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Protein

Gap junction gamma-3 protein

Gene

Gjc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.By similarity

GO - Molecular functioni

  • gap junction channel activity Source: MGI
  • protein homodimerization activity Source: MGI

GO - Biological processi

  • cell-cell signaling Source: MGI
  • myelination Source: MGI
  • sensory perception of sound Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction gamma-3 protein
Alternative name(s):
Connexin-29
Short name:
Cx29
Gap junction epsilon-1 protein
Gene namesi
Name:Gjc3
Synonyms:Cx29, Gje1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2153041. Gjc3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33ExtracellularSequence analysisAdd BLAST33
Transmembranei34 – 54HelicalSequence analysisAdd BLAST21
Topological domaini55 – 86CytoplasmicSequence analysisAdd BLAST32
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Topological domaini108 – 145ExtracellularSequence analysisAdd BLAST38
Transmembranei146 – 166HelicalSequence analysisAdd BLAST21
Topological domaini167 – 205CytoplasmicSequence analysisAdd BLAST39
Transmembranei206 – 226HelicalSequence analysisAdd BLAST21
Topological domaini227 – 269ExtracellularSequence analysisAdd BLAST43

GO - Cellular componenti

  • connexin complex Source: InterPro
  • gap junction Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • myelin sheath Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003547061 – 269Gap junction gamma-3 proteinAdd BLAST269

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei261PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ921C1.
PaxDbiQ921C1.
PeptideAtlasiQ921C1.
PRIDEiQ921C1.

PTM databases

iPTMnetiQ921C1.
PhosphoSitePlusiQ921C1.
SwissPalmiQ921C1.

Expressioni

Tissue specificityi

CNS specific. Expression is restricted to brain, spinal cord, and sciatic nerve.

Gene expression databases

BgeeiENSMUSG00000056966.
CleanExiMM_GJE1.
GenevisibleiQ921C1. MM.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.By similarity

GO - Molecular functioni

  • protein homodimerization activity Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076367.

Structurei

3D structure databases

ProteinModelPortaliQ921C1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the connexin family. Gamma-type subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J8Q3. Eukaryota.
ENOG4111D69. LUCA.
GeneTreeiENSGT00860000133694.
HOGENOMiHOG000231127.
HOVERGENiHBG107788.
InParanoidiQ921C1.
KOiK07628.
OMAiIFLKTMF.
OrthoDBiEOG091G06LA.
PhylomeDBiQ921C1.
TreeFamiTF329606.

Family and domain databases

InterProiIPR000500. Connexin.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiPF00029. Connexin. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q921C1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLLELPIKC RMCGRFLRQL LAQESQHSTP VGRFLLPMLM GFRLLILVSS
60 70 80 90 100
GPGVFGNDEN EFICHLGQPG CKTICYDVFR PLSPLRFWAF QVILMAVPSA
110 120 130 140 150
IYVAFTLYHV IGYWEVPGKE NKEQETQISK GDHSKDVSGA KSLKLLWAYV
160 170 180 190 200
AHLGVRLALE GAALGVQYNL YGFKMSSTFI CREDPCIGST TCFQSHPSEK
210 220 230 240 250
TIFLNIMFGI SGACFLFIFL ELALLGLGRF WRIYKHKLSF LKKLPTSESS
260
VRSKDTTDEL SVVEAKEPF
Length:269
Mass (Da):30,293
Last modified:November 25, 2008 - v2
Checksum:i13D9FF9C25C85D6A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY823670 Genomic DNA. Translation: AAX39497.1.
AY289210 mRNA. Translation: AAP41202.1.
AY293564 mRNA. Translation: AAP50246.1.
AY297108 mRNA. Translation: AAP51160.1.
AK034037 mRNA. Translation: BAC28554.1.
AK045577 mRNA. Translation: BAC32421.1.
AK047368 mRNA. Translation: BAC33038.1.
AK147913 mRNA. Translation: BAE28224.1.
CH466529 Genomic DNA. Translation: EDL19225.1.
CH466529 Genomic DNA. Translation: EDL19226.1.
BC125305 mRNA. Translation: AAI25306.1.
AJ297318 Genomic DNA. Translation: CAC29245.1.
AF503616 Genomic DNA. Translation: AAM21146.1.
CCDSiCCDS19782.1.
RefSeqiNP_536698.2. NM_080450.4.
UniGeneiMm.332771.

Genome annotation databases

EnsembliENSMUST00000077119; ENSMUSP00000076367; ENSMUSG00000056966.
GeneIDi118446.
KEGGimmu:118446.
UCSCiuc009aeg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY823670 Genomic DNA. Translation: AAX39497.1.
AY289210 mRNA. Translation: AAP41202.1.
AY293564 mRNA. Translation: AAP50246.1.
AY297108 mRNA. Translation: AAP51160.1.
AK034037 mRNA. Translation: BAC28554.1.
AK045577 mRNA. Translation: BAC32421.1.
AK047368 mRNA. Translation: BAC33038.1.
AK147913 mRNA. Translation: BAE28224.1.
CH466529 Genomic DNA. Translation: EDL19225.1.
CH466529 Genomic DNA. Translation: EDL19226.1.
BC125305 mRNA. Translation: AAI25306.1.
AJ297318 Genomic DNA. Translation: CAC29245.1.
AF503616 Genomic DNA. Translation: AAM21146.1.
CCDSiCCDS19782.1.
RefSeqiNP_536698.2. NM_080450.4.
UniGeneiMm.332771.

3D structure databases

ProteinModelPortaliQ921C1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076367.

PTM databases

iPTMnetiQ921C1.
PhosphoSitePlusiQ921C1.
SwissPalmiQ921C1.

Proteomic databases

MaxQBiQ921C1.
PaxDbiQ921C1.
PeptideAtlasiQ921C1.
PRIDEiQ921C1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000077119; ENSMUSP00000076367; ENSMUSG00000056966.
GeneIDi118446.
KEGGimmu:118446.
UCSCiuc009aeg.1. mouse.

Organism-specific databases

CTDi349149.
MGIiMGI:2153041. Gjc3.

Phylogenomic databases

eggNOGiENOG410J8Q3. Eukaryota.
ENOG4111D69. LUCA.
GeneTreeiENSGT00860000133694.
HOGENOMiHOG000231127.
HOVERGENiHBG107788.
InParanoidiQ921C1.
KOiK07628.
OMAiIFLKTMF.
OrthoDBiEOG091G06LA.
PhylomeDBiQ921C1.
TreeFamiTF329606.

Miscellaneous databases

PROiQ921C1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000056966.
CleanExiMM_GJE1.
GenevisibleiQ921C1. MM.

Family and domain databases

InterProiIPR000500. Connexin.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiPF00029. Connexin. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCXG3_MOUSE
AccessioniPrimary (citable) accession number: Q921C1
Secondary accession number(s): Q53ZP5, Q8BHJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: November 25, 2008
Last modified: November 30, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-12 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.