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Protein

Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase

Gene

ST8SIA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the production of gangliosides GD3 and GT3 from GM3; gangliosides are a subfamily of complex glycosphinglolipds that contain one or more residues of sialic acid.4 Publications

Catalytic activityi

CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R.4 Publications

Pathway: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

Pathway: sphingolipid metabolism

This protein is involved in the pathway sphingolipid metabolism, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway sphingolipid metabolism and in Lipid metabolism.

GO - Molecular functioni

  • alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity Source: UniProtKB-EC
  • sialyltransferase activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid metabolism, Sphingolipid metabolism

Enzyme and pathway databases

BRENDAi2.4.99.8. 2681.
ReactomeiREACT_264366. Sialic acid metabolism.
UniPathwayiUPA00222.
UPA00378.

Protein family/group databases

CAZyiGT29. Glycosyltransferase Family 29.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase (EC:2.4.99.8)
Alternative name(s):
Alpha-2,8-sialyltransferase 8A
Ganglioside GD3 synthase
Ganglioside GT3 synthase
Sialyltransferase 8A
Short name:
SIAT8-A
Sialyltransferase St8Sia I
Short name:
ST8SiaI
Gene namesi
Name:ST8SIA1
Synonyms:SIAT8, SIAT8A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:10869. ST8SIA1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2929CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei30 – 4819Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini49 – 356308LumenalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • Golgi membrane Source: Reactome
  • integral component of Golgi membrane Source: InterPro
  • integral component of membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35770.

Polymorphism and mutation databases

BioMutaiST8SIA1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 356356Alpha-N-acetylneuraminide alpha-2,8-sialyltransferasePRO_0000149282Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi71 – 711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi138 ↔ 287By similarity
Glycosylationi214 – 2141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi245 – 2451N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ92185.
PeptideAtlasiQ92185.
PRIDEiQ92185.

PTM databases

PhosphoSiteiQ92185.

Expressioni

Tissue specificityi

Strongly expressed in melanoma cell lines, adult and fetal brain and to a lesser extent in adult and fetal lung.2 Publications

Gene expression databases

BgeeiQ92185.
CleanExiHS_ST8SIA1.
ExpressionAtlasiQ92185. baseline and differential.
GenevisibleiQ92185. HS.

Organism-specific databases

HPAiHPA026775.

Interactioni

Protein-protein interaction databases

BioGridi112380. 9 interactions.
STRINGi9606.ENSP00000379353.

Structurei

3D structure databases

ProteinModelPortaliQ92185.
SMRiQ92185. Positions 136-315.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 29 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG272094.
GeneTreeiENSGT00550000074407.
HOGENOMiHOG000090201.
HOVERGENiHBG106106.
InParanoidiQ92185.
KOiK03371.
OMAiCGRARRH.
OrthoDBiEOG7SV0V9.
PhylomeDBiQ92185.
TreeFamiTF323961.

Family and domain databases

InterProiIPR001675. Glyco_trans_29.
IPR012163. Sialyl_trans.
[Graphical view]
PfamiPF00777. Glyco_transf_29. 1 hit.
[Graphical view]
PIRSFiPIRSF005557. Sialyl_trans. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q92185-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSPCGRARRQ TSRGAMAVLA WKFPRTRLPM GASALCVVVL CWLYIFPVYR
60 70 80 90 100
LPNEKEIVQG VLQQGTAWRR NQTAARAFRK QMEDCCDPAH LFAMTKMNSP
110 120 130 140 150
MGKSMWYDGE FLYSFTIDNS TYSLFPQATP FQLPLKKCAV VGNGGILKKS
160 170 180 190 200
GCGRQIDEAN FVMRCNLPPL SSEYTKDVGS KSQLVTANPS IIRQRFQNLL
210 220 230 240 250
WSRKTFVDNM KIYNHSYIYM PAFSMKTGTE PSLRVYYTLS DVGANQTVLF
260 270 280 290 300
ANPNFLRSIG KFWKSRGIHA KRLSTGLFLV SAALGLCEEV AIYGFWPFSV
310 320 330 340 350
NMHEQPISHH YYDNVLPFSG FHAMPEEFLQ LWYLHKIGAL RMQLDPCEDT

SLQPTS
Length:356
Mass (Da):40,519
Last modified:February 1, 1997 - v1
Checksum:i452FE04856964395
GO
Isoform 2 (identifier: Q92185-2) [UniParc]FASTAAdd to basket

Also known as: Sat-2

The sequence of this isoform differs from the canonical sequence as follows:
     128-135: ATPFQLPL → MQSPSFVK
     136-356: Missing.

