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Protein

Aromatase

Gene

CYP19A1

Organism
Taeniopygia guttata (Zebra finch) (Poephila guttata)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Catalytic activityi

Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.
Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi437Iron (heme axial ligand)By similarity1

GO - Molecular functioni

  • aromatase activity Source: AgBase
  • heme binding Source: InterPro
  • iron ion binding Source: InterPro

GO - Biological processi

  • brain development Source: AgBase
  • cellular response to estradiol stimulus Source: AgBase
  • estrogen biosynthetic process Source: AgBase
  • memory Source: AgBase
  • negative regulation of testosterone secretion Source: AgBase
  • positive regulation of cell proliferation Source: AgBase
  • positive regulation of estradiol secretion Source: AgBase
  • regulation of organ morphogenesis Source: AgBase
  • response to aromatase inhibitor Source: AgBase
  • social behavior Source: AgBase
  • tissue development Source: AgBase
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Aromatase (EC:1.14.14.14)
Alternative name(s):
CYPXIX
Cytochrome P-450AROM
Cytochrome P450 19A1
Estrogen synthase
Gene namesi
Name:CYP19A1
Synonyms:CYP19
OrganismiTaeniopygia guttata (Zebra finch) (Poephila guttata)
Taxonomic identifieri59729 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaePasseriformesPasseroideaEstrildidaeEstrildinaeTaeniopygia
Proteomesi
  • UP000007754 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  • cell Source: AgBase
  • cell body Source: AgBase
  • dendrite Source: AgBase
  • membrane Source: UniProtKB-SubCell
  • neuronal cell body Source: AgBase
  • terminal bouton Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000519731 – 509AromataseAdd BLAST509

Interactioni

Protein-protein interaction databases

STRINGi59729.ENSTGUP00000007225.

Structurei

3D structure databases

ProteinModelPortaliQ92112.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0157. Eukaryota.
COG2124. LUCA.
HOGENOMiHOG000111912.
HOVERGENiHBG050750.
InParanoidiQ92112.
KOiK07434.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92112-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLETLNPLH YNITSLVPDT MPVATVPILI LMCFLFLIWN HEETSSIPGP
60 70 80 90 100
GYCMGIGPLI SHGRFLWMGV GNACNYYNKT YGDFVRVWIS GEETFIISKS
110 120 130 140 150
SSVSHVMKHW HYVSRFGSKL GLQCIGMYEN GIIFNNNPAH WKEIRPFFTK
160 170 180 190 200
ALSGPGLVRM IAICVESTTE HLDRLQEVTT ELGNINALNL MRRIMLDTSN
210 220 230 240 250
KLFLGVPLDE NAIVLKIQNY FDAWQALLLK PDIFFKISWL CKKYKDAVKD
260 270 280 290 300
LKGAMEILIE QKRQKLSTVE KLDEHMDFAS QLIFAQNRGD LTAENVNQCV
310 320 330 340 350
LEMMIAAPDT LSVTLFFMLI LIAEHPTVEE EMMREIETVV GDRDIQSDDM
360 370 380 390 400
PNLKIVENFI YESMRYQPVV DLIMRKALQD DVIDGYPVKK GTNIILNIGR
410 420 430 440 450
MHKLEFFPKP NEFSLENFEK NVPSRYFQPF GFGPRSCVGK FIAMVMMKAI
460 470 480 490 500
LVTLLRRCRV QTMKGRGLNN IQKNNDLSMH PIERQPLLEM VFTPRRNANE

NQGDGMDQH
Length:509
Mass (Da):58,390
Last modified:November 1, 1996 - v1
Checksum:iB127ED20F18E3260
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L81143 mRNA. Translation: AAL77515.1.
S75898 mRNA. Translation: AAB32404.1.
PIRiI51271.
RefSeqiNP_001070159.1. NM_001076691.2.
UniGeneiTgu.6794.

Genome annotation databases

GeneIDi751777.
KEGGitgu:751777.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L81143 mRNA. Translation: AAL77515.1.
S75898 mRNA. Translation: AAB32404.1.
PIRiI51271.
RefSeqiNP_001070159.1. NM_001076691.2.
UniGeneiTgu.6794.

3D structure databases

ProteinModelPortaliQ92112.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi59729.ENSTGUP00000007225.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi751777.
KEGGitgu:751777.

Organism-specific databases

CTDi1588.

Phylogenomic databases

eggNOGiKOG0157. Eukaryota.
COG2124. LUCA.
HOGENOMiHOG000111912.
HOVERGENiHBG050750.
InParanoidiQ92112.
KOiK07434.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCP19A_TAEGU
AccessioniPrimary (citable) accession number: Q92112
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: February 17, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.