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Protein

Proton myo-inositol cotransporter

Gene

Slc2a13

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

H+-myo-inositol cotransporter. Can also transport related stereoisomers.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-RNO-429593 Inositol transporters

Names & Taxonomyi

Protein namesi
Recommended name:
Proton myo-inositol cotransporter
Short name:
H(+)-myo-inositol cotransporter
Short name:
Hmit
Alternative name(s):
H(+)-myo-inositol symporter
Solute carrier family 2 member 13
Gene namesi
Name:Slc2a13
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi621814 Slc2a13

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 65CytoplasmicSequence analysisAdd BLAST65
Transmembranei66 – 86Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini87 – 114ExtracellularSequence analysisAdd BLAST28
Transmembranei115 – 135Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini136 – 137CytoplasmicSequence analysis2
Transmembranei138 – 158Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini159 – 167ExtracellularSequence analysis9
Transmembranei168 – 188Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini189 – 201CytoplasmicSequence analysisAdd BLAST13
Transmembranei202 – 222Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini223 – 228ExtracellularSequence analysis6
Transmembranei229 – 249Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini250 – 313CytoplasmicSequence analysisAdd BLAST64
Transmembranei314 – 334Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini335 – 352ExtracellularSequence analysisAdd BLAST18
Transmembranei353 – 373Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini374 – 382CytoplasmicSequence analysis9
Transmembranei383 – 403Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini404 – 497ExtracellularSequence analysisAdd BLAST94
Transmembranei498 – 518Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini519 – 538CytoplasmicSequence analysisAdd BLAST20
Transmembranei539 – 559Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini560 – 562ExtracellularSequence analysis3
Transmembranei563 – 583Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini584 – 637CytoplasmicSequence analysisAdd BLAST54

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000504571 – 637Proton myo-inositol cotransporterAdd BLAST637

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6PhosphoserineBy similarity1
Modified residuei44PhosphoserineCombined sources1
Modified residuei47PhosphoserineCombined sources1
Glycosylationi422N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi447N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi474N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei629PhosphoserineCombined sources1
Modified residuei634PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ921A2
PRIDEiQ921A2

PTM databases

iPTMnetiQ921A2
PhosphoSitePlusiQ921A2

Expressioni

Gene expression databases

BgeeiENSRNOG00000015741
GenevisibleiQ921A2 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021153

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0254 Eukaryota
ENOG410XNQK LUCA
GeneTreeiENSGT00910000144116
HOGENOMiHOG000202868
HOVERGENiHBG031722
InParanoidiQ921A2
KOiK08150
OMAiSWGVVVW
OrthoDBiEOG091G046D
PhylomeDBiQ921A2
TreeFamiTF314916

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 2 hits
PRINTSiPR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 2 hits
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit
PS00217 SUGAR_TRANSPORT_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q921A2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRKASEDVE YTLRSLSSLM GERRRRQPEP GAPGGERSLL AAESAASLQG
60 70 80 90 100
AELERAARRQ FQRDETPAFV YAAAAFSALG GFLFGYDTGV VSGAMLLLRR
110 120 130 140 150
QMRLGAMWQE LLVSGAVGAA AVAALAGGAL NGALGRRSAI LLASALCTVG
160 170 180 190 200
SAVLAAAANK ETLLAGRLVV GLGIGIASMT VPVYIAEVSP PNLRGRLVTI
210 220 230 240 250
NTLFITGGQF FASVVDGAFS YLQKDGWRYM LGLAAIPAVI QFLGFLFLPE
260 270 280 290 300
SPRWLIQKGQ TQKARRILSQ MRGNQTIDEE YDSIRNSIEE EEKEASAAGP
310 320 330 340 350
IICRMLSYPP TRRALAVGCG LQMFQQLSGI NTIMYYSATI LQMSGVEDDR
360 370 380 390 400
LAIWLASITA FTNFIFTLVG VWLVEKVGRR KLTFGSLAGT TVALTILALG
410 420 430 440 450
FLLSAQVSPR VTFRPTAPSG QNATCTEYSY CNECMLDPDC GFCYKINSSA
460 470 480 490 500
VIDSSCVPVN KASTNEAAWG RCENETKFKA EDVHWAYSFC PTPYSWTALV
510 520 530 540 550
GLVLYLVFFA PGMGPMPWTV NSEIYPLWAR STGNACSAGI NWIFNVLVSL
560 570 580 590 600
TFLHTAEYLT YYGAFFLYAG FAAVGLLFVY GCLPETKGKK LEEIESLFDH
610 620 630
RLCTCGTADS DEGRYIEYIR VKGSNYHLSD NDASDVE
Length:637
Mass (Da):69,149
Last modified:April 20, 2010 - v2
Checksum:iE8539A372600FBD9
GO

Sequence cautioni

The sequence CAC51117 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ315643 mRNA Translation: CAC51117.1 Different initiation.
RefSeqiNP_598295.2, NM_133611.2
UniGeneiRn.7568

Genome annotation databases

EnsembliENSRNOT00000021153; ENSRNOP00000021153; ENSRNOG00000015741
GeneIDi171147
KEGGirno:171147

Similar proteinsi

Entry informationi

Entry nameiMYCT_RAT
AccessioniPrimary (citable) accession number: Q921A2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: April 20, 2010
Last modified: April 25, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health