Show »
Length:135
Mass (Da):15,504
Checksum:iC6807FD99973BDDC
GO

Sequence cautioni

The sequence AAC37586.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAA54891.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei128 – 1358ATPFQLPL → MQSPSFVK in isoform 2. 2 PublicationsVSP_047583
Alternative sequencei136 – 356221Missing in isoform 2. 2 PublicationsVSP_047584Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77922 mRNA. Translation: CAA54891.1. Different initiation.
D26360 mRNA. Translation: BAA05391.1.
L32867 mRNA. Translation: AAA62366.1.
L43494 mRNA. Translation: AAC37586.1. Different initiation.
AY569975 mRNA. Translation: AAS75783.1.
EU041716 mRNA. Translation: ABU62753.1.
AK290941 mRNA. Translation: BAF83630.1.
AK315340 mRNA. Translation: BAG37739.1.
AC007544 Genomic DNA. No translation available.
AC007671 Genomic DNA. No translation available.
AC053513 Genomic DNA. No translation available.
AC087318 Genomic DNA. No translation available.
AC138468 Genomic DNA. No translation available.
CH471094 Genomic DNA. Translation: EAW96468.1.
BC117285 mRNA. Translation: AAI17286.1.
BC126162 mRNA. Translation: AAI26163.1.
CCDSiCCDS8697.1. [Q92185-1]
PIRiA54032.
RefSeqiNP_003025.1. NM_003034.3. [Q92185-1]
UniGeneiHs.408614.

Genome annotation databases

EnsembliENST00000261197; ENSP00000261197; ENSG00000111728. [Q92185-2]
ENST00000396037; ENSP00000379353; ENSG00000111728. [Q92185-1]
GeneIDi6489.
KEGGihsa:6489.
UCSCiuc001rfo.4. human. [Q92185-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

GGDB

GlycoGene database

Functional Glycomics Gateway - GTase

ST8Sia I

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77922 mRNA. Translation: CAA54891.1. Different initiation.
D26360 mRNA. Translation: BAA05391.1.
L32867 mRNA. Translation: AAA62366.1.
L43494 mRNA. Translation: AAC37586.1. Different initiation.
AY569975 mRNA. Translation: AAS75783.1.
EU041716 mRNA. Translation: ABU62753.1.
AK290941 mRNA. Translation: BAF83630.1.
AK315340 mRNA. Translation: BAG37739.1.
AC007544 Genomic DNA. No translation available.
AC007671 Genomic DNA. No translation available.
AC053513 Genomic DNA. No translation available.
AC087318 Genomic DNA. No translation available.
AC138468 Genomic DNA. No translation available.
CH471094 Genomic DNA. Translation: EAW96468.1.
BC117285 mRNA. Translation: AAI17286.1.
BC126162 mRNA. Translation: AAI26163.1.
CCDSiCCDS8697.1. [Q92185-1]
PIRiA54032.
RefSeqiNP_003025.1. NM_003034.3. [Q92185-1]
UniGeneiHs.408614.

3D structure databases

ProteinModelPortaliQ92185.
SMRiQ92185. Positions 136-315.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112380. 9 interactions.
STRINGi9606.ENSP00000379353.

Protein family/group databases

CAZyiGT29. Glycosyltransferase Family 29.

PTM databases

PhosphoSiteiQ92185.

Polymorphism and mutation databases

BioMutaiST8SIA1.

Proteomic databases

PaxDbiQ92185.
PeptideAtlasiQ92185.
PRIDEiQ92185.

Protocols and materials databases

DNASUi6489.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261197; ENSP00000261197; ENSG00000111728. [Q92185-2]
ENST00000396037; ENSP00000379353; ENSG00000111728. [Q92185-1]
GeneIDi6489.
KEGGihsa:6489.
UCSCiuc001rfo.4. human. [Q92185-1]

Organism-specific databases

CTDi6489.
GeneCardsiGC12M022119.
HGNCiHGNC:10869. ST8SIA1.
HPAiHPA026775.
MIMi601123. gene.
neXtProtiNX_Q92185.
PharmGKBiPA35770.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG272094.
GeneTreeiENSGT00550000074407.
HOGENOMiHOG000090201.
HOVERGENiHBG106106.
InParanoidiQ92185.
KOiK03371.
OMAiCGRARRH.
OrthoDBiEOG7SV0V9.
PhylomeDBiQ92185.
TreeFamiTF323961.

Enzyme and pathway databases

UniPathwayiUPA00222.
UPA00378.
BRENDAi2.4.99.8. 2681.
ReactomeiREACT_264366. Sialic acid metabolism.

Miscellaneous databases

ChiTaRSiST8SIA1. human.
GeneWikiiST8SIA1.
GenomeRNAii6489.
NextBioi25217.
PROiQ92185.
SOURCEiSearch...

Gene expression databases

BgeeiQ92185.
CleanExiHS_ST8SIA1.
ExpressionAtlasiQ92185. baseline and differential.
GenevisibleiQ92185. HS.

Family and domain databases

InterProiIPR001675. Glyco_trans_29.
IPR012163. Sialyl_trans.
[Graphical view]
PfamiPF00777. Glyco_transf_29. 1 hit.
[Graphical view]
PIRSFiPIRSF005557. Sialyl_trans. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression cloning of a GM3-specific alpha-2,8-sialyltransferase (GD3 synthase)."
    Sasaki K., Kurata K., Kojima N., Kurosawa N., Ohta S., Hanai N., Tsuji S., Nishi T.
    J. Biol. Chem. 269:15950-15956(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY.
    Tissue: Melanoma.
  2. "Expression cloning of a CMP-NeuAc:NeuAc alpha 2-3Gal beta 1-4Glc beta 1-1'Cer alpha 2,8-sialyltransferase (GD3 synthase) from human melanoma cells."
    Nara K., Watanabe Y., Maruyama K., Kasahara K., Nagai Y., Sanai Y.
    Proc. Natl. Acad. Sci. U.S.A. 91:7952-7956(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY.
    Tissue: Melanoma.
  3. "Isolation of GD3 synthase gene by expression cloning of GM3 alpha-2,8-sialyltransferase cDNA using anti-GD2 monoclonal antibody."
    Haraguchi M., Yamashiro S., Yamamoto A., Furukawa K., Takamiya K., Lloyd K.O., Shiku H., Furukawa K.
    Proc. Natl. Acad. Sci. U.S.A. 91:10455-10459(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, TISSUE SPECIFICITY.
  4. "Expression cloning of a human GT3 synthase. GD3 and GT3 are synthesized by a single enzyme."
    Nakayama J., Fukuda M.N., Hirabayashi Y., Kanamori A., Sasaki K., Nishi T., Fukuda M.
    J. Biol. Chem. 271:3684-3691(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, CATALYTIC ACTIVITY, TISSUE SPECIFICITY.
  5. "Cloning of alternative human SAT-2 mRNA."
    Rimoldi S., Papis E., Bernardini G., Gornati R.
    Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING.
  6. "Alternative splice variant of the ST8SIA1 gene."
    Konta L., Laws S.M., Riemenschneider M., Adamski J.
    Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING.
  7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Stomach and Teratocarcinoma.
  8. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon.
  11. "The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach."
    Harduin-Lepers A., Mollicone R., Delannoy P., Oriol R.
    Glycobiology 15:805-817(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiSIA8A_HUMAN
AccessioniPrimary (citable) accession number: Q92185
Secondary accession number(s): A8K4H6
, Q17RL0, Q6PZN5, Q93064
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: June 24, 2015
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.