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Protein

Proton myo-inositol cotransporter

Gene

Slc2a13

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

H+-myo-inositol cotransporter. Can also transport related stereoisomers.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-RNO-429593. Inositol transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Proton myo-inositol cotransporter
Short name:
H(+)-myo-inositol cotransporter
Short name:
Hmit
Alternative name(s):
H(+)-myo-inositol symporter
Solute carrier family 2 member 13
Gene namesi
Name:Slc2a13
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi621814. Slc2a13.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 65CytoplasmicSequence analysisAdd BLAST65
Transmembranei66 – 86Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini87 – 114ExtracellularSequence analysisAdd BLAST28
Transmembranei115 – 135Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini136 – 137CytoplasmicSequence analysis2
Transmembranei138 – 158Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini159 – 167ExtracellularSequence analysis9
Transmembranei168 – 188Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini189 – 201CytoplasmicSequence analysisAdd BLAST13
Transmembranei202 – 222Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini223 – 228ExtracellularSequence analysis6
Transmembranei229 – 249Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini250 – 313CytoplasmicSequence analysisAdd BLAST64
Transmembranei314 – 334Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini335 – 352ExtracellularSequence analysisAdd BLAST18
Transmembranei353 – 373Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini374 – 382CytoplasmicSequence analysis9
Transmembranei383 – 403Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini404 – 497ExtracellularSequence analysisAdd BLAST94
Transmembranei498 – 518Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini519 – 538CytoplasmicSequence analysisAdd BLAST20
Transmembranei539 – 559Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini560 – 562ExtracellularSequence analysis3
Transmembranei563 – 583Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini584 – 637CytoplasmicSequence analysisAdd BLAST54

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000504571 – 637Proton myo-inositol cotransporterAdd BLAST637

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6PhosphoserineBy similarity1
Modified residuei44PhosphoserineCombined sources1
Modified residuei47PhosphoserineCombined sources1
Glycosylationi422N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi447N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi474N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei629PhosphoserineCombined sources1
Modified residuei634PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ921A2.
PRIDEiQ921A2.

PTM databases

iPTMnetiQ921A2.
PhosphoSitePlusiQ921A2.

Expressioni

Gene expression databases

BgeeiENSRNOG00000015741.
GenevisibleiQ921A2. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021153.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0254. Eukaryota.
ENOG410XNQK. LUCA.
GeneTreeiENSGT00890000139365.
HOGENOMiHOG000202868.
HOVERGENiHBG031722.
InParanoidiQ921A2.
KOiK08150.
OMAiSWGVVVW.
OrthoDBiEOG091G046D.
PhylomeDBiQ921A2.
TreeFamiTF314916.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiView protein in InterPro
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
PfamiView protein in Pfam
PF00083. Sugar_tr. 2 hits.
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiView protein in PROSITE
PS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q921A2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRKASEDVE YTLRSLSSLM GERRRRQPEP GAPGGERSLL AAESAASLQG
60 70 80 90 100
AELERAARRQ FQRDETPAFV YAAAAFSALG GFLFGYDTGV VSGAMLLLRR
110 120 130 140 150
QMRLGAMWQE LLVSGAVGAA AVAALAGGAL NGALGRRSAI LLASALCTVG
160 170 180 190 200
SAVLAAAANK ETLLAGRLVV GLGIGIASMT VPVYIAEVSP PNLRGRLVTI
210 220 230 240 250
NTLFITGGQF FASVVDGAFS YLQKDGWRYM LGLAAIPAVI QFLGFLFLPE
260 270 280 290 300
SPRWLIQKGQ TQKARRILSQ MRGNQTIDEE YDSIRNSIEE EEKEASAAGP
310 320 330 340 350
IICRMLSYPP TRRALAVGCG LQMFQQLSGI NTIMYYSATI LQMSGVEDDR
360 370 380 390 400
LAIWLASITA FTNFIFTLVG VWLVEKVGRR KLTFGSLAGT TVALTILALG
410 420 430 440 450
FLLSAQVSPR VTFRPTAPSG QNATCTEYSY CNECMLDPDC GFCYKINSSA
460 470 480 490 500
VIDSSCVPVN KASTNEAAWG RCENETKFKA EDVHWAYSFC PTPYSWTALV
510 520 530 540 550
GLVLYLVFFA PGMGPMPWTV NSEIYPLWAR STGNACSAGI NWIFNVLVSL
560 570 580 590 600
TFLHTAEYLT YYGAFFLYAG FAAVGLLFVY GCLPETKGKK LEEIESLFDH
610 620 630
RLCTCGTADS DEGRYIEYIR VKGSNYHLSD NDASDVE
Length:637
Mass (Da):69,149
Last modified:April 20, 2010 - v2
Checksum:iE8539A372600FBD9
GO

Sequence cautioni

The sequence CAC51117 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ315643 mRNA. Translation: CAC51117.1. Different initiation.
RefSeqiNP_598295.2. NM_133611.2.
UniGeneiRn.7568.

Genome annotation databases

EnsembliENSRNOT00000021153; ENSRNOP00000021153; ENSRNOG00000015741.
GeneIDi171147.
KEGGirno:171147.

Similar proteinsi

Entry informationi

Entry nameiMYCT_RAT
AccessioniPrimary (citable) accession number: Q921A2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: April 20, 2010
Last modified: August 30, 2017
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families