Q92197 (CHSC_ASPFU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chitin synthase C
EC=2.4.1.16

Alternative name(s):
Chitin-UDP acetyl-glucosaminyl transferase C
Class-III chitin synthase C

Gene names

Name:	chsC
ORF Names:	AFUA_5G00760

Organism

Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)

Taxonomic identifier

330879 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

Protein attributes

Sequence length	893 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Plays a major role in cell wall biogenesis.
Catalytic activity	UDP-N-acetyl-D-glucosamine + (1,4-(N-acetyl-beta-D-glucosaminyl))(n) = UDP + (1,4-(N-acetyl-beta-D-glucosaminyl))(n+1).
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the chitin synthase family. Class III subfamily.
Sequence caution	The sequence EAL86225.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Cell wall biogenesis/degradation
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW chitin biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	chitin synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 893	893	Chitin synthase C		PRO_0000193680
Regions
	Transmembrane	565 – 585	21	Helical; Potential
	Transmembrane	606 – 626	21	Helical; Potential
	Transmembrane	640 – 660	21	Helical; Potential
	Transmembrane	690 – 710	21	Helical; Potential
	Transmembrane	721 – 741	21	Helical; Potential
	Transmembrane	822 – 842	21	Helical; Potential
	Transmembrane	861 – 881	21	Helical; Potential
Experimental info
	Sequence conflict	29	1	Missing in EAL86225. Ref.2
	Sequence conflict	198	1	L → R in CAA63929. Ref.1
	Sequence conflict	633 – 636	4	Missing in CAA63929. Ref.1
	Sequence conflict	769	1	G → A in CAA63929. Ref.1
	Sequence conflict	796	1	A → R in CAA63929. Ref.1
	Sequence conflict	839	1	N → S in CAA63929. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q92197 [UniParc]. Last modified December 6, 2005. Version 2. Checksum: 193A30241858960A	FASTA	893	101,041
	10 20 30 40 50 60 MGTPRPYSAH SPQESRSSFY SQPSQSPTQP TYGRDDAEDQ QQSLLRRSLA SPNGWSYDDP 70 80 90 100 110 120 NVSTDSLRRY TLHDPGITAF APPYPESEAA DVRSARMSGY SGIEMDAWQR RQGVKPSALR 130 140 150 160 170 180 RYGTRKINLV QGSVLSVDYP VPSAIQNAIQ AEYRDAEEAF HEEFTHMRYT AATCDPDEFT 190 200 210 220 230 240 LRNGYNLRPA MYNRHTELLI AITYYNEDKV LTARTLHGVM QNVRDIVNLK KSEFWNKGGP 250 260 270 280 290 300 AWQKIVVCLV FDGIEPCDKN TLDVLATIGV YQDGVMKKDV DGRETVAHIF EYTTQLSVTP 310 320 330 340 350 360 TQQLVRPQPN DPSNLPPVQM LFCLKQKNSK KINSHRWLFN AFSRILNPEI CILLDAGTKP 370 380 390 400 410 420 GSKSLLALWE AFYNDKTLGG ACGEIHAMLG RGWRNVLNPL VAAQNFEYKI SNILDKPLES 430 440 450 460 470 480 AFGYVSVLPG AFSAYRYRAI MGRPLEQYFH GDHTLSKRLG KKGIEGMNIF KKNMFLAEDR 490 500 510 520 530 540 ILCFELVAKA GYKWHLTYVK ASKGETDVPE AAPEYISQRR RWLNGSFAAS LYSIMHFGRI 550 560 570 580 590 600 YKSGHSFVRM FFLHIQMIYN CCQLIMTWFS LASYWLTSSV IMDLVGTPSS HNKYKAWPFG 610 620 630 640 650 660 NDASPIVNFF VKYGYLLVLM LQFVLALGNR PKGTKLAYTM SFLWFSLVQF YVLILSFYLV 670 680 690 700 710 720 ANAFMGGMID FDFDQGVGNF LSSFFSSTGG GIVLIALVST YGIYIVASIL YMDPWHILTS 730 740 750 760 770 780 SWAYFLGMTT SINILMVYAF CNWHDVSWGT KGSDKADALP SAQTKKADGS KSNFIEEIDK 790 800 810 820 830 840 PQADIDSQFE ATVKRALAPY QEPKEDSTIS LDDSYRNFRT SLVLLWILSN LLVSLLITND 850 860 870 880 890 GIRKMCLTNT STTRTQYYFQ VILWATAGLS IFRFIGSIYF LGKSGILCCV TRR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The Aspergillus fumigatus chsC and chsG genes encode class III chitin synthases with different functions." Mellado E., Aufauvre-Brown A., Gow N.A.R., Holden D.W. Mol. Microbiol. 20:667-679(1996) [PubMed: 8736545] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: H237.
[2]	"Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus." Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L. , Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.G., Denning D.W. Nature 438:1151-1156(2005) [PubMed: 16372009] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X94245 Genomic DNA. Translation: CAA63929.1. AAHF01000011 Genomic DNA. Translation: EAL86225.1. Sequence problems.
PIR	JC6015.
RefSeq	XP_748263.1. XM_743170.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q92197.
Protein family/group databases
CAZy	GT2. Glycosyltransferase Family 2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3505740.
GenomeReviews	Gene locus chsC in contig CM000173_GR.
KEGG	afm:AFUA_5G00760.
Phylogenomic databases
eggNOG	fuNOG07505.
GeneTree	EFGT00050000001909.
HOGENOM	HBG327157.
OrthoDB	EOG4Z39NW.
Enzyme and pathway databases
BRENDA	2.4.1.16. 517.
Family and domain databases
InterPro	IPR004834. Chitin_synth. IPR013616. Chitin_synth_N. [Graphical view]
KO	K00698.
Pfam	PF01644. Chitin_synth_1. 1 hit. PF08407. Chitin_synth_1N. 1 hit. [Graphical view]
ProDom	PD002998. Chitin_synth. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

CHSC_ASPFU

Accession

Primary (citable) accession number: Q92197
Secondary accession number(s): Q4WDV2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	December 6, 2005
Last modified:	December 14, 2011
This is version 78 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program