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Q92123

- AT1A1_XENLA

UniProt

Q92123 - AT1A1_XENLA

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Protein

Sodium/potassium-transporting ATPase subunit alpha-1

Gene
atp1a1
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

Catalytic activityi

ATP + H2O + Na+(In) + K+(Out) = ADP + phosphate + Na+(Out) + K+(In).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei378 – 37814-aspartylphosphate intermediate By similarity
Binding sitei489 – 4891ATP By similarity
Metal bindingi719 – 7191Magnesium By similarity
Metal bindingi723 – 7231Magnesium By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sodium:potassium-exchanging ATPase activity Source: UniProtKB-EC

GO - Biological processi

  1. ATP biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit alpha-1 (EC:3.6.3.9)
Short name:
Na(+)/K(+) ATPase alpha-1 subunit
Alternative name(s):
Sodium pump subunit alpha-1
Gene namesi
Name:atp1a1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6254180. atp1a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8989Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei90 – 11021Helical; Reviewed predictionAdd
BLAST
Topological domaini111 – 13323Extracellular Reviewed predictionAdd
BLAST
Transmembranei134 – 15421Helical; Reviewed predictionAdd
BLAST
Topological domaini155 – 290136Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei291 – 31020Helical; Reviewed predictionAdd
BLAST
Topological domaini311 – 32212Extracellular Reviewed predictionAdd
BLAST
Transmembranei323 – 34018Helical; Reviewed predictionAdd
BLAST
Topological domaini341 – 774434Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei775 – 79420Helical; Reviewed predictionAdd
BLAST
Topological domaini795 – 80410Extracellular Reviewed prediction
Transmembranei805 – 82521Helical; Reviewed predictionAdd
BLAST
Topological domaini826 – 84520Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei846 – 86823Helical; Reviewed predictionAdd
BLAST
Topological domaini869 – 92052Extracellular Reviewed predictionAdd
BLAST
Transmembranei921 – 94020Helical; Reviewed predictionAdd
BLAST
Topological domaini941 – 95313Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei954 – 97219Helical; Reviewed predictionAdd
BLAST
Topological domaini973 – 98715Extracellular Reviewed predictionAdd
BLAST
Transmembranei988 – 100821Helical; Reviewed predictionAdd
BLAST
Topological domaini1009 – 102517Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10251025Sodium/potassium-transporting ATPase subunit alpha-1PRO_0000046296Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei16 – 161Phosphoserine; by PKC By similarity
Modified residuei945 – 9451Phosphoserine; by PKA By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ92123.

Interactioni

Subunit structurei

Composed of three subunits: alpha (catalytic), beta and gamma.

Structurei

3D structure databases

ProteinModelPortaliQ92123.
SMRiQ92123. Positions 30-1025.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni84 – 863Interaction with phosphoinositide-3 kinase By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi21 – 288Poly-Lys

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004298.
KOiK01539.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92123-1 [UniParc]FASTAAdd to Basket

