Q92183 (SIA7A_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
EC=2.4.99.3

Alternative name(s):
GalNAc alpha-2,6-sialyltransferase I
ST6GalNAc I
Short name=ST6GalNAcI
Sialyltransferase 7A
Short name=SIAT7-A

Gene names

Name:	ST6GALNAC1
Synonyms:	SIAT7A

Organism

Gallus gallus (Chicken) [Reference proteome]

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	566 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-((2->6)-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein.
Pathway	Protein modification; protein glycosylation.
Subcellular location	Golgi apparatus membrane; Single-pass type II membrane protein Potential.
Tissue specificity	Heart, kidney, testes, brain, liver and lung.
Developmental stage	Embryo.
Sequence similarities	Belongs to the glycosyltransferase 29 family.

Ontologies

Keywords
Cellular component	Golgi apparatus Membrane
Domain	Repeat Signal-anchor Transmembrane Transmembrane helix
Molecular function	Glycosyltransferase Transferase
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	oligosaccharide biosynthetic process Inferred from electronic annotation. Source: Compara protein glycosylation Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 566	566	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1		PRO_0000149271
Regions
	Topological domain	1 – 16	16	Cytoplasmic Potential
	Transmembrane	17 – 37	21	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	38 – 566	529	Lumenal Potential
	Repeat	247 – 254	8	1
	Repeat	330 – 337	8	2
	Region	247 – 337	91	2 X 8 AA repeats of S-S-S-X-V-S-T-C
Amino acid modifications
	Glycosylation	66	1	N-linked (GlcNAc...) Potential
	Glycosylation	132	1	N-linked (GlcNAc...) Potential
	Glycosylation	192	1	N-linked (GlcNAc...) Potential
	Glycosylation	275	1	N-linked (GlcNAc...) Potential
	Glycosylation	286	1	N-linked (GlcNAc...) Potential
	Glycosylation	306	1	N-linked (GlcNAc...) Potential
	Glycosylation	329	1	N-linked (GlcNAc...) Potential
	Glycosylation	333	1	N-linked (GlcNAc...) Potential
	Disulfide bond	340 ↔ 508		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q92183 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: E529CA94027757DF	FASTA	566	64,781
	10 20 30 40 50 60 MGFLIRRLPK DSRIFRWLLI LTVFSFIITS FSALFGMEKS IFRQLKIYQS IAHMLQVDTQ 70 80 90 100 110 120 DQQGSNYSAN GRISKVGLER DIAWLELNTA VSTPSGEGKE EQKKTVKPVA KVEEAKEKVT 130 140 150 160 170 180 VKPFPEVMGI TNTTASTASV VERTKEKTTA RPVPGVGEAD GKRTTIALPS MKEDKEKATV 190 200 210 220 230 240 KPSFGMKVAH ANSTSKDKPK AEEPPASVKA IRPVTQAATV TEKKKLRAAD FKTEPQWDFD 250 260 270 280 290 300 DEYILDSSSP VSTCSESVRA KAAKSDWLRD LFLPNITLFI DKSYFNVSEW DRLEHFAPPY 310 320 330 340 350 360 GFMELNYSLV EEVMSRLPPN PHQQLLLANS SSNVSTCISC AVVGNGGILN NSGMGQEIDS 370 380 390 400 410 420 HDYVFRVSGA VIKGYEKDVG TKTSFYGFTA YSLVSSLQNL GHKGFKKIPQ GKHIRYIHFL 430 440 450 460 470 480 EAVRDYEWLK ALLLDKDIRK GFLNYYGRRP RERFDEDFTM NKYLVAHPDF LRYLKNRFLK 490 500 510 520 530 540 SKNLQKPYWR LYRPTTGALL LLTALHLCDR VSAYGYITEG HQKYSDHYYD KEWKRLVFYV 550 560 NHDFNLEKQV WKRLHDENIM KLYQRS

References

[1]	"Molecular cloning and expression of GalNAc alpha 2,6-sialyltransferase." Kurosawa N., Hamamoto T., Lee Y.-C., Nakaoka T., Kojima N., Tsuji S. J. Biol. Chem. 269:1402-1409(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Embryo.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X74946 mRNA. Translation: CAA52902.1.
IPI	IPI00599291.
PIR	A49880.
RefSeq	NP_990571.1. NM_205240.1.
UniGene	Gga.688.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	9031.ENSGALP00000002878.
Protein family/group databases
CAZy	GT29. Glycosyltransferase Family 29.
Proteomic databases
PaxDb	Q92183.
PRIDE	Q92183.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSGALT00000002882; ENSGALP00000002878; ENSGALG00000001862.
GeneID	396168.
KEGG	gga:396168.
Organism-specific databases
CTD	55808.
Phylogenomic databases
eggNOG	NOG292294.
GeneTree	ENSGT00620000087743.
HOGENOM	HOG000231097.
HOVERGEN	HBG073351.
InParanoid	Q92183.
KO	K03479.
OMA	GYITEGH.
OrthoDB	EOG4CJVHZ.
Enzyme and pathway databases
UniPathway	UPA00378.
Family and domain databases
InterPro	IPR001675. Glyco_trans_29. [Graphical view]
Pfam	PF00777. Glyco_transf_29. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20816222.

Entry information

Entry name

SIA7A_CHICK

Accession

Primary (citable) accession number: Q92183

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	May 29, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program