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Protein
Submitted name:

Cytochrome P-450

Gene

cyp2a6

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

MonooxygenaseUniRule annotation, Oxidoreductase

Keywords - Ligandi

HemeUniRule annotation, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Cytochrome P-450Imported
Submitted name:
LOC100036770 proteinImported
Gene namesi
Name:cyp2a6Imported
Synonyms:LOC100036770Imported
OrganismiXenopus laevis (African clawed frog)Imported
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-1007455. cyp2a6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2419HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Structurei

3D structure databases

SMRiQ92129. Positions 30-494.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

HOVERGENiHBG015789.
KOiK07411.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008067. Cyt_P450_E_grp-I_CYP2A-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01684. EP450ICYP2A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92129-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTSWLWTLL LSLLISCILI YSTWNKMYRK RNLPPGPTPI PLFGNVLQIK
60 70 80 90 100
RGEMVKSLIE YGKKYGDTYT LYFGPSPVII LCSYRATKEA LIDQAEDFSG
110 120 130 140 150
RGAMPSFDQY FQGYGVVFTN GEEWKQLRRF SLTTLRNFGM GKRGIEERIQ
160 170 180 190 200
EEAQFVVEEI KSYKKKPFDP TDILVQCVSN VICSVVFGNR FEYDNKDFQN
210 220 230 240 250
LLSLFQSVFR ESSSAWGQLL NMFPLIMNHI PGPHKKVIRD MNKLEAFVLQ
260 270 280 290 300
RVKENEKTLD SNSPRDIIDS FLIKMQQENE NPTSAFHMKN LLATVLSIFF
310 320 330 340 350
AGTETVSTTL RHGFLILLIY PEIEAKLREE IDRVIGQNRS PTIEDRSKMP
360 370 380 390 400
YTDAVIHEIQ RFSDVIPMNV PHLVTKDTQF RGYTIPKGTD VYPLLCAVLR
410 420 430 440 450
DPEKFATPYE FNPNHFLDDN GCFKSNDGFM PFSTGKRICL GEGLARMELF
460 470 480 490
LFLTNILQHF KLHTESRLIE DDIAPKMNGF ANYPTSYQLS FIPR
Length:494
Mass (Da):56,985
Last modified:November 1, 1996 - v1
Checksum:iA5E3AEFFCFAAFE51
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC074204 mRNA. Translation: AAH74204.1.
D50560 mRNA. Translation: BAA09124.1.
RefSeqiNP_001090537.1. NM_001097068.1.
UniGeneiXl.43.

Genome annotation databases

GeneIDi100036770.
KEGGixla:100036770.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC074204 mRNA. Translation: AAH74204.1.
D50560 mRNA. Translation: BAA09124.1.
RefSeqiNP_001090537.1. NM_001097068.1.
UniGeneiXl.43.

3D structure databases

SMRiQ92129. Positions 30-494.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100036770.
KEGGixla:100036770.

Organism-specific databases

CTDi1548.
XenbaseiXB-GENE-1007455. cyp2a6.

Phylogenomic databases

HOVERGENiHBG015789.
KOiK07411.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008067. Cyt_P450_E_grp-I_CYP2A-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01684. EP450ICYP2A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression analysis of a novel gene for cytochrome P450 in Xenopus laevis."
    Ohi H., Sugata E., Saitoh H., Murayama N., Higuchi S.
    Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: LiverImported.
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: KidneyImported.

Entry informationi

Entry nameiQ92129_XENLA
AccessioniPrimary (citable) accession number: Q92129
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: April 13, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.