Reviewed,
UniProtKB/Swiss-Prot Q92142 (TPH_XENLA)
Last modified
October 13, 2009.
Version 61.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Tryptophan 5-hydroxylase EC=1.14.16.4 Alternative name(s): Tryptophan 5-monooxygenase | ||
| Gene names |
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| Organism | Xenopus laevis (African clawed frog) | ||
| Taxonomic identifier | 8355 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Protein attributes
| Sequence length | 481 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin. |
| Cofactor | Fe2+ ion. |
| Pathway | Aromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2. |
| Subunit structure | Multimer of identical subunits By similarity. |
| Sequence similarities | Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. Contains 1 ACT domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Serotonin biosynthesis |
| Ligand | Iron Metal-binding |
| Molecular function | Monooxygenase Oxidoreductase |
| Gene Ontology (GO) | |
| Biological process | aromatic amino acid family metabolic process Inferred from electronic annotation. Source: InterPro oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW serotonin biosynthetic processInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | amino acid binding Inferred from electronic annotation. Source: InterPro iron ion bindingInferred from electronic annotation. Source: UniProtKB-KW tryptophan 5-monooxygenase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | "Tryptophan hydroxylase expression is regulated by a circadian clock in Xenopus laevis retina." Green C.B., Besharse J.C. J. Neurochem. 62:2420-2428(1994) [PubMed: 8189245] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Retina. |
Cross-references
Sequence databases | |
|---|---|
| L20679 mRNA. Translation: AAA21306.1. | |
| PIR | I51567. |
| RefSeq | NP_001080923.1. |
| UniGene | Xl.1144 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1MLW based on UniProtKB P17752. |
| SMR | Q92142. Positions 141-430. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 387560. |
| KEGG | xla:387560. |
Organism-specific databases | |
| CTD | 387560. |
| Xenbase | XB-FEAT-996925. tph1. |
Phylogenomic databases | |
| HOVERGEN | Q92142. |
Enzyme and pathway databases | |
| BRENDA | 1.14.16.4. 648. |
Family and domain databases | |
| InterPro | IPR002912. ACT_bd. IPR001273. ArAA_hydroxylase. IPR018301. ArAA_hydroxylase_Fe/CU_BS. IPR019774. Aromatic-AA_hydroxylase_C. IPR005963. Trp_5_mOase. IPR019773. Tyrosine_3-monooxygenase-like. [Graphical view] |
| Gene3D | G3DSA:1.10.800.10. Aaa_hydroxylase. 1 hit. |
| PANTHER | PTHR11473. Aaa_hydroxylase. 1 hit. |
| Pfam | PF01842. ACT. 1 hit. PF00351. Biopterin_H. 1 hit. [Graphical view] |
| PIRSF | PIRSF000336. TH. 1 hit. |
| PRINTS | PR00372. FYWHYDRXLASE. |
| ProDom | PD002559. Aaa_hydroxylase. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| TIGRFAMs | TIGR01270. Trp_5_monoox. 1 hit. |
| PROSITE | PS00367. BIOPTERIN_HYDROXYL. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | TPH_XENLA | ||||||||
| Accession | Primary (citable) accession number: Q92142 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Xenopus annotation project | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


