Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Poly [ADP-ribose] polymerase

Gene

Parp1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GlycosyltransferaseUniRule annotation, Transferase

Keywords - Ligandi

Metal-binding, NADUniRule annotation, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-110362. POLB-Dependent Long Patch Base Excision Repair.
R-MMU-2173795. Downregulation of SMAD2/3:SMAD4 transcriptional activity.
R-MMU-3108214. SUMOylation of DNA damage response and repair proteins.
R-MMU-5685939. HDR through MMEJ (alt-NHEJ).
R-MMU-5696394. DNA Damage Recognition in GG-NER.
R-MMU-5696395. Formation of Incision Complex in GG-NER.
R-MMU-5696400. Dual Incision in GG-NER.

Names & Taxonomyi

Protein namesi
Recommended name:
Poly [ADP-ribose] polymeraseUniRule annotation (EC:2.4.2.30UniRule annotation)
Short name:
PARPUniRule annotation
Gene namesi
Name:Parp1Imported
Synonyms:Adprt1Imported
ORF Names:mCG_19846Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1340806. Parp1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Expressioni

Gene expression databases

BgeeiENSMUSG00000026496.

Interactioni

Protein-protein interaction databases

MINTiMINT-4122491.
STRINGi10090.ENSMUSP00000027777.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 93PARP-typeInterPro annotationAdd BLAST85
Domaini113 – 203PARP-typeInterPro annotationAdd BLAST91
Domaini386 – 462BRCTInterPro annotationAdd BLAST77
Domaini662 – 779PARP alpha-helicalInterPro annotationAdd BLAST118
Domaini788 – 1014PARP catalyticInterPro annotationAdd BLAST227

Sequence similaritiesi

Contains 1 BRCT domain.UniRule annotation
Contains 1 PARP alpha-helical domain.UniRule annotation
Contains 1 PARP catalytic domain.UniRule annotation
Contains 2 PARP-type zinc fingers.UniRule annotation

Keywords - Domaini

Zinc-fingerUniRule annotation

Phylogenomic databases

eggNOGiKOG1037. Eukaryota.
ENOG410XP18. LUCA.
GeneTreeiENSGT00390000017341.
HOVERGENiHBG053513.
KOiK10798.
OMAiEIEVAYN.
OrthoDBiEOG091G13H1.
TreeFamiTF316616.

Family and domain databases

CDDicd00027. BRCT. 1 hit.
Gene3Di1.20.142.10. 1 hit.
2.20.140.10. 1 hit.
3.30.1740.10. 2 hits.
3.40.50.10190. 1 hit.
3.90.228.10. 1 hit.
InterProiIPR001357. BRCT_dom.
IPR012982. PADR1.
IPR008288. PARP.
IPR012317. Poly(ADP-ribose)pol_cat_dom.
IPR004102. Poly(ADP-ribose)pol_reg_dom.
IPR008893. WGR_domain.
IPR001510. Znf_PARP.
[Graphical view]
PfamiPF00533. BRCT. 1 hit.
PF08063. PADR1. 1 hit.
PF00644. PARP. 1 hit.
PF02877. PARP_reg. 1 hit.
PF05406. WGR. 1 hit.
PF00645. zf-PARP. 2 hits.
[Graphical view]
PIRSFiPIRSF000489. NAD_ADPRT. 1 hit.
SMARTiSM00292. BRCT. 1 hit.
SM01335. PADR1. 1 hit.
SM00773. WGR. 1 hit.
SM01336. zf-PARP. 2 hits.
[Graphical view]
SUPFAMiSSF142921. SSF142921. 1 hit.
SSF47587. SSF47587. 1 hit.
SSF52113. SSF52113. 1 hit.
PROSITEiPS50172. BRCT. 1 hit.
PS51060. PARP_ALPHA_HD. 1 hit.
PS51059. PARP_CATALYTIC. 1 hit.
PS00347. PARP_ZN_FINGER_1. 2 hits.
PS50064. PARP_ZN_FINGER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q921K2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEASERLYR VEYAKSGRAS CKKCSESIPK DSLRMAIMVQ SPMFDGKVPH
60 70 80 90 100
WYHFSCFWKV GHSIRQPDVE VDGFSELRWD DQQKVKKTAE AGGVAGKGQD
110 120 130 140 150
GSGGKAEKTL GDFLAEYAKS NRSMCKGCLE KIEKGQMRLS KKMVDPEKPQ
160 170 180 190 200
LGMIDRWYHP TCFVKKRDEL GFRPEYSASQ LKGFSLLSAE DKEALKKQLP
210 220 230 240 250
AIKNEGKRKG DEVDGTDEVA KKKSKKGKDK DSSKLEKALK AQNELIWNIK
260 270 280 290 300
DELKKACSTN DLKELLIFNQ QQVPSGESAI LDRVADGMAF GALLPCKECS
310 320 330 340 350
GQLVFKSDAY YCTGDVTAWT KCMVKTQNPS RKEWVTPKEF REISYLKKLK
360 370 380 390 400
VKKQDRIFPP ESSAPAPLAL PLSVTSAPTA VNSSAPADKP LSNMKILTLG
410 420 430 440 450
KLSQNKDEAK AVIEKLGGKL TGSANKASLC ISTKKEVEKM SKKMEEVKAA
460 470 480 490 500
NVRVVCEDFL QDVSASTKSL QELLSAHSLS SWGAEVKAEP GEVVAPKGKS
510 520 530 540 550
AAPSKKSKGA VKEEGVNKSE KRMKLTLKGG AAVDPDSGLE HSAHVLEKGG
560 570 580 590 600
KVFSATLGLV DIVKGTNSYY KLQLLEDDKE SRYWIFRSWG RVGTVIGSNK
610 620 630 640 650
LEQMPSKEDA VEHFMKLYEE KTGNAWHSKN FTKYPKKFYP LEIDYGQDEE
660 670 680 690 700
AVKKLTVKPG TKSKLPKPVQ ELVGMIFDVE SMKKALVEYE IDLQKMPLGK
710 720 730 740 750
LSRRQIQAAY SILSEVQQAV SQGSSESQIL DLSNRFYTLI PHDFGMKKPP
760 770 780 790 800
LLNNADSVQA KVEMLDNLLD IEVAYSLLRG GSDDSSKDPI DVNYEKLKTD
810 820 830 840 850
IKVVDRDSEE AEVIRKYVKN THATTHNAYD LEVIDIFKIE REGESQRYKP
860 870 880 890 900
FRQLHNRRLL WHGSRTTNFA GILSQGLRIA PPEAPVTGYM FGKGIYFADM
910 920 930 940 950
VSKSANYCHT SQGDPIGLIL LGEVALGNMY ELKHASHISK LPKGKHSVKG
960 970 980 990 1000
LGKTTPDPSA SITLEGVEVP LGTGIPSGVN DTCLLYNEYI VYDIAQVNLK
1010
YLLKLKFNFK TSLW
Length:1,014
Mass (Da):112,721
Last modified:December 1, 2001 - v1
Checksum:i5DCE68E4CB3F46EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC121810 Genomic DNA. No translation available.
BC012041 mRNA. Translation: AAH12041.1.
AK030889 mRNA. Translation: BAC27173.1.
AK088679 mRNA. Translation: BAC40500.1.
CH466555 Genomic DNA. Translation: EDL13152.1.
RefSeqiNP_031441.2. NM_007415.2.
UniGeneiMm.277779.

