Ras-related protein Rab-31 - Mus musculus (Mouse)

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Q921E2 (RAB31_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 92. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Ras-related protein Rab-31

Gene names

Name:

Rab31

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	194 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium By similarity. Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes. Ref.3 Ref.6
Subunit structure	Interacts with OCRL. Interacts (in GDP-bound form) with RIN3 and GAPVD1, which function as guanine exchange factors (GEF). Interacts with EGFR By similarity. Interacts with NGFR. Interacts (in GTP-bound form) with EEA1. Ref.6
Subcellular location	Golgi apparatus › trans-Golgi network By similarity. Golgi apparatus › trans-Golgi network membrane; Lipid-anchor; Cytoplasmic side By similarity. Early endosome By similarity. Cytoplasmic vesicle › phagosome By similarity. Cytoplasmic vesicle › phagosome membrane; Lipid-anchor; Cytoplasmic side By similarity. Note: Rapidly recruited to phagosomes containing S.aureus or Mycobacterium By similarity.
Tissue specificity	Detected in brain astrocytes (at protein level). Ref.5
Sequence similarities	Belongs to the small GTPase superfamily. Rab family.
Sequence caution	The sequence BAC34585.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasmic vesicle Endosome Golgi apparatus Membrane
Ligand	GTP-binding Nucleotide-binding
PTM	Lipoprotein Phosphoprotein Prenylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	Golgi to plasma membrane protein transport Inferred from sequence or structural similarity. Source: UniProtKB cellular response to insulin stimulus Inferred from sequence or structural similarity. Source: UniProtKB phagosome maturation Inferred from sequence or structural similarity. Source: UniProtKB receptor internalization Inferred from sequence or structural similarity. Source: UniProtKB regulated secretory pathway Inferred from sequence or structural similarity. Source: UniProtKB small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-SubCell early endosome Inferred from sequence or structural similarity. Source: UniProtKB phagocytic vesicle Inferred from sequence or structural similarity. Source: UniProtKB phagocytic vesicle membrane Inferred from electronic annotation. Source: UniProtKB-SubCell trans-Golgi network membrane Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	GDP binding Inferred from sequence or structural similarity. Source: UniProtKB GTP binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 194

194

Ras-related protein Rab-31

PRO_0000121233

Regions

Nucleotide binding

12 – 19

GTP By similarity

Nucleotide binding

60 – 64

GTP By similarity

Nucleotide binding

118 – 121

GTP By similarity

Motif

34 – 42

Effector region By similarity

Amino acid modifications

Modified residue

Phosphoserine Ref.4

Lipidation

193

S-geranylgeranyl cysteine By similarity

Lipidation

194

S-geranylgeranyl cysteine By similarity

Experimental info

Sequence conflict

C → W in BAC34585. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

Q921E2 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 4EBCAF6E2431AD02
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FASTA

194

21,331

        10         20         30         40         50         60 
MAIRELKVCL LGDTGVGKSS IVCRFVQDHF DHNISPTIGA SFMTKTVPCG NELHKFLIWD 

        70         80         90        100        110        120 
TAGQERFHSL APMYYRGSAA AVIVYDITKQ DSFHTLKKWV KELKEHGPEN IVMAIAGNKC 

       130        140        150        160        170        180 
DLSDIREVPL KDAKEYAESI GAIVVETSAK NAINIEELFQ GISRQIPPLG PQENGNSGGI 

       190 
KLGNQSLQAS RRCC

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Spinal ganglion.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Mammary tumor.
[3]	"Transport of mannose-6-phosphate receptors from the trans-Golgi network to endosomes requires Rab31." Rodriguez-Gabin A.G., Yin X., Si Q., Larocca J.N. Exp. Cell Res. 315:2215-2230(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[4]	"The phagosomal proteome in interferon-gamma-activated macrophages." Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P. Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-35, MASS SPECTROMETRY. Tissue: Macrophage.
[5]	"Rab22B is expressed in the CNS astroglia lineage and plays a role in epidermal growth factor receptor trafficking in A431 cells." Ng E.L., Ng J.J., Liang F., Tang B.L. J. Cell. Physiol. 221:716-728(2009) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[6]	"p75 neurotrophin receptor regulates glucose homeostasis and insulin sensitivity." Baeza-Raja B., Li P., Le Moan N., Sachs B.D., Schachtrup C., Davalos D., Vagena E., Bridges D., Kim C., Saltiel A.R., Olefsky J.M., Akassoglou K. Proc. Natl. Acad. Sci. U.S.A. 109:5838-5843(2012) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH EEA1 AND NGFR.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK051270 mRNA. Translation: BAC34585.1. Different initiation. BC013063 mRNA. Translation: AAH13063.1.
IPI	IPI00222632.
RefSeq	NP_598446.2. NM_133685.2.
UniGene	Mm.29274.
3D structure databases
ProteinModelPortal	Q921E2.
SMR	Q921E2. Positions 3-167.
ModBase	Search...
PTM databases
PhosphoSite	Q921E2.
Proteomic databases
PaxDb	Q921E2.
PRIDE	Q921E2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	106572.
KEGG	mmu:106572.
Organism-specific databases
CTD	11031.
MGI	MGI:1914603. Rab31.
Phylogenomic databases
eggNOG	COG1100.
HOVERGEN	HBG009351.
InParanoid	Q921E2.
KO	K07892.
OMA	SKQIPPL.
OrthoDB	EOG48KRC8.
Gene expression databases
ArrayExpress	Q921E2.
Bgee	Q921E2.
CleanEx	MM_RAB31.
Genevestigator	Q921E2.
GermOnline	ENSMUSG00000056515. Mus musculus.
Family and domain databases
InterPro	IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. IPR003579. Small_GTPase_Rab_type. [Graphical view]
Pfam	PF00071. Ras. 1 hit. [Graphical view]
PRINTS	PR00449. RASTRNSFRMNG.
SMART	SM00175. RAB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00231. small_GTP. 1 hit.
PROSITE	PS51419. RAB. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	358266.
SOURCE	Search...

Entry information

Entry name

RAB31_MOUSE

Accession

Primary (citable) accession number: Q921E2
Secondary accession number(s): Q8BKP0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 92 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents