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Q92112

- CP19A_TAEGU

UniProt

Q92112 - CP19A_TAEGU

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Protein

Aromatase

Gene

CYP19A1

Organism
Taeniopygia guttata (Zebra finch) (Poephila guttata)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

Catalytic activityi

Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.
Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

Cofactori

Heme group.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi437 – 4371Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. monooxygenase activity Source: UniProtKB-KW
  4. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Aromatase (EC:1.14.14.14)
Alternative name(s):
CYPXIX
Cytochrome P-450AROM
Cytochrome P450 19A1
Estrogen synthase
Gene namesi
Name:CYP19A1
Synonyms:CYP19
OrganismiTaeniopygia guttata (Zebra finch) (Poephila guttata)
Taxonomic identifieri59729 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaePasseriformesPasseroideaEstrildidaeEstrildinaeTaeniopygia
ProteomesiUP000007754: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 509509AromatasePRO_0000051973Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi59729.ENSTGUP00000007225.

Structurei

3D structure databases

ProteinModelPortaliQ92112.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000111912.
HOVERGENiHBG050750.
InParanoidiQ92112.
KOiK07434.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92112-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVLETLNPLH YNITSLVPDT MPVATVPILI LMCFLFLIWN HEETSSIPGP
60 70 80 90 100
GYCMGIGPLI SHGRFLWMGV GNACNYYNKT YGDFVRVWIS GEETFIISKS
110 120 130 140 150
SSVSHVMKHW HYVSRFGSKL GLQCIGMYEN GIIFNNNPAH WKEIRPFFTK
160 170 180 190 200
ALSGPGLVRM IAICVESTTE HLDRLQEVTT ELGNINALNL MRRIMLDTSN
210 220 230 240 250
KLFLGVPLDE NAIVLKIQNY FDAWQALLLK PDIFFKISWL CKKYKDAVKD
260 270 280 290 300
LKGAMEILIE QKRQKLSTVE KLDEHMDFAS QLIFAQNRGD LTAENVNQCV
310 320 330 340 350
LEMMIAAPDT LSVTLFFMLI LIAEHPTVEE EMMREIETVV GDRDIQSDDM
360 370 380 390 400
PNLKIVENFI YESMRYQPVV DLIMRKALQD DVIDGYPVKK GTNIILNIGR
410 420 430 440 450
MHKLEFFPKP NEFSLENFEK NVPSRYFQPF GFGPRSCVGK FIAMVMMKAI
460 470 480 490 500
LVTLLRRCRV QTMKGRGLNN IQKNNDLSMH PIERQPLLEM VFTPRRNANE

NQGDGMDQH
Length:509
Mass (Da):58,390
Last modified:November 1, 1996 - v1
Checksum:iB127ED20F18E3260
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L81143 mRNA. Translation: AAL77515.1.
S75898 mRNA. Translation: AAB32404.1.
PIRiI51271.
RefSeqiNP_001070159.1. NM_001076691.2.
UniGeneiTgu.6794.

Genome annotation databases

GeneIDi751777.
KEGGitgu:751777.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L81143 mRNA. Translation: AAL77515.1 .
S75898 mRNA. Translation: AAB32404.1 .
PIRi I51271.
RefSeqi NP_001070159.1. NM_001076691.2.
UniGenei Tgu.6794.

3D structure databases

ProteinModelPortali Q92112.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 59729.ENSTGUP00000007225.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 751777.
KEGGi tgu:751777.

Organism-specific databases

CTDi 1588.

Phylogenomic databases

eggNOGi COG2124.
HOGENOMi HOG000111912.
HOVERGENi HBG050750.
InParanoidi Q92112.
KOi K07434.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and characterization of a zebra finch aromatase cDNA: in situ hybridization reveals high aromatase expression in brain."
    Shen P., Campagnoni C.W., Kampf K., Schlinger B.A., Arnold A.P., Campagnoni A.T.
    Brain Res. Mol. Brain Res. 24:227-237(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiCP19A_TAEGU
AccessioniPrimary (citable) accession number: Q92112
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3