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Protein

Phosphoinositide phospholipase C

Gene

plcb3

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei332 – 3321UniRule annotation
Active sitei379 – 3791UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationImported, TransducerSAAS annotation

Keywords - Biological processi

Lipid degradationUniRule annotation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoinositide phospholipase CUniRule annotation (EC:3.1.4.11UniRule annotation)
Gene namesi
Name:plcb3Imported
Synonyms:PLC1Imported
OrganismiXenopus laevis (African clawed frog)Imported
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-1008416. plcb3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini317 – 468152PI-PLC X-boxInterPro annotationAdd
BLAST
Domaini576 – 691116PI-PLC Y-boxInterPro annotationAdd
BLAST
Domaini699 – 79698C2InterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1049 – 107325Sequence analysisAdd
BLAST
Coiled coili1105 – 114743Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 C2 domain.UniRule annotation
Contains 1 PI-PLC X-box domain.UniRule annotation
Contains 1 PI-PLC Y-box domain.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

HOVERGENiHBG053609.
KOiK05858.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProiIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR011993. PH_dom-like.
IPR001192. PI-PLC_fam.
IPR016280. PLC-beta.
IPR028390. PLC-beta3.
IPR014815. PLC-beta_C.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLC_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 1 hit.
PTHR10336:SF11. PTHR10336:SF11. 1 hit.
PfamiPF00168. C2. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
PF08703. PLC-beta_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000956. PLC-beta. 1 hit.
PRINTSiPR00390. PHPHLIPASEC.
SMARTiSM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF51695. SSF51695. 2 hits.
PROSITEiPS50004. C2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92137-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGARPGVHS LQLEPVKVPE TLIKGSKFIK WDEESSSKSL VTLRVDTMGF
60 70 80 90 100
YLYWTCPNME VDILDISVIR DTRTGKYAKI PKDIKMREIL GFTGPEQRPE
110 120 130 140 150
DKLVTVVYGN DIVNISFLNF MAVQEDTAKI WTEELFKLAH NILAQNSSRN
160 170 180 190 200
TFLQKAYTKL KLQVNQDGRI PVKNILKMFA ADKKRVETAL ESCGLNFNRG
210 220 230 240 250
DSIKPEEFTL DIFERFLNKL CLRPDIDKIL LELGAKGKPY LTLEQLMDFL
260 270 280 290 300
NQKQRDPRLN EILFPPLKRD QVRQLIEKYE PNRQFLDRDQ MSMEGFSRFL
310 320 330 340 350
GGHENSIVPP EILDLSDDMN QPLSSYFINS SHNTYLTAGQ LTGNSSVEMY
360 370 380 390 400
RQVLLTGCRC IELDCWKGRP QDEEPFITHG FTMTTEIPFK EVIEAIAESA
410 420 430 440 450
FKTSPFPVIL SFENHVDSSK QQAKMAEYCR NIFGDALLID PLEKYPLQPG
460 470 480 490 500
VALPSPQELM GKILVKNKKR HKVAVKGPEG SVKRRVSEQT SNTYSDSSSV
510 520 530 540 550
CESSATGLPP SESADVSLTL SNGDEKIEEK PPKYTKPRKS IDHDAYSEEE
560 570 580 590 600
EEEEPSDPKK SDEGTASSEV NATEEMSTLV NYVEPVKFKS FDAAKKRNKY
610 620 630 640 650
YEMSSFVETK ALEQLTKSPM EFVEYNKKQL SRIYPKGTRV DSSNYMPQLF
660 670 680 690 700
WNAGCQMVAL NFQTLDLPMQ LNVGIFEYNR RSGYLLKPEF MCRTDKHFDP
710 720 730 740 750
FTENIVDGIV ANTVKIKIIS GQFLSEKRVG IFVEVDMFGL PVDTKRKFRT
760 770 780 790 800
KTSQGNSFNP VWDEEPFILP KVVLPTLATL RIAVFEEGGK FVGHRILPVS
810 820 830 840 850
AIRPGYHYIC LRNELNQPVC LPALLVYTEV NDYIPDDHQG YANALTNPIK
860 870 880 890 900
HISLMDQRAK QLAALMGENE QPFNKDKIDW DPISKPPIRS RDDTPEKIKI
910 920 930 940 950
PIIPVPSPPA QRDDHIASVL TDIQAPSMEE LKSQKSFEKL ICRQYRELRQ
960 970 980 990 1000
LRRKHLRKVS SLCKEQSTWV TPLQSLRRRK PFGRSHRGVS GADQDAEQKL
1010 1020 1030 1040 1050
MDMQRDQQKR LLELREIQHE QERKLKHSHL LQAVQKLQEV AISYHSTQLK
1060 1070 1080 1090 1100
KLKEINEKEK KELQKILDRK RHNSITEAKS RERQKKDVEL TEINRRHINE
1110 1120 1130 1140 1150
SVSSIRRLEE AQKRRQEKLQ TAHQETLQRI KDEEPKLQAQ LDEACQAEFC
1160 1170 1180 1190 1200
QLPQEVRRYL QEDGWVGSGS GPPSSSHSSP PSITRSWGSE SGEKDSLHSP
1210
GDSSDEATRL
Length:1,210
Mass (Da):138,650
Last modified:November 1, 1996 - v1
Checksum:iE414CF70EC0F36DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20816 mRNA. Translation: AAA03065.1.
Y15901 mRNA. Translation: CAA75861.1.
PIRiA48001.
RefSeqiNP_001081169.1. NM_001087700.1.
UniGeneiXl.55410.

Genome annotation databases

GeneIDi397692.
KEGGixla:397692.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20816 mRNA. Translation: AAA03065.1.
Y15901 mRNA. Translation: CAA75861.1.
PIRiA48001.
RefSeqiNP_001081169.1. NM_001087700.1.
UniGeneiXl.55410.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi397692.
KEGGixla:397692.

Organism-specific databases

CTDi5331.
XenbaseiXB-GENE-1008416. plcb3.

Phylogenomic databases

HOVERGENiHBG053609.
KOiK05858.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProiIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR011993. PH_dom-like.
IPR001192. PI-PLC_fam.
IPR016280. PLC-beta.
IPR028390. PLC-beta3.
IPR014815. PLC-beta_C.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLC_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 1 hit.
PTHR10336:SF11. PTHR10336:SF11. 1 hit.
PfamiPF00168. C2. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
PF08703. PLC-beta_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000956. PLC-beta. 1 hit.
PRINTSiPR00390. PHPHLIPASEC.
SMARTiSM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF51695. SSF51695. 2 hits.
PROSITEiPS50004. C2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Receptor-evoked Cl- current in Xenopus oocytes is mediated through a beta-type phospholipase C. Cloning of a new form of the enzyme."
    Ma H.W., Blitzer R.D., Healy E.C., Premont R.T., Landau E.M., Iyengar R.
    J. Biol. Chem. 268:19915-19918(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Rawlings N.D.
    Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. Rawlings N.
    Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ92137_XENLA
AccessioniPrimary (citable) accession number: Q92137
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.