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Protein

Coronin-1A

Gene

CORO1A

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected macrophages, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Coronin-1A
Alternative name(s):
Coronin-like protein A
Short name:
Clipin-A
Coronin-like protein p57
Tryptophan aspartate-containing coat protein
Short name:
TACO
Gene namesi
Name:CORO1A
Synonyms:CORO1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 25

Subcellular locationi

  • Cytoplasmcytoskeleton By similarity
  • Cytoplasmcell cortex By similarity
  • Cytoplasmic vesiclephagosome membrane By similarity

  • Note: In non-infected macrophages, associated with the cortical microtubule network. In mycobacteria-infected macrophages, becomes progressively relocalized and retained around the mycobacterial phagosomes. Retention on the phagosomal membrane is strictly dependent on mycobacterial viability and not due to impaired acidification (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000509192 – 461Coronin-1AAdd BLAST460

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2Phosphoserine; by PKCBy similarity1
Modified residuei412Phosphothreonine; by PKCBy similarity1
Modified residuei418PhosphothreonineBy similarity1
Modified residuei422PhosphoserineBy similarity1
Modified residuei449N6-acetyllysineBy similarity1

Post-translational modificationi

phosphorylation at Thr-412 by PKC strongly down-regulates the association with actin.By similarity
Polyubiquitinated by RNF128 with 'Lys-48'-linked chains, leading to proteasomal degradation.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ92176.
PeptideAtlasiQ92176.
PRIDEiQ92176.

Expressioni

Tissue specificityi

Expressed in brain, thymus, spleen, bone marrow and lymph node. Low in lung and gut.

Gene expression databases

BgeeiENSBTAG00000008631.

Interactioni

Subunit structurei

Binds actin.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000051462.

Structurei

3D structure databases

ProteinModelPortaliQ92176.
SMRiQ92176.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati13 – 63WD 1Add BLAST51
Repeati73 – 110WD 2Add BLAST38
Repeati123 – 160WD 3Add BLAST38
Repeati164 – 204WD 4Add BLAST41
Repeati207 – 251WD 5Add BLAST45
Repeati258 – 296WD 6Add BLAST39
Repeati302 – 349WD 7Add BLAST48

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili424 – 460Sequence analysisAdd BLAST37

Sequence similaritiesi

Belongs to the WD repeat coronin family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0303. Eukaryota.
ENOG410XQAD. LUCA.
GeneTreeiENSGT00760000119195.
HOGENOMiHOG000166356.
HOVERGENiHBG059978.
InParanoidiQ92176.
KOiK13882.
OMAiHAVFVSE.
OrthoDBiEOG091G03H5.
TreeFamiTF314280.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR029508. CORO1A.
IPR015505. Coronin.
IPR015048. DUF1899.
IPR015049. Trimer_CC.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR10856. PTHR10856. 1 hit.
PTHR10856:SF18. PTHR10856:SF18. 1 hit.
PfamiPF08953. DUF1899. 1 hit.
PF08954. Trimer_CC. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM01166. DUF1899. 1 hit.
SM00320. WD40. 3 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q92176-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRQVVRSSK FRHVFGQPAK ADQCYEDVRV SQNTWDSGFC AVNPKFVALI
60 70 80 90 100
CEASGGGAFL VLPLGKTGRV DKNVPMVCGH TAPVLDIAWC PHNDNVIASG
110 120 130 140 150
SEDCSVMVWE IPDGGLTLPL REPVVTLEGH TKRVGIVAWH PTAQNVLLSA
160 170 180 190 200
GCDNVILVWD VGTGVAVLTL GSDVHPDTIY SVDWSRDGAL ICTSCRDKRV
210 220 230 240 250
RIIEPRKGTI VAEKDRPHEG TRPVRAVFVS DGKILTTGFS RMSERQVALW
260 270 280 290 300
DTKHLEEPLS LQELDTSSGV LLPFFDPDTN IVYLCGKGDS SIRYFEITSE
310 320 330 340 350
APFLHYLSMF SSKESQRGMG YMPKRGLEVN KCEIARFYKL HERKCEPIAM
360 370 380 390 400
TVPRKSDLFQ EDLYPPTAGP DAALTAEEWL GGRDAGPLLI SLKDGYVPPK
410 420 430 440 450
SRELRVNRGL DTGRKRTTPE ASGAPSSDAI SRLEEEMRKL QATVQELQKR
460
LDRLEETVQA K
Length:461
Mass (Da):50,979
Last modified:January 23, 2007 - v3
Checksum:i1721A5D093C1130A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D44496 mRNA. Translation: BAA07939.1.
BT025463 mRNA. Translation: ABF57419.1.
BC102876 mRNA. Translation: AAI02877.1.
PIRiS65666.
RefSeqiNP_776946.1. NM_174521.2.
XP_005224888.1. XM_005224831.3.
XP_005224890.1. XM_005224833.3.
UniGeneiBt.351.

Genome annotation databases

EnsembliENSBTAT00000011382; ENSBTAP00000011382; ENSBTAG00000008631.
ENSBTAT00000051969; ENSBTAP00000051462; ENSBTAG00000008631.
GeneIDi282196.
KEGGibta:282196.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D44496 mRNA. Translation: BAA07939.1.
BT025463 mRNA. Translation: ABF57419.1.
BC102876 mRNA. Translation: AAI02877.1.
PIRiS65666.
RefSeqiNP_776946.1. NM_174521.2.
XP_005224888.1. XM_005224831.3.
XP_005224890.1. XM_005224833.3.
UniGeneiBt.351.

3D structure databases

ProteinModelPortaliQ92176.
SMRiQ92176.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000051462.

Proteomic databases

PaxDbiQ92176.
PeptideAtlasiQ92176.
PRIDEiQ92176.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000011382; ENSBTAP00000011382; ENSBTAG00000008631.
ENSBTAT00000051969; ENSBTAP00000051462; ENSBTAG00000008631.
GeneIDi282196.
KEGGibta:282196.

Organism-specific databases

CTDi11151.

Phylogenomic databases

eggNOGiKOG0303. Eukaryota.
ENOG410XQAD. LUCA.
GeneTreeiENSGT00760000119195.
HOGENOMiHOG000166356.
HOVERGENiHBG059978.
InParanoidiQ92176.
KOiK13882.
OMAiHAVFVSE.
OrthoDBiEOG091G03H5.
TreeFamiTF314280.

Gene expression databases

BgeeiENSBTAG00000008631.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR029508. CORO1A.
IPR015505. Coronin.
IPR015048. DUF1899.
IPR015049. Trimer_CC.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR10856. PTHR10856. 1 hit.
PTHR10856:SF18. PTHR10856:SF18. 1 hit.
PfamiPF08953. DUF1899. 1 hit.
PF08954. Trimer_CC. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM01166. DUF1899. 1 hit.
SM00320. WD40. 3 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOR1A_BOVIN
AccessioniPrimary (citable) accession number: Q92176
Secondary accession number(s): Q3SZF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.