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Protein

Serotransferrin

Gene

Tf

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transferrins are iron binding transport proteins which can bind two Fe3+ ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi82Iron 1PROSITE-ProRule annotation1
Metal bindingi114Iron 1PROSITE-ProRule annotation1
Binding sitei139Carbonate 1PROSITE-ProRule annotation1
Binding sitei143Carbonate 1PROSITE-ProRule annotation1
Binding sitei145Carbonate 1; via amide nitrogenPROSITE-ProRule annotation1
Binding sitei146Carbonate 1; via amide nitrogenPROSITE-ProRule annotation1
Metal bindingi207Iron 1PROSITE-ProRule annotation1
Metal bindingi268Iron 1PROSITE-ProRule annotation1
Metal bindingi410Iron 2PROSITE-ProRule annotation1
Metal bindingi448Iron 2PROSITE-ProRule annotation1
Binding sitei474Carbonate 2PROSITE-ProRule annotation1
Binding sitei478Carbonate 2PROSITE-ProRule annotation1
Binding sitei480Carbonate 2; via amide nitrogenPROSITE-ProRule annotation1
Binding sitei481Carbonate 2; via amide nitrogenPROSITE-ProRule annotation1
Metal bindingi537Iron 2PROSITE-ProRule annotation1
Metal bindingi605Iron 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • actin filament organization Source: DFLAT
  • activation of JUN kinase activity Source: DFLAT
  • cellular iron ion homeostasis Source: InterPro
  • cellular response to iron ion Source: MGI
  • ERK1 and ERK2 cascade Source: DFLAT
  • ferrous iron import into cell Source: MGI
  • iron ion transport Source: MGI
  • osteoclast differentiation Source: DFLAT
  • positive regulation of bone resorption Source: DFLAT
  • positive regulation of cell motility Source: DFLAT
  • positive regulation of phosphorylation Source: DFLAT
  • positive regulation of receptor-mediated endocytosis Source: MGI
  • positive regulation of transcription, DNA-templated Source: DFLAT
  • SMAD protein signal transduction Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.
R-MMU-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-MMU-8856828. Clathrin-mediated endocytosis.
R-MMU-917937. Iron uptake and transport.
R-MMU-917977. Transferrin endocytosis and recycling.

Protein family/group databases

MEROPSiS60.972.

Names & Taxonomyi

Protein namesi
Recommended name:
Serotransferrin
Short name:
Transferrin
Alternative name(s):
Beta-1 metal-binding globulin
Siderophilin
Gene namesi
Name:Tf
Synonyms:Trf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:98821. Trf.

Subcellular locationi

GO - Cellular componenti

  • apical plasma membrane Source: MGI
  • basal part of cell Source: MGI
  • basal plasma membrane Source: MGI
  • blood microparticle Source: MGI
  • cell surface Source: MGI
  • clathrin-coated pit Source: MGI
  • cytoplasmic, membrane-bounded vesicle Source: MGI
  • dense body Source: MGI
  • early endosome Source: MGI
  • endocytic vesicle Source: MGI
  • endosome Source: MGI
  • extracellular exosome Source: MGI
  • extracellular region Source: MGI
  • extracellular space Source: MGI
  • extrinsic component of external side of plasma membrane Source: MGI
  • HFE-transferrin receptor complex Source: MGI
  • late endosome Source: MGI
  • membrane Source: ParkinsonsUK-UCL
  • perinuclear region of cytoplasm Source: MGI
  • recycling endosome Source: MGI
  • vesicle Source: MGI
  • vesicle coat Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19By similarityAdd BLAST19
ChainiPRO_000003571620 – 697SerotransferrinAdd BLAST678

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 67PROSITE-ProRule annotation
Disulfide bondi38 ↔ 58PROSITE-ProRule annotation
Modified residuei42Dimethylated arginineBy similarity1
Disulfide bondi137 ↔ 213PROSITE-ProRule annotation
Disulfide bondi156 ↔ 350PROSITE-ProRule annotation
Disulfide bondi177 ↔ 193PROSITE-ProRule annotation
Disulfide bondi180 ↔ 196PROSITE-ProRule annotation
Disulfide bondi190 ↔ 198PROSITE-ProRule annotation
Disulfide bondi246 ↔ 260PROSITE-ProRule annotation
Disulfide bondi363 ↔ 395PROSITE-ProRule annotation
Disulfide bondi373 ↔ 386PROSITE-ProRule annotation
Modified residuei388PhosphoserineBy similarity1
Disulfide bondi420 ↔ 692PROSITE-ProRule annotation
Disulfide bondi435 ↔ 655PROSITE-ProRule annotation
Disulfide bondi472 ↔ 543PROSITE-ProRule annotation
Disulfide bondi496 ↔ 683PROSITE-ProRule annotation
Disulfide bondi506 ↔ 520PROSITE-ProRule annotation
Glycosylationi513N-linked (GlcNAc...)1 Publication1
Disulfide bondi517 ↔ 526PROSITE-ProRule annotation
Disulfide bondi583 ↔ 597PROSITE-ProRule annotation
Disulfide bondi633 ↔ 638PROSITE-ProRule annotation
Modified residuei684PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

MaxQBiQ921I1.
PaxDbiQ921I1.
PeptideAtlasiQ921I1.
PRIDEiQ921I1.

2D gel databases

REPRODUCTION-2DPAGEIPI00139788.
Q921I1.

PTM databases

iPTMnetiQ921I1.
PhosphoSitePlusiQ921I1.
SwissPalmiQ921I1.

Expressioni

Tissue specificityi

Expressed by the liver and secreted in plasma.1 Publication

Gene expression databases

BgeeiENSMUSG00000032554.
CleanExiMM_TRF.
ExpressionAtlasiQ921I1. baseline and differential.
GenevisibleiQ921I1. MM.

Interactioni

Subunit structurei

Monomer.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204313. 1 interactor.
IntActiQ921I1. 8 interactors.
MINTiMINT-1202663.
STRINGi10090.ENSMUSP00000035158.

Structurei

3D structure databases

ProteinModelPortaliQ921I1.
SMRiQ921I1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 347Transferrin-like 1PROSITE-ProRule annotationAdd BLAST323
Domaini360 – 682Transferrin-like 2PROSITE-ProRule annotationAdd BLAST323

Sequence similaritiesi

Belongs to the transferrin family.PROSITE-ProRule annotation
Contains 2 transferrin-like domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IEAI. Eukaryota.
ENOG410XQ36. LUCA.
GeneTreeiENSGT00390000001619.
HOVERGENiHBG000055.
InParanoidiQ921I1.
KOiK14736.
OrthoDBiEOG091G0242.
PhylomeDBiQ921I1.
TreeFamiTF324013.

