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Protein

Potassium-transporting ATPase alpha chain 1

Gene

atp4a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the hydrolysis of ATP coupled with the exchange of H+ and K+ ions across the plasma membrane. Responsible for acid production in the stomach.

Catalytic activityi

ATP + H2O + H+(In) + K+(Out) = ADP + phosphate + H+(Out) + K+(In).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei383 – 38314-aspartylphosphate intermediateBy similarity
Metal bindingi724 – 7241MagnesiumBy similarity
Metal bindingi728 – 7281MagnesiumBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Hydrogen ion transport, Ion transport, Potassium transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium-transporting ATPase alpha chain 1 (EC:3.6.3.10)
Alternative name(s):
Gastric H(+)/K(+) ATPase subunit alpha
Proton pump
Gene namesi
Name:atp4a
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-486108. atp4a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 9493CytoplasmicSequence analysisAdd
BLAST
Transmembranei95 – 11521HelicalSequence analysisAdd
BLAST
Topological domaini116 – 13823LumenalSequence analysisAdd
BLAST
Transmembranei139 – 15921HelicalSequence analysisAdd
BLAST
Topological domaini160 – 295136CytoplasmicSequence analysisAdd
BLAST
Transmembranei296 – 31520HelicalSequence analysisAdd
BLAST
Topological domaini316 – 32712LumenalSequence analysisAdd
BLAST
Transmembranei328 – 34518HelicalSequence analysisAdd
BLAST
Topological domaini346 – 779434CytoplasmicSequence analysisAdd
BLAST
Transmembranei780 – 79920HelicalSequence analysisAdd
BLAST
Topological domaini800 – 80910LumenalSequence analysis
Transmembranei810 – 83021HelicalSequence analysisAdd
BLAST
Topological domaini831 – 85020CytoplasmicSequence analysisAdd
BLAST
Transmembranei851 – 87323HelicalSequence analysisAdd
BLAST
Topological domaini874 – 92552LumenalSequence analysisAdd
BLAST
Transmembranei926 – 94520HelicalSequence analysisAdd
BLAST
Topological domaini946 – 95914CytoplasmicSequence analysisAdd
BLAST
Transmembranei960 – 97819HelicalSequence analysisAdd
BLAST
Topological domaini979 – 99315LumenalSequence analysisAdd
BLAST
Transmembranei994 – 101421HelicalSequence analysisAdd
BLAST
Topological domaini1015 – 103117CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 10311030Potassium-transporting ATPase alpha chain 1PRO_0000046258Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei950 – 9501Phosphoserine; by PKABy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ92126.

Expressioni

Tissue specificityi

Exclusively expressed in stomach mucosa.

Interactioni

Subunit structurei

Composed of two subunits: alpha (catalytic) and beta.

Structurei

3D structure databases

ProteinModelPortaliQ92126.
SMRiQ92126. Positions 33-1031.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004298.
KOiK01542.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR005775. P-type_ATPase_IIC.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q92126-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKKEQYDMY SVEMEREGDG AMDVKVMKKN KASKKKEKLE SMKKEMDIND
60 70 80 90 100
HEITVEELEQ KYTTSVSKGL KSAFAAEVIL RDGPNELKPP KGTPEYIKFA
110 120 130 140 150
RQLAGGLQCL MWVAAVICLI AFGIEESQGD LTSADNLYLA ITLIAVVVVT
160 170 180 190 200
GCFGYYQEFK STNIIASFKN LVPQQATVVR DGDKFQINAN QLVVGDLVEI
210 220 230 240 250
KGGDRVPADI RIITSQGCKV DNSSLTGESE PQTRSPEYTH ESPLETRNIA
260 270 280 290 300
FFSTMCLEGT ATGIIINTGD RTIIGRIATL ASGVGNEKTP IAIEIEHFVD
310 320 330 340 350
IIAGLAIFFG ATFFVVAMVI GYTFLRAMVF FMAIVVAYVP EGLLATVTVC
360 370 380 390 400
LSLTAKRLAR KNCVVKNLEA VETLGSTSVI CSDKTGTLTQ NRMTVSHLWF
410 420 430 440 450
DNHIHSADTT EDQSGQSFDQ TSDTWRALSK VVSLCNRAFF KSGQDGIPVP
460 470 480 490 500
KRIVIGDASE TALVKFSEIT VGNVMEYRER FKKVTEVPFN STNKFQLSIH
510 520 530 540 550
ELQDPLDLRY LMVMKGAPER ILERCSTIMI KGQELPLDEQ WKEAFQTAYM
560 570 580 590 600
DLGGLGERVL GFCHLYLNEK EYSRGFNFDT EEMNFPTSGL CFAGLISMID
610 620 630 640 650
PPRATVPDAV MKCRTAGIRV IMVTGDHPIT AKAIAASVGI ISEGSETVED
660 670 680 690 700
IAARLRIPVE QVNKRDARAC VINGGQLKEM SSEELVEALK LHPEMVFART
710 720 730 740 750
SPQQKLIIVE SCQKLGAIVA VTGDGVNDSP ALKKADIGVA MGIAGSDAAK
760 770 780 790 800
NAADMILLDD NFASIVTGVE QGRLIFDNLK KSIAYTLTKN IPELAPYLIY
810 820 830 840 850
ITASVPLPLG CITILFIELC TDIFPSVSLA YERAESDIMH LKPRNPRRDR
860 870 880 890 900
LVNEALAVYS YFQIGIIQSF AGFVDYFTVM AQEGWFPAYV LGLRSHWENQ
910 920 930 940 950
HLQDLQDSYG QEWTFSQRLY QQYTCYTVFF ISYEICQISD VLIRKTRRLS
960 970 980 990 1000
VFQQGFFRNK VLVIAIVFQL CLGNFLCYCP GMPNVFNFMP IRFQWWLVPL
1010 1020 1030
PFGILIFVYD EIRKLGVRRH PGSWFDKEMY Y
Length:1,031
Mass (Da):115,037
Last modified:January 23, 2007 - v3
Checksum:i9366AC1C6ED4D5FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17249 mRNA. Translation: AAA76601.1.
PIRiI51674.
RefSeqiNP_001084343.1. NM_001090874.1.
UniGeneiXl.971.

Genome annotation databases

GeneIDi399450.
KEGGixla:399450.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17249 mRNA. Translation: AAA76601.1.
PIRiI51674.
RefSeqiNP_001084343.1. NM_001090874.1.
UniGeneiXl.971.

3D structure databases

ProteinModelPortaliQ92126.
SMRiQ92126. Positions 33-1031.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ92126.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi399450.
KEGGixla:399450.

Organism-specific databases

CTDi495.
XenbaseiXB-GENE-486108. atp4a.

Phylogenomic databases

HOVERGENiHBG004298.
KOiK01542.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR005775. P-type_ATPase_IIC.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATP4A_XENLA
AccessioniPrimary (citable) accession number: Q92126
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 23, 2007
Last modified: April 13, 2016
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.