Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Gap junction gamma-3 protein

Gene

Gjc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.By similarity

Caution

It is uncertain whether Met-1 or Met-12 is the initiator.Curated

GO - Molecular functioni

  • gap junction channel activity Source: MGI
  • protein homodimerization activity Source: MGI

GO - Biological processi

  • cell-cell signaling Source: MGI
  • myelination Source: MGI
  • sensory perception of sound Source: MGI

Protein family/group databases

TCDBi1.A.24.1.12 the gap junction-forming connexin (connexin) family

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction gamma-3 protein
Alternative name(s):
Connexin-29
Short name:
Cx29
Gap junction epsilon-1 protein
Gene namesi
Name:Gjc3
Synonyms:Cx29, Gje1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2153041 Gjc3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33ExtracellularSequence analysisAdd BLAST33
Transmembranei34 – 54HelicalSequence analysisAdd BLAST21
Topological domaini55 – 86CytoplasmicSequence analysisAdd BLAST32
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Topological domaini108 – 145ExtracellularSequence analysisAdd BLAST38
Transmembranei146 – 166HelicalSequence analysisAdd BLAST21
Topological domaini167 – 205CytoplasmicSequence analysisAdd BLAST39
Transmembranei206 – 226HelicalSequence analysisAdd BLAST21
Topological domaini227 – 269ExtracellularSequence analysisAdd BLAST43

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003547061 – 269Gap junction gamma-3 proteinAdd BLAST269

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei261PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ921C1
PaxDbiQ921C1
PeptideAtlasiQ921C1
PRIDEiQ921C1

PTM databases

iPTMnetiQ921C1
PhosphoSitePlusiQ921C1
SwissPalmiQ921C1

Expressioni

Tissue specificityi

CNS specific. Expression is restricted to brain, spinal cord, and sciatic nerve.

Gene expression databases

BgeeiENSMUSG00000056966
CleanExiMM_GJE1
GenevisibleiQ921C1 MM

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.By similarity

GO - Molecular functioni

  • protein homodimerization activity Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000076367

Structurei

3D structure databases

ProteinModelPortaliQ921C1
SMRiQ921C1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the connexin family. Gamma-type subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J8Q3 Eukaryota
ENOG4111D69 LUCA
GeneTreeiENSGT00910000144026
HOGENOMiHOG000231127
HOVERGENiHBG107788
InParanoidiQ921C1
KOiK07628
OMAiIFLKTMF
OrthoDBiEOG091G06LA
PhylomeDBiQ921C1
TreeFamiTF329606

Family and domain databases

Gene3Di1.20.1440.80, 1 hit
InterProiView protein in InterPro
IPR000500 Connexin
IPR019570 Connexin_CCC
IPR017990 Connexin_CS
IPR013092 Connexin_N
IPR038359 Connexin_N_sf
PANTHERiPTHR11984 PTHR11984, 1 hit
PfamiView protein in Pfam
PF00029 Connexin, 1 hit
PRINTSiPR00206 CONNEXIN
SMARTiView protein in SMART
SM00037 CNX, 1 hit
SM01089 Connexin_CCC, 1 hit
PROSITEiView protein in PROSITE
PS00407 CONNEXINS_1, 1 hit
PS00408 CONNEXINS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q921C1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLLELPIKC RMCGRFLRQL LAQESQHSTP VGRFLLPMLM GFRLLILVSS
60 70 80 90 100
GPGVFGNDEN EFICHLGQPG CKTICYDVFR PLSPLRFWAF QVILMAVPSA
110 120 130 140 150
IYVAFTLYHV IGYWEVPGKE NKEQETQISK GDHSKDVSGA KSLKLLWAYV
160 170 180 190 200
AHLGVRLALE GAALGVQYNL YGFKMSSTFI CREDPCIGST TCFQSHPSEK
210 220 230 240 250
TIFLNIMFGI SGACFLFIFL ELALLGLGRF WRIYKHKLSF LKKLPTSESS
260
VRSKDTTDEL SVVEAKEPF
Length:269
Mass (Da):30,293
Last modified:November 25, 2008 - v2
Checksum:i13D9FF9C25C85D6A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY823670 Genomic DNA Translation: AAX39497.1
AY289210 mRNA Translation: AAP41202.1
AY293564 mRNA Translation: AAP50246.1
AY297108 mRNA Translation: AAP51160.1
AK034037 mRNA Translation: BAC28554.1
AK045577 mRNA Translation: BAC32421.1
AK047368 mRNA Translation: BAC33038.1
AK147913 mRNA Translation: BAE28224.1
CH466529 Genomic DNA Translation: EDL19225.1
CH466529 Genomic DNA Translation: EDL19226.1
BC125305 mRNA Translation: AAI25306.1
AJ297318 Genomic DNA Translation: CAC29245.1
AF503616 Genomic DNA Translation: AAM21146.1
CCDSiCCDS19782.1
RefSeqiNP_536698.2, NM_080450.4
UniGeneiMm.332771
Mm.475501

Genome annotation databases

EnsembliENSMUST00000077119; ENSMUSP00000076367; ENSMUSG00000056966
GeneIDi118446
KEGGimmu:118446
UCSCiuc009aeg.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCXG3_MOUSE
AccessioniPrimary (citable) accession number: Q921C1
Secondary accession number(s): Q53ZP5, Q8BHJ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: November 25, 2008
Last modified: March 28, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health