SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q92179

- CHST3_CHICK

UniProt

Q92179 - CHST3_CHICK

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Carbohydrate sulfotransferase 3
Gene
CHST3
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices By similarity.

Catalytic activityi

3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi121 – 1277PAPS By similarity
Nucleotide bindingi281 – 2899PAPS By similarity

GO - Molecular functioni

  1. chondroitin 6-sulfotransferase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. carbohydrate metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Carbohydrate metabolism

Enzyme and pathway databases

BRENDAi2.8.2.17. 1306.

Names & Taxonomyi

Protein namesi
Recommended name:
Carbohydrate sulfotransferase 3 (EC:2.8.2.17)
Alternative name(s):
Chondroitin 6-O-sulfotransferase 1
Short name:
C6ST-1
Gene namesi
Name:CHST3
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei24 – 3714Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini38 – 458421Lumenal Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 458458Carbohydrate sulfotransferase 3
PRO_0000085191Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi62 – 621N-linked (GlcNAc...) Reviewed prediction
Glycosylationi73 – 731N-linked (GlcNAc...) Reviewed prediction
Glycosylationi95 – 951N-linked (GlcNAc...) Reviewed prediction
Glycosylationi236 – 2361N-linked (GlcNAc...) Reviewed prediction
Glycosylationi399 – 3991N-linked (GlcNAc...) Reviewed prediction
Glycosylationi443 – 4431N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ92179.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000039793.

Structurei

3D structure databases

ProteinModelPortaliQ92179.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG80862.
HOGENOMiHOG000261614.
HOVERGENiHBG106811.
InParanoidiQ92179.
KOiK01020.
PhylomeDBiQ92179.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR016469. Carbohydrate_sulfotransferase.
IPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view]
PfamiPF00685. Sulfotransfer_1. 1 hit.
[Graphical view]
PIRSFiPIRSF005883. Carbohydrate_sulfotransferase. 1 hit.
SUPFAMiSSF52540. SSF52540. 2 hits.

Sequencei

Sequence statusi: Complete.

Q92179-1 [UniParc]FASTAAdd to Basket

« Hide

MERRSALPQD FREVLHCLKM RSKYAVLLVF VVGLVIIEKE NNFISRVSDK    50
LKQSPQVLPE ANETEASPVQ AENGSLASLR QLDTAFSQLR TRLRNVTLQL 100
AGELGIAAPE PRRHVLLMAT TRTGSSFVGE FFNQQGNIFY LFEPLWHIER 150
TVTFEPGGAN AVGSALVYRD VLQQLLLCDL YILESFISPA PEEHLTAALF 200
RRGSSHSLCE EPVCTPSLKK VFEKYHCKNR RCGPLNITLA AEACRRKQHM 250
ALKTVRIRQL EFLQPLAEDP RLDLRIIQLV RDPRAVLVSR MVAFSGKYES 300
WKKWAAEGEA PLQEDEVQRL RGNCESIRLS AELGLRQPRW LRGRYMLVRY 350
EDVARAPLRK ALEMYRFAGI HPTPQVEEWI RANTQAPQDS NGIYSTQKNS 400
SEQFEKWRFS IPFKLAQVVQ DACEPAMRLF GYKLASSAQE LTNRSLSLLE 450
EGPPTRIT 458
Length:458
Mass (Da):52,253
Last modified:November 1, 1997 - v1
Checksum:iC9A3B7D0A5086F0C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D49915 mRNA. Translation: BAA08655.1.
PIRiA57397.
RefSeqiNP_990452.1. NM_205121.1.
UniGeneiGga.599.

Genome annotation databases

GeneIDi396018.
KEGGigga:396018.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D49915 mRNA. Translation: BAA08655.1 .
PIRi A57397.
RefSeqi NP_990452.1. NM_205121.1.
UniGenei Gga.599.

3D structure databases

ProteinModelPortali Q92179.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000039793.

Proteomic databases

PaxDbi Q92179.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396018.
KEGGi gga:396018.

Organism-specific databases

CTDi 9469.

Phylogenomic databases

eggNOGi NOG80862.
HOGENOMi HOG000261614.
HOVERGENi HBG106811.
InParanoidi Q92179.
KOi K01020.
PhylomeDBi Q92179.

Enzyme and pathway databases

BRENDAi 2.8.2.17. 1306.

Miscellaneous databases

NextBioi 20816080.
PROi Q92179.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR016469. Carbohydrate_sulfotransferase.
IPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view ]
Pfami PF00685. Sulfotransfer_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005883. Carbohydrate_sulfotransferase. 1 hit.
SUPFAMi SSF52540. SSF52540. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and expression of chick chondrocyte chondroitin 6-sulfotransferase."
    Fukuta M., Uchimura K., Nakashima K., Kato M., Kimata K., Shinomura T., Habuchi O.
    J. Biol. Chem. 270:18575-18580(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 38-44; 46-52 AND 186-192.
    Strain: White leghorn.
    Tissue: Embryonic chondrocyte.

Entry informationi

Entry nameiCHST3_CHICK
AccessioniPrimary (citable) accession number: Q92179
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 16, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi