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Q92112 (CP19A_TAEGU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aromatase

EC=1.14.14.14
Alternative name(s):
CYPXIX
Cytochrome P-450AROM
Cytochrome P450 19A1
Estrogen synthase
Gene names
Name:CYP19A1
Synonyms:CYP19
OrganismTaeniopygia guttata (Zebra finch) (Poephila guttata) [Reference proteome]
Taxonomic identifier59729 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaePasseriformesPasseroideaEstrildidaeEstrildinaeTaeniopygia

Protein attributes

Sequence length509 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Catalytic activity

Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.

Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

Cofactor

Heme group By similarity.

Subcellular location

Membrane; Peripheral membrane protein.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 509509Aromatase
PRO_0000051973

Sites

Metal binding4371Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q92112 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: B127ED20F18E3260

FASTA50958,390
        10         20         30         40         50         60 
MVLETLNPLH YNITSLVPDT MPVATVPILI LMCFLFLIWN HEETSSIPGP GYCMGIGPLI 

        70         80         90        100        110        120 
SHGRFLWMGV GNACNYYNKT YGDFVRVWIS GEETFIISKS SSVSHVMKHW HYVSRFGSKL 

       130        140        150        160        170        180 
GLQCIGMYEN GIIFNNNPAH WKEIRPFFTK ALSGPGLVRM IAICVESTTE HLDRLQEVTT 

       190        200        210        220        230        240 
ELGNINALNL MRRIMLDTSN KLFLGVPLDE NAIVLKIQNY FDAWQALLLK PDIFFKISWL 

       250        260        270        280        290        300 
CKKYKDAVKD LKGAMEILIE QKRQKLSTVE KLDEHMDFAS QLIFAQNRGD LTAENVNQCV 

       310        320        330        340        350        360 
LEMMIAAPDT LSVTLFFMLI LIAEHPTVEE EMMREIETVV GDRDIQSDDM PNLKIVENFI 

       370        380        390        400        410        420 
YESMRYQPVV DLIMRKALQD DVIDGYPVKK GTNIILNIGR MHKLEFFPKP NEFSLENFEK 

       430        440        450        460        470        480 
NVPSRYFQPF GFGPRSCVGK FIAMVMMKAI LVTLLRRCRV QTMKGRGLNN IQKNNDLSMH 

       490        500 
PIERQPLLEM VFTPRRNANE NQGDGMDQH 

« Hide

References

[1]"Isolation and characterization of a zebra finch aromatase cDNA: in situ hybridization reveals high aromatase expression in brain."
Shen P., Campagnoni C.W., Kampf K., Schlinger B.A., Arnold A.P., Campagnoni A.T.
Brain Res. Mol. Brain Res. 24:227-237(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Ovary.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L81143 mRNA. Translation: AAL77515.1.
S75898 mRNA. Translation: AAB32404.1.
PIRI51271.
RefSeqNP_001070159.1. NM_001076691.2.
UniGeneTgu.6794.

3D structure databases

ProteinModelPortalQ92112.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING59729.ENSTGUP00000007225.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID751777.
KEGGtgu:751777.

Organism-specific databases

CTD1588.

Phylogenomic databases

eggNOGCOG2124.
HOGENOMHOG000111912.
HOVERGENHBG050750.
KOK07434.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP19A_TAEGU
AccessionPrimary (citable) accession number: Q92112
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: January 22, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families