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Protein

Leucine-rich repeat and calponin homology domain-containing protein 4

Gene

Lrch4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • negative regulation of transcription, DNA-templated Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat and calponin homology domain-containing protein 4
Gene namesi
Name:Lrch4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1917193. Lrch4.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • PML body Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 680680Leucine-rich repeat and calponin homology domain-containing protein 4PRO_0000084481Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei279 – 2791PhosphoserineCombined sources
Modified residuei281 – 2811PhosphoserineCombined sources
Modified residuei313 – 3131PhosphoserineCombined sources
Modified residuei511 – 5111PhosphoserineBy similarity
Modified residuei517 – 5171PhosphoserineBy similarity
Modified residuei521 – 5211PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ921G6.
MaxQBiQ921G6.
PaxDbiQ921G6.
PRIDEiQ921G6.

PTM databases

iPTMnetiQ921G6.
PhosphoSiteiQ921G6.

Expressioni

Gene expression databases

BgeeiQ921G6.
ExpressionAtlasiQ921G6. baseline.
GenevisibleiQ921G6. MM.

Interactioni

Protein-protein interaction databases

BioGridi231166. 1 interaction.
STRINGi10090.ENSMUSP00000135286.

Structurei

3D structure databases

ProteinModelPortaliQ921G6.
SMRiQ921G6. Positions 37-267, 556-655.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati43 – 6422LRR 1Add
BLAST
Repeati69 – 9022LRR 2Add
BLAST
Repeati92 – 11423LRR 3Add
BLAST
Repeati115 – 13622LRR 4Add
BLAST
Repeati137 – 15822LRR 5Add
BLAST
Repeati160 – 18223LRR 6Add
BLAST
Repeati183 – 20523LRR 7Add
BLAST
Repeati206 – 22621LRR 8Add
BLAST
Repeati228 – 24922LRR 9Add
BLAST
Domaini531 – 644114CHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 CH (calponin-homology) domain.PROSITE-ProRule annotation
Contains 9 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0532. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00840000129676.
HOGENOMiHOG000049055.
HOVERGENiHBG052350.
InParanoidiQ921G6.
OMAiGHRYDGG.
OrthoDBiEOG7288QT.
PhylomeDBiQ921G6.
TreeFamiTF318428.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR001715. CH-domain.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF00307. CH. 1 hit.
PF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00033. CH. 1 hit.
SM00369. LRR_TYP. 5 hits.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50021. CH. 1 hit.
PS51450. LRR. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q921G6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAVAGPLA AGGEEAAASV SLPGSPGLPG SRSAERALEE AVATGTLNLS
60 70 80 90 100
NRRLKHFPRG AARSYDLSDI TQADLSRNRF PEVPEAACQL VSLEGLSLYH
110 120 130 140 150
NCLKCLNPAL GNLTALTYLN LSRNQLSSLP PYICQLPLRV LIISNNKLGA
160 170 180 190 200
LPPDISTLGS LRQLDVSSNE LQSLPVELCS LRSLRDLNVR RNQLSTLPDE
210 220 230 240 250
LGDLPLVRLD FSCNRISRIP VSFCRLRHLQ VVLLDSNPLQ SPPAQICLKG
260 270 280 290 300
KLHIFKYLTM EAGRRGAALG DLVPSRPPSF SPCPAEDLFP GRRYDGGLDS
310 320 330 340 350
GFHSVDSGSK RWSGNESTDD FSELSFRISE LARDPRGPRQ PREDGAGDGD
360 370 380 390 400
LEQIDFIDSH VPGEDEDRSA AEEQLPSELS LVAGDVEKPS SSRREEPAGE
410 420 430 440 450
ERRRPDTLQL WQERERKQQQ QSGGWGSPRK DSVLKRGIRA AGAGASAPST
460 470 480 490 500
QATCNGPPKS STTQLGVSGG QGAPTPPPTS QDPLPVSGPV TAPVPRPLGS
510 520 530 540 550
IQRPNSFLFR SSSQSGSSPS SPESVLRPRP FPQEKELISQ LRQVLESRLQ
560 570 580 590 600
QPLPEDLAEA LANGVLLCQL ANQLRPRSVP FIHVPSPAVP KLSALKSRKN
610 620 630 640 650
VESFLEACRK MGVPEADLCS PSDLLRGTAQ GLQTVLEAVI LVGGKAPLPV
660 670 680
QPSSGLGGFL LFYVVFMLLL YVVYTRLLGS
Length:680
Mass (Da):73,163
Last modified:December 1, 2001 - v1
Checksum:iBE7A0567B346C251
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC012525 mRNA. Translation: AAH12525.1.
CCDSiCCDS19772.1.
RefSeqiNP_666276.1. NM_146164.2.
UniGeneiMm.200763.

Genome annotation databases

EnsembliENSMUST00000031734; ENSMUSP00000031734; ENSMUSG00000093445.
ENSMUST00000177545; ENSMUSP00000135286; ENSMUSG00000029720.
GeneIDi231798.
KEGGimmu:231798.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC012525 mRNA. Translation: AAH12525.1.
CCDSiCCDS19772.1.
RefSeqiNP_666276.1. NM_146164.2.
UniGeneiMm.200763.

3D structure databases

ProteinModelPortaliQ921G6.
SMRiQ921G6. Positions 37-267, 556-655.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231166. 1 interaction.
STRINGi10090.ENSMUSP00000135286.

PTM databases

iPTMnetiQ921G6.
PhosphoSiteiQ921G6.

Proteomic databases

EPDiQ921G6.
MaxQBiQ921G6.
PaxDbiQ921G6.
PRIDEiQ921G6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031734; ENSMUSP00000031734; ENSMUSG00000093445.
ENSMUST00000177545; ENSMUSP00000135286; ENSMUSG00000029720.
GeneIDi231798.
KEGGimmu:231798.

Organism-specific databases

CTDi4034.
MGIiMGI:1917193. Lrch4.

Phylogenomic databases

eggNOGiKOG0532. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00840000129676.
HOGENOMiHOG000049055.
HOVERGENiHBG052350.
InParanoidiQ921G6.
OMAiGHRYDGG.
OrthoDBiEOG7288QT.
PhylomeDBiQ921G6.
TreeFamiTF318428.

Miscellaneous databases

PROiQ921G6.
SOURCEiSearch...

Gene expression databases

BgeeiQ921G6.
ExpressionAtlasiQ921G6. baseline.
GenevisibleiQ921G6. MM.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR001715. CH-domain.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF00307. CH. 1 hit.
PF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00033. CH. 1 hit.
SM00369. LRR_TYP. 5 hits.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS50021. CH. 1 hit.
PS51450. LRR. 7 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-279; SER-281 AND SER-313, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney, Lung, Spleen and Testis.

Entry informationi

Entry nameiLRCH4_MOUSE
AccessioniPrimary (citable) accession number: Q921G6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2004
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.