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Protein

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1

Gene

ST6GALNAC1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-((2->6)-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-GGA-4085001. Sialic acid metabolism.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT29. Glycosyltransferase Family 29.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 (EC:2.4.99.3)
Alternative name(s):
GalNAc alpha-2,6-sialyltransferase I
ST6GalNAc I
Short name:
ST6GalNAcI
Sialyltransferase 7A
Short name:
SIAT7-A
Gene namesi
Name:ST6GALNAC1
Synonyms:SIAT7A
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 18

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1616CytoplasmicSequence analysisAdd
BLAST
Transmembranei17 – 3721Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini38 – 566529LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 566566Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1PRO_0000149271Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi66 – 661N-linked (GlcNAc...)Sequence analysis
Glycosylationi132 – 1321N-linked (GlcNAc...)Sequence analysis
Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence analysis
Glycosylationi275 – 2751N-linked (GlcNAc...)Sequence analysis
Glycosylationi286 – 2861N-linked (GlcNAc...)Sequence analysis
Glycosylationi306 – 3061N-linked (GlcNAc...)Sequence analysis
Glycosylationi329 – 3291N-linked (GlcNAc...)Sequence analysis
Glycosylationi333 – 3331N-linked (GlcNAc...)Sequence analysis
Disulfide bondi340 ↔ 508By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ92183.
PRIDEiQ92183.

Expressioni

Tissue specificityi

Heart, kidney, testes, brain, liver and lung.

Developmental stagei

Embryo.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000002878.

Structurei

3D structure databases

ProteinModelPortaliQ92183.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati247 – 25481
Repeati330 – 33782

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni247 – 337912 X 8 AA repeats of S-S-S-X-V-S-T-CAdd
BLAST

Sequence similaritiesi

Belongs to the glycosyltransferase 29 family.Curated

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2692. Eukaryota.
ENOG410XT8P. LUCA.
GeneTreeiENSGT00760000119095.
HOGENOMiHOG000231097.
HOVERGENiHBG073351.
InParanoidiQ92183.
KOiK03479.
OMAiTCISCAV.
OrthoDBiEOG7J17ZK.
PhylomeDBiQ92183.
TreeFamiTF354325.

Family and domain databases

InterProiIPR001675. Glyco_trans_29.
[Graphical view]
PfamiPF00777. Glyco_transf_29. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92183-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFLIRRLPK DSRIFRWLLI LTVFSFIITS FSALFGMEKS IFRQLKIYQS
60 70 80 90 100
IAHMLQVDTQ DQQGSNYSAN GRISKVGLER DIAWLELNTA VSTPSGEGKE
110 120 130 140 150
EQKKTVKPVA KVEEAKEKVT VKPFPEVMGI TNTTASTASV VERTKEKTTA
160 170 180 190 200
RPVPGVGEAD GKRTTIALPS MKEDKEKATV KPSFGMKVAH ANSTSKDKPK
210 220 230 240 250
AEEPPASVKA IRPVTQAATV TEKKKLRAAD FKTEPQWDFD DEYILDSSSP
260 270 280 290 300
VSTCSESVRA KAAKSDWLRD LFLPNITLFI DKSYFNVSEW DRLEHFAPPY
310 320 330 340 350
GFMELNYSLV EEVMSRLPPN PHQQLLLANS SSNVSTCISC AVVGNGGILN
360 370 380 390 400
NSGMGQEIDS HDYVFRVSGA VIKGYEKDVG TKTSFYGFTA YSLVSSLQNL
410 420 430 440 450
GHKGFKKIPQ GKHIRYIHFL EAVRDYEWLK ALLLDKDIRK GFLNYYGRRP
460 470 480 490 500
RERFDEDFTM NKYLVAHPDF LRYLKNRFLK SKNLQKPYWR LYRPTTGALL
510 520 530 540 550
LLTALHLCDR VSAYGYITEG HQKYSDHYYD KEWKRLVFYV NHDFNLEKQV
560
WKRLHDENIM KLYQRS
Length:566
Mass (Da):64,781
Last modified:November 1, 1997 - v1
Checksum:iE529CA94027757DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74946 mRNA. Translation: CAA52902.1.
PIRiA49880.
RefSeqiNP_990571.1. NM_205240.1.
UniGeneiGga.688.

Genome annotation databases

EnsembliENSGALT00000002882; ENSGALP00000002878; ENSGALG00000001862.
GeneIDi396168.
KEGGigga:396168.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74946 mRNA. Translation: CAA52902.1.
PIRiA49880.
RefSeqiNP_990571.1. NM_205240.1.
UniGeneiGga.688.

3D structure databases

ProteinModelPortaliQ92183.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000002878.

Protein family/group databases

CAZyiGT29. Glycosyltransferase Family 29.

Proteomic databases

PaxDbiQ92183.
PRIDEiQ92183.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000002882; ENSGALP00000002878; ENSGALG00000001862.
GeneIDi396168.
KEGGigga:396168.

Organism-specific databases

CTDi55808.

Phylogenomic databases

eggNOGiKOG2692. Eukaryota.
ENOG410XT8P. LUCA.
GeneTreeiENSGT00760000119095.
HOGENOMiHOG000231097.
HOVERGENiHBG073351.
InParanoidiQ92183.
KOiK03479.
OMAiTCISCAV.
OrthoDBiEOG7J17ZK.
PhylomeDBiQ92183.
TreeFamiTF354325.

Enzyme and pathway databases

UniPathwayiUPA00378.
ReactomeiR-GGA-4085001. Sialic acid metabolism.

Miscellaneous databases

NextBioi20816222.
PROiQ92183.

Family and domain databases

InterProiIPR001675. Glyco_trans_29.
[Graphical view]
PfamiPF00777. Glyco_transf_29. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and expression of GalNAc alpha 2,6-sialyltransferase."
    Kurosawa N., Hamamoto T., Lee Y.-C., Nakaoka T., Kojima N., Tsuji S.
    J. Biol. Chem. 269:1402-1409(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiSIA7A_CHICK
AccessioniPrimary (citable) accession number: Q92183
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 11, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.