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Q921C1

- CXG3_MOUSE

UniProt

Q921C1 - CXG3_MOUSE

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Protein
Gap junction gamma-3 protein
Gene
Gjc3, Cx29, Gje1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell By similarity.

GO - Molecular functioni

  1. gap junction channel activity Source: MGI
  2. protein homodimerization activity Source: MGI

GO - Biological processi

  1. cell-cell signaling Source: MGI
  2. myelination Source: MGI
  3. sensory perception of sound Source: MGI
  4. transmembrane transport Source: GOC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction gamma-3 protein
Alternative name(s):
Connexin-29
Short name:
Cx29
Gap junction epsilon-1 protein
Gene namesi
Name:Gjc3
Synonyms:Cx29, Gje1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:2153041. Gjc3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3333Extracellular Reviewed prediction
Add
BLAST
Transmembranei34 – 5421Helical; Reviewed prediction
Add
BLAST
Topological domaini55 – 8632Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei87 – 10721Helical; Reviewed prediction
Add
BLAST
Topological domaini108 – 14538Extracellular Reviewed prediction
Add
BLAST
Transmembranei146 – 16621Helical; Reviewed prediction
Add
BLAST
Topological domaini167 – 20539Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei206 – 22621Helical; Reviewed prediction
Add
BLAST
Topological domaini227 – 26943Extracellular Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. connexon complex Source: InterPro
  2. gap junction Source: MGI
  3. integral component of membrane Source: UniProtKB-KW
  4. myelin sheath Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269Gap junction gamma-3 protein
PRO_0000354706Add
BLAST

Proteomic databases

MaxQBiQ921C1.
PaxDbiQ921C1.
PRIDEiQ921C1.

PTM databases

PhosphoSiteiQ921C1.

Expressioni

Tissue specificityi

CNS specific. Expression is restricted to brain, spinal cord, and sciatic nerve.

Gene expression databases

BgeeiQ921C1.
CleanExiMM_GJE1.
GenevestigatoriQ921C1.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ921C1.
SMRiQ921C1. Positions 17-225.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG42371.
GeneTreeiENSGT00640000091490.
HOGENOMiHOG000231127.
HOVERGENiHBG107788.
InParanoidiQ53ZP5.
KOiK07628.
OMAiCHRENES.
OrthoDBiEOG7WHHBG.
PhylomeDBiQ921C1.
TreeFamiTF329606.

Family and domain databases

InterProiIPR000500. Connexin.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiPF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
SMARTiSM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q921C1-1 [UniParc]FASTAAdd to Basket

« Hide

MLLLELPIKC RMCGRFLRQL LAQESQHSTP VGRFLLPMLM GFRLLILVSS    50
GPGVFGNDEN EFICHLGQPG CKTICYDVFR PLSPLRFWAF QVILMAVPSA 100
IYVAFTLYHV IGYWEVPGKE NKEQETQISK GDHSKDVSGA KSLKLLWAYV 150
AHLGVRLALE GAALGVQYNL YGFKMSSTFI CREDPCIGST TCFQSHPSEK 200
TIFLNIMFGI SGACFLFIFL ELALLGLGRF WRIYKHKLSF LKKLPTSESS 250
VRSKDTTDEL SVVEAKEPF 269
Length:269
Mass (Da):30,293
Last modified:November 25, 2008 - v2
Checksum:i13D9FF9C25C85D6A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY823670 Genomic DNA. Translation: AAX39497.1.
AY289210 mRNA. Translation: AAP41202.1.
AY293564 mRNA. Translation: AAP50246.1.
AY297108 mRNA. Translation: AAP51160.1.
AK034037 mRNA. Translation: BAC28554.1.
AK045577 mRNA. Translation: BAC32421.1.
AK047368 mRNA. Translation: BAC33038.1.
AK147913 mRNA. Translation: BAE28224.1.
CH466529 Genomic DNA. Translation: EDL19225.1.
CH466529 Genomic DNA. Translation: EDL19226.1.
BC125305 mRNA. Translation: AAI25306.1.
AJ297318 Genomic DNA. Translation: CAC29245.1.
AF503616 Genomic DNA. Translation: AAM21146.1.
CCDSiCCDS19782.1.
RefSeqiNP_536698.2. NM_080450.4.
XP_006504615.1. XM_006504552.1.
UniGeneiMm.332771.

