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Q92148

- CP1A1_MICTO

UniProt

Q92148 - CP1A1_MICTO

Protein

Cytochrome P450 1A1

Gene

cyp1a1

Organism
Microgadus tomcod (Atlantic tomcod)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei225 – 2251SubstrateBy similarity
    Metal bindingi459 – 4591Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 1A1 (EC:1.14.14.1)
    Alternative name(s):
    CYPIA1
    Gene namesi
    Name:cyp1a1
    OrganismiMicrogadus tomcod (Atlantic tomcod)
    Taxonomic identifieri34823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataZeiogadariaGadariaeGadiformesGadoideiGadidaeMicrogadus

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 515515Cytochrome P450 1A1PRO_0000051640Add
    BLAST

    Expressioni

    Inductioni

    By benzo[a]pyrene (B[A]P) and beta-naphthoflavone (beta-NF).

    Structurei

    3D structure databases

    ProteinModelPortaliQ92148.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    HOVERGENiHBG106944.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view]
    PfamiPF00067. p450. 2 hits.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92148-1 [UniParc]FASTAAdd to Basket

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    MALMILPLIG SVSVSETLVA MITVCMIYML MKFLHPDVPE APPAPGPQAL    50
    PIIGNVWSWE NGLPEPHGHG QRYGDILQIQ IGMRSVVVLS GHETVRQALI 100
    KQGHDLRPPD LYSFQFINDG KSLAFSTDQA GVWSPPKAGH ECPALLFHAR 150
    GHHAAVLLHV GGACLQGGRL PRQAAVQRHG TDASFDPFRH IVVSVANVIC 200
    GMCFGRRYGH EDQELLSLVN LTDEFGKVVG SGNLADFIPL LRFLPNATMK 250
    RFMAINERFM TFVQKIVTEH YNTYDKDNIR DITDSLIDHC EDRKLDENSN 300
    IQMSDEKIVG IVNDLFGAGF DTVSTALSWS VMYLVAHPEI QERLHQEIKD 350
    KVGLSRSPVL TDRHNLPILE AFIFEIFRHS SFLPFTIPHC ATKDTSLDGY 400
    FIPKDTCVFI NQWQINHDPE LWKEPSTFNP DRFLSADASE LNKLAGEKVM 450
    LFGMGKRRCI GEMVARNEVF LFLAILVQRL TFHAVPGEPL DMTPEYGLTM 500
    KHKRCHLRAT VRTTE 515
    Length:515
    Mass (Da):57,826
    Last modified:November 1, 1996 - v1
    Checksum:iCB73707629A01C25
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L41917 Genomic DNA. Translation: AAB00085.1.
    L41886 mRNA. Translation: AAB00082.1.
    PIRiS66464.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L41917 Genomic DNA. Translation: AAB00085.1 .
    L41886 mRNA. Translation: AAB00082.1 .
    PIRi S66464.

    3D structure databases

    ProteinModelPortali Q92148.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG106944.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view ]
    Pfami PF00067. p450. 2 hits.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization and prevalence of a polymorphism in the 3' untranslated region of cytochrome P4501A1 in cancer-prone Atlantic tomcod."
      Roy N.K., Kreamer G.L., Konkle B., Grunwald C., Wirgin I.
      Arch. Biochem. Biophys. 322:204-213(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Strain: Hudson river.
      Tissue: Liver.
    2. "Characterization of CYP1A1 gene regulatory elements in cancer-prone Atlantic tomcod."
      Roy N.K., Konkle B., Wirgin I.
      Pharmacogenetics 6:273-277(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiCP1A1_MICTO
    AccessioniPrimary (citable) accession number: Q92148
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3