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Protein

Cellular tumor antigen p53

Gene

tp53

Organism
Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity).By similarity

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi142ZincBy similarity1
Metal bindingi145ZincBy similarity1
Metal bindingi201ZincBy similarity1
Metal bindingi205ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi68 – 255By similarityAdd BLAST188

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processApoptosis, Cell cycle, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cellular tumor antigen p53
Alternative name(s):
Tumor suppressor p53
Gene namesi
Name:tp53
Synonyms:p53
OrganismiXiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus)
Taxonomic identifieri8083 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeCyprinodontiformesPoeciliidaePoeciliinaeXiphophorus
Proteomesi
  • UP000002852 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001857241 – 342Cellular tumor antigen p53Add BLAST342

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Binds DNA as a homotetramer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei86Interaction with DNABy similarity1

Protein-protein interaction databases

STRINGi8083.ENSXMAP00000015753

Structurei

3D structure databases

ProteinModelPortaliQ92143
SMRiQ92143
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 35Transcription activation (acidic)Add BLAST35
Regioni236 – 243Interaction with DNABy similarity8
Regioni288 – 317OligomerizationAdd BLAST30
Regioni319 – 336Basic (repression of DNA-binding)Add BLAST18

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi261 – 278Bipartite nuclear localization signalBy similarityAdd BLAST18
Motifi302 – 313Nuclear export signalBy similarityAdd BLAST12

Sequence similaritiesi

Belongs to the p53 family.Curated

Phylogenomic databases

eggNOGiENOG410IITK Eukaryota
ENOG410ZSWV LUCA
GeneTreeiENSGT00390000015092
HOVERGENiHBG005201
InParanoidiQ92143
KOiK04451
OMAiSFMCNSS
OrthoDBiEOG091G0XY5

Family and domain databases

CDDicd08367 P53, 1 hit
Gene3Di2.60.40.720, 1 hit
4.10.170.10, 1 hit
InterProiView protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR012346 p53/RUNT-type_TF_DNA-bd_sf
IPR011615 p53_DNA-bd
IPR036674 p53_tetramer_sf
IPR010991 p53_tetrameristn
IPR013872 p53_transactivation_domain
IPR002117 p53_tumour_suppressor
PANTHERiPTHR11447 PTHR11447, 1 hit
PfamiView protein in Pfam
PF00870 P53, 1 hit
PF08563 P53_TAD, 1 hit
PF07710 P53_tetramer, 1 hit
PRINTSiPR00386 P53SUPPRESSR
SUPFAMiSSF47719 SSF47719, 1 hit
SSF49417 SSF49417, 1 hit
PROSITEiView protein in PROSITE
PS00348 P53, 1 hit

Sequencei

Sequence statusi: Complete.

Q92143-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEADLTLPL SQDTFHDLWN NVFLSTENES LPPPEGLLSQ NMDFWEDPET
60 70 80 90 100
MQETKNVPTA PTVPAISNYA GEHGFNLEFN DSGTAKSVTS TYSVKLGKLF
110 120 130 140 150
CQLAKTTPIG VLVKEEPPQG AVIRATAVYK KTEHVGEVVK RCPHHQSEDL
160 170 180 190 200
SDNKSHLIRV EGSQLAQYFE DPNTRRHSVT VPYERPQLGS EMTTILLSFM
210 220 230 240 250
CNSSCMGGMN RRPILTILTL ETTEGEVLGR RCFEVRVCAC PGRDRKTEEG
260 270 280 290 300
NLEKSGTKQT KKRKSAPAPD TSTAKKSKSA SSGEDEDKEI YTLSIRGRNR
310 320 330 340
YLWFKSLNDG LELMDKTGPK IKQEIPAPSS GKRLLKGGSD SD
Length:342
Mass (Da):37,958
Last modified:November 1, 1998 - v2
Checksum:i290739636108CEA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF043947 mRNA Translation: AAC31134.1
AF043948 Genomic DNA Translation: AAC26190.1
U34751 Genomic DNA Translation: AAA92052.1
RefSeqiNP_001273218.1, NM_001286289.1

Genome annotation databases

EnsembliENSXMAT00000015776; ENSXMAP00000015753; ENSXMAG00000015716
GeneIDi102219062
KEGGixma:102219062

Similar proteinsi

Entry informationi

Entry nameiP53_XIPMA
AccessioniPrimary (citable) accession number: Q92143
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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