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Protein

Mediator of RNA polymerase II transcription subunit 6

Gene

Med6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 6
Alternative name(s):
Mediator complex subunit 6
Gene namesi
Name:Med6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1917042 Med6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003030421 – 246Mediator of RNA polymerase II transcription subunit 6Add BLAST246

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki208Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei236N6-acetyllysineCombined sources1
Modified residuei241N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ921D4
PaxDbiQ921D4
PeptideAtlasiQ921D4
PRIDEiQ921D4

PTM databases

iPTMnetiQ921D4
PhosphoSitePlusiQ921D4

Expressioni

Gene expression databases

BgeeiENSMUSG00000002679
ExpressionAtlasiQ921D4 baseline and differential
GenevisibleiQ921D4 MM

Interactioni

Subunit structurei

Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Interacts with CTNNB1 and GLI3 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi213683, 2 interactors
CORUMiQ921D4
DIPiDIP-60703N
IntActiQ921D4, 5 interactors
MINTiQ921D4
STRINGi10090.ENSMUSP00000002756

Structurei

3D structure databases

ProteinModelPortaliQ921D4
SMRiQ921D4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Mediator complex subunit 6 family.Curated

Phylogenomic databases

eggNOGiKOG3169 Eukaryota
COG5097 LUCA
GeneTreeiENSGT00390000017666
HOGENOMiHOG000035127
HOVERGENiHBG006825
InParanoidiQ921D4
KOiK15128
OMAiYARYHPN
OrthoDBiEOG091G0MJA
PhylomeDBiQ921D4
TreeFamiTF313577

Family and domain databases

Gene3Di3.10.450.580, 1 hit
InterProiView protein in InterPro
IPR038566 Med6_sf
IPR007018 Mediator_Med6
IPR016820 Mediator_Med6_met/pln
PANTHERiPTHR13104 PTHR13104, 1 hit
PfamiView protein in Pfam
PF04934 Med6, 1 hit
PIRSFiPIRSF023869 Mediator_MED6_meta/pln, 1 hit

Sequencei

Sequence statusi: Complete.

Q921D4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVDIRDNL LGISWVDSSW IPILNSGSVL DYFSERSNPF YDRTCNNEVV
60 70 80 90 100
KMQRLTLEHL NQMVGIEYIL LHAQEPILFI IRKQQRQSPA QVIPLADYYI
110 120 130 140 150
IAGVIYQAPD LGSVINSRVL TAVHGIQSAF DEAMSYCRYH PSKGYWWHFK
160 170 180 190 200
DHEEQEKVKP KAKRKEEPSS IFQRQRVDAL LIDLRQKFPP RFVQQKSGEK
210 220 230 240
PVPVDQAKKE AEPLPETVKS EEKESTKNIQ QTVSTKGPPE KRMRLQ
Length:246
Mass (Da):28,434
Last modified:September 11, 2007 - v2
Checksum:i51DB8A599B24DCF6
GO

Sequence cautioni

The sequence AAH13096 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAE42663 differs from that shown. Reason: Frameshift at position 210.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK089101 mRNA Translation: BAC40749.1
AK171784 mRNA Translation: BAE42663.1 Frameshift.
BC013096 mRNA Translation: AAH13096.1 Different initiation.
CCDSiCCDS83983.1
RefSeqiNP_001334313.1, NM_001347384.1
NP_001334315.1, NM_001347386.1
NP_081489.2, NM_027213.2
UniGeneiMm.279993

Genome annotation databases

EnsembliENSMUST00000161211; ENSMUSP00000125156; ENSMUSG00000002679
GeneIDi69792
KEGGimmu:69792
UCSCiuc007ocl.1 mouse

Similar proteinsi

Entry informationi

Entry nameiMED6_MOUSE
AccessioniPrimary (citable) accession number: Q921D4
Secondary accession number(s): Q3TAK5, Q8BTP9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: May 23, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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