Family and domain databases

InterProiIPR030685. Serotransferrin_mammal.
IPR016357. Transferrin.
IPR001156. Transferrin-like_dom.
IPR018195. Transferrin_Fe_BS.
[Graphical view]
PfamiPF00405. Transferrin. 2 hits.
[Graphical view]
PIRSFiPIRSF500682. Serotransferrin. 1 hit.
PIRSF002549. Transferrin. 1 hit.
PRINTSiPR00422. TRANSFERRIN.
SMARTiSM00094. TR_FER. 2 hits.
[Graphical view]
PROSITEiPS00205. TRANSFERRIN_LIKE_1. 1 hit.
PS00206. TRANSFERRIN_LIKE_2. 2 hits.
PS00207. TRANSFERRIN_LIKE_3. 2 hits.
PS51408. TRANSFERRIN_LIKE_4. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q921I1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLTVGALLA CAALGLCLAV PDKTVKWCAV SEHENTKCIS FRDHMKTVLP
60 70 80 90 100
PDGPRLACVK KTSYPDCIKA ISASEADAMT LDGGWVYDAG LTPNNLKPVA
110 120 130 140 150
AEFYGSVEHP QTYYYAVAVV KKGTDFQLNQ LEGKKSCHTG LGRSAGWVIP
160 170 180 190 200
IGLLFCKLSE PRSPLEKAVS SFFSGSCVPC ADPVAFPKLC QLCPGCGCSS
210 220 230 240 250
TQPFFGYVGA FKCLKDGGGD VAFVKHTTIF EVLPEKADRD QYELLCLDNT
260 270 280 290 300
RKPVDQYEDC YLARIPSHAV VARKNNGKED LIWEILKVAQ EHFGKGKSKD
310 320 330 340 350
FQLFSSPLGK DLLFKDSAFG LLRVPPRMDY RLYLGHNYVT AIRNQQEGVC
360 370 380 390 400
PEGSIDNSPV KWCALSHLER TKCDEWSIIS EGKIECESAE TTEDCIEKIV
410 420 430 440 450
NGEADAMTLD GGHAYIAGQC GLVPVMAEYY ESSNCAIPSQ QGIFPKGYYA
460 470 480 490 500
VAVVKASDTS ITWNNLKGKK SCHTGVDRTA GWNIPMGMLY NRINHCKFDE
510 520 530 540 550
FFSQGCAPGY EKNSTLCDLC IGPLKCAPNN KEEYNGYTGA FRCLVEKGDV
560 570 580 590 600
AFVKHQTVLD NTEGKNPAEW AKNLKQEDFE LLCPDGTRKP VKDFASCHLA
610 620 630 640 650
QAPNHVVVSR KEKAARVKAV LTSQETLFGG SDCTGNFCLF KSTTKDLLFR
660 670 680 690
DDTKCFVKLP EGTTPEKYLG AEYMQSVGNM RKCSTSRLLE ACTFHKH
Length:697
Mass (Da):76,724
Last modified:December 1, 2001 - v1
Checksum:i0996A0C3B64CB1B9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3 – 4LT → FA in AAL34533 (Ref. 1) Curated2
Sequence conflicti69K → R in AAA40488 (PubMed:3693348).Curated1
Sequence conflicti71 – 74ISAS → HASG in AAH08559 (PubMed:15489334).Curated4
Sequence conflicti72S → A in AAA40488 (PubMed:3693348).Curated1
Sequence conflicti85W → L in AAA40488 (PubMed:3693348).Curated1
Sequence conflicti104Y → C in AAA40488 (PubMed:3693348).Curated1
Sequence conflicti113Y → S in AAA40488 (PubMed:3693348).Curated1
Sequence conflicti123 – 124GT → ER in AAA40488 (PubMed:3693348).Curated2
Sequence conflicti135K → E in BAE29847 (PubMed:16141072).Curated1
Sequence conflicti283W → L in AAB28966 (PubMed:8248032).Curated1
Sequence conflicti307P → L in AAB28966 (PubMed:8248032).Curated1
Sequence conflicti350 – 351CP → SA in AAA39438 (PubMed:3611056).Curated2
Sequence conflicti487G → C in AAA40490 (PubMed:3693348).Curated1
Sequence conflicti527A → D in AAA40491 (PubMed:3693348).Curated1
Sequence conflicti529N → S in BAE29847 (PubMed:16141072).Curated1
Sequence conflicti575K → N in AAA40491 (PubMed:3693348).Curated1
Sequence conflicti697H → S in AAL34533 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF440692 mRNA. Translation: AAL34533.1.
AK085754 mRNA. Translation: BAC39532.1.
AK142599 mRNA. Translation: BAE25124.1.
AK146549 mRNA. Translation: BAE27253.1.
AK149559 mRNA. Translation: BAE28960.1.
AK149595 mRNA. Translation: BAE28981.1.
AK150782 mRNA. Translation: BAE29847.1.
AK168419 mRNA. Translation: BAE40332.1.
AK168938 mRNA. Translation: BAE40747.1.
BC008559 mRNA. Translation: AAH08559.1.
BC012313 mRNA. Translation: AAH12313.1.
BC022986 mRNA. Translation: AAH22986.1.
BC092046 mRNA. Translation: AAH92046.1.
AF027336 Genomic DNA. Translation: AAB84034.1.
M23013 mRNA. Translation: AAA40488.1.
M23014 mRNA. Translation: AAA40489.1.
M23015 mRNA. Translation: AAA40490.1.
M23016 mRNA. Translation: AAA40491.1.
S67217 mRNA. Translation: AAB28966.2.
J03299 mRNA. Translation: AAA39438.1.
CCDSiCCDS23451.1.
PIRiA28446.
RefSeqiNP_598738.1. NM_133977.2.
UniGeneiMm.37214.

