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Protein

Gamma-tubulin complex component 2

Gene

Tubgcp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-380270. Recruitment of mitotic centrosome proteins and complexes.
R-MMU-380320. Recruitment of NuMA to mitotic centrosomes.

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-tubulin complex component 2
Short name:
GCP-2
Gene namesi
Name:Tubgcp2
Synonyms:Gcp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1921487. Tubgcp2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 905905Gamma-tubulin complex component 2PRO_0000078114Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei83 – 831PhosphotyrosineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ921G8.
MaxQBiQ921G8.
PaxDbiQ921G8.
PRIDEiQ921G8.

PTM databases

iPTMnetiQ921G8.
PhosphoSiteiQ921G8.

Expressioni

Gene expression databases

CleanExiMM_TUBGCP2.
GenevisibleiQ921G8. MM.

Interactioni

Subunit structurei

Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6. Interacts with ATF5; the ATF5:PCNT:polyglutamylated tubulin (PGT) tripartite unites the mother centriole and the pericentriolar material (PCM) in the centrosome.By similarity

Protein-protein interaction databases

BioGridi216597. 7 interactions.
IntActiQ921G8. 5 interactions.
MINTiMINT-4611145.
STRINGi10090.ENSMUSP00000026547.

Structurei

3D structure databases

ProteinModelPortaliQ921G8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TUBGCP family.Curated

Phylogenomic databases

eggNOGiKOG2001. Eukaryota.
ENOG410XNRE. LUCA.
GeneTreeiENSGT00840000129807.
HOGENOMiHOG000273895.
HOVERGENiHBG026103.
InParanoidiQ921G8.
KOiK16569.
OMAiSMINIIY.
OrthoDBiEOG7FFMR6.
TreeFamiTF324047.

Family and domain databases

InterProiIPR007259. GCP.
[Graphical view]
PANTHERiPTHR19302. PTHR19302. 2 hits.
PfamiPF04130. Spc97_Spc98. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q921G8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEFRIHHDV NELLSLLRIH GGDGAEVYID LLQKNRTPYV TTTVSAHSAK
60 70 80 90 100
VKIAEFSRTP EDFLKKYDEL KSKNTRNLDP LVYLLSKLTE DKETLQFLQQ
110 120 130 140 150
NAKERAELAA SAATSNTTSF SIPVAASKMS TQELEELRKQ LGSVSTGSTL
160 170 180 190 200
QQSLELTRKM LRDKQNKKNS GQPLPVFPAW VYERPTLAGD FLIGSGLSSD
210 220 230 240 250
TVLPIGTLPL ASQESAVVED LLYVLVGVDG RYITAQPLAG RQNRTFLVDP
260 270 280 290 300
NLDLSIRELV NRILPVAASY STVTRFIEEK SSFEYGQVNH ALAAAMRTLV
310 320 330 340 350
KEYLILVTQL EQLHRQGLLS LQKLWFYIQP AMRTIDILAS LATSVDKGEC
360 370 380 390 400
VGGSTLSLLH DRSFNYTGDS QAQELCLYLT KAASAPYFEI LEKWIYRGII
410 420 430 440 450
HDPYSEFMVE EHELRKEKIQ EDYNDKYWDQ RYTVLPQQIP SFLQKVAGKI
460 470 480 490 500
LSTGKYLNVV RECGHDVTCP VAKEIIYTLK ERAYVEQIEK AFNYASKVLL
510 520 530 540 550
DFLMEEKELV AHLRSIKRYF LMDQGDFFVH FMDLTEEELR KPVEDIILTR
560 570 580 590 600
LEALLELALR MSTANTDPFK DDLKIELMPH DLITQLLRVL AIETKQEKAM
610 620 630 640 650
THADPTELTL SGLEAFSFDY MVKWPLSLII NRKALTRYQM LFRHMFYCKH
660 670 680 690 700
VERQLCSVWI SNKTAKQHAL HSAKWFAGAF TLRQRMLNFV QNIQYYMMFE
710 720 730 740 750
VMEPTWHILE KNLKSASNID DVLGHHTSFL DNCLKDCMLT NPELLKVFSK
760 770 780 790 800
LMSVCVMFTN CMQKFTQSMK LDSELGRLTL DQGSVQGPPT ETERIEDRPR
810 820 830 840 850
KELTRKHLSE HVDAPQLASG FEATINNFDK NFSAHLLDLL ARLSVYSTSD
860 870 880 890 900
CEHGMASVIS RLDFNGFYAE RLERLSAERS QKAAPQVPVP RGPSAPAPRV

AIPAQ
Length:905
Mass (Da):103,223
Last modified:October 3, 2012 - v2
Checksum:iD5FEFF23AC4AB52E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti727 – 7271T → I in AAH12519 (PubMed:15489334).Curated
Sequence conflicti727 – 7271T → I in AAH25582 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC107822 Genomic DNA. No translation available.
AC109205 Genomic DNA. No translation available.
CH466531 Genomic DNA. Translation: EDL17885.1.
BC012519 mRNA. Translation: AAH12519.1.
BC025582 mRNA. Translation: AAH25582.1.
CCDSiCCDS21960.1.
RefSeqiNP_001272936.1. NM_001286007.1.
NP_598516.2. NM_133755.2.
UniGeneiMm.40888.

Genome annotation databases

EnsembliENSMUST00000026547; ENSMUSP00000026547; ENSMUSG00000025474.
GeneIDi74237.
KEGGimmu:74237.
UCSCiuc009kgl.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC107822 Genomic DNA. No translation available.
AC109205 Genomic DNA. No translation available.
CH466531 Genomic DNA. Translation: EDL17885.1.
BC012519 mRNA. Translation: AAH12519.1.
BC025582 mRNA. Translation: AAH25582.1.
CCDSiCCDS21960.1.
RefSeqiNP_001272936.1. NM_001286007.1.
NP_598516.2. NM_133755.2.
UniGeneiMm.40888.

3D structure databases

ProteinModelPortaliQ921G8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi216597. 7 interactions.
IntActiQ921G8. 5 interactions.
MINTiMINT-4611145.
STRINGi10090.ENSMUSP00000026547.

PTM databases

iPTMnetiQ921G8.
PhosphoSiteiQ921G8.

Proteomic databases

EPDiQ921G8.
MaxQBiQ921G8.
PaxDbiQ921G8.
PRIDEiQ921G8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026547; ENSMUSP00000026547; ENSMUSG00000025474.
GeneIDi74237.
KEGGimmu:74237.
UCSCiuc009kgl.2. mouse.

Organism-specific databases

CTDi10844.
MGIiMGI:1921487. Tubgcp2.

Phylogenomic databases

eggNOGiKOG2001. Eukaryota.
ENOG410XNRE. LUCA.
GeneTreeiENSGT00840000129807.
HOGENOMiHOG000273895.
HOVERGENiHBG026103.
InParanoidiQ921G8.
KOiK16569.
OMAiSMINIIY.
OrthoDBiEOG7FFMR6.
TreeFamiTF324047.

Enzyme and pathway databases

ReactomeiR-MMU-380270. Recruitment of mitotic centrosome proteins and complexes.
R-MMU-380320. Recruitment of NuMA to mitotic centrosomes.

Miscellaneous databases

PROiQ921G8.
SOURCEiSearch...

Gene expression databases

CleanExiMM_TUBGCP2.
GenevisibleiQ921G8. MM.

Family and domain databases

InterProiIPR007259. GCP.
[Graphical view]
PANTHERiPTHR19302. PTHR19302. 2 hits.
PfamiPF04130. Spc97_Spc98. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Kidney, Lung, Spleen and Testis.

Entry informationi

Entry nameiGCP2_MOUSE
AccessioniPrimary (citable) accession number: Q921G8
Secondary accession number(s): G5E859
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: October 3, 2012
Last modified: June 8, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.