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Q92123

- AT1A1_XENLA

UniProt

Q92123 - AT1A1_XENLA

Protein

Sodium/potassium-transporting ATPase subunit alpha-1

Gene

atp1a1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

    Catalytic activityi

    ATP + H2O + Na+(In) + K+(Out) = ADP + phosphate + Na+(Out) + K+(In).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei378 – 37814-aspartylphosphate intermediateBy similarity
    Binding sitei489 – 4891ATPBy similarity
    Metal bindingi719 – 7191MagnesiumBy similarity
    Metal bindingi723 – 7231MagnesiumBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sodium:potassium-exchanging ATPase activity Source: UniProtKB-EC

    GO - Biological processi

    1. ATP biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium/potassium-transporting ATPase subunit alpha-1 (EC:3.6.3.9)
    Short name:
    Na(+)/K(+) ATPase alpha-1 subunit
    Alternative name(s):
    Sodium pump subunit alpha-1
    Gene namesi
    Name:atp1a1
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-6254180. atp1a1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB
    2. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10251025Sodium/potassium-transporting ATPase subunit alpha-1PRO_0000046296Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei16 – 161Phosphoserine; by PKCBy similarity
    Modified residuei945 – 9451Phosphoserine; by PKABy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ92123.

    Interactioni

    Subunit structurei

    Composed of three subunits: alpha (catalytic), beta and gamma.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92123.
    SMRiQ92123. Positions 30-1025.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 8989CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini111 – 13323ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini155 – 290136CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini311 – 32212ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini341 – 774434CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini795 – 80410ExtracellularSequence Analysis
    Topological domaini826 – 84520CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini869 – 92052ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini941 – 95313CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini973 – 98715ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1009 – 102517CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei90 – 11021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei134 – 15421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei291 – 31020HelicalSequence AnalysisAdd
    BLAST
    Transmembranei323 – 34018HelicalSequence AnalysisAdd
    BLAST
    Transmembranei775 – 79420HelicalSequence AnalysisAdd
    BLAST
    Transmembranei805 – 82521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei846 – 86823HelicalSequence AnalysisAdd
    BLAST
    Transmembranei921 – 94020HelicalSequence AnalysisAdd
    BLAST
    Transmembranei954 – 97219HelicalSequence AnalysisAdd
    BLAST
    Transmembranei988 – 100821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni84 – 863Interaction with phosphoinositide-3 kinaseBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi21 – 288Poly-Lys

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG004298.
    KOiK01539.

    Family and domain databases

    Gene3Di1.20.1110.10. 2 hits.
    2.70.150.10. 2 hits.
    3.40.1110.10. 1 hit.
    InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
    IPR004014. ATPase_P-typ_cation-transptr_N.
    IPR023299. ATPase_P-typ_cyto_domN.
    IPR005775. ATPase_P-typ_Na/K_IIC.
    IPR018303. ATPase_P-typ_P_site.
    IPR023298. ATPase_P-typ_TM_dom.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view]
    PfamiPF00689. Cation_ATPase_C. 1 hit.
    PF00690. Cation_ATPase_N. 1 hit.
    PF00122. E1-E2_ATPase. 1 hit.
    PF00702. Hydrolase. 1 hit.
    [Graphical view]
    PRINTSiPR00119. CATATPASE.
    SMARTiSM00831. Cation_ATPase_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 1 hit.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
    TIGR01494. ATPase_P-type. 2 hits.
    PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92123-1 [UniParc]FASTAAdd to Basket

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    MGYGAGRDKY EPAATSEQGG KKKKGKGKGK EKDMDELKKE VTMEDHKLSL     50
    DELHRKFGTD MQRGLTTARA AEILARDGPN ALTPPPTTPE WVKFCRQLFG 100
    GFSMLLWIGA ILCFLAYGIQ AAMEEEPQND NLYLGVVLSA VVIITGCFSY 150
    YQEAKSSKIM ESFKNMVPQQ ALVIRSGEKL SINAEEVVLG DLVEVKGGDR 200
    IPADLRVISS HGCKVDNSSL TGESEPQTRS PDFTNENPLE TRNIAFFSTN 250
    CVEGTARGIV VNTGDRTVMG RIATLASGLD GGRTPIAIEI EHFIHIITGV 300
    AVFLGVSFFI LSLILQYTWL EAVIFLIGII VANVPEGLLA TVTVCLTLTA 350
    KRMARKNCLV KNLEAVETLG STSTICSDKT GTLTQNRMTV AHMWFDNQIH 400
    EADTTENQSG ASFDKSSPTW TALSRVAGLC NRAVFQAGQE NTPILKRDVA 450
    GDASESALLK CIELCCGSVR DMREKNHKVA EIPFNSTNKY QLSVHKNANP 500
    SESRYILVMK GAPERILDRC TSIILQGKEQ PLDEELKDAF QNAYLELGGL 550
    GERVLGFCHL ALPDDQFPDG FQFDTEEVNF PTENLCFVGL ISMIDPPRAA 600
    VPDAVGKCRS AGIKVIMVTG DHPITAKAIA KGVGIISEGN ETVEDIAARL 650
    NIPVNQVNPR DAKACVIHGT DLKDMTEEQI DDILRHHTEI VFARTSPQQK 700
    LIIVEGCQRQ GAIVAVTGDG VNDSPALKKA DIGIAMGIAG SDVSKQAADM 750
    ILLDDNFASI VTGVEEGRLI FDNLKKSIAY TLTSNIPEIT PFLIFIIANI 800
    PLPLGTVTIL CIDLGTDMVP AISLAYEQAE SDIMKRQPRN PKTDKLVNER 850
    LISMAYGQIG MIQALGGFFT YFVILAENGF LPWTLLGIRV NWDDRWTNDV 900
    EDSYGQQWTY EQRKIVEFTC HTSFFISIVV VQWADLIICK TRRNSVFQQG 950
    MKNKILIFGL FEETALAAFL SYCPGMDVAL RMYPLKPTWW FCAFPYSLII 1000
    FIYDEVRKLI IRRSPGGWVE KESYY 1025
    Length:1,025
    Mass (Da):113,084
    Last modified:November 1, 1996 - v1
    Checksum:iB5F9B4EB6D86EEA0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti9 – 91K → Q in AAC59760. (PubMed:8631513)Curated
    Sequence conflicti29 – 302Missing in AAC59759. (PubMed:8631513)Curated
    Sequence conflicti29 – 302Missing in AAC59760. (PubMed:8631513)Curated
    Sequence conflicti31 – 311E → D in AAC59760. (PubMed:8631513)Curated
    Sequence conflicti61 – 633MQR → LQK in AAC59760. (PubMed:8631513)Curated
    Sequence conflicti67 – 671T → S in AAC59760. (PubMed:8631513)Curated
    Sequence conflicti81 – 811A → S in AAC59760. (PubMed:8631513)Curated
    Sequence conflicti92 – 921V → G in AAC59760. (PubMed:8631513)Curated
    Sequence conflicti102 – 1021F → L in AAC59760. (PubMed:8631513)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U10108 mRNA. Translation: AAA19022.1.
    U49238 mRNA. Translation: AAC59759.1.
    U49239 mRNA. Translation: AAC59760.1.
    PIRiA60444.
    RefSeqiNP_001084064.1. NM_001090595.1.
    UniGeneiXl.3792.

    Genome annotation databases

    GeneIDi399285.
    KEGGixla:399285.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U10108 mRNA. Translation: AAA19022.1 .
    U49238 mRNA. Translation: AAC59759.1 .
    U49239 mRNA. Translation: AAC59760.1 .
    PIRi A60444.
    RefSeqi NP_001084064.1. NM_001090595.1.
    UniGenei Xl.3792.

    3D structure databases

    ProteinModelPortali Q92123.
    SMRi Q92123. Positions 30-1025.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q92123.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 399285.
    KEGGi xla:399285.

    Organism-specific databases

    CTDi 399285.
    Xenbasei XB-GENE-6254180. atp1a1.

    Phylogenomic databases

    HOVERGENi HBG004298.
    KOi K01539.

    Family and domain databases

    Gene3Di 1.20.1110.10. 2 hits.
    2.70.150.10. 2 hits.
    3.40.1110.10. 1 hit.
    InterProi IPR006068. ATPase_P-typ_cation-transptr_C.
    IPR004014. ATPase_P-typ_cation-transptr_N.
    IPR023299. ATPase_P-typ_cyto_domN.
    IPR005775. ATPase_P-typ_Na/K_IIC.
    IPR018303. ATPase_P-typ_P_site.
    IPR023298. ATPase_P-typ_TM_dom.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view ]
    Pfami PF00689. Cation_ATPase_C. 1 hit.
    PF00690. Cation_ATPase_N. 1 hit.
    PF00122. E1-E2_ATPase. 1 hit.
    PF00702. Hydrolase. 1 hit.
    [Graphical view ]
    PRINTSi PR00119. CATATPASE.
    SMARTi SM00831. Cation_ATPase_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 1 hit.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsi TIGR01106. ATPase-IIC_X-K. 1 hit.
    TIGR01494. ATPase_P-type. 2 hits.
    PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Primary sequence of Xenopus laevis Na+-K+-ATPase and its localization in A6 kidney cells."
      Verrey F., Kairouz P., Schaerer E., Fuentes P., Geering K., Rossier B.C., Kraehenbuhl J.-P.
      Am. J. Physiol. 256:F1034-F1043(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Kidney epithelium.
    2. "Primary sequence and developmental expression pattern of mRNAs and protein for an alpha1 subunit of the sodium pump cloned from the neural plate of Xenopus laevis."
      Davies C.S., Messenger N.J., Craig R., Warner A.E.
      Dev. Biol. 174:431-447(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Neural plate.

    Entry informationi

    Entry nameiAT1A1_XENLA
    AccessioniPrimary (citable) accession number: Q92123
    Secondary accession number(s): Q91683, Q92127
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 18, 2001
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3