Genome annotation databases

EnsembliENSMUST00000027777; ENSMUSP00000027777; ENSMUSG00000026496.
GeneIDi11545.
KEGGimmu:11545.
UCSCiuc007dwi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC121810 Genomic DNA. No translation available.
BC012041 mRNA. Translation: AAH12041.1.
AK030889 mRNA. Translation: BAC27173.1.
AK088679 mRNA. Translation: BAC40500.1.
CH466555 Genomic DNA. Translation: EDL13152.1.
RefSeqiNP_031441.2. NM_007415.2.
UniGeneiMm.277779.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4122491.
STRINGi10090.ENSMUSP00000027777.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027777; ENSMUSP00000027777; ENSMUSG00000026496.
GeneIDi11545.
KEGGimmu:11545.
UCSCiuc007dwi.1. mouse.

Organism-specific databases

CTDi142.
MGIiMGI:1340806. Parp1.

Phylogenomic databases

eggNOGiKOG1037. Eukaryota.
ENOG410XP18. LUCA.
GeneTreeiENSGT00390000017341.
HOVERGENiHBG053513.
KOiK10798.
OMAiEIEVAYN.
OrthoDBiEOG091G13H1.
TreeFamiTF316616.

Enzyme and pathway databases

ReactomeiR-MMU-110362. POLB-Dependent Long Patch Base Excision Repair.
R-MMU-2173795. Downregulation of SMAD2/3:SMAD4 transcriptional activity.
R-MMU-3108214. SUMOylation of DNA damage response and repair proteins.
R-MMU-5685939. HDR through MMEJ (alt-NHEJ).
R-MMU-5696394. DNA Damage Recognition in GG-NER.
R-MMU-5696395. Formation of Incision Complex in GG-NER.
R-MMU-5696400. Dual Incision in GG-NER.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026496.

Family and domain databases

CDDicd00027. BRCT. 1 hit.
Gene3Di1.20.142.10. 1 hit.
2.20.140.10. 1 hit.
3.30.1740.10. 2 hits.
3.40.50.10190. 1 hit.
3.90.228.10. 1 hit.
InterProiIPR001357. BRCT_dom.
IPR012982. PADR1.
IPR008288. PARP.
IPR012317. Poly(ADP-ribose)pol_cat_dom.
IPR004102. Poly(ADP-ribose)pol_reg_dom.
IPR008893. WGR_domain.
IPR001510. Znf_PARP.
[Graphical view]
PfamiPF00533. BRCT. 1 hit.
PF08063. PADR1. 1 hit.
PF00644. PARP. 1 hit.
PF02877. PARP_reg. 1 hit.
PF05406. WGR. 1 hit.
PF00645. zf-PARP. 2 hits.
[Graphical view]
PIRSFiPIRSF000489. NAD_ADPRT. 1 hit.
SMARTiSM00292. BRCT. 1 hit.
SM01335. PADR1. 1 hit.
SM00773. WGR. 1 hit.
SM01336. zf-PARP. 2 hits.
[Graphical view]
SUPFAMiSSF142921. SSF142921. 1 hit.
SSF47587. SSF47587. 1 hit.
SSF52113. SSF52113. 1 hit.
PROSITEiPS50172. BRCT. 1 hit.
PS51060. PARP_ALPHA_HD. 1 hit.
PS51059. PARP_CATALYTIC. 1 hit.
PS00347. PARP_ZN_FINGER_1. 2 hits.
PS50064. PARP_ZN_FINGER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ921K2_MOUSE
AccessioniPrimary (citable) accession number: Q921K2
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.