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Q92116 (CP1A1_STECH) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 1A1

EC=1.14.14.1
Alternative name(s):
CYPIA1
Gene names
Name:cyp1a1
OrganismStenotomus chrysops (Scup) (Sparus chrysops)
Taxonomic identifier35579 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataPercomorphariaSpariformesSparidaeStenotomus

Protein attributes

Sequence length521 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
Membrane
Microsome
   LigandHeme
Iron
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaromatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

heme binding

Inferred from electronic annotation. Source: InterPro

iron ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 521521Cytochrome P450 1A1
PRO_0000051648

Sites

Metal binding4631Iron (heme axial ligand) By similarity
Binding site2291Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q92116 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 8BDC4312074025D4

FASTA52159,020
        10         20         30         40         50         60 
MVLMILPVIG SVSVSEGLVA MITMCLAYLI LRLFRTEIPE GLLQLPGPKP LPIIGNVLEV 

        70         80         90        100        110        120 
GRNPYLSLTA MSKRYGDVFQ IQIGMRPVVV LSGSETVRQA LIKQGDXFAG RPDLYSFRFI 

       130        140        150        160        170        180 
NDGKSLAFST DQAGVWRARR KLAYSALRSF ATLEGTTPEY SCALEEHVSK EAEYLVKQLH 

       190        200        210        220        230        240 
TVMEADGSFD PFRHIVVSVA NVICGMCFGR RYDHNHQELL NLVNLSDEFG QVVASGNPAD 

       250        260        270        280        290        300 
FIPILQYLPS TTMKKFLNIN DRFNTFVQKI VSEHYTTFDK DNIRDITDSL IDHCEDRKLD 

       310        320        330        340        350        360 
ENSNVQMSDE KIVGIVNDLF GAGFDTISTA LSWSVMYLVA YPEIQERLYQ EMNETVGPDR 

       370        380        390        400        410        420 
TPCLSDKPKL PFLEAFILET FRHSSFLPFT IPHCTSKDTS LNGYFIPKDT CVFINQWQIN 

       430        440        450        460        470        480 
HDAELWKDPS SFNPDRFLNA DGTEVNKLEG EKMMVFGMGK RRCIGEVIAR SEVFLFLAIL 

       490        500        510        520 
VQNLRFHSMP GEPLDMTPEY GLTMKHKRCQ LRAAMRARNE E 

« Hide

References

[1]"Identification of cytochrome P-450 1A (CYP1A) genes from two teleost fish, toadfish (Opsanus tau) and scup (Stenotomus chrysops), and phylogenetic analysis of CYP1A genes."
Morrison H.G., Oleksiak M.F., Cornell N.W., Sogin M.L., Stegeman J.J.
Biochem. J. 308:97-104(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U14162 mRNA. Translation: AAA74969.1.
PIRS55318.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG106944.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008066. Cyt_P450_E_grp-I_CYP1.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01683. EP450ICYP1A.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP1A1_STECH
AccessionPrimary (citable) accession number: Q92116
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families