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Reviewed, UniProtKB/Swiss-Prot Q92126 (ATP4A_XENLA)

Last modified February 9, 2010. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Potassium-transporting ATPase alpha chain 1
    EC=3.6.3.10
Alternative name(s):
    Proton pump
    Gastric H(+)/K(+) ATPase subunit alpha
Gene names
Name: atp4a
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

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Protein attributes

Sequence length1031 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Catalyzes the hydrolysis of ATP coupled with the exchange of H+ and K+ ions across the plasma membrane. Responsible for acid production in the stomach.

Catalytic activity

ATP + H2O + H+(In) + K+(Out) = ADP + phosphate + H+(Out) + K+(In).

Subunit structure

Composed of two subunits: alpha (catalytic) and beta.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Exclusively expressed in stomach mucosa.

Sequence similarities

Belongs to the cation transport ATPase (P-type) family. Type IIC subfamily.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 10311030Potassium-transporting ATPase alpha chain 1
PRO_0000046258

Regions

Topological domain2 – 9493Cytoplasmic Potential
Transmembrane95 – 11521 Potential
Topological domain116 – 13823Lumenal Potential
Transmembrane139 – 15921 Potential
Topological domain160 – 295136Cytoplasmic Potential
Transmembrane296 – 31520 Potential
Topological domain316 – 32712Lumenal Potential
Transmembrane328 – 34518 Potential
Topological domain346 – 779434Cytoplasmic Potential
Transmembrane780 – 79920 Potential
Topological domain800 – 80910Lumenal Potential
Transmembrane810 – 83021 Potential
Topological domain831 – 85020Cytoplasmic Potential
Transmembrane851 – 87323 Potential
Topological domain874 – 92552Lumenal Potential
Transmembrane926 – 94520 Potential
Topological domain946 – 95914Cytoplasmic Potential
Transmembrane960 – 97819 Potential
Topological domain979 – 99315Lumenal Potential
Transmembrane994 – 101421 Potential
Topological domain1015 – 103117Cytoplasmic Potential

Sites

Active site38314-aspartylphosphate intermediate By similarity
Metal binding7241Magnesium By similarity
Metal binding7281Magnesium By similarity

Amino acid modifications

Modified residue9501Phosphoserine; by PKA By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q92126-1 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 9366AC1C6ED4D5FC

FASTA1,031115,037
        10         20         30         40         50         60 
MGKKEQYDMY SVEMEREGDG AMDVKVMKKN KASKKKEKLE SMKKEMDIND HEITVEELEQ 

        70         80         90        100        110        120 
KYTTSVSKGL KSAFAAEVIL RDGPNELKPP KGTPEYIKFA RQLAGGLQCL MWVAAVICLI 

       130        140        150        160        170        180 
AFGIEESQGD LTSADNLYLA ITLIAVVVVT GCFGYYQEFK STNIIASFKN LVPQQATVVR 

       190        200        210        220        230        240 
DGDKFQINAN QLVVGDLVEI KGGDRVPADI RIITSQGCKV DNSSLTGESE PQTRSPEYTH 

       250        260        270        280        290        300 
ESPLETRNIA FFSTMCLEGT ATGIIINTGD RTIIGRIATL ASGVGNEKTP IAIEIEHFVD 

       310        320        330        340        350        360 
IIAGLAIFFG ATFFVVAMVI GYTFLRAMVF FMAIVVAYVP EGLLATVTVC LSLTAKRLAR 

       370        380        390        400        410        420 
KNCVVKNLEA VETLGSTSVI CSDKTGTLTQ NRMTVSHLWF DNHIHSADTT EDQSGQSFDQ 

       430        440        450        460        470        480 
TSDTWRALSK VVSLCNRAFF KSGQDGIPVP KRIVIGDASE TALVKFSEIT VGNVMEYRER 

       490        500        510        520        530        540 
FKKVTEVPFN STNKFQLSIH ELQDPLDLRY LMVMKGAPER ILERCSTIMI KGQELPLDEQ 

       550        560        570        580        590        600 
WKEAFQTAYM DLGGLGERVL GFCHLYLNEK EYSRGFNFDT EEMNFPTSGL CFAGLISMID 

       610        620        630        640        650        660 
PPRATVPDAV MKCRTAGIRV IMVTGDHPIT AKAIAASVGI ISEGSETVED IAARLRIPVE 

       670        680        690        700        710        720 
QVNKRDARAC VINGGQLKEM SSEELVEALK LHPEMVFART SPQQKLIIVE SCQKLGAIVA 

       730        740        750        760        770        780 
VTGDGVNDSP ALKKADIGVA MGIAGSDAAK NAADMILLDD NFASIVTGVE QGRLIFDNLK 

       790        800        810        820        830        840 
KSIAYTLTKN IPELAPYLIY ITASVPLPLG CITILFIELC TDIFPSVSLA YERAESDIMH 

       850        860        870        880        890        900 
LKPRNPRRDR LVNEALAVYS YFQIGIIQSF AGFVDYFTVM AQEGWFPAYV LGLRSHWENQ 

       910        920        930        940        950        960 
HLQDLQDSYG QEWTFSQRLY QQYTCYTVFF ISYEICQISD VLIRKTRRLS VFQQGFFRNK 

       970        980        990       1000       1010       1020 
VLVIAIVFQL CLGNFLCYCP GMPNVFNFMP IRFQWWLVPL PFGILIFVYD EIRKLGVRRH 

      1030 
PGSWFDKEMY Y

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References

[1]"Primary structure and functional expression of the mouse and frog alpha-subunit of the gastric H(+)-K(+)-ATPase."
Mathews P.M., Claeys D., Jaisser F., Geering K., Horisberger J.-D., Kraehenbuhl J.-P., Rossier B.C.
Am. J. Physiol. 268:C1207-C1214(1995) [PubMed: 7762614] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Gastric mucosa.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U17249 mRNA. Translation: AAA76601.1.
PIRI51674.
RefSeqNP_001084343.1.
UniGeneXl.971

3D structure databases

SMRQ92126. Positions 33-1031.
ModBaseSearch...

Genome annotation databases

GeneID399450.
KEGGxla:399450.

Organism-specific databases

CTD399450.
XenbaseXB-FEAT-486103. atp4a.

Phylogenomic databases

HOVERGENQ92126.

Enzyme and pathway databases

BRENDA3.6.3.10. 648.

Family and domain databases

InterProIPR008250. ATPase_P-typ_ATPase-assoc-dom.
IPR005775. ATPase_P-typ_cation-ex_asu_euk.
IPR006069. ATPase_P-typ_cation-exchng_asu.
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR001757. ATPase_P-typ_ion-transptr.
IPR018303. ATPase_P-typ_P_site.
IPR005834. Dehalogen-like_hydro.
[Graphical view]
PANTHERPTHR11939. ATPase_P. 1 hit.
PfamPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSPR00119. CATATPASE.
PR00121. NAKATPASE.
SMARTSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 4 hits.
PROSITEPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameATP4A_XENLA
AccessionPrimary (citable) accession number: Q92126
Entry history
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 23, 2007
Last modified: February 9, 2010
This is version 81 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectXenopus annotation project

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents