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Protein

Heterogeneous nuclear ribonucleoprotein L-like

Gene

Hnrnpll

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

RNA-binding protein that functions as regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein L-like
Gene namesi
Name:Hnrnpll
Synonyms:Hnrpll
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1919942. Hnrnpll.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi136V → D: Alters RRM 1 stability. Abolishes regulation of alternative splicing. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000816101 – 591Heterogeneous nuclear ribonucleoprotein L-likeAdd BLAST591

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki28Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei37PhosphoserineCombined sources1
Modified residuei48PhosphothreonineBy similarity1
Modified residuei107PhosphoserineBy similarity1
Modified residuei117PhosphoserineBy similarity1
Modified residuei124PhosphoserineBy similarity1
Cross-linki540Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ921F4.
PaxDbiQ921F4.
PeptideAtlasiQ921F4.
PRIDEiQ921F4.

PTM databases

iPTMnetiQ921F4.
PhosphoSitePlusiQ921F4.

Expressioni

Inductioni

Up-regulated in stimulated T-cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000024095.
CleanExiMM_HNRPLL.
ExpressionAtlasiQ921F4. baseline and differential.
GenevisibleiQ921F4. MM.

Interactioni

Subunit structurei

Interacts with HNRNPL.By similarity

Protein-protein interaction databases

BioGridi215518. 2 interactors.
STRINGi10090.ENSMUSP00000058308.

Structurei

Secondary structure

1591
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi125 – 131Combined sources7
Helixi138 – 145Combined sources8
Turni146 – 148Combined sources3
Beta strandi151 – 157Combined sources7
Turni158 – 161Combined sources4
Beta strandi162 – 169Combined sources8
Helixi170 – 182Combined sources13
Beta strandi186 – 191Combined sources6
Beta strandi193 – 196Combined sources4
Beta strandi198 – 201Combined sources4
Beta strandi216 – 224Combined sources9
Helixi231 – 238Combined sources8
Turni239 – 241Combined sources3
Beta strandi244 – 263Combined sources20
Helixi264 – 274Combined sources11
Beta strandi283 – 289Combined sources7
Beta strandi302 – 309Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WEXNMR-A117-207[»]
2E5INMR-A200-316[»]
ProteinModelPortaliQ921F4.
SMRiQ921F4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ921F4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini125 – 199RRM 1PROSITE-ProRule annotationAdd BLAST75
Domaini215 – 293RRM 2PROSITE-ProRule annotationAdd BLAST79
Domaini384 – 458RRM 3PROSITE-ProRule annotationAdd BLAST75

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 8Poly-Ser7
Compositional biasi58 – 116Gly-richAdd BLAST59

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1456. Eukaryota.
ENOG410XQHN. LUCA.
GeneTreeiENSGT00550000074508.
HOGENOMiHOG000293298.
HOVERGENiHBG105786.
InParanoidiQ921F4.
KOiK13159.
OMAiQIRIPNG.
OrthoDBiEOG091G0PR3.
PhylomeDBiQ921F4.
TreeFamiTF354318.

