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Q92179

- CHST3_CHICK

UniProt

Q92179 - CHST3_CHICK

Protein

Carbohydrate sulfotransferase 3

Gene

CHST3

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices By similarity.By similarity

    Catalytic activityi

    3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi121 – 1277PAPSBy similarity
    Nucleotide bindingi281 – 2899PAPSBy similarity

    GO - Molecular functioni

    1. chondroitin 6-sulfotransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Carbohydrate metabolism

    Enzyme and pathway databases

    BRENDAi2.8.2.17. 1306.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carbohydrate sulfotransferase 3 (EC:2.8.2.17)
    Alternative name(s):
    Chondroitin 6-O-sulfotransferase 1
    Short name:
    C6ST-1
    Gene namesi
    Name:CHST3
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 458458Carbohydrate sulfotransferase 3PRO_0000085191Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi62 – 621N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi73 – 731N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi95 – 951N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi236 – 2361N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi399 – 3991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi443 – 4431N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ92179.

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000039793.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92179.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2323CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini38 – 458421LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei24 – 3714Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG80862.
    HOGENOMiHOG000261614.
    HOVERGENiHBG106811.
    InParanoidiQ92179.
    KOiK01020.
    PhylomeDBiQ92179.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR016469. Carbohydrate_sulfotransferase.
    IPR027417. P-loop_NTPase.
    IPR000863. Sulfotransferase_dom.
    [Graphical view]
    PfamiPF00685. Sulfotransfer_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005883. Carbohydrate_sulfotransferase. 1 hit.
    SUPFAMiSSF52540. SSF52540. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Q92179-1 [UniParc]FASTAAdd to Basket

    « Hide

    MERRSALPQD FREVLHCLKM RSKYAVLLVF VVGLVIIEKE NNFISRVSDK    50
    LKQSPQVLPE ANETEASPVQ AENGSLASLR QLDTAFSQLR TRLRNVTLQL 100
    AGELGIAAPE PRRHVLLMAT TRTGSSFVGE FFNQQGNIFY LFEPLWHIER 150
    TVTFEPGGAN AVGSALVYRD VLQQLLLCDL YILESFISPA PEEHLTAALF 200
    RRGSSHSLCE EPVCTPSLKK VFEKYHCKNR RCGPLNITLA AEACRRKQHM 250
    ALKTVRIRQL EFLQPLAEDP RLDLRIIQLV RDPRAVLVSR MVAFSGKYES 300
    WKKWAAEGEA PLQEDEVQRL RGNCESIRLS AELGLRQPRW LRGRYMLVRY 350
    EDVARAPLRK ALEMYRFAGI HPTPQVEEWI RANTQAPQDS NGIYSTQKNS 400
    SEQFEKWRFS IPFKLAQVVQ DACEPAMRLF GYKLASSAQE LTNRSLSLLE 450
    EGPPTRIT 458
    Length:458
    Mass (Da):52,253
    Last modified:November 1, 1997 - v1
    Checksum:iC9A3B7D0A5086F0C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D49915 mRNA. Translation: BAA08655.1.
    PIRiA57397.
    RefSeqiNP_990452.1. NM_205121.1.
    UniGeneiGga.599.

    Genome annotation databases

    GeneIDi396018.
    KEGGigga:396018.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D49915 mRNA. Translation: BAA08655.1 .
    PIRi A57397.
    RefSeqi NP_990452.1. NM_205121.1.
    UniGenei Gga.599.

    3D structure databases

    ProteinModelPortali Q92179.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000039793.

    Proteomic databases

    PaxDbi Q92179.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 396018.
    KEGGi gga:396018.

    Organism-specific databases

    CTDi 9469.

    Phylogenomic databases

    eggNOGi NOG80862.
    HOGENOMi HOG000261614.
    HOVERGENi HBG106811.
    InParanoidi Q92179.
    KOi K01020.
    PhylomeDBi Q92179.

    Enzyme and pathway databases

    BRENDAi 2.8.2.17. 1306.

    Miscellaneous databases

    NextBioi 20816080.
    PROi Q92179.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR016469. Carbohydrate_sulfotransferase.
    IPR027417. P-loop_NTPase.
    IPR000863. Sulfotransferase_dom.
    [Graphical view ]
    Pfami PF00685. Sulfotransfer_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005883. Carbohydrate_sulfotransferase. 1 hit.
    SUPFAMi SSF52540. SSF52540. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and expression of chick chondrocyte chondroitin 6-sulfotransferase."
      Fukuta M., Uchimura K., Nakashima K., Kato M., Kimata K., Shinomura T., Habuchi O.
      J. Biol. Chem. 270:18575-18580(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 38-44; 46-52 AND 186-192.
      Strain: White leghorn.
      Tissue: Embryonic chondrocyte.

    Entry informationi

    Entry nameiCHST3_CHICK
    AccessioniPrimary (citable) accession number: Q92179
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3