Genome annotation databases

EnsembliENSMUST00000035158; ENSMUSP00000035158; ENSMUSG00000032554.
ENSMUST00000112645; ENSMUSP00000108264; ENSMUSG00000032554.
GeneIDi22041.
KEGGimmu:22041.
UCSCiuc009rgj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF440692 mRNA. Translation: AAL34533.1.
AK085754 mRNA. Translation: BAC39532.1.
AK142599 mRNA. Translation: BAE25124.1.
AK146549 mRNA. Translation: BAE27253.1.
AK149559 mRNA. Translation: BAE28960.1.
AK149595 mRNA. Translation: BAE28981.1.
AK150782 mRNA. Translation: BAE29847.1.
AK168419 mRNA. Translation: BAE40332.1.
AK168938 mRNA. Translation: BAE40747.1.
BC008559 mRNA. Translation: AAH08559.1.
BC012313 mRNA. Translation: AAH12313.1.
BC022986 mRNA. Translation: AAH22986.1.
BC092046 mRNA. Translation: AAH92046.1.
AF027336 Genomic DNA. Translation: AAB84034.1.
M23013 mRNA. Translation: AAA40488.1.
M23014 mRNA. Translation: AAA40489.1.
M23015 mRNA. Translation: AAA40490.1.
M23016 mRNA. Translation: AAA40491.1.
S67217 mRNA. Translation: AAB28966.2.
J03299 mRNA. Translation: AAA39438.1.
CCDSiCCDS23451.1.
PIRiA28446.
RefSeqiNP_598738.1. NM_133977.2.
UniGeneiMm.37214.

3D structure databases

ProteinModelPortaliQ921I1.
SMRiQ921I1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204313. 1 interactor.
IntActiQ921I1. 8 interactors.
MINTiMINT-1202663.
STRINGi10090.ENSMUSP00000035158.

Protein family/group databases

MEROPSiS60.972.

PTM databases

iPTMnetiQ921I1.
PhosphoSitePlusiQ921I1.
SwissPalmiQ921I1.

2D gel databases

REPRODUCTION-2DPAGEIPI00139788.
Q921I1.

Proteomic databases

MaxQBiQ921I1.
PaxDbiQ921I1.
PeptideAtlasiQ921I1.
PRIDEiQ921I1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035158; ENSMUSP00000035158; ENSMUSG00000032554.
ENSMUST00000112645; ENSMUSP00000108264; ENSMUSG00000032554.
GeneIDi22041.
KEGGimmu:22041.
UCSCiuc009rgj.1. mouse.

Organism-specific databases

CTDi22041.
MGIiMGI:98821. Trf.

Phylogenomic databases

eggNOGiENOG410IEAI. Eukaryota.
ENOG410XQ36. LUCA.
GeneTreeiENSGT00390000001619.
HOVERGENiHBG000055.
InParanoidiQ921I1.
KOiK14736.
OrthoDBiEOG091G0242.
PhylomeDBiQ921I1.
TreeFamiTF324013.

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.
R-MMU-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-MMU-8856828. Clathrin-mediated endocytosis.
R-MMU-917937. Iron uptake and transport.
R-MMU-917977. Transferrin endocytosis and recycling.

Miscellaneous databases

PROiQ921I1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032554.
CleanExiMM_TRF.
ExpressionAtlasiQ921I1. baseline and differential.
GenevisibleiQ921I1. MM.

Family and domain databases

InterProiIPR030685. Serotransferrin_mammal.
IPR016357. Transferrin.
IPR001156. Transferrin-like_dom.
IPR018195. Transferrin_Fe_BS.
[Graphical view]
PfamiPF00405. Transferrin. 2 hits.
[Graphical view]
PIRSFiPIRSF500682. Serotransferrin. 1 hit.
PIRSF002549. Transferrin. 1 hit.
PRINTSiPR00422. TRANSFERRIN.
SMARTiSM00094. TR_FER. 2 hits.
[Graphical view]
PROSITEiPS00205. TRANSFERRIN_LIKE_1. 1 hit.
PS00206. TRANSFERRIN_LIKE_2. 2 hits.
PS00207. TRANSFERRIN_LIKE_3. 2 hits.
PS51408. TRANSFERRIN_LIKE_4. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRFE_MOUSE
AccessioniPrimary (citable) accession number: Q921I1
Secondary accession number(s): O35421
, Q3UBW7, Q58E69, Q61803, Q62357, Q62358, Q62359, Q63915, Q64515, Q8VII5, Q922C0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 149 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.