Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serotransferrin

Gene

Tf

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transferrins are iron binding transport proteins which can bind two Fe3+ ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi82Iron 1PROSITE-ProRule annotation1
Metal bindingi114Iron 1PROSITE-ProRule annotation1
Binding sitei139Carbonate 1PROSITE-ProRule annotation1
Binding sitei143Carbonate 1PROSITE-ProRule annotation1
Binding sitei145Carbonate 1; via amide nitrogenPROSITE-ProRule annotation1
Binding sitei146Carbonate 1; via amide nitrogenPROSITE-ProRule annotation1
Metal bindingi207Iron 1PROSITE-ProRule annotation1
Metal bindingi268Iron 1PROSITE-ProRule annotation1
Metal bindingi410Iron 2PROSITE-ProRule annotation1
Metal bindingi448Iron 2PROSITE-ProRule annotation1
Binding sitei474Carbonate 2PROSITE-ProRule annotation1
Binding sitei478Carbonate 2PROSITE-ProRule annotation1
Binding sitei480Carbonate 2; via amide nitrogenPROSITE-ProRule annotation1
Binding sitei481Carbonate 2; via amide nitrogenPROSITE-ProRule annotation1
Metal bindingi537Iron 2PROSITE-ProRule annotation1
Metal bindingi605Iron 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • actin filament organization Source: DFLAT
  • activation of JUN kinase activity Source: DFLAT
  • cellular iron ion homeostasis Source: InterPro
  • cellular response to iron ion Source: MGI
  • ERK1 and ERK2 cascade Source: DFLAT
  • ferrous iron import across plasma membrane Source: MGI
  • iron ion transport Source: MGI
  • osteoclast differentiation Source: DFLAT
  • positive regulation of bone resorption Source: DFLAT
  • positive regulation of cell motility Source: DFLAT
  • positive regulation of phosphorylation Source: DFLAT
  • positive regulation of receptor-mediated endocytosis Source: MGI
  • positive regulation of transcription, DNA-templated Source: DFLAT
  • SMAD protein signal transduction Source: MGI

Keywordsi

Biological processIon transport, Iron transport, Transport
LigandIron, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis
R-MMU-8856828 Clathrin-mediated endocytosis
R-MMU-8957275 Post-translational protein phosphorylation
R-MMU-917937 Iron uptake and transport
R-MMU-917977 Transferrin endocytosis and recycling

Protein family/group databases

MEROPSiS60.972

Names & Taxonomyi

Protein namesi
Recommended name:
Serotransferrin
Short name:
Transferrin
Alternative name(s):
Beta-1 metal-binding globulin
Siderophilin
Gene namesi
Name:Tf
Synonyms:Trf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:98821 Trf

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19By similarityAdd BLAST19
ChainiPRO_000003571620 – 697SerotransferrinAdd BLAST678

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 67PROSITE-ProRule annotation
Disulfide bondi38 ↔ 58PROSITE-ProRule annotation
Modified residuei42Dimethylated arginineBy similarity1
Disulfide bondi137 ↔ 213PROSITE-ProRule annotation
Disulfide bondi156 ↔ 350PROSITE-ProRule annotation
Disulfide bondi177 ↔ 193PROSITE-ProRule annotation
Disulfide bondi180 ↔ 196PROSITE-ProRule annotation
Disulfide bondi190 ↔ 198PROSITE-ProRule annotation
Disulfide bondi246 ↔ 260PROSITE-ProRule annotation
Disulfide bondi363 ↔ 395PROSITE-ProRule annotation
Disulfide bondi373 ↔ 386PROSITE-ProRule annotation
Modified residuei388PhosphoserineBy similarity1
Disulfide bondi420 ↔ 692PROSITE-ProRule annotation
Disulfide bondi435 ↔ 655PROSITE-ProRule annotation
Disulfide bondi472 ↔ 543PROSITE-ProRule annotation
Disulfide bondi496 ↔ 683PROSITE-ProRule annotation
Disulfide bondi506 ↔ 520PROSITE-ProRule annotation
Glycosylationi513N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi517 ↔ 526PROSITE-ProRule annotation
Disulfide bondi583 ↔ 597PROSITE-ProRule annotation
Disulfide bondi633 ↔ 638PROSITE-ProRule annotation
Modified residuei684PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

