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Q921C1 (CXG3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Gap junction gamma-3 protein
Alternative name(s):
Connexin-29
Short name=Cx29
Gap junction epsilon-1 protein
Gene names
Name:Gjc3
Synonyms:Cx29, Gje1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length269 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell By similarity.

Subunit structure

A connexon is composed of a hexamer of connexins By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity. Cell junctiongap junction By similarity.

Tissue specificity

CNS specific. Expression is restricted to brain, spinal cord, and sciatic nerve.

Sequence similarities

Belongs to the connexin family. Gamma-type subfamily.

Caution

It is uncertain whether Met-1 or Met-12 is the initiator.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 269269Gap junction gamma-3 protein
PRO_0000354706

Regions

Topological domain1 – 3333Extracellular Potential
Transmembrane34 – 5421Helical; Potential
Topological domain55 – 8632Cytoplasmic Potential
Transmembrane87 – 10721Helical; Potential
Topological domain108 – 14538Extracellular Potential
Transmembrane146 – 16621Helical; Potential
Topological domain167 – 20539Cytoplasmic Potential
Transmembrane206 – 22621Helical; Potential
Topological domain227 – 26943Extracellular Potential

Sequences

Sequence LengthMass (Da)Tools
Q921C1 [UniParc].

Last modified November 25, 2008. Version 2.
Checksum: 13D9FF9C25C85D6A

FASTA26930,293
        10         20         30         40         50         60 
MLLLELPIKC RMCGRFLRQL LAQESQHSTP VGRFLLPMLM GFRLLILVSS GPGVFGNDEN 

        70         80         90        100        110        120 
EFICHLGQPG CKTICYDVFR PLSPLRFWAF QVILMAVPSA IYVAFTLYHV IGYWEVPGKE 

       130        140        150        160        170        180 
NKEQETQISK GDHSKDVSGA KSLKLLWAYV AHLGVRLALE GAALGVQYNL YGFKMSSTFI 

       190        200        210        220        230        240 
CREDPCIGST TCFQSHPSEK TIFLNIMFGI SGACFLFIFL ELALLGLGRF WRIYKHKLSF 

       250        260 
LKKLPTSESS VRSKDTTDEL SVVEAKEPF 

« Hide

References

« Hide 'large scale' references
[1]"Comparative analysis of the paired immunoglobulin-like receptor (PILR) locus in six mammalian genomes: duplication, conversion, and the birth of new genes."
Wilson M.D., Cheung J., Martindale D.W., Scherer S.W., Koop B.F.
Physiol. Genomics 27:201-218(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/Sv.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Cerebellum, Corpora quadrigemina and Diencephalon.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[5]"The mouse gap junction gene Connexin29 is highly expressed in sciatic nerve and regulated during brain development."
Soehl G., Eiberger J., Jung Y., Kozak C., Willecke K.
Biol. Chem. 382:973-978(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 12-269.
[6]"Connexin29 is uniquely distributed within myelinating glial cells of the central and peripheral nervous systems."
Altevogt B.M., Kleopa K.A., Postma F.R., Scherer S.S., Paul D.L.
J. Neurosci. 22:6458-6470(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 12-269.
Strain: 129/SvEv.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY823670 Genomic DNA. Translation: AAX39497.1.
AY289210 mRNA. Translation: AAP41202.1.
AY293564 mRNA. Translation: AAP50246.1.
AY297108 mRNA. Translation: AAP51160.1.
AK034037 mRNA. Translation: BAC28554.1.
AK045577 mRNA. Translation: BAC32421.1.
AK047368 mRNA. Translation: BAC33038.1.
AK147913 mRNA. Translation: BAE28224.1.
CH466529 Genomic DNA. Translation: EDL19225.1.
CH466529 Genomic DNA. Translation: EDL19226.1.
BC125305 mRNA. Translation: AAI25306.1.
AJ297318 Genomic DNA. Translation: CAC29245.1.
AF503616 Genomic DNA. Translation: AAM21146.1.
CCDSCCDS19782.1.
RefSeqNP_536698.2. NM_080450.4.
XP_006504615.1. XM_006504552.1.
UniGeneMm.332771.

3D structure databases

ProteinModelPortalQ921C1.
SMRQ921C1. Positions 17-225.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ921C1.

Proteomic databases

MaxQBQ921C1.
PaxDbQ921C1.
PRIDEQ921C1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000077119; ENSMUSP00000076367; ENSMUSG00000056966.
GeneID118446.
KEGGmmu:118446.
UCSCuc009aeg.1. mouse.

Organism-specific databases

CTD349149.
MGIMGI:2153041. Gjc3.

Phylogenomic databases

eggNOGNOG42371.
GeneTreeENSGT00640000091490.
HOGENOMHOG000231127.
HOVERGENHBG107788.
InParanoidQ53ZP5.
KOK07628.
OMACHRENES.
OrthoDBEOG7WHHBG.
PhylomeDBQ921C1.
TreeFamTF329606.

Gene expression databases

BgeeQ921C1.
CleanExMM_GJE1.
GenevestigatorQ921C1.

Family and domain databases

InterProIPR000500. Connexin.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERPTHR11984. PTHR11984. 1 hit.
PfamPF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
PRINTSPR00206. CONNEXIN.
SMARTSM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio369722.
PROQ921C1.
SOURCESearch...

Entry information

Entry nameCXG3_MOUSE
AccessionPrimary (citable) accession number: Q921C1
Secondary accession number(s): Q53ZP5, Q8BHJ3
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: November 25, 2008
Last modified: July 9, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot