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Protein

Cellular tumor antigen p53

Gene

tp53

Organism
Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity).By similarity

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi142 – 1421ZincBy similarity
Metal bindingi145 – 1451ZincBy similarity
Metal bindingi201 – 2011ZincBy similarity
Metal bindingi205 – 2051ZincBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi68 – 255188By similarityAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Apoptosis, Cell cycle, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cellular tumor antigen p53
Alternative name(s):
Tumor suppressor p53
Gene namesi
Name:tp53
Synonyms:p53
OrganismiXiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus)
Taxonomic identifieri8083 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeCyprinodontiformesPoeciliidaePoeciliinaeXiphophorus
Proteomesi
  • UP000002852 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 342342Cellular tumor antigen p53PRO_0000185724Add
BLAST

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Binds DNA as a homotetramer.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei86 – 861Interaction with DNABy similarity

Protein-protein interaction databases

STRINGi8083.ENSXMAP00000015753.

Structurei

3D structure databases

ProteinModelPortaliQ92143.
SMRiQ92143. Positions 62-254.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 3535Transcription activation (acidic)Add
BLAST
Regioni236 – 2438Interaction with DNABy similarity
Regioni288 – 31730OligomerizationAdd
BLAST
Regioni319 – 33618Basic (repression of DNA-binding)Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi261 – 27818Bipartite nuclear localization signalBy similarityAdd
BLAST
Motifi302 – 31312Nuclear export signalBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the p53 family.Curated

Phylogenomic databases

eggNOGiENOG410IITK. Eukaryota.
ENOG410ZSWV. LUCA.
GeneTreeiENSGT00390000015092.
HOVERGENiHBG005201.
InParanoidiQ92143.
KOiK04451.
OMAiSQKTYPG.
OrthoDBiEOG7JQBNW.

Family and domain databases

Gene3Di2.60.40.720. 1 hit.
4.10.170.10. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR012346. p53/RUNT-type_TF_DNA-bd.
IPR011615. p53_DNA-bd.
IPR010991. p53_tetrameristn.
IPR013872. p53_transactivation_domain.
IPR002117. p53_tumour_suppressor.
[Graphical view]
PANTHERiPTHR11447. PTHR11447. 1 hit.
PfamiPF00870. P53. 1 hit.
PF08563. P53_TAD. 1 hit.
PF07710. P53_tetramer. 1 hit.
[Graphical view]
PRINTSiPR00386. P53SUPPRESSR.
SUPFAMiSSF47719. SSF47719. 1 hit.
SSF49417. SSF49417. 1 hit.
PROSITEiPS00348. P53. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92143-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEADLTLPL SQDTFHDLWN NVFLSTENES LPPPEGLLSQ NMDFWEDPET
60 70 80 90 100
MQETKNVPTA PTVPAISNYA GEHGFNLEFN DSGTAKSVTS TYSVKLGKLF
110 120 130 140 150
CQLAKTTPIG VLVKEEPPQG AVIRATAVYK KTEHVGEVVK RCPHHQSEDL
160 170 180 190 200
SDNKSHLIRV EGSQLAQYFE DPNTRRHSVT VPYERPQLGS EMTTILLSFM
210 220 230 240 250
CNSSCMGGMN RRPILTILTL ETTEGEVLGR RCFEVRVCAC PGRDRKTEEG
260 270 280 290 300
NLEKSGTKQT KKRKSAPAPD TSTAKKSKSA SSGEDEDKEI YTLSIRGRNR
310 320 330 340
YLWFKSLNDG LELMDKTGPK IKQEIPAPSS GKRLLKGGSD SD
Length:342
Mass (Da):37,958
Last modified:November 1, 1998 - v2
Checksum:i290739636108CEA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043947 mRNA. Translation: AAC31134.1.
AF043948 Genomic DNA. Translation: AAC26190.1.
U34751 Genomic DNA. Translation: AAA92052.1.
RefSeqiNP_001273218.1. NM_001286289.1.

Genome annotation databases

EnsembliENSXMAT00000015776; ENSXMAP00000015753; ENSXMAG00000015716.
GeneIDi102219062.
KEGGixma:102219062.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043947 mRNA. Translation: AAC31134.1.
AF043948 Genomic DNA. Translation: AAC26190.1.
U34751 Genomic DNA. Translation: AAA92052.1.
RefSeqiNP_001273218.1. NM_001286289.1.

3D structure databases

ProteinModelPortaliQ92143.
SMRiQ92143. Positions 62-254.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8083.ENSXMAP00000015753.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSXMAT00000015776; ENSXMAP00000015753; ENSXMAG00000015716.
GeneIDi102219062.
KEGGixma:102219062.

Organism-specific databases

CTDi7157.

Phylogenomic databases

eggNOGiENOG410IITK. Eukaryota.
ENOG410ZSWV. LUCA.
GeneTreeiENSGT00390000015092.
HOVERGENiHBG005201.
InParanoidiQ92143.
KOiK04451.
OMAiSQKTYPG.
OrthoDBiEOG7JQBNW.

Family and domain databases

Gene3Di2.60.40.720. 1 hit.
4.10.170.10. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR012346. p53/RUNT-type_TF_DNA-bd.
IPR011615. p53_DNA-bd.
IPR010991. p53_tetrameristn.
IPR013872. p53_transactivation_domain.
IPR002117. p53_tumour_suppressor.
[Graphical view]
PANTHERiPTHR11447. PTHR11447. 1 hit.
PfamiPF00870. P53. 1 hit.
PF08563. P53_TAD. 1 hit.
PF07710. P53_tetramer. 1 hit.
[Graphical view]
PRINTSiPR00386. P53SUPPRESSR.
SUPFAMiSSF47719. SSF47719. 1 hit.
SSF49417. SSF49417. 1 hit.
PROSITEiPS00348. P53. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and comparative sequence analysis of TP53 in xiphophorus fish hybrid melanoma models."
    Kazianis S., Gan L., Della Coletta L., Santi B., Morizot D.C., Nairn R.S.
    Gene 212:31-38(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Rio Jamapa / JP 163 A.
  2. Nairn R.S.
    Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE OF 190-254.
    Strain: Rio Jamapa / JP 163 A.

Entry informationi

Entry nameiP53_XIPMA
AccessioniPrimary (citable) accession number: Q92143
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1998
Last modified: May 11, 2016
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.