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Q921I9

- EXOS4_MOUSE

UniProt

Q921I9 - EXOS4_MOUSE

Protein

Exosome complex component RRP41

Gene

Exosc4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC4 binds to ARE-containing RNAs By similarity.By similarity

    GO - Molecular functioni

    1. AU-rich element binding Source: Ensembl
    2. protein binding Source: MGI

    GO - Biological processi

    1. defense response to virus Source: Ensembl
    2. DNA deamination Source: Ensembl
    3. histone mRNA catabolic process Source: UniProtKB
    4. maturation of 5.8S rRNA Source: Ensembl
    5. nuclear mRNA surveillance Source: Ensembl
    6. positive regulation of cell growth Source: Ensembl

    Keywords - Biological processi

    rRNA processing

    Keywords - Ligandi

    RNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_198696. KSRP destabilizes mRNA.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Exosome complex component RRP41
    Alternative name(s):
    Exosome component 4
    Ribosomal RNA-processing protein 41
    Gene namesi
    Name:Exosc4
    Synonyms:Rrp41
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:1923576. Exosc4.

    Subcellular locationi

    Cytoplasm By similarity. Nucleusnucleolus By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. exosome (RNase complex) Source: UniProtKB
    3. nucleolus Source: UniProtKB-SubCell
    4. transcriptionally active chromatin Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Exosome, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 245244Exosome complex component RRP41PRO_0000139959Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ921I9.
    PRIDEiQ921I9.

    PTM databases

    PhosphoSiteiQ921I9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ921I9.
    BgeeiQ921I9.
    CleanExiMM_EXOSC4.
    GenevestigatoriQ921I9.

    Interactioni

    Subunit structurei

    Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core (Exo-9) complex which is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric ring of RNase PH domain-containing subunits specifically containing the heterodimers EXOSC4-EXOSC9, EXOSC5-EXOSC8 and EXOSC6-EXOSC7, and peripheral S1 domain-containing components EXOSC1, EXOSC2 and EXOSC3 located on the top of the ring structure By similarity. Interacts with DDX60 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi224543. 2 interactions.
    IntActiQ921I9. 1 interaction.
    MINTiMINT-4094786.

    Structurei

    3D structure databases

    ProteinModelPortaliQ921I9.
    SMRiQ921I9. Positions 7-241.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RNase PH family.Curated

    Phylogenomic databases

    eggNOGiCOG0689.
    GeneTreeiENSGT00550000074804.
    HOGENOMiHOG000229515.
    HOVERGENiHBG051519.
    InParanoidiQ921I9.
    KOiK11600.
    OMAiDYVCACT.
    OrthoDBiEOG74J98C.
    PhylomeDBiQ921I9.
    TreeFamiTF313915.

    Family and domain databases

    Gene3Di3.30.230.70. 1 hit.
    InterProiIPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR027408. PNPase/RNase_PH_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    [Graphical view]
    PfamiPF01138. RNase_PH. 1 hit.
    PF03725. RNase_PH_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF54211. SSF54211. 1 hit.
    SSF55666. SSF55666. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q921I9-1 [UniParc]FASTAAdd to Basket

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    MAGLELLSDQ GYRIDGRRAG ELRKIQARMG VFAQADGSAY IEQGNTKALA    50
    VVYGPHEIRG SRSRALPDRA LVNCQYSSAT FSTGERKRRP HGDRKSCEMG 100
    LQLRQTFEAA ILTQLHPRSQ IDIYVQVLQA DGGTYAACVN AATLAVMDAG 150
    IPMRDFVCAC SAGFVDGTAL ADLSHVEEAA GGPQLALALL PASGQIALLE 200
    MDSRLHEDHL EQVLEAAAQA ARGVHTLLDL VVRQHVQEAS VSLGD 245
    Length:245
    Mass (Da):26,250
    Last modified:January 23, 2007 - v3
    Checksum:iE06C1CA2CA1FBF57
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC012277 mRNA. Translation: AAH12277.1.
    CCDSiCCDS37119.1.
    RefSeqiNP_780608.1. NM_175399.4.
    UniGeneiMm.322752.

    Genome annotation databases

    EnsembliENSMUST00000059045; ENSMUSP00000050940; ENSMUSG00000034259.
    GeneIDi109075.
    KEGGimmu:109075.
    UCSCiuc007wjp.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC012277 mRNA. Translation: AAH12277.1 .
    CCDSi CCDS37119.1.
    RefSeqi NP_780608.1. NM_175399.4.
    UniGenei Mm.322752.

    3D structure databases

    ProteinModelPortali Q921I9.
    SMRi Q921I9. Positions 7-241.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 224543. 2 interactions.
    IntActi Q921I9. 1 interaction.
    MINTi MINT-4094786.

    PTM databases

    PhosphoSitei Q921I9.

    Proteomic databases

    PaxDbi Q921I9.
    PRIDEi Q921I9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000059045 ; ENSMUSP00000050940 ; ENSMUSG00000034259 .
    GeneIDi 109075.
    KEGGi mmu:109075.
    UCSCi uc007wjp.1. mouse.

    Organism-specific databases

    CTDi 54512.
    MGIi MGI:1923576. Exosc4.

    Phylogenomic databases

    eggNOGi COG0689.
    GeneTreei ENSGT00550000074804.
    HOGENOMi HOG000229515.
    HOVERGENi HBG051519.
    InParanoidi Q921I9.
    KOi K11600.
    OMAi DYVCACT.
    OrthoDBi EOG74J98C.
    PhylomeDBi Q921I9.
    TreeFami TF313915.

    Enzyme and pathway databases

    Reactomei REACT_198696. KSRP destabilizes mRNA.

    Miscellaneous databases

    ChiTaRSi EXOSC4. mouse.
    NextBioi 361620.
    PROi Q921I9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q921I9.
    Bgeei Q921I9.
    CleanExi MM_EXOSC4.
    Genevestigatori Q921I9.

    Family and domain databases

    Gene3Di 3.30.230.70. 1 hit.
    InterProi IPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR027408. PNPase/RNase_PH_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    [Graphical view ]
    Pfami PF01138. RNase_PH. 1 hit.
    PF03725. RNase_PH_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54211. SSF54211. 1 hit.
    SSF55666. SSF55666. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiEXOS4_MOUSE
    AccessioniPrimary (citable) accession number: Q921I9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2002
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 102 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3