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Q921C1

- CXG3_MOUSE

UniProt

Q921C1 - CXG3_MOUSE

Protein

Gap junction gamma-3 protein

Gene

Gjc3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 2 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.By similarity

    GO - Molecular functioni

    1. gap junction channel activity Source: MGI
    2. protein homodimerization activity Source: MGI

    GO - Biological processi

    1. cell-cell signaling Source: MGI
    2. myelination Source: MGI
    3. sensory perception of sound Source: MGI
    4. transmembrane transport Source: GOC

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gap junction gamma-3 protein
    Alternative name(s):
    Connexin-29
    Short name:
    Cx29
    Gap junction epsilon-1 protein
    Gene namesi
    Name:Gjc3
    Synonyms:Cx29, Gje1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:2153041. Gjc3.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity. Cell junctiongap junction By similarity

    GO - Cellular componenti

    1. connexon complex Source: InterPro
    2. gap junction Source: MGI
    3. integral component of membrane Source: UniProtKB-KW
    4. myelin sheath Source: MGI

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Gap junction, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 269269Gap junction gamma-3 proteinPRO_0000354706Add
    BLAST

    Proteomic databases

    MaxQBiQ921C1.
    PaxDbiQ921C1.
    PRIDEiQ921C1.

    PTM databases

    PhosphoSiteiQ921C1.

    Expressioni

    Tissue specificityi

    CNS specific. Expression is restricted to brain, spinal cord, and sciatic nerve.

    Gene expression databases

    BgeeiQ921C1.
    CleanExiMM_GJE1.
    GenevestigatoriQ921C1.

    Interactioni

    Subunit structurei

    A connexon is composed of a hexamer of connexins.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ921C1.
    SMRiQ921C1. Positions 17-225.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3333ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini55 – 8632CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini108 – 14538ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini167 – 20539CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini227 – 26943ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei34 – 5421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei87 – 10721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei146 – 16621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei206 – 22621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the connexin family. Gamma-type subfamily.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG42371.
    GeneTreeiENSGT00640000091490.
    HOGENOMiHOG000231127.
    HOVERGENiHBG107788.
    InParanoidiQ53ZP5.
    KOiK07628.
    OMAiCHRENES.
    OrthoDBiEOG7WHHBG.
    PhylomeDBiQ921C1.
    TreeFamiTF329606.

    Family and domain databases

    InterProiIPR000500. Connexin.
    IPR019570. Connexin_CCC.
    IPR017990. Connexin_CS.
    IPR013092. Connexin_N.
    [Graphical view]
    PANTHERiPTHR11984. PTHR11984. 1 hit.
    PfamiPF00029. Connexin. 1 hit.
    PF10582. Connexin_CCC. 1 hit.
    [Graphical view]
    PRINTSiPR00206. CONNEXIN.
    SMARTiSM01089. Connexin_CCC. 1 hit.
    [Graphical view]
    PROSITEiPS00407. CONNEXINS_1. 1 hit.
    PS00408. CONNEXINS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q921C1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLLLELPIKC RMCGRFLRQL LAQESQHSTP VGRFLLPMLM GFRLLILVSS    50
    GPGVFGNDEN EFICHLGQPG CKTICYDVFR PLSPLRFWAF QVILMAVPSA 100
    IYVAFTLYHV IGYWEVPGKE NKEQETQISK GDHSKDVSGA KSLKLLWAYV 150
    AHLGVRLALE GAALGVQYNL YGFKMSSTFI CREDPCIGST TCFQSHPSEK 200
    TIFLNIMFGI SGACFLFIFL ELALLGLGRF WRIYKHKLSF LKKLPTSESS 250
    VRSKDTTDEL SVVEAKEPF 269
    Length:269
    Mass (Da):30,293
    Last modified:November 25, 2008 - v2
    Checksum:i13D9FF9C25C85D6A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY823670 Genomic DNA. Translation: AAX39497.1.
    AY289210 mRNA. Translation: AAP41202.1.
    AY293564 mRNA. Translation: AAP50246.1.
    AY297108 mRNA. Translation: AAP51160.1.
    AK034037 mRNA. Translation: BAC28554.1.
    AK045577 mRNA. Translation: BAC32421.1.
    AK047368 mRNA. Translation: BAC33038.1.
    AK147913 mRNA. Translation: BAE28224.1.
    CH466529 Genomic DNA. Translation: EDL19225.1.
    CH466529 Genomic DNA. Translation: EDL19226.1.
    BC125305 mRNA. Translation: AAI25306.1.
    AJ297318 Genomic DNA. Translation: CAC29245.1.
    AF503616 Genomic DNA. Translation: AAM21146.1.
    CCDSiCCDS19782.1.
    RefSeqiNP_536698.2. NM_080450.4.
    XP_006504615.1. XM_006504552.1.
    UniGeneiMm.332771.

    Genome annotation databases

    EnsembliENSMUST00000077119; ENSMUSP00000076367; ENSMUSG00000056966.
    GeneIDi118446.
    KEGGimmu:118446.
    UCSCiuc009aeg.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY823670 Genomic DNA. Translation: AAX39497.1 .
    AY289210 mRNA. Translation: AAP41202.1 .
    AY293564 mRNA. Translation: AAP50246.1 .
    AY297108 mRNA. Translation: AAP51160.1 .
    AK034037 mRNA. Translation: BAC28554.1 .
    AK045577 mRNA. Translation: BAC32421.1 .
    AK047368 mRNA. Translation: BAC33038.1 .
    AK147913 mRNA. Translation: BAE28224.1 .
    CH466529 Genomic DNA. Translation: EDL19225.1 .
    CH466529 Genomic DNA. Translation: EDL19226.1 .
    BC125305 mRNA. Translation: AAI25306.1 .
    AJ297318 Genomic DNA. Translation: CAC29245.1 .
    AF503616 Genomic DNA. Translation: AAM21146.1 .
    CCDSi CCDS19782.1.
    RefSeqi NP_536698.2. NM_080450.4.
    XP_006504615.1. XM_006504552.1.
    UniGenei Mm.332771.

    3D structure databases

    ProteinModelPortali Q921C1.
    SMRi Q921C1. Positions 17-225.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q921C1.

    Proteomic databases

    MaxQBi Q921C1.
    PaxDbi Q921C1.
    PRIDEi Q921C1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000077119 ; ENSMUSP00000076367 ; ENSMUSG00000056966 .
    GeneIDi 118446.
    KEGGi mmu:118446.
    UCSCi uc009aeg.1. mouse.

    Organism-specific databases

    CTDi 349149.
    MGIi MGI:2153041. Gjc3.

    Phylogenomic databases

    eggNOGi NOG42371.
    GeneTreei ENSGT00640000091490.
    HOGENOMi HOG000231127.
    HOVERGENi HBG107788.
    InParanoidi Q53ZP5.
    KOi K07628.
    OMAi CHRENES.
    OrthoDBi EOG7WHHBG.
    PhylomeDBi Q921C1.
    TreeFami TF329606.

    Miscellaneous databases

    NextBioi 369722.
    PROi Q921C1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q921C1.
    CleanExi MM_GJE1.
    Genevestigatori Q921C1.

    Family and domain databases

    InterProi IPR000500. Connexin.
    IPR019570. Connexin_CCC.
    IPR017990. Connexin_CS.
    IPR013092. Connexin_N.
    [Graphical view ]
    PANTHERi PTHR11984. PTHR11984. 1 hit.
    Pfami PF00029. Connexin. 1 hit.
    PF10582. Connexin_CCC. 1 hit.
    [Graphical view ]
    PRINTSi PR00206. CONNEXIN.
    SMARTi SM01089. Connexin_CCC. 1 hit.
    [Graphical view ]
    PROSITEi PS00407. CONNEXINS_1. 1 hit.
    PS00408. CONNEXINS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative analysis of the paired immunoglobulin-like receptor (PILR) locus in six mammalian genomes: duplication, conversion, and the birth of new genes."
      Wilson M.D., Cheung J., Martindale D.W., Scherer S.W., Koop B.F.
      Physiol. Genomics 27:201-218(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Cerebellum, Corpora quadrigemina and Diencephalon.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    5. "The mouse gap junction gene Connexin29 is highly expressed in sciatic nerve and regulated during brain development."
      Soehl G., Eiberger J., Jung Y., Kozak C., Willecke K.
      Biol. Chem. 382:973-978(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 12-269.
    6. "Connexin29 is uniquely distributed within myelinating glial cells of the central and peripheral nervous systems."
      Altevogt B.M., Kleopa K.A., Postma F.R., Scherer S.S., Paul D.L.
      J. Neurosci. 22:6458-6470(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 12-269.
      Strain: 129/SvEv.

    Entry informationi

    Entry nameiCXG3_MOUSE
    AccessioniPrimary (citable) accession number: Q921C1
    Secondary accession number(s): Q53ZP5, Q8BHJ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2003
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 101 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-12 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3