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MGYGAGRDKY EPAATSEQGG KKKKGKGKGK EKDMDELKKE VTMEDHKLSL     50
DELHRKFGTD MQRGLTTARA AEILARDGPN ALTPPPTTPE WVKFCRQLFG 100
GFSMLLWIGA ILCFLAYGIQ AAMEEEPQND NLYLGVVLSA VVIITGCFSY 150
YQEAKSSKIM ESFKNMVPQQ ALVIRSGEKL SINAEEVVLG DLVEVKGGDR 200
IPADLRVISS HGCKVDNSSL TGESEPQTRS PDFTNENPLE TRNIAFFSTN 250
CVEGTARGIV VNTGDRTVMG RIATLASGLD GGRTPIAIEI EHFIHIITGV 300
AVFLGVSFFI LSLILQYTWL EAVIFLIGII VANVPEGLLA TVTVCLTLTA 350
KRMARKNCLV KNLEAVETLG STSTICSDKT GTLTQNRMTV AHMWFDNQIH 400
EADTTENQSG ASFDKSSPTW TALSRVAGLC NRAVFQAGQE NTPILKRDVA 450
GDASESALLK CIELCCGSVR DMREKNHKVA EIPFNSTNKY QLSVHKNANP 500
SESRYILVMK GAPERILDRC TSIILQGKEQ PLDEELKDAF QNAYLELGGL 550
GERVLGFCHL ALPDDQFPDG FQFDTEEVNF PTENLCFVGL ISMIDPPRAA 600
VPDAVGKCRS AGIKVIMVTG DHPITAKAIA KGVGIISEGN ETVEDIAARL 650
NIPVNQVNPR DAKACVIHGT DLKDMTEEQI DDILRHHTEI VFARTSPQQK 700
LIIVEGCQRQ GAIVAVTGDG VNDSPALKKA DIGIAMGIAG SDVSKQAADM 750
ILLDDNFASI VTGVEEGRLI FDNLKKSIAY TLTSNIPEIT PFLIFIIANI 800
PLPLGTVTIL CIDLGTDMVP AISLAYEQAE SDIMKRQPRN PKTDKLVNER 850
LISMAYGQIG MIQALGGFFT YFVILAENGF LPWTLLGIRV NWDDRWTNDV 900
EDSYGQQWTY EQRKIVEFTC HTSFFISIVV VQWADLIICK TRRNSVFQQG 950
MKNKILIFGL FEETALAAFL SYCPGMDVAL RMYPLKPTWW FCAFPYSLII 1000
FIYDEVRKLI IRRSPGGWVE KESYY 1025
Length:1,025
Mass (Da):113,084
Last modified:November 1, 1996 - v1
Checksum:iB5F9B4EB6D86EEA0
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91K → Q in AAC59760. 1 Publication
Sequence conflicti29 – 302Missing in AAC59759. 1 Publication
Sequence conflicti29 – 302Missing in AAC59760. 1 Publication
Sequence conflicti31 – 311E → D in AAC59760. 1 Publication
Sequence conflicti61 – 633MQR → LQK in AAC59760. 1 Publication
Sequence conflicti67 – 671T → S in AAC59760. 1 Publication
Sequence conflicti81 – 811A → S in AAC59760. 1 Publication
Sequence conflicti92 – 921V → G in AAC59760. 1 Publication
Sequence conflicti102 – 1021F → L in AAC59760. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U10108 mRNA. Translation: AAA19022.1.
U49238 mRNA. Translation: AAC59759.1.
U49239 mRNA. Translation: AAC59760.1.
PIRiA60444.
RefSeqiNP_001084064.1. NM_001090595.1.
UniGeneiXl.3792.

Genome annotation databases

GeneIDi399285.
KEGGixla:399285.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U10108 mRNA. Translation: AAA19022.1 .
U49238 mRNA. Translation: AAC59759.1 .
U49239 mRNA. Translation: AAC59760.1 .
PIRi A60444.
RefSeqi NP_001084064.1. NM_001090595.1.
UniGenei Xl.3792.

3D structure databases

ProteinModelPortali Q92123.
SMRi Q92123. Positions 30-1025.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q92123.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 399285.
KEGGi xla:399285.

Organism-specific databases

CTDi 399285.
Xenbasei XB-GENE-6254180. atp1a1.

Phylogenomic databases

HOVERGENi HBG004298.
KOi K01539.

Family and domain databases

Gene3Di 1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProi IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view ]
Pfami PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view ]
PRINTSi PR00119. CATATPASE.
SMARTi SM00831. Cation_ATPase_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 1 hit.
SSF81660. SSF81660. 1 hit.
TIGRFAMsi TIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Primary sequence of Xenopus laevis Na+-K+-ATPase and its localization in A6 kidney cells."
    Verrey F., Kairouz P., Schaerer E., Fuentes P., Geering K., Rossier B.C., Kraehenbuhl J.-P.
    Am. J. Physiol. 256:F1034-F1043(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney epithelium.
  2. "Primary sequence and developmental expression pattern of mRNAs and protein for an alpha1 subunit of the sodium pump cloned from the neural plate of Xenopus laevis."
    Davies C.S., Messenger N.J., Craig R., Warner A.E.
    Dev. Biol. 174:431-447(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Neural plate.

Entry informationi

Entry nameiAT1A1_XENLA
AccessioniPrimary (citable) accession number: Q92123
Secondary accession number(s): Q91683, Q92127
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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