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Q92113

- CP17A_SQUAC

UniProt

Q92113 - CP17A_SQUAC

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Protein

Steroid 17-alpha-hydroxylase/17,20 lyase

Gene

CYP17A1

Organism
Squalus acanthias (Spiny dogfish)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction.

Catalytic activityi

A C(21)-steroid + (reduced NADPH--hemoprotein reductase) + O2 = a 17-alpha-hydroxy-C(21)-steroid + (oxidized NADPH--hemoprotein reductase) + H2O.
17-alpha-hydroxyprogesterone = androst-4-ene-3,17-dione + acetaldehyde.

Cofactori

hemeBy similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi445 – 4451Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. 17-alpha-hydroxyprogesterone aldolase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
  4. steroid 17-alpha-monooxygenase activity Source: UniProtKB-EC

GO - Biological processi

  1. steroid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase, Monooxygenase, Oxidoreductase

Keywords - Biological processi

Steroidogenesis

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00062.

Names & Taxonomyi

Protein namesi
Recommended name:
Steroid 17-alpha-hydroxylase/17,20 lyase (EC:1.14.99.9, EC:4.1.2.30)
Alternative name(s):
17-alpha-hydroxyprogesterone aldolase
CYPXVII
Cytochrome P450 17A1
Cytochrome P450-C17
Short name:
Cytochrome P450c17
Gene namesi
Name:CYP17A1
Synonyms:CYP17
OrganismiSqualus acanthias (Spiny dogfish)
Taxonomic identifieri7797 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataChondrichthyesElasmobranchiiSqualimorphiiSqualiformesSqualidaeSqualus

Subcellular locationi

Membrane Curated

GO - Cellular componenti

  1. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 509509Steroid 17-alpha-hydroxylase/17,20 lyasePRO_0000051947Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ92113.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG106944.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92113-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLMLAALIL TVAFVICSLT GFTQRKLSGG RLPKCLPSFP LIGSLLSLRS
60 70 80 90 100
DLPPHLLFQK LQKTYGNLFS LMMGPHYAVV INNHQHAKEV LLKKGKIFAG
110 120 130 140 150
RPSMVTTDLL SRGGKDIAFG KYGPAWKFHR KLVLSALHLF GDGSAGIEKM
160 170 180 190 200
ICQEATSMCS TFERLNNAAH DMMPDVTRAV TNVICLLCFN STYEKEDPEF
210 220 230 240 250
QTMRKYSQGI VNTVAKDSLI DIFPWLQFFP NENLHTLKQC IATRDSILQK
260 270 280 290 300
KFEDHKANYS SDSANDLFNI LLKAKMNAEN NNSSVHEAGL TDDHMVMTVA
310 320 330 340 350
DIFGAGVETS STAFAWMIIY LIHHPEVQKK IQEEIDSNIG FERTPKMSDK
360 370 380 390 400
GNMNFLNATI HEILRIQPVS PLLIPHVALA DSSIGDYTIP KGTRVIINLW
410 420 430 440 450
AIHHDEKEWK NPDAFDPGRF LDEDGKYVCS SSESYLPFGA GTRVCLGEML
460 470 480 490 500
ARMELFLFTS WILQRFTVQV PPGYPPPDKE GKFGIVLQPL KFKVQLKLRK

AWENRGLHD
Length:509
Mass (Da):57,208
Last modified:November 1, 1996 - v1
Checksum:i9D9F1CA18050EF60
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S77384 mRNA. Translation: AAB34256.1.
PIRiI51281.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S77384 mRNA. Translation: AAB34256.1 .
PIRi I51281.

3D structure databases

ProteinModelPortali Q92113.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG106944.

Enzyme and pathway databases

UniPathwayi UPA00062 .

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and characterization of the cDNA encoding the spiny dogfish shark (Squalus acanthias) form of cytochrome P450c17."
    Trant J.M.
    J. Exp. Zool. 272:25-33(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCP17A_SQUAC
AccessioniPrimary (citable) accession number: Q92113
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3