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Q92148 (CP1A1_MICTO) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 1A1

EC=1.14.14.1
Alternative name(s):
CYPIA1
Gene names
Name:cyp1a1
OrganismMicrogadus tomcod (Atlantic tomcod)
Taxonomic identifier34823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiEuteleosteiNeoteleosteiAcanthomorphaParacanthopterygiiGadiformesGadidaeMicrogadus

Protein attributes

Sequence length515 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Induction

By benzo[a]pyrene (B[A]P) and beta-naphthoflavone (beta-NF).

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
Membrane
Microsome
   LigandHeme
Iron
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaromatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

heme binding

Inferred from electronic annotation. Source: InterPro

iron ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 515515Cytochrome P450 1A1
PRO_0000051640

Sites

Metal binding4591Iron (heme axial ligand) By similarity
Binding site2251Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q92148 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: CB73707629A01C25

FASTA51557,826
        10         20         30         40         50         60 
MALMILPLIG SVSVSETLVA MITVCMIYML MKFLHPDVPE APPAPGPQAL PIIGNVWSWE 

        70         80         90        100        110        120 
NGLPEPHGHG QRYGDILQIQ IGMRSVVVLS GHETVRQALI KQGHDLRPPD LYSFQFINDG 

       130        140        150        160        170        180 
KSLAFSTDQA GVWSPPKAGH ECPALLFHAR GHHAAVLLHV GGACLQGGRL PRQAAVQRHG 

       190        200        210        220        230        240 
TDASFDPFRH IVVSVANVIC GMCFGRRYGH EDQELLSLVN LTDEFGKVVG SGNLADFIPL 

       250        260        270        280        290        300 
LRFLPNATMK RFMAINERFM TFVQKIVTEH YNTYDKDNIR DITDSLIDHC EDRKLDENSN 

       310        320        330        340        350        360 
IQMSDEKIVG IVNDLFGAGF DTVSTALSWS VMYLVAHPEI QERLHQEIKD KVGLSRSPVL 

       370        380        390        400        410        420 
TDRHNLPILE AFIFEIFRHS SFLPFTIPHC ATKDTSLDGY FIPKDTCVFI NQWQINHDPE 

       430        440        450        460        470        480 
LWKEPSTFNP DRFLSADASE LNKLAGEKVM LFGMGKRRCI GEMVARNEVF LFLAILVQRL 

       490        500        510 
TFHAVPGEPL DMTPEYGLTM KHKRCHLRAT VRTTE 

« Hide

References

[1]"Characterization and prevalence of a polymorphism in the 3' untranslated region of cytochrome P4501A1 in cancer-prone Atlantic tomcod."
Roy N.K., Kreamer G.L., Konkle B., Grunwald C., Wirgin I.
Arch. Biochem. Biophys. 322:204-213(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Strain: Hudson river.
Tissue: Liver.
[2]"Characterization of CYP1A1 gene regulatory elements in cancer-prone Atlantic tomcod."
Roy N.K., Konkle B., Wirgin I.
Pharmacogenetics 6:273-277(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L41917 Genomic DNA. Translation: AAB00085.1.
L41886 mRNA. Translation: AAB00082.1.
PIRS66464.

3D structure databases

ProteinModelPortalQ92148.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG106944.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamPF00067. p450. 2 hits.
[Graphical view]
PRINTSPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP1A1_MICTO
AccessionPrimary (citable) accession number: Q92148
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: December 11, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families