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Q92133

- Q92133_XENLA

UniProt

Q92133 - Q92133_XENLA

Protein

Histone H3

Gene

hist1h3g

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei3 – 31Sulfate 1Imported
    Binding sitei3 – 31Sulfate 2Imported

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. nucleosome assembly Source: InterPro

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone H3UniRule annotation
    Gene namesi
    Name:hist1h3gImported
    Synonyms:H3lImported
    OrganismiXenopus laevis (African clawed frog)Imported
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-5784387. hist1h3g.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleosome Source: UniProtKB-KW
    2. nucleus Source: UniProtKB-KW

    Keywords - Cellular componenti

    Chromosome, Nucleosome coreUniRule annotation, NucleusUniRule annotationSAAS annotation

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei28 – 281N6,N6,N6-trimethyllysine

    Interactioni

    Subunit structurei

    The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.UniRule annotation

    Protein-protein interaction databases

    DIPiDIP-60191N.
    IntActiQ92133. 1 interaction.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2L11NMR-B2-16[»]
    2L12NMR-B2-16[»]
    2L1BNMR-B20-34[»]
    3GL6X-ray1.90B2-10[»]
    3H91X-ray1.50C/D20-34[»]
    3ME9X-ray1.37C/D2-12[»]
    3MEAX-ray1.26B2-12[»]
    3METX-ray2.00C/D2-12[»]
    3MEUX-ray1.28C/D2-14[»]
    3MEVX-ray1.83C/D2-9[»]
    3O7AX-ray1.67B2-12[»]
    4HSUX-ray1.99C2-31[»]
    4QEOX-ray2.00P2-16[»]
    ProteinModelPortaliQ92133.
    SMRiQ92133. Positions 2-136.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ92133.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histone H3 family.UniRule annotation

    Phylogenomic databases

    HOVERGENiHBG001172.
    KOiK11253.

    Family and domain databases

    Gene3Di1.10.20.10. 1 hit.
    InterProiIPR009072. Histone-fold.
    IPR007125. Histone_core_D.
    IPR000164. Histone_H3.
    [Graphical view]
    PANTHERiPTHR11426. PTHR11426. 1 hit.
    PfamiPF00125. Histone. 1 hit.
    [Graphical view]
    PRINTSiPR00622. HISTONEH3.
    SMARTiSM00428. H3. 1 hit.
    [Graphical view]
    SUPFAMiSSF47113. SSF47113. 1 hit.
    PROSITEiPS00322. HISTONE_H3_1. 1 hit.
    PS00959. HISTONE_H3_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92133-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARTKQTARK STGGKAPRKQ LATKAARKSA PATGGVKKPH RYRPGTVALR    50
    EIRRYQKSTE LLIRKLPFQR LVREIAQDFK TDLRFQSSAV MALQEASEAY 100
    LVGLFEDTNL CGIHAKRVTI MPKDIQLARR IRGERA 136
    Length:136
    Mass (Da):15,374
    Last modified:November 1, 1996 - v1
    Checksum:i69B8368EA50A0EEC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X72950 Genomic DNA. Translation: CAA51455.1.
    PIRiS32638.
    RefSeqiNP_001091119.1. NM_001097650.1.
    UniGeneiXl.79618.

    Genome annotation databases

    GeneIDi399088.
    KEGGixla:399088.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X72950 Genomic DNA. Translation: CAA51455.1 .
    PIRi S32638.
    RefSeqi NP_001091119.1. NM_001097650.1.
    UniGenei Xl.79618.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2L11 NMR - B 2-16 [» ]
    2L12 NMR - B 2-16 [» ]
    2L1B NMR - B 20-34 [» ]
    3GL6 X-ray 1.90 B 2-10 [» ]
    3H91 X-ray 1.50 C/D 20-34 [» ]
    3ME9 X-ray 1.37 C/D 2-12 [» ]
    3MEA X-ray 1.26 B 2-12 [» ]
    3MET X-ray 2.00 C/D 2-12 [» ]
    3MEU X-ray 1.28 C/D 2-14 [» ]
    3MEV X-ray 1.83 C/D 2-9 [» ]
    3O7A X-ray 1.67 B 2-12 [» ]
    4HSU X-ray 1.99 C 2-31 [» ]
    4QEO X-ray 2.00 P 2-16 [» ]
    ProteinModelPortali Q92133.
    SMRi Q92133. Positions 2-136.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-60191N.
    IntActi Q92133. 1 interaction.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 399088.
    KEGGi xla:399088.

    Organism-specific databases

    CTDi 8355.
    Xenbasei XB-GENE-5784387. hist1h3g.

    Phylogenomic databases

    HOVERGENi HBG001172.
    KOi K11253.

    Miscellaneous databases

    EvolutionaryTracei Q92133.

    Family and domain databases

    Gene3Di 1.10.20.10. 1 hit.
    InterProi IPR009072. Histone-fold.
    IPR007125. Histone_core_D.
    IPR000164. Histone_H3.
    [Graphical view ]
    PANTHERi PTHR11426. PTHR11426. 1 hit.
    Pfami PF00125. Histone. 1 hit.
    [Graphical view ]
    PRINTSi PR00622. HISTONEH3.
    SMARTi SM00428. H3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47113. SSF47113. 1 hit.
    PROSITEi PS00322. HISTONE_H3_1. 1 hit.
    PS00959. HISTONE_H3_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolutionary relations between histone gene clusters in the genome of Xenopus laevis."
      Schilthuis J.G., Hagenaar M., Destree O.H.J.
      Submitted (MAR-1993) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger."
      Wang G.G., Song J., Wang Z., Dormann H.L., Casadio F., Li H., Luo J.L., Patel D.J., Allis C.D.
      Nature 459:847-851(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 2-10.
    3. "Crystal structure of PHF13 in complex with Tri-methylated histone H3K4."
      Bian C.B., Xu C., Lam R., Bountra C., Arrowsmith C.H., Weigelt J., Edwards A.M., Bochkarev A., Min J.
      Submitted (JUL-2010) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.67 ANGSTROMS) OF 2-12.
    4. "Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation."
      Bian C., Xu C., Ruan J., Lee K.K., Burke T.L., Tempel W., Barsyte D., Li J., Wu M., Zhou B.O., Fleharty B.E., Paulson A., Allali-Hassani A., Zhou J.Q., Mer G., Grant P.A., Workman J.L., Zang J., Min J.
      EMBO J. 30:2829-2842(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.26 ANGSTROMS) OF 2-12.
    5. Cited for: X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) OF 20-34.
    6. "Structural insight into substrate recognition by histone demethylase LSD2/KDM1b."
      Chen F., Yang H., Dong Z., Fang J., Wang P., Zhu T., Gong W., Fang R., Shi Y.G., Li Z., Xu Y.
      Cell Res. 23:306-309(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.99 ANGSTROMS) OF 2-31.
    7. "Mechanism of DNA Methylation-Directed Histone Methylation by KRYPTONITE."
      Du J., Johnson L.M., Groth M., Feng S., Hale C.J., Li S., Vashisht A.A., Gallego-Bartolome J., Wohlschlegel J.A., Patel D.J., Jacobsen S.E.
      Mol. Cell 0:0-0(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 2-16.

    Entry informationi

    Entry nameiQ92133_XENLA
    AccessioniPrimary (citable) accession number: Q92133
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 1, 1996
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3