRSVRAET RSRAKDDIKK VMAAIEKVRK WEKKWVTVGD TSLRIFKWVP
60 70 80 90 100
VTDSKEKEKS KSNNTAAREP NGFPSDASAN SSLLLEFQDE NSNQSSVSDV
110 120 130 140 150
YQLKVDSSTN SSPSPQQSES LSPAHTSDFR TDDSQPPTLG QEILEEPSLP
160 170 180 190 200
ASEVADEPPT LTKEEPVPVE TQTTEEEEDS GAPPLKRFCV DQPVVPQTTS

ES
Length:202
Mass (Da):22,238
Last modified:December 1, 2001 - v1
Checksum:iB5976CFF00AB3CC3
GO
Isoform 2 (identifier: Q921K9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     57-58: KE → GF
     59-202: Missing.

Note: No experimental confirmation available.
Show »
Length:58
Mass (Da):6,740
Checksum:i9E6FE7621B1D07D0
GO

Sequence cautioni

The sequence CAA09501 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24A → D in BAE33030 (PubMed:16141072).Curated1
Sequence conflicti192Q → K in BAE33030 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01928057 – 58KE → GF in isoform 2. 1 Publication2
Alternative sequenceiVSP_01928159 – 202Missing in isoform 2. 1 PublicationAdd BLAST144

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011145 mRNA. Translation: CAA09501.1. Different initiation.
AK131643 mRNA. Translation: BAE20736.1.
AK155076 mRNA. Translation: BAE33030.1.
AK160439 mRNA. Translation: BAE35789.1.
BC011471 mRNA. Translation: AAH11471.1.
CCDSiCCDS51660.1. [Q921K9-1]
RefSeqiNP_033875.2. NM_009745.2. [Q921K9-1]
UniGeneiMm.405834.

Genome annotation databases

EnsembliENSMUST00000031692; ENSMUSP00000031692; ENSMUSG00000029681. [Q921K9-1]
ENSMUST00000111187; ENSMUSP00000106818; ENSMUSG00000029681. [Q921K9-2]
GeneIDi12054.
KEGGimmu:12054.
UCSCiuc012een.1. mouse. [Q921K9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ011145 mRNA. Translation: CAA09501.1. Different initiation.
AK131643 mRNA. Translation: BAE20736.1.
AK155076 mRNA. Translation: BAE33030.1.
AK160439 mRNA. Translation: BAE35789.1.
BC011471 mRNA. Translation: AAH11471.1.
CCDSiCCDS51660.1. [Q921K9-1]
RefSeqiNP_033875.2. NM_009745.2. [Q921K9-1]
UniGeneiMm.405834.

3D structure databases

ProteinModelPortaliQ921K9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198328. 19 interactors.
IntActiQ921K9. 18 interactors.
STRINGi10090.ENSMUSP00000031692.

PTM databases

iPTMnetiQ921K9.
PhosphoSitePlusiQ921K9.

Proteomic databases

EPDiQ921K9.
PaxDbiQ921K9.
PeptideAtlasiQ921K9.
PRIDEiQ921K9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031692; ENSMUSP00000031692; ENSMUSG00000029681. [Q921K9-1]
ENSMUST00000111187; ENSMUSP00000106818; ENSMUSG00000029681. [Q921K9-2]
GeneIDi12054.
KEGGimmu:12054.
UCSCiuc012een.1. mouse. [Q921K9-1]

Organism-specific databases

CTDi9275.
MGIiMGI:1332238. Bcl7b.

Phylogenomic databases

eggNOGiKOG4095. Eukaryota.
ENOG4111TES. LUCA.
GeneTreeiENSGT00390000002172.
HOGENOMiHOG000232196.
HOVERGENiHBG008481.
InParanoidiQ921K9.
OMAiDSQPPML.
OrthoDBiEOG091G0T7O.
PhylomeDBiQ921K9.
TreeFamiTF317441.

Miscellaneous databases

PROiQ921K9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029681.
CleanExiMM_BCL7B.
ExpressionAtlasiQ921K9. baseline and differential.
GenevisibleiQ921K9. MM.

Family and domain databases

InterProiIPR006804. BCL7.
[Graphical view]
PANTHERiPTHR12767. PTHR12767. 1 hit.
PfamiPF04714. BCL_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBCL7B_MOUSE
AccessioniPrimary (citable) accession number: Q921K9
Secondary accession number(s): O89022, Q3TV31, Q3U2W0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.