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Q92112

- CP19A_TAEGU

UniProt

Q92112 - CP19A_TAEGU

Protein

Aromatase

Gene

CYP19A1

Organism
Taeniopygia guttata (Zebra finch) (Poephila guttata)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

    Catalytic activityi

    Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.
    Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi437 – 4371Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. monooxygenase activity Source: UniProtKB-KW
    4. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aromatase (EC:1.14.14.14)
    Alternative name(s):
    CYPXIX
    Cytochrome P-450AROM
    Cytochrome P450 19A1
    Estrogen synthase
    Gene namesi
    Name:CYP19A1
    Synonyms:CYP19
    OrganismiTaeniopygia guttata (Zebra finch) (Poephila guttata)
    Taxonomic identifieri59729 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaePasseriformesPasseroideaEstrildidaeEstrildinaeTaeniopygia
    ProteomesiUP000007754: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 509509AromatasePRO_0000051973Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi59729.ENSTGUP00000007225.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92112.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000111912.
    HOVERGENiHBG050750.
    KOiK07434.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92112-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVLETLNPLH YNITSLVPDT MPVATVPILI LMCFLFLIWN HEETSSIPGP    50
    GYCMGIGPLI SHGRFLWMGV GNACNYYNKT YGDFVRVWIS GEETFIISKS 100
    SSVSHVMKHW HYVSRFGSKL GLQCIGMYEN GIIFNNNPAH WKEIRPFFTK 150
    ALSGPGLVRM IAICVESTTE HLDRLQEVTT ELGNINALNL MRRIMLDTSN 200
    KLFLGVPLDE NAIVLKIQNY FDAWQALLLK PDIFFKISWL CKKYKDAVKD 250
    LKGAMEILIE QKRQKLSTVE KLDEHMDFAS QLIFAQNRGD LTAENVNQCV 300
    LEMMIAAPDT LSVTLFFMLI LIAEHPTVEE EMMREIETVV GDRDIQSDDM 350
    PNLKIVENFI YESMRYQPVV DLIMRKALQD DVIDGYPVKK GTNIILNIGR 400
    MHKLEFFPKP NEFSLENFEK NVPSRYFQPF GFGPRSCVGK FIAMVMMKAI 450
    LVTLLRRCRV QTMKGRGLNN IQKNNDLSMH PIERQPLLEM VFTPRRNANE 500
    NQGDGMDQH 509
    Length:509
    Mass (Da):58,390
    Last modified:November 1, 1996 - v1
    Checksum:iB127ED20F18E3260
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L81143 mRNA. Translation: AAL77515.1.
    S75898 mRNA. Translation: AAB32404.1.
    PIRiI51271.
    RefSeqiNP_001070159.1. NM_001076691.2.
    UniGeneiTgu.6794.

    Genome annotation databases

    GeneIDi751777.
    KEGGitgu:751777.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L81143 mRNA. Translation: AAL77515.1 .
    S75898 mRNA. Translation: AAB32404.1 .
    PIRi I51271.
    RefSeqi NP_001070159.1. NM_001076691.2.
    UniGenei Tgu.6794.

    3D structure databases

    ProteinModelPortali Q92112.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 59729.ENSTGUP00000007225.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 751777.
    KEGGi tgu:751777.

    Organism-specific databases

    CTDi 1588.

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000111912.
    HOVERGENi HBG050750.
    KOi K07434.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of a zebra finch aromatase cDNA: in situ hybridization reveals high aromatase expression in brain."
      Shen P., Campagnoni C.W., Kampf K., Schlinger B.A., Arnold A.P., Campagnoni A.T.
      Brain Res. Mol. Brain Res. 24:227-237(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Ovary.

    Entry informationi

    Entry nameiCP19A_TAEGU
    AccessioniPrimary (citable) accession number: Q92112
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3