Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Potassium-transporting ATPase alpha chain 1

Gene

atp4a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the hydrolysis of ATP coupled with the exchange of H+ and K+ ions across the plasma membrane. Responsible for acid production in the stomach.

Catalytic activityi

ATP + H2O + H+(In) + K+(Out) = ADP + phosphate + H+(Out) + K+(In).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei3834-aspartylphosphate intermediateBy similarity1
Metal bindingi724MagnesiumBy similarity1
Metal bindingi728MagnesiumBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processHydrogen ion transport, Ion transport, Potassium transport, Transport
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium-transporting ATPase alpha chain 1 (EC:3.6.3.10)
Alternative name(s):
Gastric H(+)/K(+) ATPase subunit alpha
Proton pump
Gene namesi
Name:atp4a
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-486108 atp4a

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 94CytoplasmicSequence analysisAdd BLAST93
Transmembranei95 – 115HelicalSequence analysisAdd BLAST21
Topological domaini116 – 138LumenalSequence analysisAdd BLAST23
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21
Topological domaini160 – 295CytoplasmicSequence analysisAdd BLAST136
Transmembranei296 – 315HelicalSequence analysisAdd BLAST20
Topological domaini316 – 327LumenalSequence analysisAdd BLAST12
Transmembranei328 – 345HelicalSequence analysisAdd BLAST18
Topological domaini346 – 779CytoplasmicSequence analysisAdd BLAST434
Transmembranei780 – 799HelicalSequence analysisAdd BLAST20
Topological domaini800 – 809LumenalSequence analysis10
Transmembranei810 – 830HelicalSequence analysisAdd BLAST21
Topological domaini831 – 850CytoplasmicSequence analysisAdd BLAST20
Transmembranei851 – 873HelicalSequence analysisAdd BLAST23
Topological domaini874 – 925LumenalSequence analysisAdd BLAST52
Transmembranei926 – 945HelicalSequence analysisAdd BLAST20
Topological domaini946 – 959CytoplasmicSequence analysisAdd BLAST14
Transmembranei960 – 978HelicalSequence analysisAdd BLAST19
Topological domaini979 – 993LumenalSequence analysisAdd BLAST15
Transmembranei994 – 1014HelicalSequence analysisAdd BLAST21
Topological domaini1015 – 1031CytoplasmicSequence analysisAdd BLAST17

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000462582 – 1031Potassium-transporting ATPase alpha chain 1Add BLAST1030

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei950Phosphoserine; by PKABy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ92126

Expressioni

Tissue specificityi

Exclusively expressed in stomach mucosa.

Interactioni

Subunit structurei

Composed of two subunits: alpha (catalytic) and beta.

Structurei

3D structure databases

ProteinModelPortaliQ92126
SMRiQ92126
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004298
KOiK01542

Family and domain databases

CDDicd02608 P-type_ATPase_Na-K_like, 1 hit
Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR006068 ATPase_P-typ_cation-transptr_C
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR005775 P-type_ATPase_IIC
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00689 Cation_ATPase_C, 1 hit
PF00690 Cation_ATPase_N, 1 hit
SMARTiView protein in SMART
SM00831 Cation_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 3 hits
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01106 ATPase-IIC_X-K, 1 hit
TIGR01494 ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q92126-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKKEQYDMY SVEMEREGDG AMDVKVMKKN KASKKKEKLE SMKKEMDIND
60 70 80 90 100
HEITVEELEQ KYTTSVSKGL KSAFAAEVIL RDGPNELKPP KGTPEYIKFA
110 120 130 140 150
RQLAGGLQCL MWVAAVICLI AFGIEESQGD LTSADNLYLA ITLIAVVVVT
160 170 180 190 200
GCFGYYQEFK STNIIASFKN LVPQQATVVR DGDKFQINAN QLVVGDLVEI
210 220 230 240 250
KGGDRVPADI RIITSQGCKV DNSSLTGESE PQTRSPEYTH ESPLETRNIA
260 270 280 290 300
FFSTMCLEGT ATGIIINTGD RTIIGRIATL ASGVGNEKTP IAIEIEHFVD
310 320 330 340 350
IIAGLAIFFG ATFFVVAMVI GYTFLRAMVF FMAIVVAYVP EGLLATVTVC
360 370 380 390 400
LSLTAKRLAR KNCVVKNLEA VETLGSTSVI CSDKTGTLTQ NRMTVSHLWF
410 420 430 440 450
DNHIHSADTT EDQSGQSFDQ TSDTWRALSK VVSLCNRAFF KSGQDGIPVP
460 470 480 490 500
KRIVIGDASE TALVKFSEIT VGNVMEYRER FKKVTEVPFN STNKFQLSIH
510 520 530 540 550
ELQDPLDLRY LMVMKGAPER ILERCSTIMI KGQELPLDEQ WKEAFQTAYM
560 570 580 590 600
DLGGLGERVL GFCHLYLNEK EYSRGFNFDT EEMNFPTSGL CFAGLISMID
610 620 630 640 650
PPRATVPDAV MKCRTAGIRV IMVTGDHPIT AKAIAASVGI ISEGSETVED
660 670 680 690 700
IAARLRIPVE QVNKRDARAC VINGGQLKEM SSEELVEALK LHPEMVFART
710 720 730 740 750
SPQQKLIIVE SCQKLGAIVA VTGDGVNDSP ALKKADIGVA MGIAGSDAAK
760 770 780 790 800
NAADMILLDD NFASIVTGVE QGRLIFDNLK KSIAYTLTKN IPELAPYLIY
810 820 830 840 850
ITASVPLPLG CITILFIELC TDIFPSVSLA YERAESDIMH LKPRNPRRDR
860 870 880 890 900
LVNEALAVYS YFQIGIIQSF AGFVDYFTVM AQEGWFPAYV LGLRSHWENQ
910 920 930 940 950
HLQDLQDSYG QEWTFSQRLY QQYTCYTVFF ISYEICQISD VLIRKTRRLS
960 970 980 990 1000
VFQQGFFRNK VLVIAIVFQL CLGNFLCYCP GMPNVFNFMP IRFQWWLVPL
1010 1020 1030
PFGILIFVYD EIRKLGVRRH PGSWFDKEMY Y
Length:1,031
Mass (Da):115,037
Last modified:January 23, 2007 - v3
Checksum:i9366AC1C6ED4D5FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17249 mRNA Translation: AAA76601.1
PIRiI51674
RefSeqiNP_001084343.1, NM_001090874.1
UniGeneiXl.971

Genome annotation databases

GeneIDi399450
KEGGixla:399450

Similar proteinsi

Entry informationi

Entry nameiATP4A_XENLA
AccessioniPrimary (citable) accession number: Q92126
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 121 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health