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Q92148

- CP1A1_MICTO

UniProt

Q92148 - CP1A1_MICTO

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Protein

Cytochrome P450 1A1

Gene
cyp1a1
Organism
Microgadus tomcod (Atlantic tomcod)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei225 – 2251Substrate By similarity
Metal bindingi459 – 4591Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 1A1 (EC:1.14.14.1)
Alternative name(s):
CYPIA1
Gene namesi
Name:cyp1a1
OrganismiMicrogadus tomcod (Atlantic tomcod)
Taxonomic identifieri34823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataZeiogadariaGadariaeGadiformesGadoideiGadidaeMicrogadus

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 515515Cytochrome P450 1A1PRO_0000051640Add
BLAST

Expressioni

Inductioni

By benzo[a]pyrene (B[A]P) and beta-naphthoflavone (beta-NF).

Structurei

3D structure databases

ProteinModelPortaliQ92148.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Phylogenomic databases

HOVERGENiHBG106944.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 2 hits.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92148-1 [UniParc]FASTAAdd to Basket

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MALMILPLIG SVSVSETLVA MITVCMIYML MKFLHPDVPE APPAPGPQAL    50
PIIGNVWSWE NGLPEPHGHG QRYGDILQIQ IGMRSVVVLS GHETVRQALI 100
KQGHDLRPPD LYSFQFINDG KSLAFSTDQA GVWSPPKAGH ECPALLFHAR 150
GHHAAVLLHV GGACLQGGRL PRQAAVQRHG TDASFDPFRH IVVSVANVIC 200
GMCFGRRYGH EDQELLSLVN LTDEFGKVVG SGNLADFIPL LRFLPNATMK 250
RFMAINERFM TFVQKIVTEH YNTYDKDNIR DITDSLIDHC EDRKLDENSN 300
IQMSDEKIVG IVNDLFGAGF DTVSTALSWS VMYLVAHPEI QERLHQEIKD 350
KVGLSRSPVL TDRHNLPILE AFIFEIFRHS SFLPFTIPHC ATKDTSLDGY 400
FIPKDTCVFI NQWQINHDPE LWKEPSTFNP DRFLSADASE LNKLAGEKVM 450
LFGMGKRRCI GEMVARNEVF LFLAILVQRL TFHAVPGEPL DMTPEYGLTM 500
KHKRCHLRAT VRTTE 515
Length:515
Mass (Da):57,826
Last modified:November 1, 1996 - v1
Checksum:iCB73707629A01C25
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L41917 Genomic DNA. Translation: AAB00085.1.
L41886 mRNA. Translation: AAB00082.1.
PIRiS66464.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L41917 Genomic DNA. Translation: AAB00085.1 .
L41886 mRNA. Translation: AAB00082.1 .
PIRi S66464.

3D structure databases

ProteinModelPortali Q92148.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG106944.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view ]
Pfami PF00067. p450. 2 hits.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization and prevalence of a polymorphism in the 3' untranslated region of cytochrome P4501A1 in cancer-prone Atlantic tomcod."
    Roy N.K., Kreamer G.L., Konkle B., Grunwald C., Wirgin I.
    Arch. Biochem. Biophys. 322:204-213(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Strain: Hudson river.
    Tissue: Liver.
  2. "Characterization of CYP1A1 gene regulatory elements in cancer-prone Atlantic tomcod."
    Roy N.K., Konkle B., Wirgin I.
    Pharmacogenetics 6:273-277(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCP1A1_MICTO
AccessioniPrimary (citable) accession number: Q92148
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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