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Protein

Cytochrome P450 1A1

Gene

cyp1a1

Organism
Microgadus tomcod (Atlantic tomcod)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei225 – 2251SubstrateBy similarity
Metal bindingi459 – 4591Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 1A1 (EC:1.14.14.1)
Alternative name(s):
CYPIA1
Gene namesi
Name:cyp1a1
OrganismiMicrogadus tomcod (Atlantic tomcod)
Taxonomic identifieri34823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataZeiogadariaGadariaeGadiformesGadoideiGadidaeMicrogadus

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 515515Cytochrome P450 1A1PRO_0000051640Add
BLAST

Expressioni

Inductioni

By benzo[a]pyrene (B[A]P) and beta-naphthoflavone (beta-NF).

Structurei

3D structure databases

ProteinModelPortaliQ92148.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG106944.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 2 hits.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92148-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALMILPLIG SVSVSETLVA MITVCMIYML MKFLHPDVPE APPAPGPQAL
60 70 80 90 100
PIIGNVWSWE NGLPEPHGHG QRYGDILQIQ IGMRSVVVLS GHETVRQALI
110 120 130 140 150
KQGHDLRPPD LYSFQFINDG KSLAFSTDQA GVWSPPKAGH ECPALLFHAR
160 170 180 190 200
GHHAAVLLHV GGACLQGGRL PRQAAVQRHG TDASFDPFRH IVVSVANVIC
210 220 230 240 250
GMCFGRRYGH EDQELLSLVN LTDEFGKVVG SGNLADFIPL LRFLPNATMK
260 270 280 290 300
RFMAINERFM TFVQKIVTEH YNTYDKDNIR DITDSLIDHC EDRKLDENSN
310 320 330 340 350
IQMSDEKIVG IVNDLFGAGF DTVSTALSWS VMYLVAHPEI QERLHQEIKD
360 370 380 390 400
KVGLSRSPVL TDRHNLPILE AFIFEIFRHS SFLPFTIPHC ATKDTSLDGY
410 420 430 440 450
FIPKDTCVFI NQWQINHDPE LWKEPSTFNP DRFLSADASE LNKLAGEKVM
460 470 480 490 500
LFGMGKRRCI GEMVARNEVF LFLAILVQRL TFHAVPGEPL DMTPEYGLTM
510
KHKRCHLRAT VRTTE
Length:515
Mass (Da):57,826
Last modified:November 1, 1996 - v1
Checksum:iCB73707629A01C25
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41917 Genomic DNA. Translation: AAB00085.1.
L41886 mRNA. Translation: AAB00082.1.
PIRiS66464.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41917 Genomic DNA. Translation: AAB00085.1.
L41886 mRNA. Translation: AAB00082.1.
PIRiS66464.

3D structure databases

ProteinModelPortaliQ92148.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG106944.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 2 hits.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization and prevalence of a polymorphism in the 3' untranslated region of cytochrome P4501A1 in cancer-prone Atlantic tomcod."
    Roy N.K., Kreamer G.L., Konkle B., Grunwald C., Wirgin I.
    Arch. Biochem. Biophys. 322:204-213(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: Hudson river.
    Tissue: Liver.
  2. "Characterization of CYP1A1 gene regulatory elements in cancer-prone Atlantic tomcod."
    Roy N.K., Konkle B., Wirgin I.
    Pharmacogenetics 6:273-277(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCP1A1_MICTO
AccessioniPrimary (citable) accession number: Q92148
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: January 7, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.