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Q92179

- CHST3_CHICK

UniProt

Q92179 - CHST3_CHICK

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Protein

Carbohydrate sulfotransferase 3

Gene

CHST3

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices (By similarity).By similarity

Catalytic activityi

3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi121 – 1277PAPSBy similarity
Nucleotide bindingi281 – 2899PAPSBy similarity

GO - Molecular functioni

  1. chondroitin 6-sulfotransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Carbohydrate metabolism

Enzyme and pathway databases

BRENDAi2.8.2.17. 1306.

Names & Taxonomyi

Protein namesi
Recommended name:
Carbohydrate sulfotransferase 3 (EC:2.8.2.17)
Alternative name(s):
Chondroitin 6-O-sulfotransferase 1
Short name:
C6ST-1
Gene namesi
Name:CHST3
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. Golgi membrane Source: InterPro
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 458458Carbohydrate sulfotransferase 3PRO_0000085191Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi62 – 621N-linked (GlcNAc...)Sequence Analysis
Glycosylationi73 – 731N-linked (GlcNAc...)Sequence Analysis
Glycosylationi95 – 951N-linked (GlcNAc...)Sequence Analysis
Glycosylationi236 – 2361N-linked (GlcNAc...)Sequence Analysis
Glycosylationi399 – 3991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi443 – 4431N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ92179.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000039793.

Structurei

3D structure databases

ProteinModelPortaliQ92179.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini38 – 458421LumenalSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei24 – 3714Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG80862.
HOGENOMiHOG000261614.
HOVERGENiHBG106811.
InParanoidiQ92179.
KOiK01020.
PhylomeDBiQ92179.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR016469. Carbohydrate_sulfotransferase.
IPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view]
PfamiPF00685. Sulfotransfer_1. 1 hit.
[Graphical view]
PIRSFiPIRSF005883. Carbohydrate_sulfotransferase. 1 hit.
SUPFAMiSSF52540. SSF52540. 2 hits.

Sequencei

Sequence statusi: Complete.

Q92179-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MERRSALPQD FREVLHCLKM RSKYAVLLVF VVGLVIIEKE NNFISRVSDK
60 70 80 90 100
LKQSPQVLPE ANETEASPVQ AENGSLASLR QLDTAFSQLR TRLRNVTLQL
110 120 130 140 150
AGELGIAAPE PRRHVLLMAT TRTGSSFVGE FFNQQGNIFY LFEPLWHIER
160 170 180 190 200
TVTFEPGGAN AVGSALVYRD VLQQLLLCDL YILESFISPA PEEHLTAALF
210 220 230 240 250
RRGSSHSLCE EPVCTPSLKK VFEKYHCKNR RCGPLNITLA AEACRRKQHM
260 270 280 290 300
ALKTVRIRQL EFLQPLAEDP RLDLRIIQLV RDPRAVLVSR MVAFSGKYES
310 320 330 340 350
WKKWAAEGEA PLQEDEVQRL RGNCESIRLS AELGLRQPRW LRGRYMLVRY
360 370 380 390 400
EDVARAPLRK ALEMYRFAGI HPTPQVEEWI RANTQAPQDS NGIYSTQKNS
410 420 430 440 450
SEQFEKWRFS IPFKLAQVVQ DACEPAMRLF GYKLASSAQE LTNRSLSLLE

EGPPTRIT
Length:458
Mass (Da):52,253
Last modified:November 1, 1997 - v1
Checksum:iC9A3B7D0A5086F0C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D49915 mRNA. Translation: BAA08655.1.
PIRiA57397.
RefSeqiNP_990452.1. NM_205121.1.
UniGeneiGga.599.

Genome annotation databases

GeneIDi396018.
KEGGigga:396018.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D49915 mRNA. Translation: BAA08655.1 .
PIRi A57397.
RefSeqi NP_990452.1. NM_205121.1.
UniGenei Gga.599.

3D structure databases

ProteinModelPortali Q92179.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000039793.

Proteomic databases

PaxDbi Q92179.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396018.
KEGGi gga:396018.

Organism-specific databases

CTDi 9469.

Phylogenomic databases

eggNOGi NOG80862.
HOGENOMi HOG000261614.
HOVERGENi HBG106811.
InParanoidi Q92179.
KOi K01020.
PhylomeDBi Q92179.

Enzyme and pathway databases

BRENDAi 2.8.2.17. 1306.

Miscellaneous databases

NextBioi 20816080.
PROi Q92179.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR016469. Carbohydrate_sulfotransferase.
IPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view ]
Pfami PF00685. Sulfotransfer_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005883. Carbohydrate_sulfotransferase. 1 hit.
SUPFAMi SSF52540. SSF52540. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and expression of chick chondrocyte chondroitin 6-sulfotransferase."
    Fukuta M., Uchimura K., Nakashima K., Kato M., Kimata K., Shinomura T., Habuchi O.
    J. Biol. Chem. 270:18575-18580(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 38-44; 46-52 AND 186-192.
    Strain: White leghorn.
    Tissue: Embryonic chondrocyte.

Entry informationi

Entry nameiCHST3_CHICK
AccessioniPrimary (citable) accession number: Q92179
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3