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Protein

Carbohydrate sulfotransferase 3

Gene

CHST3

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices (By similarity).By similarity

Catalytic activityi

3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi121 – 127PAPSBy similarity7
Nucleotide bindingi281 – 289PAPSBy similarity9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Carbohydrate metabolism

Enzyme and pathway databases

BRENDAi2.8.2.17. 1306.

Names & Taxonomyi

Protein namesi
Recommended name:
Carbohydrate sulfotransferase 3 (EC:2.8.2.17)
Alternative name(s):
Chondroitin 6-O-sulfotransferase 1
Short name:
C6ST-1
Gene namesi
Name:CHST3
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23CytoplasmicSequence analysisAdd BLAST23
Transmembranei24 – 37Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST14
Topological domaini38 – 458LumenalSequence analysisAdd BLAST421

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000851911 – 458Carbohydrate sulfotransferase 3Add BLAST458

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi62N-linked (GlcNAc...)Sequence analysis1
Glycosylationi73N-linked (GlcNAc...)Sequence analysis1
Glycosylationi95N-linked (GlcNAc...)Sequence analysis1
Glycosylationi236N-linked (GlcNAc...)Sequence analysis1
Glycosylationi399N-linked (GlcNAc...)Sequence analysis1
Glycosylationi443N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ92179.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000039793.

Structurei

3D structure databases

ProteinModelPortaliQ92179.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIAV. Eukaryota.
ENOG410YDA4. LUCA.
HOGENOMiHOG000261614.
HOVERGENiHBG106811.
InParanoidiQ92179.
KOiK01020.
PhylomeDBiQ92179.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR016469. Carbohydrate_sulfotransferase.
IPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view]
PfamiPF00685. Sulfotransfer_1. 1 hit.
[Graphical view]
PIRSFiPIRSF005883. Carbohydrate_sulfotransferase. 1 hit.
SUPFAMiSSF52540. SSF52540. 2 hits.

Sequencei

Sequence statusi: Complete.

Q92179-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERRSALPQD FREVLHCLKM RSKYAVLLVF VVGLVIIEKE NNFISRVSDK
60 70 80 90 100
LKQSPQVLPE ANETEASPVQ AENGSLASLR QLDTAFSQLR TRLRNVTLQL
110 120 130 140 150
AGELGIAAPE PRRHVLLMAT TRTGSSFVGE FFNQQGNIFY LFEPLWHIER
160 170 180 190 200
TVTFEPGGAN AVGSALVYRD VLQQLLLCDL YILESFISPA PEEHLTAALF
210 220 230 240 250
RRGSSHSLCE EPVCTPSLKK VFEKYHCKNR RCGPLNITLA AEACRRKQHM
260 270 280 290 300
ALKTVRIRQL EFLQPLAEDP RLDLRIIQLV RDPRAVLVSR MVAFSGKYES
310 320 330 340 350
WKKWAAEGEA PLQEDEVQRL RGNCESIRLS AELGLRQPRW LRGRYMLVRY
360 370 380 390 400
EDVARAPLRK ALEMYRFAGI HPTPQVEEWI RANTQAPQDS NGIYSTQKNS
410 420 430 440 450
SEQFEKWRFS IPFKLAQVVQ DACEPAMRLF GYKLASSAQE LTNRSLSLLE

EGPPTRIT
Length:458
Mass (Da):52,253
Last modified:November 1, 1997 - v1
Checksum:iC9A3B7D0A5086F0C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49915 mRNA. Translation: BAA08655.1.
PIRiA57397.
RefSeqiNP_990452.1. NM_205121.1.
UniGeneiGga.599.

Genome annotation databases

GeneIDi396018.
KEGGigga:396018.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49915 mRNA. Translation: BAA08655.1.
PIRiA57397.
RefSeqiNP_990452.1. NM_205121.1.
UniGeneiGga.599.

3D structure databases

ProteinModelPortaliQ92179.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000039793.

Proteomic databases

PaxDbiQ92179.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396018.
KEGGigga:396018.

Organism-specific databases

CTDi9469.

Phylogenomic databases

eggNOGiENOG410IIAV. Eukaryota.
ENOG410YDA4. LUCA.
HOGENOMiHOG000261614.
HOVERGENiHBG106811.
InParanoidiQ92179.
KOiK01020.
PhylomeDBiQ92179.

Enzyme and pathway databases

BRENDAi2.8.2.17. 1306.

Miscellaneous databases

PROiQ92179.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR016469. Carbohydrate_sulfotransferase.
IPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view]
PfamiPF00685. Sulfotransfer_1. 1 hit.
[Graphical view]
PIRSFiPIRSF005883. Carbohydrate_sulfotransferase. 1 hit.
SUPFAMiSSF52540. SSF52540. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiCHST3_CHICK
AccessioniPrimary (citable) accession number: Q92179
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 8, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.