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Protein

Cytoglobin

Gene

Cygb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer. Plays a role in the development of liver fibrosis. Has a peroxidase activity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi81 – 811Iron (heme distal ligand)PROSITE-ProRule annotation
Metal bindingi113 – 1131Iron (heme proximal ligand)PROSITE-ProRule annotation

GO - Molecular functioni

  • catalase activity Source: RGD
  • fatty acid peroxidase activity Source: RGD
  • heme binding Source: RGD
  • iron ion binding Source: InterPro
  • oxygen binding Source: InterPro
  • oxygen transporter activity Source: UniProtKB-KW
  • peroxidase activity Source: UniProtKB

GO - Biological processi

  • fatty acid oxidation Source: RGD
  • negative regulation of collagen biosynthetic process Source: RGD
  • negative regulation of fibroblast migration Source: RGD
  • negative regulation of hepatic stellate cell activation Source: RGD
  • response to hypoxia Source: RGD
  • response to oxidative stress Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-203615. eNOS activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytoglobin
Alternative name(s):
Histoglobin
Short name:
HGb
Stellate cell activation-associated protein
Gene namesi
Name:Cygb
Synonyms:Stap
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi69415. Cygb.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • neuronal cell body Source: Ensembl
  • neuron projection Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 190190CytoglobinPRO_0000053386Add
BLAST

Proteomic databases

PaxDbiQ921A4.
PRIDEiQ921A4.

PTM databases

PhosphoSiteiQ921A4.

Expressioni

Tissue specificityi

Stellate cells and liver.

Gene expression databases

GenevisibleiQ921A4. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016067.

Structurei

3D structure databases

ProteinModelPortaliQ921A4.
SMRiQ921A4. Positions 17-188.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni17 – 167151GlobinAdd
BLAST

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
GeneTreeiENSGT00730000110844.
HOGENOMiHOG000112127.
HOVERGENiHBG100250.
InParanoidiQ921A4.
OMAiTHVTAAY.
OrthoDBiEOG7KSX9V.
PhylomeDBiQ921A4.
TreeFamiTF332967.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR013314. Globin_lamprey/hagfish.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR01906. FISHGLOBIN.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q921A4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKVPGDMEI ERRERNEELS EAERKAVQAT WARLYANCED VGVAILVRFF
60 70 80 90 100
VNFPSAKQYF SQFKHMEDPL EMERSPQLRK HACRVMGALN TVVENLHDPD
110 120 130 140 150
KVSSVLALVG KAHALKHKVE PMYFKILSGV ILDVIAEEFA NDFPVETQKA
160 170 180 190
WTKLRGLIYS HVTAAYKEVG WVQQVPNTTT LPATLPSSGP
Length:190
Mass (Da):21,497
Last modified:December 1, 2001 - v1
Checksum:i7EC3CB390DCEC804
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ245663 mRNA. Translation: CAC59827.1.
BC088455 mRNA. Translation: AAH88455.1.
RefSeqiNP_570100.1. NM_130744.2.
UniGeneiRn.105938.

Genome annotation databases

EnsembliENSRNOT00000016067; ENSRNOP00000016067; ENSRNOG00000011541.
GeneIDi170520.
KEGGirno:170520.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ245663 mRNA. Translation: CAC59827.1.
BC088455 mRNA. Translation: AAH88455.1.
RefSeqiNP_570100.1. NM_130744.2.
UniGeneiRn.105938.

3D structure databases

ProteinModelPortaliQ921A4.
SMRiQ921A4. Positions 17-188.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016067.

PTM databases

PhosphoSiteiQ921A4.

Proteomic databases

PaxDbiQ921A4.
PRIDEiQ921A4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000016067; ENSRNOP00000016067; ENSRNOG00000011541.
GeneIDi170520.
KEGGirno:170520.

Organism-specific databases

CTDi114757.
RGDi69415. Cygb.

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
GeneTreeiENSGT00730000110844.
HOGENOMiHOG000112127.
HOVERGENiHBG100250.
InParanoidiQ921A4.
OMAiTHVTAAY.
OrthoDBiEOG7KSX9V.
PhylomeDBiQ921A4.
TreeFamiTF332967.

Enzyme and pathway databases

ReactomeiR-RNO-203615. eNOS activation.

Miscellaneous databases

PROiQ921A4.

Gene expression databases

GenevisibleiQ921A4. RN.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR013314. Globin_lamprey/hagfish.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR01906. FISHGLOBIN.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a stellate cell activation-associated protein (STAP) with peroxidase activity found in rat hepatic stellate cells."
    Kawada N., Kristensen D.B., Asahina K., Nakatani K., Minamiyama Y., Seki S., Yoshizato K.
    J. Biol. Chem. 276:25318-25323(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 5-12 AND 36-44.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiCYGB_RAT
AccessioniPrimary (citable) accession number: Q921A4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.