MaxQBiQ921I1
PaxDbiQ921I1
PeptideAtlasiQ921I1
PRIDEiQ921I1

2D gel databases

REPRODUCTION-2DPAGEiIPI00139788
Q921I1

PTM databases

CarbonylDBiQ921I1
GlyConnecti556
iPTMnetiQ921I1
PhosphoSitePlusiQ921I1
SwissPalmiQ921I1

Expressioni

Tissue specificityi

Expressed by the liver and secreted in plasma.1 Publication

Gene expression databases

BgeeiENSMUSG00000032554
CleanExiMM_TRF
ExpressionAtlasiQ921I1 baseline and differential
GenevisibleiQ921I1 MM

Interactioni

Subunit structurei

Monomer.

Binary interactionsi

WithEntry#Exp.IntActNotes
PrkceP160542EBI-761948,EBI-298451

GO - Molecular functioni

Protein-protein interaction databases

BioGridi2043131 interactor.
IntActiQ921I1 9 interactors.
MINTiQ921I1
STRINGi10090.ENSMUSP00000035158

Structurei

3D structure databases

ProteinModelPortaliQ921I1
SMRiQ921I1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 347Transferrin-like 1PROSITE-ProRule annotationAdd BLAST323
Domaini360 – 682Transferrin-like 2PROSITE-ProRule annotationAdd BLAST323

Sequence similaritiesi

Belongs to the transferrin family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IEAI Eukaryota
ENOG410XQ36 LUCA
GeneTreeiENSGT00390000001619
HOVERGENiHBG000055
InParanoidiQ921I1
KOiK14736
OrthoDBiEOG091G0242
PhylomeDBiQ921I1
TreeFamiTF324013

