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Q92122

- KPYM_XENLA

UniProt

Q92122 - KPYM_XENLA

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Protein

Pyruvate kinase PKM

Gene

pkm

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

May modulate the metamorphic process by regulating the level of intracellular thyroid hormones.

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactori

Magnesium.By similarity
Potassium.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei69 – 691SubstrateBy similarity
Metal bindingi71 – 711PotassiumBy similarity
Metal bindingi73 – 731PotassiumBy similarity
Metal bindingi109 – 1091PotassiumBy similarity
Metal bindingi110 – 1101Potassium; via carbonyl oxygenBy similarity
Sitei266 – 2661Transition state stabilizerBy similarity
Metal bindingi268 – 2681MagnesiumSequence Analysis
Binding sitei291 – 2911Substrate; via amide nitrogenBy similarity
Metal bindingi292 – 2921MagnesiumBy similarity
Binding sitei292 – 2921Substrate; via amide nitrogenBy similarity
Binding sitei324 – 3241SubstrateBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. magnesium ion binding Source: InterPro
  3. potassium ion binding Source: InterPro
  4. pyruvate kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Pyruvate

Enzyme and pathway databases

UniPathwayiUPA00109; UER00188.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinase PKM (EC:2.7.1.40)
Alternative name(s):
Cytosolic thyroid hormone-binding protein
Short name:
CTHBP
Gene namesi
Name:pkm
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-485877. pkm.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 527527Pyruvate kinase PKMPRO_0000112098Add
BLAST

Proteomic databases

PRIDEiQ92122.

Expressioni

Developmental stagei

Expressed in all stages of tadpole development. In the tail, high levels found in the premetamorphic stage (levels 54-60). Levels decrease with tail resorption. In the hindlimb, low expression during limb morphogenesis (stages 54-56), increased levels with limb growth (stages 58-66). Levels increase only slightly during intestine remodeling.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

BioGridi100773. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ92122.
SMRiQ92122. Positions 9-527.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pyruvate kinase family.Curated

Phylogenomic databases

HOVERGENiHBG000941.
KOiK00873.

Family and domain databases

Gene3Di2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProiIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
PROSITEiPS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92122-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSEAGSAFIQ TQQLHAAMAD TFLEHMCRLD IDSEPIVARN TGIICTIGPA
60 70 80 90 100
SRSVEMLKEM IKSGMNIARL NFSHGTHEYH AGTIKNVREA TESLASNPIH
110 120 130 140 150
YRPVAVALDT KGPEIRTGLI KGSGTAEVEL KKGATMRITL DDAFQENCDE
160 170 180 190 200
NVLWVDYKNL TKVVKPGSKI YVDDGLISLL VKEIGPDFCV TEIENGGMLG
210 220 230 240 250
SKKGVNLPGA AVDLPAVSSK DIQDLQFGVE QDVDMVFASF IRKAADVHEV
260 270 280 290 300
REVLGEKGKN IKIISKIENH EGVRRFDEIL EASDGIMVAR GDLGIEIPAE
310 320 330 340 350
KVFLAQKMMI GRCNRAGKPV ICATQMLESM IKKPRPTRAE GSDVANAVLD
360 370 380 390 400
GADCIMLSGE TAKGDYPLEA VRMQHAIARE AEAAIFHRQL FEELRRVSPL
410 420 430 440 450
TRDPTEATAV GAVEASFKCS SGAIIVLTKS GRSAHLLSRY RPRAPIISVT
460 470 480 490 500
RNGQTARQAH LYRGIFPVLY REAVHEAWAE DVDSRVNFAM DIGKARGFFK
510 520
SGDVVIVLTG WRPGSGFTNT MRVVPVP
Length:527
Mass (Da):57,525
Last modified:November 1, 1996 - v1
Checksum:iA8379F0E65325A66
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U03878 mRNA. Translation: AAA63581.1.
BC079921 mRNA. Translation: AAH79921.1.
RefSeqiNP_001084341.1. NM_001090872.1.
UniGeneiXl.21936.

Genome annotation databases

GeneIDi399448.
KEGGixla:399448.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U03878 mRNA. Translation: AAA63581.1 .
BC079921 mRNA. Translation: AAH79921.1 .
RefSeqi NP_001084341.1. NM_001090872.1.
UniGenei Xl.21936.

3D structure databases

ProteinModelPortali Q92122.
SMRi Q92122. Positions 9-527.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 100773. 1 interaction.

Proteomic databases

PRIDEi Q92122.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 399448.
KEGGi xla:399448.

Organism-specific databases

CTDi 5315.
Xenbasei XB-GENE-485877. pkm.

Phylogenomic databases

HOVERGENi HBG000941.
KOi K00873.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00188 .

Family and domain databases

Gene3Di 2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProi IPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view ]
PANTHERi PTHR11817. PTHR11817. 1 hit.
Pfami PF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view ]
PRINTSi PR01050. PYRUVTKNASE.
SUPFAMi SSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsi TIGR01064. pyruv_kin. 1 hit.
PROSITEi PS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Tissue-dependent developmental expression of a cytosolic thyroid hormone protein gene in Xenopus: its role in the regulation of amphibian metamorphosis."
    Shi Y.-B., Liang V.C.-T., Parkison C., Cheng S.-Y.
    FEBS Lett. 355:61-64(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Intestine.
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.

Entry informationi

Entry nameiKPYM_XENLA
AccessioniPrimary (citable) accession number: Q92122
Secondary accession number(s): Q68FC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 1, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3