Family and domain databases

CDDicd12781. RRM1_hnRPLL. 1 hit.
cd12786. RRM2_hnRPLL. 1 hit.
cd12700. RRM3_hnRPLL. 1 hit.
cd12705. RRM4_hnRPLL. 1 hit.
InterProiView protein in InterPro
IPR006536. HnRNP-L/PTB.
IPR034985. hnRPLL_RRM1.
IPR034986. hnRPLL_RRM2.
IPR034983. hnRPLL_RRM3.
IPR034987. hnRPLL_RRM4.
IPR000504. RRM_dom.
PfamiView protein in Pfam
PF00076. RRM_1. 2 hits.
SMARTiView protein in SMART
SM00360. RRM. 3 hits.
SUPFAMiSSF54928. SSF54928. 3 hits.
TIGRFAMsiTIGR01649. hnRNP-L_PTB. 1 hit.
PROSITEiView protein in PROSITE
PS50102. RRM. 2 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q921F4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSSSSSSPK EETYEEDREF ESQAKRLKTE EGEIVYSAEE SENRQEATPQ
60 70 80 90 100
AGSDSDSGGG DGGDGDGGSG GGGDGEEGEG GEEGDEGDGD EGGSGGDEGG
110 120 130 140 150
SGGGPRSMPL STEGGGSHHK VSVSPVVHVR GLCESVVEAD LVEALEKFGT
160 170 180 190 200
ICYVMMMPFK RQALVEFENI DSAKECVTFA ADVPVYIAGQ QAFFNYSTSK
210 220 230 240 250
RITRPGNTDD PSGGNKVLLL SIQNPLYPIT VDVLYTVCNP VGKVQRIVIF
260 270 280 290 300
KRNGIQAMVE FESVLCAQKA KAALNGADIY AGCCTLKIEY ARPTRLNVIR
310 320 330 340 350
NDNDSWDYTK PYLGRRDRGK GRQRQAILGD HPSSFRHDGY GSHGPLLPLP
360 370 380 390 400
SRYRMGSRDT PELVAYPLPQ ASSSYMHGGS PSGSVVMVSG LHQLKMNCSR
410 420 430 440 450
VFNLFCLYGN IEKVKFMKTI PGTALVEMGD EYAVERAVTH LNNVKLFGKR
460 470 480 490 500
LNVCVSKQHS VVPSQIFELE DGTSSYKDFA MSKNNRFTSA GQASKNIIQP
510 520 530 540 550
PSCVLHYYNV PLCVTEETFT KLCNDHEVLP FIKYKVFDAK ASAKTLSGLL
560 570 580 590
EWKCKTDAVE ALTALNHYQI RVPNGSNPYT LKLCFSTSSH L
Length:591
Mass (Da):64,125
Last modified:March 29, 2005 - v3
Checksum:i431C0167DF619FB7
GO
Isoform 2 (identifier: Q921F4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     317-326: DRGKGRQRQA → GRYFTNFRMY
     327-591: Missing.

Note: No experimental confirmation available.
Show »
Length:326
Mass (Da):34,938
Checksum:iC0EC9B1EE165C671
GO
Isoform 3 (identifier: Q921F4-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-480: Missing.
     522-591: LCNDHEVLPF...KLCFSTSSHL → VGTEESSVRM...RLVVLDGFLC

Show »
Length:100
Mass (Da):11,485
Checksum:i912DB4EB7D70EDE3
GO

Sequence cautioni

The sequence BAE27500 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4S → T in AAH12849 (PubMed:15489334).Curated1
Sequence conflicti101S → SGGG in AAH12849 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0261321 – 480Missing in isoform 3. 1 PublicationAdd BLAST480
Alternative sequenceiVSP_013290317 – 326DRGKGRQRQA → GRYFTNFRMY in isoform 2. 1 Publication10
Alternative sequenceiVSP_013291327 – 591Missing in isoform 2. 1 PublicationAdd BLAST265
Alternative sequenceiVSP_026133522 – 591LCNDH…TSSHL → VGTEESSVRMLRFVFYVYVV FHSSASFENFSKILLFVVSL VWVCVRRAYRLVVLDGFLC in isoform 3. 1 PublicationAdd BLAST70

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034860 mRNA. Translation: BAC28858.1.
AK146879 mRNA. Translation: BAE27500.1. Different initiation.
BC004763 mRNA. Translation: AAH04763.1.
BC012849 mRNA. Translation: AAH12849.2.
BC071184 mRNA. Translation: AAH71184.1.
CCDSiCCDS70845.1. [Q921F4-1]
RefSeqiNP_659051.3. NM_144802.4. [Q921F4-1]
UniGeneiMm.64579.

Genome annotation databases

EnsembliENSMUST00000061331; ENSMUSP00000058308; ENSMUSG00000024095. [Q921F4-1]
ENSMUST00000184635; ENSMUSP00000139372; ENSMUSG00000024095. [Q921F4-1]
GeneIDi72692.
KEGGimmu:72692.
UCSCiuc008dqk.2. mouse. [Q921F4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiHNRLL_MOUSE
AccessioniPrimary (citable) accession number: Q921F4
Secondary accession number(s): Q3UIK6
, Q6IR44, Q8BIP6, Q91W02, Q99J40
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 29, 2005
Last modified: August 30, 2017
This is version 138 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references