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Q921E2

- RAB31_MOUSE

UniProt

Q921E2 - RAB31_MOUSE

Protein

Ras-related protein Rab-31

Gene

Rab31

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium By similarity. Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes.By similarity2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi12 – 198GTPBy similarity
    Nucleotide bindingi60 – 645GTPBy similarity
    Nucleotide bindingi118 – 1214GTPBy similarity

    GO - Molecular functioni

    1. GDP binding Source: UniProtKB
    2. GTP binding Source: UniProtKB

    GO - Biological processi

    1. cellular response to insulin stimulus Source: UniProtKB
    2. Golgi to plasma membrane protein transport Source: UniProtKB
    3. phagosome maturation Source: UniProtKB
    4. receptor internalization Source: UniProtKB
    5. regulated secretory pathway Source: UniProtKB
    6. small GTPase mediated signal transduction Source: InterPro

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras-related protein Rab-31
    Gene namesi
    Name:Rab31
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1914603. Rab31.

    Subcellular locationi

    Golgi apparatustrans-Golgi network By similarity. Golgi apparatustrans-Golgi network membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity. Early endosome By similarity. Cytoplasmic vesiclephagosome By similarity. Cytoplasmic vesiclephagosome membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity
    Note: Rapidly recruited to phagosomes containing S.aureus or Mycobacterium.By similarity

    GO - Cellular componenti

    1. early endosome Source: UniProtKB
    2. phagocytic vesicle Source: UniProtKB
    3. phagocytic vesicle membrane Source: UniProtKB-SubCell
    4. trans-Golgi network membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Endosome, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 194194Ras-related protein Rab-31PRO_0000121233Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei35 – 351Phosphoserine1 Publication
    Lipidationi193 – 1931S-geranylgeranyl cysteineBy similarity
    Lipidationi194 – 1941S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Phosphoprotein, Prenylation

    Proteomic databases

    MaxQBiQ921E2.
    PaxDbiQ921E2.
    PRIDEiQ921E2.

    PTM databases

    PhosphoSiteiQ921E2.

    Expressioni

    Tissue specificityi

    Detected in brain astrocytes (at protein level).1 Publication

    Gene expression databases

    ArrayExpressiQ921E2.
    BgeeiQ921E2.
    CleanExiMM_RAB31.
    GenevestigatoriQ921E2.

    Interactioni

    Subunit structurei

    Interacts with OCRL. Interacts (in GDP-bound form) with RIN3 and GAPVD1, which function as guanine exchange factors (GEF). Interacts with EGFR By similarity. Interacts with NGFR. Interacts (in GTP-bound form) with EEA1.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi223081. 1 interaction.
    IntActiQ921E2. 4 interactions.
    MINTiMINT-4997919.

    Structurei

    3D structure databases

    ProteinModelPortaliQ921E2.
    SMRiQ921E2. Positions 3-167.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi34 – 429Effector regionBy similarity

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rab family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    HOVERGENiHBG009351.
    InParanoidiQ921E2.
    KOiK07891.
    OMAiIANSCER.
    PhylomeDBiQ921E2.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00175. RAB. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51419. RAB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q921E2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAIRELKVCL LGDTGVGKSS IVCRFVQDHF DHNISPTIGA SFMTKTVPCG    50
    NELHKFLIWD TAGQERFHSL APMYYRGSAA AVIVYDITKQ DSFHTLKKWV 100
    KELKEHGPEN IVMAIAGNKC DLSDIREVPL KDAKEYAESI GAIVVETSAK 150
    NAINIEELFQ GISRQIPPLG PQENGNSGGI KLGNQSLQAS RRCC 194
    Length:194
    Mass (Da):21,331
    Last modified:December 1, 2001 - v1
    Checksum:i4EBCAF6E2431AD02
    GO

    Sequence cautioni

    The sequence BAC34585.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti49 – 491C → W in BAC34585. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK051270 mRNA. Translation: BAC34585.1. Different initiation.
    BC013063 mRNA. Translation: AAH13063.1.
    RefSeqiNP_598446.2. NM_133685.2.
    UniGeneiMm.29274.

    Genome annotation databases

    GeneIDi106572.
    KEGGimmu:106572.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK051270 mRNA. Translation: BAC34585.1 . Different initiation.
    BC013063 mRNA. Translation: AAH13063.1 .
    RefSeqi NP_598446.2. NM_133685.2.
    UniGenei Mm.29274.

    3D structure databases

    ProteinModelPortali Q921E2.
    SMRi Q921E2. Positions 3-167.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 223081. 1 interaction.
    IntActi Q921E2. 4 interactions.
    MINTi MINT-4997919.

    PTM databases

    PhosphoSitei Q921E2.

    Proteomic databases

    MaxQBi Q921E2.
    PaxDbi Q921E2.
    PRIDEi Q921E2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 106572.
    KEGGi mmu:106572.

    Organism-specific databases

    CTDi 11031.
    MGIi MGI:1914603. Rab31.

    Phylogenomic databases

    eggNOGi COG1100.
    HOVERGENi HBG009351.
    InParanoidi Q921E2.
    KOi K07891.
    OMAi IANSCER.
    PhylomeDBi Q921E2.

    Miscellaneous databases

    NextBioi 358266.
    PROi Q921E2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q921E2.
    Bgeei Q921E2.
    CleanExi MM_RAB31.
    Genevestigatori Q921E2.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00175. RAB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Spinal ganglion.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary tumor.
    3. "Transport of mannose-6-phosphate receptors from the trans-Golgi network to endosomes requires Rab31."
      Rodriguez-Gabin A.G., Yin X., Si Q., Larocca J.N.
      Exp. Cell Res. 315:2215-2230(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    4. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-35, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    5. "Rab22B is expressed in the CNS astroglia lineage and plays a role in epidermal growth factor receptor trafficking in A431 cells."
      Ng E.L., Ng J.J., Liang F., Tang B.L.
      J. Cell. Physiol. 221:716-728(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    6. Cited for: FUNCTION, INTERACTION WITH EEA1 AND NGFR.

    Entry informationi

    Entry nameiRAB31_MOUSE
    AccessioniPrimary (citable) accession number: Q921E2
    Secondary accession number(s): Q8BKP0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3