Q921G8 (GCP2_MOUSE) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 71.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Gamma-tubulin complex component 2 Short name=GCP-2 | ||||
| Gene names |
| ||||
| Organism | Mus musculus (Mouse) [Reference proteome] | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus |
Protein attributes
| Sequence length | 905 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome By similarity. |
| Subunit structure | Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6 By similarity. |
| Subcellular location | Cytoplasm › cytoskeleton › centrosome By similarity. |
| Sequence similarities | Belongs to the TUBGCP family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm Cytoskeleton Microtubule |
| PTM | Phosphoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | microtubule cytoskeleton organization Inferred from electronic annotation. Source: InterPro |
| Cellular_component | centrosome Inferred from electronic annotation. Source: Compara cytoplasmInferred from electronic annotation. Source: UniProtKB-KW microtubuleInferred from electronic annotation. Source: UniProtKB-KW nucleusInferred from electronic annotation. Source: Compara spindle poleInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 905 | 905 | Gamma-tubulin complex component 2 | PRO_0000078114 | |||||
Amino acid modifications | |||||||||
| Modified residue | 83 | 1 | Phosphotyrosine By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 727 | 1 | T → I in AAH12519. Ref.3 | ||||||
| Sequence conflict | 727 | 1 | T → I in AAH25582. Ref.3 | ||||||
Sequences
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References
| [1] | "Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.  Ponting C.P.PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J. |
| [2] | Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Mammary tumor. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AC107822 Genomic DNA. No translation available. AC109205 Genomic DNA. No translation available. CH466531 Genomic DNA. Translation: EDL17885.1. BC012519 mRNA. Translation: AAH12519.1. BC025582 mRNA. Translation: AAH25582.1. |
| IPI | IPI00121787. |
| RefSeq | NP_598516.2. NM_133755.2. |
| UniGene | Mm.40888. |
3D structure databases | |
| ProteinModelPortal | Q921G8. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q921G8. 4 interactions. |
| STRING | 10090.ENSMUSP00000026547. |
PTM databases | |
| PhosphoSite | Q921G8. |
Proteomic databases | |
| PaxDb | Q921G8. |
| PRIDE | Q921G8. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENSMUST00000026547; ENSMUSP00000026547; ENSMUSG00000025474. |
| GeneID | 74237. |
| KEGG | mmu:74237. |
Organism-specific databases | |
| CTD | 10844. |
| MGI | MGI:1921487. Tubgcp2. |
Phylogenomic databases | |
| eggNOG | NOG268971. |
| GeneTree | ENSGT00530000063146. |
| HOGENOM | HOG000273895. |
| HOVERGEN | HBG026103. |
| InParanoid | Q921G8. |
| KO | K16569. |
| OMA | VYERPAL. |
| OrthoDB | EOG4KSPJ2. |
Gene expression databases | |
| CleanEx | MM_TUBGCP2. |
| Genevestigator | Q921G8. |
| GermOnline | ENSMUSG00000025474. Mus musculus. |
Family and domain databases | |
| InterPro | IPR007259. Spc97_Spc98. [Graphical view] |
| PANTHER | PTHR19302. PTHR19302. 1 hit. |
| Pfam | PF04130. Spc97_Spc98. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 340196. |
| SOURCE | Search... |
Entry information
| Entry name | GCP2_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q921G8 Secondary accession number(s): G5E859 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |