Reviewed, UniProtKB/Swiss-Prot Q92148 (CP1A1_MICTO)

Names and origin

Protein names

Recommended name:
    Cytochrome P450 1A1
    EC=1.14.14.1
Alternative name(s):
    CYPIA1

Gene names

Name:

cyp1a1

Organism

Microgadus tomcod (Atlantic tomcod)

Taxonomic identifier

34823 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Neoteleostei › Acanthomorpha › Paracanthopterygii › Gadiformes › Gadidae › Microgadus

Protein attributes

Sequence length	515 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Catalytic activity	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.
Cofactor	Heme group By similarity.
Subcellular location	Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Induction	By benzo[a]pyrene (B[A]P) and beta-naphthoflavone (beta-NF).
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-KW extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell microsome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	aromatase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 515	515	Cytochrome P450 1A1		PRO_0000051640
Sites
	Metal binding	459	1	Iron (heme axial ligand) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q92148-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: CB73707629A01C25	FASTA	515	57,826
	10 20 30 40 50 60 MALMILPLIG SVSVSETLVA MITVCMIYML MKFLHPDVPE APPAPGPQAL PIIGNVWSWE 70 80 90 100 110 120 NGLPEPHGHG QRYGDILQIQ IGMRSVVVLS GHETVRQALI KQGHDLRPPD LYSFQFINDG 130 140 150 160 170 180 KSLAFSTDQA GVWSPPKAGH ECPALLFHAR GHHAAVLLHV GGACLQGGRL PRQAAVQRHG 190 200 210 220 230 240 TDASFDPFRH IVVSVANVIC GMCFGRRYGH EDQELLSLVN LTDEFGKVVG SGNLADFIPL 250 260 270 280 290 300 LRFLPNATMK RFMAINERFM TFVQKIVTEH YNTYDKDNIR DITDSLIDHC EDRKLDENSN 310 320 330 340 350 360 IQMSDEKIVG IVNDLFGAGF DTVSTALSWS VMYLVAHPEI QERLHQEIKD KVGLSRSPVL 370 380 390 400 410 420 TDRHNLPILE AFIFEIFRHS SFLPFTIPHC ATKDTSLDGY FIPKDTCVFI NQWQINHDPE 430 440 450 460 470 480 LWKEPSTFNP DRFLSADASE LNKLAGEKVM LFGMGKRRCI GEMVARNEVF LFLAILVQRL 490 500 510 TFHAVPGEPL DMTPEYGLTM KHKRCHLRAT VRTTE

References

[1]	"Characterization and prevalence of a polymorphism in the 3' untranslated region of cytochrome P4501A1 in cancer-prone Atlantic tomcod." Roy N.K., Kreamer G.L., Konkle B., Grunwald C., Wirgin I. Arch. Biochem. Biophys. 322:204-213(1995) [PubMed: 7574676] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Strain: Hudson river. Tissue: Liver.
[2]	"Characterization of CYP1A1 gene regulatory elements in cancer-prone Atlantic tomcod." Roy N.K., Konkle B., Wirgin I. Pharmacogenetics 6:273-277(1996) [PubMed: 8807670] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	L41917 Genomic DNA. Translation: AAB00085.1. L41886 mRNA. Translation: AAB00082.1.
PIR	S66464.
3D structure databases
SMR	Q92148. Positions 45-507.
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q92148.
Enzyme and pathway databases
BRENDA	1.14.14.1. 292506.
Family and domain databases
InterPro	IPR001128. Cyt_P450. IPR017973. Cyt_P450_C. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. IPR008066. Cyt_P450_E_grp-I_CYP1. [Graphical view]
Gene3D	G3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHER	PTHR19383. Cyt_P450. 1 hit. PTHR19383:SF63. Cyt_P450_E_grp-I_CYP1. 1 hit.
Pfam	PF00067. p450. 2 hits. [Graphical view]
PRINTS	PR00463. EP450I. PR01683. EP450ICYP1A. PR00385. P450.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CP1A1_MICTO

Accession

Primary (citable) accession number: Q92148

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	November 1, 1996
Last modified:	January 19, 2010
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)