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Protein

Ras-related protein Rab-31

Gene

Rab31

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium (By similarity). Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes.By similarity2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 19GTPBy similarity8
Nucleotide bindingi60 – 64GTPBy similarity5
Nucleotide bindingi118 – 121GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-31
Gene namesi
Name:Rab31
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1914603. Rab31.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001212331 – 194Ras-related protein Rab-31Add BLAST194

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei35PhosphoserineCombined sources1
Lipidationi193S-geranylgeranyl cysteineBy similarity1
Lipidationi194S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Phosphoprotein, Prenylation

Proteomic databases

EPDiQ921E2.
MaxQBiQ921E2.
PaxDbiQ921E2.
PRIDEiQ921E2.

PTM databases

iPTMnetiQ921E2.
PhosphoSitePlusiQ921E2.

Expressioni

Tissue specificityi

Detected in brain astrocytes (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000056515.
CleanExiMM_RAB31.

Interactioni

Subunit structurei

Interacts with OCRL. Interacts (in GDP-bound form) with RIN3 and GAPVD1, which function as guanine exchange factors (GEF). Interacts with EGFR (By similarity). Interacts with NGFR. Interacts (in GTP-bound form) with EEA1.By similarity1 Publication

Protein-protein interaction databases

BioGridi223081. 1 interactor.
IntActiQ921E2. 11 interactors.
MINTiMINT-4997919.
STRINGi10090.ENSMUSP00000068195.

Structurei

3D structure databases

ProteinModelPortaliQ921E2.
SMRiQ921E2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi34 – 42Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0092. Eukaryota.
ENOG410YCCP. LUCA.
HOVERGENiHBG009351.
InParanoidiQ921E2.
KOiK07891.
OMAiQTGRRCC.
PhylomeDBiQ921E2.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q921E2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIRELKVCL LGDTGVGKSS IVCRFVQDHF DHNISPTIGA SFMTKTVPCG
60 70 80 90 100
NELHKFLIWD TAGQERFHSL APMYYRGSAA AVIVYDITKQ DSFHTLKKWV
110 120 130 140 150
KELKEHGPEN IVMAIAGNKC DLSDIREVPL KDAKEYAESI GAIVVETSAK
160 170 180 190
NAINIEELFQ GISRQIPPLG PQENGNSGGI KLGNQSLQAS RRCC
Length:194
Mass (Da):21,331
Last modified:December 1, 2001 - v1
Checksum:i4EBCAF6E2431AD02
GO

Sequence cautioni

The sequence BAC34585 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti49C → W in BAC34585 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK051270 mRNA. Translation: BAC34585.1. Different initiation.
BC013063 mRNA. Translation: AAH13063.1.
RefSeqiNP_598446.2. NM_133685.2.
UniGeneiMm.29274.

Genome annotation databases

GeneIDi106572.
KEGGimmu:106572.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK051270 mRNA. Translation: BAC34585.1. Different initiation.
BC013063 mRNA. Translation: AAH13063.1.
RefSeqiNP_598446.2. NM_133685.2.
UniGeneiMm.29274.

3D structure databases

ProteinModelPortaliQ921E2.
SMRiQ921E2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi223081. 1 interactor.
IntActiQ921E2. 11 interactors.
MINTiMINT-4997919.
STRINGi10090.ENSMUSP00000068195.

PTM databases

iPTMnetiQ921E2.
PhosphoSitePlusiQ921E2.

Proteomic databases

EPDiQ921E2.
MaxQBiQ921E2.
PaxDbiQ921E2.
PRIDEiQ921E2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi106572.
KEGGimmu:106572.

Organism-specific databases

CTDi11031.
MGIiMGI:1914603. Rab31.

Phylogenomic databases

eggNOGiKOG0092. Eukaryota.
ENOG410YCCP. LUCA.
HOVERGENiHBG009351.
InParanoidiQ921E2.
KOiK07891.
OMAiQTGRRCC.
PhylomeDBiQ921E2.

Miscellaneous databases

ChiTaRSiRab31. mouse.
PROiQ921E2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000056515.
CleanExiMM_RAB31.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAB31_MOUSE
AccessioniPrimary (citable) accession number: Q921E2
Secondary accession number(s): Q8BKP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.