Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q92123

- AT1A1_XENLA

UniProt

Q92123 - AT1A1_XENLA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Sodium/potassium-transporting ATPase subunit alpha-1

Gene

atp1a1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

Catalytic activityi

ATP + H2O + Na+(In) + K+(Out) = ADP + phosphate + Na+(Out) + K+(In).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei378 – 37814-aspartylphosphate intermediateBy similarity
Binding sitei489 – 4891ATPBy similarity
Metal bindingi719 – 7191MagnesiumBy similarity
Metal bindingi723 – 7231MagnesiumBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sodium:potassium-exchanging ATPase activity Source: BHF-UCL

GO - Biological processi

  1. ATP biosynthetic process Source: InterPro
  2. cellular potassium ion homeostasis Source: BHF-UCL
  3. cellular sodium ion homeostasis Source: BHF-UCL
  4. membrane repolarization Source: BHF-UCL
  5. potassium ion import Source: BHF-UCL
  6. sodium ion export from cell Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit alpha-1 (EC:3.6.3.9)
Short name:
Na(+)/K(+) ATPase alpha-1 subunit
Alternative name(s):
Sodium pump subunit alpha-1
Gene namesi
Name:atp1a1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6254180. atp1a1.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. plasma membrane Source: UniProtKB
  3. sodium:potassium-exchanging ATPase complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10251025Sodium/potassium-transporting ATPase subunit alpha-1PRO_0000046296Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei16 – 161Phosphoserine; by PKCBy similarity
Modified residuei945 – 9451Phosphoserine; by PKABy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ92123.

Interactioni

Subunit structurei

Composed of three subunits: alpha (catalytic), beta and gamma.

Structurei

3D structure databases

ProteinModelPortaliQ92123.
SMRiQ92123. Positions 30-1025.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 8989CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini111 – 13323ExtracellularSequence AnalysisAdd
BLAST
Topological domaini155 – 290136CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini311 – 32212ExtracellularSequence AnalysisAdd
BLAST
Topological domaini341 – 774434CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini795 – 80410ExtracellularSequence Analysis
Topological domaini826 – 84520CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini869 – 92052ExtracellularSequence AnalysisAdd
BLAST
Topological domaini941 – 95313CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini973 – 98715ExtracellularSequence AnalysisAdd
BLAST
Topological domaini1009 – 102517CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei90 – 11021HelicalSequence AnalysisAdd
BLAST
Transmembranei134 – 15421HelicalSequence AnalysisAdd
BLAST
Transmembranei291 – 31020HelicalSequence AnalysisAdd
BLAST
Transmembranei323 – 34018HelicalSequence AnalysisAdd
BLAST
Transmembranei775 – 79420HelicalSequence AnalysisAdd
BLAST
Transmembranei805 – 82521HelicalSequence AnalysisAdd
BLAST
Transmembranei846 – 86823HelicalSequence AnalysisAdd
BLAST
Transmembranei921 – 94020HelicalSequence AnalysisAdd
BLAST
Transmembranei954 – 97219HelicalSequence AnalysisAdd
BLAST
Transmembranei988 – 100821HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni84 – 863Interaction with phosphoinositide-3 kinaseBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi21 – 288Poly-Lys

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004298.
KOiK01539.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92123-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGYGAGRDKY EPAATSEQGG KKKKGKGKGK EKDMDELKKE VTMEDHKLSL
60 70 80 90 100
DELHRKFGTD MQRGLTTARA AEILARDGPN ALTPPPTTPE WVKFCRQLFG
110 120 130 140 150
GFSMLLWIGA ILCFLAYGIQ AAMEEEPQND NLYLGVVLSA VVIITGCFSY
160 170 180 190 200
YQEAKSSKIM ESFKNMVPQQ ALVIRSGEKL SINAEEVVLG DLVEVKGGDR
210 220 230 240 250
IPADLRVISS HGCKVDNSSL TGESEPQTRS PDFTNENPLE TRNIAFFSTN
260 270 280 290 300
CVEGTARGIV VNTGDRTVMG RIATLASGLD GGRTPIAIEI EHFIHIITGV
310 320 330 340 350
AVFLGVSFFI LSLILQYTWL EAVIFLIGII VANVPEGLLA TVTVCLTLTA
360 370 380 390 400
KRMARKNCLV KNLEAVETLG STSTICSDKT GTLTQNRMTV AHMWFDNQIH
410 420 430 440 450
EADTTENQSG ASFDKSSPTW TALSRVAGLC NRAVFQAGQE NTPILKRDVA
460 470 480 490 500
GDASESALLK CIELCCGSVR DMREKNHKVA EIPFNSTNKY QLSVHKNANP
510 520 530 540 550
SESRYILVMK GAPERILDRC TSIILQGKEQ PLDEELKDAF QNAYLELGGL
560 570 580 590 600
GERVLGFCHL ALPDDQFPDG FQFDTEEVNF PTENLCFVGL ISMIDPPRAA
610 620 630 640 650
VPDAVGKCRS AGIKVIMVTG DHPITAKAIA KGVGIISEGN ETVEDIAARL
660 670 680 690 700
NIPVNQVNPR DAKACVIHGT DLKDMTEEQI DDILRHHTEI VFARTSPQQK
710 720 730 740 750
LIIVEGCQRQ GAIVAVTGDG VNDSPALKKA DIGIAMGIAG SDVSKQAADM
760 770 780 790 800
ILLDDNFASI VTGVEEGRLI FDNLKKSIAY TLTSNIPEIT PFLIFIIANI
810 820 830 840 850
PLPLGTVTIL CIDLGTDMVP AISLAYEQAE SDIMKRQPRN PKTDKLVNER
860 870 880 890 900
LISMAYGQIG MIQALGGFFT YFVILAENGF LPWTLLGIRV NWDDRWTNDV
910 920 930 940 950
EDSYGQQWTY EQRKIVEFTC HTSFFISIVV VQWADLIICK TRRNSVFQQG
960 970 980 990 1000
MKNKILIFGL FEETALAAFL SYCPGMDVAL RMYPLKPTWW FCAFPYSLII
1010 1020
FIYDEVRKLI IRRSPGGWVE KESYY
Length:1,025
Mass (Da):113,084
Last modified:November 1, 1996 - v1
Checksum:iB5F9B4EB6D86EEA0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91K → Q in AAC59760. (PubMed:8631513)Curated
Sequence conflicti29 – 302Missing in AAC59759. (PubMed:8631513)Curated
Sequence conflicti29 – 302Missing in AAC59760. (PubMed:8631513)Curated
Sequence conflicti31 – 311E → D in AAC59760. (PubMed:8631513)Curated
Sequence conflicti61 – 633MQR → LQK in AAC59760. (PubMed:8631513)Curated
Sequence conflicti67 – 671T → S in AAC59760. (PubMed:8631513)Curated
Sequence conflicti81 – 811A → S in AAC59760. (PubMed:8631513)Curated
Sequence conflicti92 – 921V → G in AAC59760. (PubMed:8631513)Curated
Sequence conflicti102 – 1021F → L in AAC59760. (PubMed:8631513)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U10108 mRNA. Translation: AAA19022.1.
U49238 mRNA. Translation: AAC59759.1.
U49239 mRNA. Translation: AAC59760.1.
PIRiA60444.
RefSeqiNP_001084064.1. NM_001090595.1.
UniGeneiXl.3792.

Genome annotation databases

GeneIDi399285.
KEGGixla:399285.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U10108 mRNA. Translation: AAA19022.1 .
U49238 mRNA. Translation: AAC59759.1 .
U49239 mRNA. Translation: AAC59760.1 .
PIRi A60444.
RefSeqi NP_001084064.1. NM_001090595.1.
UniGenei Xl.3792.

3D structure databases

ProteinModelPortali Q92123.
SMRi Q92123. Positions 30-1025.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q92123.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 399285.
KEGGi xla:399285.

Organism-specific databases

CTDi 399285.
Xenbasei XB-GENE-6254180. atp1a1.

Phylogenomic databases

HOVERGENi HBG004298.
KOi K01539.

Family and domain databases

Gene3Di 1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProi IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view ]
Pfami PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view ]
PRINTSi PR00119. CATATPASE.
SMARTi SM00831. Cation_ATPase_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 1 hit.
SSF81660. SSF81660. 1 hit.
TIGRFAMsi TIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Primary sequence of Xenopus laevis Na+-K+-ATPase and its localization in A6 kidney cells."
    Verrey F., Kairouz P., Schaerer E., Fuentes P., Geering K., Rossier B.C., Kraehenbuhl J.-P.
    Am. J. Physiol. 256:F1034-F1043(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney epithelium.
  2. "Primary sequence and developmental expression pattern of mRNAs and protein for an alpha1 subunit of the sodium pump cloned from the neural plate of Xenopus laevis."
    Davies C.S., Messenger N.J., Craig R., Warner A.E.
    Dev. Biol. 174:431-447(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Neural plate.

Entry informationi

Entry nameiAT1A1_XENLA
AccessioniPrimary (citable) accession number: Q92123
Secondary accession number(s): Q91683, Q92127
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3