Genome annotation databases

EnsembliENSMUST00000077119; ENSMUSP00000076367; ENSMUSG00000056966.
GeneIDi118446.
KEGGimmu:118446.
UCSCiuc009aeg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY823670 Genomic DNA. Translation: AAX39497.1 .
AY289210 mRNA. Translation: AAP41202.1 .
AY293564 mRNA. Translation: AAP50246.1 .
AY297108 mRNA. Translation: AAP51160.1 .
AK034037 mRNA. Translation: BAC28554.1 .
AK045577 mRNA. Translation: BAC32421.1 .
AK047368 mRNA. Translation: BAC33038.1 .
AK147913 mRNA. Translation: BAE28224.1 .
CH466529 Genomic DNA. Translation: EDL19225.1 .
CH466529 Genomic DNA. Translation: EDL19226.1 .
BC125305 mRNA. Translation: AAI25306.1 .
AJ297318 Genomic DNA. Translation: CAC29245.1 .
AF503616 Genomic DNA. Translation: AAM21146.1 .
CCDSi CCDS19782.1.
RefSeqi NP_536698.2. NM_080450.4.
XP_006504615.1. XM_006504552.1.
UniGenei Mm.332771.

3D structure databases

ProteinModelPortali Q921C1.
SMRi Q921C1. Positions 17-225.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q921C1.

Proteomic databases

MaxQBi Q921C1.
PaxDbi Q921C1.
PRIDEi Q921C1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000077119 ; ENSMUSP00000076367 ; ENSMUSG00000056966 .
GeneIDi 118446.
KEGGi mmu:118446.
UCSCi uc009aeg.1. mouse.

Organism-specific databases

CTDi 349149.
MGIi MGI:2153041. Gjc3.

Phylogenomic databases

eggNOGi NOG42371.
GeneTreei ENSGT00640000091490.
HOGENOMi HOG000231127.
HOVERGENi HBG107788.
InParanoidi Q53ZP5.
KOi K07628.
OMAi CHRENES.
OrthoDBi EOG7WHHBG.
PhylomeDBi Q921C1.
TreeFami TF329606.

Miscellaneous databases

NextBioi 369722.
PROi Q921C1.
SOURCEi Search...

Gene expression databases

Bgeei Q921C1.
CleanExi MM_GJE1.
Genevestigatori Q921C1.

Family and domain databases

InterProi IPR000500. Connexin.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view ]
PANTHERi PTHR11984. PTHR11984. 1 hit.
Pfami PF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view ]
PRINTSi PR00206. CONNEXIN.
SMARTi SM01089. Connexin_CCC. 1 hit.
[Graphical view ]
PROSITEi PS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Comparative analysis of the paired immunoglobulin-like receptor (PILR) locus in six mammalian genomes: duplication, conversion, and the birth of new genes."
    Wilson M.D., Cheung J., Martindale D.W., Scherer S.W., Koop B.F.
    Physiol. Genomics 27:201-218(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum, Corpora quadrigemina and Diencephalon.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "The mouse gap junction gene Connexin29 is highly expressed in sciatic nerve and regulated during brain development."
    Soehl G., Eiberger J., Jung Y., Kozak C., Willecke K.
    Biol. Chem. 382:973-978(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 12-269.
  6. "Connexin29 is uniquely distributed within myelinating glial cells of the central and peripheral nervous systems."
    Altevogt B.M., Kleopa K.A., Postma F.R., Scherer S.S., Paul D.L.
    J. Neurosci. 22:6458-6470(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 12-269.
    Strain: 129/SvEv.

Entry informationi

Entry nameiCXG3_MOUSE
AccessioniPrimary (citable) accession number: Q921C1
Secondary accession number(s): Q53ZP5, Q8BHJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: November 25, 2008
Last modified: July 9, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-12 is the initiator.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi