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Protein

Cytochrome P450 1A1

Gene

cyp1a1

Organism
Stenotomus chrysops (Scup) (Sparus chrysops)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei229 – 2291SubstrateBy similarity
Metal bindingi463 – 4631Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 1A1 (EC:1.14.14.1)
Alternative name(s):
CYPIA1
Gene namesi
Name:cyp1a1
OrganismiStenotomus chrysops (Scup) (Sparus chrysops)
Taxonomic identifieri35579 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaSpariformesSparidaeStenotomus

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 521521Cytochrome P450 1A1PRO_0000051648Add
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG106944.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92116-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLMILPVIG SVSVSEGLVA MITMCLAYLI LRLFRTEIPE GLLQLPGPKP
60 70 80 90 100
LPIIGNVLEV GRNPYLSLTA MSKRYGDVFQ IQIGMRPVVV LSGSETVRQA
110 120 130 140 150
LIKQGDXFAG RPDLYSFRFI NDGKSLAFST DQAGVWRARR KLAYSALRSF
160 170 180 190 200
ATLEGTTPEY SCALEEHVSK EAEYLVKQLH TVMEADGSFD PFRHIVVSVA
210 220 230 240 250
NVICGMCFGR RYDHNHQELL NLVNLSDEFG QVVASGNPAD FIPILQYLPS
260 270 280 290 300
TTMKKFLNIN DRFNTFVQKI VSEHYTTFDK DNIRDITDSL IDHCEDRKLD
310 320 330 340 350
ENSNVQMSDE KIVGIVNDLF GAGFDTISTA LSWSVMYLVA YPEIQERLYQ
360 370 380 390 400
EMNETVGPDR TPCLSDKPKL PFLEAFILET FRHSSFLPFT IPHCTSKDTS
410 420 430 440 450
LNGYFIPKDT CVFINQWQIN HDAELWKDPS SFNPDRFLNA DGTEVNKLEG
460 470 480 490 500
EKMMVFGMGK RRCIGEVIAR SEVFLFLAIL VQNLRFHSMP GEPLDMTPEY
510 520
GLTMKHKRCQ LRAAMRARNE E
Length:521
Mass (Da):59,020
Last modified:November 1, 1996 - v1
Checksum:i8BDC4312074025D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14162 mRNA. Translation: AAA74969.1.
PIRiS55318.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14162 mRNA. Translation: AAA74969.1.
PIRiS55318.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG106944.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of cytochrome P-450 1A (CYP1A) genes from two teleost fish, toadfish (Opsanus tau) and scup (Stenotomus chrysops), and phylogenetic analysis of CYP1A genes."
    Morrison H.G., Oleksiak M.F., Cornell N.W., Sogin M.L., Stegeman J.J.
    Biochem. J. 308:97-104(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiCP1A1_STECH
AccessioniPrimary (citable) accession number: Q92116
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: January 7, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.