Family and domain databases

InterProiView protein in InterPro
IPR030685 Serotransferrin_mammal
IPR016357 Transferrin
IPR001156 Transferrin-like_dom
IPR018195 Transferrin_Fe_BS
PfamiView protein in Pfam
PF00405 Transferrin, 2 hits
PIRSFiPIRSF500682 Serotransferrin, 1 hit
PIRSF002549 Transferrin, 1 hit
PRINTSiPR00422 TRANSFERRIN
SMARTiView protein in SMART
SM00094 TR_FER, 2 hits
PROSITEiView protein in PROSITE
PS00205 TRANSFERRIN_LIKE_1, 1 hit
PS00206 TRANSFERRIN_LIKE_2, 2 hits
PS00207 TRANSFERRIN_LIKE_3, 2 hits
PS51408 TRANSFERRIN_LIKE_4, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q921I1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLTVGALLA CAALGLCLAV PDKTVKWCAV SEHENTKCIS FRDHMKTVLP
60 70 80 90 100
PDGPRLACVK KTSYPDCIKA ISASEADAMT LDGGWVYDAG LTPNNLKPVA
110 120 130 140 150
AEFYGSVEHP QTYYYAVAVV KKGTDFQLNQ LEGKKSCHTG LGRSAGWVIP
160 170 180 190 200
IGLLFCKLSE PRSPLEKAVS SFFSGSCVPC ADPVAFPKLC QLCPGCGCSS
210 220 230 240 250
TQPFFGYVGA FKCLKDGGGD VAFVKHTTIF EVLPEKADRD QYELLCLDNT
260 270 280 290 300
RKPVDQYEDC YLARIPSHAV VARKNNGKED LIWEILKVAQ EHFGKGKSKD
310 320 330 340 350
FQLFSSPLGK DLLFKDSAFG LLRVPPRMDY RLYLGHNYVT AIRNQQEGVC
360 370 380 390 400
PEGSIDNSPV KWCALSHLER TKCDEWSIIS EGKIECESAE TTEDCIEKIV
410 420 430 440 450
NGEADAMTLD GGHAYIAGQC GLVPVMAEYY ESSNCAIPSQ QGIFPKGYYA
460 470 480 490 500
VAVVKASDTS ITWNNLKGKK SCHTGVDRTA GWNIPMGMLY NRINHCKFDE
510 520 530 540 550
FFSQGCAPGY EKNSTLCDLC IGPLKCAPNN KEEYNGYTGA FRCLVEKGDV
560 570 580 590 600
AFVKHQTVLD NTEGKNPAEW AKNLKQEDFE LLCPDGTRKP VKDFASCHLA
610 620 630 640 650
QAPNHVVVSR KEKAARVKAV LTSQETLFGG SDCTGNFCLF KSTTKDLLFR
660 670 680 690
DDTKCFVKLP EGTTPEKYLG AEYMQSVGNM RKCSTSRLLE ACTFHKH
Length:697
Mass (Da):76,724
Last modified:December 1, 2001 - v1
Checksum:i0996A0C3B64CB1B9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3 – 4LT → FA in AAL34533 (Ref. 1) Curated2
Sequence conflicti69K → R in AAA40488 (PubMed:3693348).Curated1
Sequence conflicti71 – 74ISAS → HASG in AAH08559 (PubMed:15489334).Curated4
Sequence conflicti72S → A in AAA40488 (PubMed:3693348).Curated1
Sequence conflicti85W → L in AAA40488 (PubMed:3693348).Curated1
Sequence conflicti104Y → C in AAA40488 (PubMed:3693348).Curated1
Sequence conflicti113Y → S in AAA40488 (PubMed:3693348).Curated1
Sequence conflicti123 – 124GT → ER in AAA40488 (PubMed:3693348).Curated2
Sequence conflicti135K → E in BAE29847 (PubMed:16141072).Curated1
Sequence conflicti283W → L in AAB28966 (PubMed:8248032).Curated1
Sequence conflicti307P → L in AAB28966 (PubMed:8248032).Curated1
Sequence conflicti350 – 351CP → SA in AAA39438 (PubMed:3611056).Curated2
Sequence conflicti487G → C in AAA40490 (PubMed:3693348).Curated1
Sequence conflicti527A → D in AAA40491 (PubMed:3693348).Curated1
Sequence conflicti529N → S in BAE29847 (PubMed:16141072).Curated1
Sequence conflicti575K → N in AAA40491 (PubMed:3693348).Curated1
Sequence conflicti697H → S in AAL34533 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF440692 mRNA Translation: AAL34533.1
AK085754 mRNA Translation: BAC39532.1
AK142599 mRNA Translation: BAE25124.1
AK146549 mRNA Translation: BAE27253.1
AK149559 mRNA Translation: BAE28960.1
AK149595 mRNA Translation: BAE28981.1
AK150782 mRNA Translation: BAE29847.1
AK168419 mRNA Translation: BAE40332.1
AK168938 mRNA Translation: BAE40747.1
BC008559 mRNA Translation: AAH08559.1
BC012313 mRNA Translation: AAH12313.1
BC022986 mRNA Translation: AAH22986.1
BC092046 mRNA Translation: AAH92046.1
AF027336 Genomic DNA Translation: AAB84034.1
M23013 mRNA Translation: AAA40488.1
M23014 mRNA Translation: AAA40489.1
M23015 mRNA Translation: AAA40490.1
M23016 mRNA Translation: AAA40491.1
S67217 mRNA Translation: AAB28966.2
J03299 mRNA Translation: AAA39438.1
CCDSiCCDS23451.1
PIRiA28446
RefSeqiNP_598738.1, NM_133977.2
UniGeneiMm.37214

Genome annotation databases

EnsembliENSMUST00000035158; ENSMUSP00000035158; ENSMUSG00000032554
ENSMUST00000112645; ENSMUSP00000108264; ENSMUSG00000032554
GeneIDi22041
KEGGimmu:22041
UCSCiuc009rgj.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTRFE_MOUSE
AccessioniPrimary (citable) accession number: Q921I1
Secondary accession number(s): O35421
, Q3UBW7, Q58E69, Q61803, Q62357, Q62358, Q62359, Q63915, Q64515, Q8VII5, Q922C0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: December 1, 2001
Last modified: April 25, 2018
This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome