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Q92116

- CP1A1_STECH

UniProt

Q92116 - CP1A1_STECH

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Protein
Cytochrome P450 1A1
Gene
cyp1a1
Organism
Stenotomus chrysops (Scup) (Sparus chrysops)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei229 – 2291Substrate By similarity
Metal bindingi463 – 4631Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 1A1 (EC:1.14.14.1)
    Alternative name(s):
    CYPIA1
    Gene namesi
    Name:cyp1a1
    OrganismiStenotomus chrysops (Scup) (Sparus chrysops)
    Taxonomic identifieri35579 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataPercomorphariaSpariformesSparidaeStenotomus

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 521521Cytochrome P450 1A1
    PRO_0000051648Add
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.

    Phylogenomic databases

    HOVERGENiHBG106944.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92116-1 [UniParc]FASTAAdd to Basket

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    MVLMILPVIG SVSVSEGLVA MITMCLAYLI LRLFRTEIPE GLLQLPGPKP    50
    LPIIGNVLEV GRNPYLSLTA MSKRYGDVFQ IQIGMRPVVV LSGSETVRQA 100
    LIKQGDXFAG RPDLYSFRFI NDGKSLAFST DQAGVWRARR KLAYSALRSF 150
    ATLEGTTPEY SCALEEHVSK EAEYLVKQLH TVMEADGSFD PFRHIVVSVA 200
    NVICGMCFGR RYDHNHQELL NLVNLSDEFG QVVASGNPAD FIPILQYLPS 250
    TTMKKFLNIN DRFNTFVQKI VSEHYTTFDK DNIRDITDSL IDHCEDRKLD 300
    ENSNVQMSDE KIVGIVNDLF GAGFDTISTA LSWSVMYLVA YPEIQERLYQ 350
    EMNETVGPDR TPCLSDKPKL PFLEAFILET FRHSSFLPFT IPHCTSKDTS 400
    LNGYFIPKDT CVFINQWQIN HDAELWKDPS SFNPDRFLNA DGTEVNKLEG 450
    EKMMVFGMGK RRCIGEVIAR SEVFLFLAIL VQNLRFHSMP GEPLDMTPEY 500
    GLTMKHKRCQ LRAAMRARNE E 521
    Length:521
    Mass (Da):59,020
    Last modified:November 1, 1996 - v1
    Checksum:i8BDC4312074025D4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U14162 mRNA. Translation: AAA74969.1.
    PIRiS55318.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U14162 mRNA. Translation: AAA74969.1 .
    PIRi S55318.

    3D structure databases

    ModBasei Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG106944.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008066. Cyt_P450_E_grp-I_CYP1.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01683. EP450ICYP1A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of cytochrome P-450 1A (CYP1A) genes from two teleost fish, toadfish (Opsanus tau) and scup (Stenotomus chrysops), and phylogenetic analysis of CYP1A genes."
      Morrison H.G., Oleksiak M.F., Cornell N.W., Sogin M.L., Stegeman J.J.
      Biochem. J. 308:97-104(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiCP1A1_STECH
    AccessioniPrimary (citable) accession number: Q92116
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: November 1, 1996
    Last modified: June 11, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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