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Q921I9

- EXOS4_MOUSE

UniProt

Q921I9 - EXOS4_MOUSE

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Protein

Exosome complex component RRP41

Gene

Exosc4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC4 binds to ARE-containing RNAs (By similarity).By similarity

GO - Molecular functioni

  1. AU-rich element binding Source: Ensembl

GO - Biological processi

  1. defense response to virus Source: Ensembl
  2. DNA deamination Source: Ensembl
  3. histone mRNA catabolic process Source: UniProtKB
  4. maturation of 5.8S rRNA Source: Ensembl
  5. nuclear mRNA surveillance Source: Ensembl
  6. positive regulation of cell growth Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiREACT_198696. KSRP destabilizes mRNA.

Names & Taxonomyi

Protein namesi
Recommended name:
Exosome complex component RRP41
Alternative name(s):
Exosome component 4
Ribosomal RNA-processing protein 41
Gene namesi
Name:Exosc4
Synonyms:Rrp41
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:1923576. Exosc4.

Subcellular locationi

Cytoplasm By similarity. Nucleusnucleolus By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. exosome (RNase complex) Source: UniProtKB
  3. nucleus Source: UniProtKB-KW
  4. transcriptionally active chromatin Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Exosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 245244Exosome complex component RRP41PRO_0000139959Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ921I9.
PaxDbiQ921I9.
PRIDEiQ921I9.

PTM databases

PhosphoSiteiQ921I9.

Expressioni

Gene expression databases

BgeeiQ921I9.
CleanExiMM_EXOSC4.
ExpressionAtlasiQ921I9. baseline and differential.
GenevestigatoriQ921I9.

Interactioni

Subunit structurei

Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core (Exo-9) complex which is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric ring of RNase PH domain-containing subunits specifically containing the heterodimers EXOSC4-EXOSC9, EXOSC5-EXOSC8 and EXOSC6-EXOSC7, and peripheral S1 domain-containing components EXOSC1, EXOSC2 and EXOSC3 located on the top of the ring structure (By similarity). Interacts with DDX60 (By similarity).By similarity

Protein-protein interaction databases

BioGridi224543. 2 interactions.
IntActiQ921I9. 1 interaction.
MINTiMINT-4094786.

Structurei

3D structure databases

ProteinModelPortaliQ921I9.
SMRiQ921I9. Positions 7-241.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase PH family.Curated

Phylogenomic databases

eggNOGiCOG0689.
GeneTreeiENSGT00550000074804.
HOGENOMiHOG000229515.
HOVERGENiHBG051519.
InParanoidiQ921I9.
KOiK11600.
OMAiDYVCACT.
OrthoDBiEOG74J98C.
PhylomeDBiQ921I9.
TreeFamiTF313915.

Family and domain databases

Gene3Di3.30.230.70. 1 hit.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR027408. PNPase/RNase_PH_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view]
PfamiPF01138. RNase_PH. 1 hit.
PF03725. RNase_PH_C. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55666. SSF55666. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q921I9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGLELLSDQ GYRIDGRRAG ELRKIQARMG VFAQADGSAY IEQGNTKALA
60 70 80 90 100
VVYGPHEIRG SRSRALPDRA LVNCQYSSAT FSTGERKRRP HGDRKSCEMG
110 120 130 140 150
LQLRQTFEAA ILTQLHPRSQ IDIYVQVLQA DGGTYAACVN AATLAVMDAG
160 170 180 190 200
IPMRDFVCAC SAGFVDGTAL ADLSHVEEAA GGPQLALALL PASGQIALLE
210 220 230 240
MDSRLHEDHL EQVLEAAAQA ARGVHTLLDL VVRQHVQEAS VSLGD
Length:245
Mass (Da):26,250
Last modified:January 23, 2007 - v3
Checksum:iE06C1CA2CA1FBF57
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC012277 mRNA. Translation: AAH12277.1.
CCDSiCCDS37119.1.
RefSeqiNP_780608.1. NM_175399.4.
UniGeneiMm.322752.

Genome annotation databases

EnsembliENSMUST00000059045; ENSMUSP00000050940; ENSMUSG00000034259.
GeneIDi109075.
KEGGimmu:109075.
UCSCiuc007wjp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC012277 mRNA. Translation: AAH12277.1 .
CCDSi CCDS37119.1.
RefSeqi NP_780608.1. NM_175399.4.
UniGenei Mm.322752.

3D structure databases

ProteinModelPortali Q921I9.
SMRi Q921I9. Positions 7-241.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 224543. 2 interactions.
IntActi Q921I9. 1 interaction.
MINTi MINT-4094786.

PTM databases

PhosphoSitei Q921I9.

Proteomic databases

MaxQBi Q921I9.
PaxDbi Q921I9.
PRIDEi Q921I9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000059045 ; ENSMUSP00000050940 ; ENSMUSG00000034259 .
GeneIDi 109075.
KEGGi mmu:109075.
UCSCi uc007wjp.1. mouse.

Organism-specific databases

CTDi 54512.
MGIi MGI:1923576. Exosc4.

Phylogenomic databases

eggNOGi COG0689.
GeneTreei ENSGT00550000074804.
HOGENOMi HOG000229515.
HOVERGENi HBG051519.
InParanoidi Q921I9.
KOi K11600.
OMAi DYVCACT.
OrthoDBi EOG74J98C.
PhylomeDBi Q921I9.
TreeFami TF313915.

Enzyme and pathway databases

Reactomei REACT_198696. KSRP destabilizes mRNA.

Miscellaneous databases

ChiTaRSi EXOSC4. mouse.
NextBioi 361620.
PROi Q921I9.
SOURCEi Search...

Gene expression databases

Bgeei Q921I9.
CleanExi MM_EXOSC4.
ExpressionAtlasi Q921I9. baseline and differential.
Genevestigatori Q921I9.

Family and domain databases

Gene3Di 3.30.230.70. 1 hit.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR027408. PNPase/RNase_PH_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
[Graphical view ]
Pfami PF01138. RNase_PH. 1 hit.
PF03725. RNase_PH_C. 1 hit.
[Graphical view ]
SUPFAMi SSF54211. SSF54211. 1 hit.
SSF55666. SSF55666. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiEXOS4_MOUSE
AccessioniPrimary (citable) accession number: Q921I9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 103 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3